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Investigation of mechanisms underlying visual processing and behavior

Research Project

Project/Area Number 17K20147
Research Category

Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)

Allocation TypeMulti-year Fund
Review Section Biological Sciences
Research InstitutionNational Institute of Genetics

Principal Investigator

KUBO Fumi  国立遺伝学研究所, 新分野創造センター, 准教授 (40786373)

Research Collaborator KITAGAWA Mako  
FIALLOS OLIVEROS Carolina  
Project Period (FY) 2018 – 2020
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥55,640,000 (Direct Cost: ¥42,800,000、Indirect Cost: ¥12,840,000)
Keywords視覚情報 / 神経回路 / オプティックフロー / ゼブラフィッシュ / Ca^<2+>イメージング / 視覚 / コネクトーム / 前視蓋 / 電子顕微鏡画像解析 / カルシウムイメージング / FuGIMA
Outline of Final Research Achievements

The pretectum is composed of several types of neurons that respond differentially to optic flow visual stimuli. Neural network generated by these pretectal neurons forms the basis for distinguishing different optic flow patterns. We have succeeded in genetically labeling pretectal neurons that respond to optic flow and found that a specific type of optic flow-responsive neurons may contribute to the computation of optic flow. Furthermore, morphological reconstructions of optic flow-responsive neurons revealed an anatomical basis for computing binocular responses from monocular responses.

Academic Significance and Societal Importance of the Research Achievements

本研究により、オプティックフロー情報処理の神経ネットワークに関する機能的および解剖学的メカニズムの一端が明らかとなった。本研究成果は、感覚-運動変換の神経メカニズムに関する基本原理の解明に貢献すると言える。また、ほ乳類大脳皮質などの高次脳機能に広く共通する神経メカニズムの理解に役立つ可能性がある。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (20 results)

All 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (6 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (12 results) (of which Int'l Joint Research: 2 results,  Invited: 8 results) Remarks (1 results)

  • [Int'l Joint Research] マックスプランク研究所神経生物学/Center of advanced European studies and research(ドイツ)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] An Optical Illusion Pinpoints an Essential Circuit Node for Global Motion Processing2020

    • Author(s)
      Yunmin Wu, Marco dal Maschio, Fumi Kubo, Herwig Baier
    • Journal Title

      Neuron

      Volume: 108 Issue: 4 Pages: 722-734

    • DOI

      10.1016/j.neuron.2020.08.027

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A calibrated optogenetic toolbox of stable zebrafish opsin lines2020

    • Author(s)
      Antinucci P, Dumitrescu A, Deleuze C, Morley HJ, Leung K, Hagley T, Kubo F, Baier H, Bianco IH, Wyart C.
    • Journal Title

      eLife

      Volume: 9

    • DOI

      10.7554/elife.54937

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neuronal Architecture of a Visual Center that Processes Optic Flow2019

    • Author(s)
      Kramer A, Wu Y, Baier H, Kubo F.
    • Journal Title

      Neuron

      Volume: 103 Issue: 1 Pages: 118-132

    • DOI

      10.1016/j.neuron.2019.04.018

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Cellular-Resolution Atlas of the Larval Zebrafish Brain2019

    • Author(s)
      Kunst M, Laurell E, Mokayes N, Kramer A, Kubo F, Fernandes AM, Förster D, Dal Maschio M, Baier H.
    • Journal Title

      Neuron

      Volume: 103 Issue: 1 Pages: 21-38

    • DOI

      10.1016/j.neuron.2019.04.034

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 視覚による行動選択の神経基盤2019

    • Author(s)
      久保 郁
    • Journal Title

      生体の科学 特集「脳神経回路のダイナミクスから探る脳の発達・疾患・老化」

      Volume: 70 Pages: 53-57

    • Related Report
      2018 Research-status Report
  • [Journal Article] Optogenetic precision toolkit to reveal form, function and connectivity of single neurons2018

    • Author(s)
      Förster D, Kramer A, Baier H, Kubo F.
    • Journal Title

      Methods

      Volume: 50 Pages: 42-48

    • DOI

      10.1016/j.ymeth.2018.08.012

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] ゼブラフィッシュにおける錯視反応とその視覚情報処理回路2020

    • Author(s)
      久保 郁
    • Organizer
      第18回 北海道大学脳科学研究教育センターシンポジウム 「感覚と運動の神経基盤の進化 ~非哺乳類脳から学ぶ計算原理~」
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 錯視反応を用いた動きの視覚情報処理を担う神経回路の解析2020

    • Author(s)
      久保 郁
    • Organizer
      第43回 日本神経科学会大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ゼブラフィッシュにおける視覚情報処理と行動制御メカニズム2019

    • Author(s)
      久保 郁
    • Organizer
      感覚器研究イニシアチブ・シンポジウム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] オプティックフロー情報処理に関わる神経回路の解剖学的基盤2019

    • Author(s)
      久保 郁
    • Organizer
      Neuro2019、シンポジウム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 全脳にわたる包括的な神経ネットワーク解析とその先2019

    • Author(s)
      久保 郁
    • Organizer
      Neuro2019、大会長企画シンポジウム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Function and connectivity of a visual circuit underlying optic flow processing in zebrafish2019

    • Author(s)
      久保 郁
    • Organizer
      The Joint Symposium on Fusion of Biomedical and Physical/Informational Sciences in Neurobiology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Neuronal architecture of a visual center that processes optic flow2019

    • Author(s)
      久保 郁
    • Organizer
      第42回日本分子生物学会年会、ワークショップ
    • Related Report
      2019 Research-status Report
  • [Presentation] 視運動の情報処理に関わる神経ネットワークのイメージング解析2019

    • Author(s)
      久保 郁
    • Organizer
      第13回バイオイメージングフォーラム&基生研重点共同利用合同シンポジウム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Cellular composition of the optic flow processing circuit in the zebrafish pretectum2018

    • Author(s)
      久保 郁
    • Organizer
      国立遺伝学研究所・研究会「哺乳類脳の機能的神経回路の構築メカニズム」
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Function and connectivity of optic flow processing circuit in the zebrafish pretectum2018

    • Author(s)
      久保 郁
    • Organizer
      Cold Spring Harbor Asia Conference “Latest Advances in Development & Function of Neuronal Circuits”
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Function and connectivity of optic flow processing circuit in the zebrafish pretectum2018

    • Author(s)
      久保 郁
    • Organizer
      第24回小型魚類研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] Function and connectivity of optic flow processing circuit in the zebrafish pretectum2018

    • Author(s)
      久保 郁
    • Organizer
      第41回神経科学大会
    • Related Report
      2018 Research-status Report
  • [Remarks] 【研究内容や研究成果に関するWebページ】 国立遺伝学研究所 久保研究室 ホームページ

    • URL

      http://kubolab.jp/wp/

    • Related Report
      2020 Annual Research Report

URL: 

Published: 2018-03-28   Modified: 2022-04-15  

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