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Study on biological response to high hydrostatic pressure

Research Project

Project/Area Number 17K20108
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering and related fields
Research InstitutionOkayama University

Principal Investigator

Naruse Keiji  岡山大学, 医歯薬学総合研究科, 教授 (40252233)

Research Collaborator FUJITA Ayano  
MATSUURA Koji  
Project Period (FY) 2017-06-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Keywordsメカノバイオロジー / メカノメディスン / 静水圧 / 生殖医療 / 圧力 / 機械刺激 / 生体工学
Outline of Final Research Achievements

Mechanical stimulus is important to maintain and increase tissue and organ homeostasis. However, the effect of pressurization on tissues is poorly understood due to the lack of methods that directly observe cells under high pressure condition. Here we designed the system to apply high hydrostatic pressure to cells and directly observe cellular response to high hydrostatic pressure in a real time. This system allows us to understand the mechanism of maintenance of homeostasis and obtain new knowledge in reproductive medicine.

Academic Significance and Societal Importance of the Research Achievements

軟骨組織への圧力受容応答メカニズムの知見は、高齢者に多く見られる変形性膝関節症の研究を加速し、歯根膜組織への圧力の指標は、機械刺激下での歯周組織の恒常性や、歯周組織リモデリングのメカニズムの解明に繋がると期待される.またヒト精子の運動能の向上については、生殖医療の向上に繋がることが期待される.

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (15 results)

All 2019 2018 2017

All Presentation (15 results) (of which Int'l Joint Research: 6 results,  Invited: 6 results)

  • [Presentation] Mechanomedicine.2019

    • Author(s)
      Naruse K
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] メカノメディスン:基礎医学研究から不妊治療・再生医療への展開のアップデート2019

    • Author(s)
      成瀬恵治
    • Organizer
      日本生物物理学会北海道支部会講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] メカノメディスン2019

    • Author(s)
      成瀬恵治
    • Organizer
      日本学術会議「心と脳など新しい領域検討小委員会」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Mechanomedicine.2018

    • Author(s)
      Naruse K
    • Organizer
      Mechanobiology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanomedicine and Piezobiology.2018

    • Author(s)
      Naruse K
    • Organizer
      The 10th International Conference on High Pressure Bioscience and Biotechnology (HPBB2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanical stress modulates the homeostasis of periodontal ligament.2018

    • Author(s)
      Fujita A, Morimatsu M, Nishiyama M, Takashiba S, Naruse K
    • Organizer
      ASCB 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Direct observation of chondrocytes under high hydrostatic pressure.2018

    • Author(s)
      Morimatsu M, Fujita A, Nishiyama M, Naruse K
    • Organizer
      ASCB 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Opening Remarks.2018

    • Author(s)
      成瀬恵治
    • Organizer
      第56回日本生物物理学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 生理的高圧下でのリアルタイム細胞動態計測2018

    • Author(s)
      森松賢順、藤田彩乃、綾 晃記、寺町一希、稲葉晃帆、成瀬恵治、西山雅祥
    • Organizer
      第59回高圧討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mechanical stress modulates the homeostasis of periodontal ligament.2018

    • Author(s)
      Fujita A, Morimatsu M, Nishiyama M, Takashiba S, Naruse K
    • Organizer
      第70回日本生理学会中国四国地方会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 静水圧負荷による軟骨細胞の圧力受容応答メカニズムの解明2018

    • Author(s)
      寺町一希、森松賢順、藤田彩乃、西山雅祥、成瀬恵治
    • Organizer
      第41回日本生体医工学会中国四国支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高圧下での細胞動態イメージング2018

    • Author(s)
      森松賢順、藤田彩乃、綾 晃記、西山雅祥、成瀬恵治
    • Organizer
      第57回日本生体医工学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 歯根膜細胞における機械刺激による恒常性への影響2018

    • Author(s)
      藤田彩乃、森松賢順、西山雅祥、高柴正悟、成瀬恵治
    • Organizer
      第57回日本生体医工学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高静水圧下におけるマウス心筋細胞への影響2018

    • Author(s)
      山口陽平、西山雅祥、甲斐寛彬、入部玄太郎、成瀬恵治、森松賢順
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Morimatsu M, Aya K, Fujita A, Nishiyama M, Naruse K2017

    • Author(s)
      Direct observation of cell mechanics under high hydrostatic pressure.
    • Organizer
      ASCB2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-07-21   Modified: 2020-03-30  

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