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The role of mTORC2/c-Myc pathway in exercise-induced skeletal muscle adaptation

Research Project

Project/Area Number 17KK0192
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionNagoya Institute of Technology

Principal Investigator

Ogasawara Riki  名古屋工業大学, 工学(系)研究科(研究院), 准教授 (10634602)

Project Period (FY) 2018 – 2020
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Keywords筋収縮 / mTOR / リボソーム / タンパク質合成 / 解糖系 / エネルギー代謝 / 遺伝子導入 / c-Myc / アデノ随伴ウィルス / リボソーム生合成 / RNA-Seq / ラパマイシン / SGK1 / mTORC1 / 筋肥大 / mTORC2 / Rictor / 遺伝子改変マウス / AAV / ミトコンドリア / 同化抵抗性
Outline of Final Research Achievements

In the present study, we found that c-Myc was increased by resistance exercise via mTORC2. In addition, we found that c-Myc increased ribosome biogenesis and muscle protein synthesis, and that c-Myc also increased proteins involved in energy metabolism, such as glucose transporters, glycolytic enzymes, and mitochondria-related proteins. c-Myc did not change significantly by endurance exercise, suggesting that c-Myc may be involved in protein anabolism and energy metabolism improvement specific to resistance exercise.

Academic Significance and Societal Importance of the Research Achievements

レジスタンス運動は筋肥大や筋力増強効果があることがよく知られているが,持久性運動のようなエネルギー代謝改善効果も観察される.本研究ではc-Mycがレジスタンス運動によるタンパク質同化作用に関わることに加え,エネルギー代謝改善にも関わることを明らかにした.c-Mycの増加はレジスタンス運動に特徴的な変化であり,持久性運動では大きく変化しない.したがって,c-Mycの増加はレジスタンス運動特異的な新規のエネルギー代謝改善メカニズムであると考えられる.今後その調節メカニズム等を詳細に解析することで,運動や栄養介入効果の最適化に貢献する魅力的な分子ターゲットとなる可能性がある.

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Open Access: 2 results,  Peer Reviewed: 2 results) Presentation (2 results) (of which Invited: 1 results) Remarks (2 results)

  • [Int'l Joint Research] University of Copenhagen(デンマーク)2018

    • Year and Date
      2018-05-08
    • Related Report
      2020 Annual Research Report
  • [Journal Article] c-Myc Overexpression Increases Ribosome Biogenesis and Protein Synthesis Independent of mTORC1 Activation in Mouse Skeletal Muscle2020

    • Author(s)
      Mori Takahiro、Ato Satoru、Knudsen Jonas R.、Henriquez-Olguin Carlos、Li Zhencheng、Wakabayashi Koki、Suginohara Takeshi、Higashida Kazuhiko、Tamura Yuki、Nakazato Koichi、Jensen Thomas E.、Ogasawara Riki
    • Journal Title

      Research Square

      Volume: -

    • DOI

      10.21203/rs.3.rs-124889/v1

    • Related Report
      2020 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] Rapamycin and mTORC2 inhibition synergistically reduce contraction‐stimulated muscle protein synthesis2020

    • Author(s)
      Ogasawara Riki、Knudsen Jonas R.、Li Jingwen、Ato Satoru、Jensen Thomas E.
    • Journal Title

      The Journal of Physiology

      Volume: 598 Issue: 23 Pages: 5453-5466

    • DOI

      10.1113/jp280528

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Resistance Exercise-Induced Hypertrophy: A Potential Role for Rapamycin-Insensitive mTOR.2019

    • Author(s)
      Ogasawara R, Jensen TE, Goodman CA, Hornberger TA
    • Journal Title

      Exercise and sport sciences reviews

      Volume: 印刷中 Issue: 3 Pages: 188-194

    • DOI

      10.1249/jes.0000000000000189

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 骨格筋の運動適応におけるmTORC2/c-Myc経路の役割2020

    • Author(s)
      小笠原 理紀
    • Organizer
      第75回日本体力医学会大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] c-Mycの過剰発現が筋収縮による筋タンパク質同化作用に及ぼす影響2019

    • Author(s)
      森 峰広、小笠原 理紀
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Remarks] 研究室ホームページ

    • URL

      http://muscle.web.nitech.ac.jp/

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
  • [Remarks] 名古屋工業大学研究者データベース

    • URL

      http://researcher.nitech.ac.jp/html/100000423_ja.html

    • Related Report
      2020 Annual Research Report

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Published: 2018-01-25   Modified: 2022-01-27  

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