| Budget Amount *help |
¥113,100,000 (Direct Cost: ¥87,000,000、Indirect Cost: ¥26,100,000)
Fiscal Year 2010: ¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000)
Fiscal Year 2009: ¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000)
Fiscal Year 2008: ¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000)
Fiscal Year 2007: ¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000)
Fiscal Year 2006: ¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
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| Research Abstract |
Functional RNAs are classified into two types : one, like antisense and microRNA, those function with the sequence complementarity to the target mRNA or DNA, while the other, like aptamer, those function independent of the sequence complementarity. In this study, we clarified superior potential of the latter class RNA that exhibits conformational plasticity by : 1) creating artificial aptamers to target proteins of therapeutic interest ; and 2)uncover the natural aptamers encoded in human genome.
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