| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Outline of Final Research Achievements |
Based on the discovery that water-soluble melanin, which was developed by our group, strongly inhibits mast cell activation and cancer cell proliferation, this study was conducted to demonstrate whether the melanin is effective at the animal level and to elucidate the molecular mechanism. More detailed analysis at the cultured cell level allowed us to elucidate further molecular mechanisms of melanin. Oral administration of water-soluble melanin showed a significant inhibitory effect in both the allergy model and the cancer cell transplantation model. Identification of new molecules that may interact with melanin suggests the possibility of novel melanin receptors.
|
