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Improtance of Golgi function in the pathogenesis of dementia and related diseases

Research Project

Project/Area Number 17KK0197
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field General anatomy (including histology/embryology)
Research InstitutionMorinomiya University of Medical Sciences (2020-2023)
Wakayama Medical University (2017-2019)

Principal Investigator

MATSUZAKI Shinsuke  森ノ宮医療大学, 医療技術学部, 教授 (60403193)

Project Period (FY) 2018 – 2023
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Keywords認知症 / タンパク質翻訳後修飾 / タウオパチー / SUMO化修飾 / SUMO1 / SUMO2 / 前頭側頭型認知症 / 進行性核上性麻痺 / 神経変性疾患 / 進行性格上性麻痺 / Tauタンパク質 / 凝集物伝播 / メチル化 / SUMO化 / golgi / SCYL1 / TDP-43 / SUMO / PRMT1
Outline of Final Research Achievements

We elucidate the effect of SUMO isoforms on the aggregation of tau protein which is very important for pathophysiology of dementia related diseases. In our data SUMO1 worsen the aggregation of tau proteins and SUMO2 and SUMO3 could inhibit the process of aggregation of tau proteins. Aggregation of tau proteins observed in a lot of dementia related neurodegenerative diseases are well known and the results suggest the possibility of SUMO2 or SUMO3 for the remedy of neurodegenerative diseases. Then we moved to the next stage to confirm the effect of SUMO2 against the tau pathology in vivo. As a result, we show the protective effects of SUMO2 in vivo by using the SUMO2 transgenic mice.

Academic Significance and Societal Importance of the Research Achievements

高齢化社会を迎えている我が国のみならず認知症患者の増加は世界中で問題となっている。しかし、研究の進んだ現在でも根本的な治療法は確立していない。これまでの多くの創薬研究はアルツハイマー病の主要病理像であるアミロイドβ蛋白質を標的として進められてきたが、他の多くの認知症で認められるTauタンパク質病変をコントロールすることは認知症制御において重要である。本研究ではSUMO化修飾制御の観点から研究を進め、SUMO2修飾制御によるタウ病理に対する神経保護効果を示した。このことは、新たな認知症治療法開発の可能性を示唆しており、非常に意義のあるものである。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (15 results)

All 2022 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (10 results) (of which Int'l Joint Research: 2 results) Remarks (1 results)

  • [Int'l Joint Research] Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto(カナダ)2018

    • Related Report
      2023 Annual Research Report
  • [Journal Article] SUMO1 Modification of Tau in Progressive Supranuclear Palsy2022

    • Author(s)
      Hironori Takamura, Yoshiaki Nakayama, Hidefumi Ito, Taiichi Katayama, Paul E. Fraser, Shinsuke Matsuzaki
    • Journal Title

      Molecular Neurobiology

      Volume: - Issue: 7 Pages: 4419-4435

    • DOI

      10.1007/s12035-022-02734-5

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tas2R signaling enhances mouse neutrophil migration via a ROCK-dependent pathway2022

    • Author(s)
      Kobayashi Daichi、Watarai Tomoya、Ozawa Madoka、Kanda Yasuhiro、Saika Fumihiro、Kiguchi Norikazu、Takeuchi Arata、Ikawa Masahito、Matsuzaki Shinsuke、Katakai Tomoya
    • Journal Title

      Frontiers in Immunology

      Volume: 13 Pages: 973880-973880

    • DOI

      10.3389/fimmu.2022.973880

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] SCYL1 arginine methylation by PRMT1 is essential for neurite outgrowth via Golgi morphogenesis.2020

    • Author(s)
      Amano G, Matsuzaki S, Mori Y, Han S, Shikada S, Takamura H, Yoshimura T, Kayatama T.
    • Journal Title

      Molecular Biology of the Cell.

      Volume: 31(18) Issue: 18 Pages: 1963-1973

    • DOI

      10.1091/mbc.e20-02-0100

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] SUMO1 Modification of Tau in Progressive Supranuclear Palsy2022

    • Author(s)
      Takamura H, Nakayama Y, Ito H, Katayama T, Fraser PE, Matsuzaki S.
    • Organizer
      Neuro2022
    • Related Report
      2022 Research-status Report
  • [Presentation] 進行性核上性麻痺発症機構におけるタウタンパク質SUMO化2022

    • Author(s)
      松﨑 伸介, 高村 孝明, 中山 宣昭, 伊東 秀文, 片山 泰一, Fraser Paul
    • Organizer
      第95回日本薬理学会年会
    • Related Report
      2021 Research-status Report
  • [Presentation] Presenilin-1/2 chimeras indicate specific combinations of protein domains responsible for differential cleavage of APP and Notch Receptor2019

    • Author(s)
      Shinsuke Matsuzaki, Melissa Eccles, Hironori Takamura, Miheer Sabale, Taiichi Katayama, David Groth, Imran Khan, Mark Agostino, Giuseppe Verdile, Paul Fraser
    • Organizer
      NEURO2019(第42回 日本神経科学大会・第62回 日本神経化学会大会)
    • Related Report
      2019 Research-status Report
  • [Presentation] Scyl1 arginine methylation by PRMT1 is essential for neurite outgrowth via Golgi morphogenesis.2019

    • Author(s)
      Genki Amano, Takeshi Yoshimura, Yasutake Mori, Ko Miyoshi, Sarina Han, Sho Shikada, Shinsuke Matsuzaki, Taiichi Katayama
    • Organizer
      NEURO2019(第42回 日本神経科学大会・第62回 日本神経化学会大会)
    • Related Report
      2019 Research-status Report
  • [Presentation] SCYL1 arginine methylation by PRMT1 is essential for Golgi morphogenesis.2019

    • Author(s)
      天野 元揮, 吉村 武, 森 泰丈, 三好 耕, 韓 薩日娜, 鹿田 星, 高村 明孝, 松崎 伸介, 片山 泰一,
    • Organizer
      第20回ORIGIN神経科学研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] プレセニリン1/2キメラ体を用いたガンマセクレターゼ活性調節機構に対する検討2019

    • Author(s)
      松﨑伸介
    • Organizer
      ニューロカンファレンス和歌山
    • Related Report
      2018 Research-status Report
  • [Presentation] SUMOYLATION IMPACT ON SYNAPTIC FUNCTION AND ALZHEIMER DISEASE PATHOLOGY2019

    • Author(s)
      H. Takamura, S. Matsuzaki, T. Katayama, O. Arancio, P. Fraser
    • Organizer
      AD/PD2019, the 14th International Conference on Alzheimer's and Parkinson's Diseases, Montreal
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Involvement of SUMO1 in Neural function and Alzheimer’s disease pathology2018

    • Author(s)
      Matsuzaki S
    • Organizer
      Wakayama-Shandong Medical and Nursing Synposium 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] SUMO1はアルツハイマー病モデルマウスにおけるアミロイドβタンパク質蓄積に影響する2018

    • Author(s)
      松﨑伸介、、Erin Knock、佐藤嘉名与、天野元揮、小林大地、雑賀史浩、木口倫一、片山泰一、Ottavio Arancio、Paul Fraser、岸岡史郎
    • Organizer
      第40回日本生物学的精神医学会 第61回日本神経化学会大会 合同年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 神経機能とアルツハイマー病におけるSUMO化の役割2018

    • Author(s)
      高村 明孝、松崎 伸介、 片山 泰一 、Arancio Ottavio、Fraser Paul E
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Research-status Report
  • [Remarks] 論文が掲載されました(診療放射線学科 松崎伸介教授)

    • URL

      https://www.morinomiya-u.ac.jp/news/?c=topics_detail&pk=1652835092&type

    • Related Report
      2021 Research-status Report

URL: 

Published: 2018-01-25   Modified: 2025-01-30  

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