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Disturbance of hepatic function and over nutrition-related diseases

Research Project

Project/Area Number 18109008
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionKanazawa University

Principal Investigator

KANEKO Shuichi  Kanazawa University, 医学系, 教授 (60185923)

Co-Investigator(Kenkyū-buntansha) NAKANUMA Yasuni  金沢大学, 医学系, 教授 (10115256)
本多 政夫  金沢大学, 医学系研究科, 教授 (00272980)
篁 俊成  金沢大学, 医学系研究科, 准教授 (00324111)
中本 安成  金沢大学, 医学部附属病院, 講師 (40293352)
Co-Investigator(Renkei-kenkyūsha) HONDA Masao  金沢大学, 保健学系, 教授 (00272980)
TAKAMURA Toshinari  金沢大学, 医学系, 准教授 (00324111)
Project Period (FY) 2006 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥100,620,000 (Direct Cost: ¥77,400,000、Indirect Cost: ¥23,220,000)
Fiscal Year 2010: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2009: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2008: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2007: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2006: ¥40,950,000 (Direct Cost: ¥31,500,000、Indirect Cost: ¥9,450,000)
Keywordsゲノム / 発現制御 / 肝臓 / 栄養 / 生活習慣病 / 糖尿病
Research Abstract

Liver uptakes varieties of nutrients, metabolizes glucose, proteins, lipids, and drugs and systemically delivers the metabolites through blood streams. We have demonstrated that nutrition related diseases such as atherosclerosis, diabetes, cancer, and inflammation are partially caused by the dysfunction of liver which uptakes excess nutrients. We established the concept of the liver related diseases, and showed the fundamental findings for the development of the diagnosis and therapy for the diseased liver.

Report

(7 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (159 results)

All 2011 2010 2009 2008 2007 2006 Other

All Journal Article (147 results) (of which Peer Reviewed: 128 results) Remarks (5 results) Patent(Industrial Property Rights) (7 results)

  • [Journal Article] Identification of a secretory protein cl9orfl0 activated in hepatocellular carcinoma.2011

    • Author(s)
      H Sunagozaka
    • Journal Title

      Int J Cancer

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A liver-derived secretory protein, selenoprotein P, causes insulin resistance.2010

    • Author(s)
      H Misu, T Takamura, H Takayama, H Hayashi, N Matsuzawa-Nagata, S Kurita, K Ishikura, H Ando, Y Takeshita, T Ota, M Sakurai, T Yamashita, E Mizukoshi, T Yamashita, M Honda, K Miyamoto, T Kubota, N Kubota, T Kadowaki, HJ Kim, IK Lee, Y Minokoshi, Y Saito, K Takahashi, Y Yamada, N Takakura, S Kaneko.
    • Journal Title

      Cell Metab 12(5)

      Pages: 483-495

    • NAID

      120002661942

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential interferon signaling in liver lobule and portal area cells under treatment for chronic hepatitis2010

    • Author(s)
      M Honda, M Nakamura, M Tateno, A Sakai, T Shimakami, T Shirasaki, T Yamashita, K Arai, T Yamashita, Y Sakai, S Kaneko.
    • Journal Title

      C.J Hepatol 53(5)

      Pages: 817-826

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hokuriku Liver Study Group. Differential gene expression profiling in blood from patients with digestive system cancers.2010

    • Author(s)
      M Honda, Y Sakai, T Yamashita, T Yamashita, A Sakai, E Mizukoshi, Y Nakamoto, I Tatsumi, Y Miyazaki, H Tanno, S Kaneko
    • Journal Title

      Biochem Biophys Res Commun 400(1)

      Pages: 7-15

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocellular Carcinoma : Signal Intensity at Gadoxetic Acid-enhanced MR Imaging-Correlation with Molecular Transporters and Histopathologic Features.2010

    • Author(s)
      A Kitao, Y Zen, O Matsui, T Gabata, S Kobayashi, W Koda, K Kozaka, N Yoneda, T Yamashita, S Kaneko, Y Nakanuma.
    • Journal Title

      Radiology 256(3)

      Pages: 817-826

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor Effect after Radiofrequency Ablation of Murine Hepatoma Is Augmented by an Active Variant of CC Chemokine Ligand 3/Macrophage Inflammatory Protein-1α.2010

    • Author(s)
      S Kaneko
    • Journal Title

      Cancer Res 70(16)

      Pages: 6556-6565

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hokuriku Liver Study Group. Hepatic ISG expression is associated with genetic variation in IL28B and the outcome of IFN therapy for chronic hepatitis C.2010

    • Author(s)
      M Honda, A Sakai, T Yamashita, Y Nakamoto, E Mizukoshi, Y Sakai, T Yamashita, M Nakamura, T Shirasaki, K Horimoto, Y Tanaka, K Tokunaga, M Mizokami, S Kaneko
    • Journal Title

      Gastroenterology 139(2)

      Pages: 499-509

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation.2010

    • Author(s)
      T Yamashita, M Honda, K Nio, Y Nakamoto, T Yamashita, H Takamura, T Tani, Y Zen, S Kaneko.
    • Journal Title

      Cancer Res 70(11)

      Pages: 4687-4697

    • NAID

      120002220837

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of tumor-specific T cell responses by transcatheter arterial embolization with dendritic cell infusion for hepatocellular carcinoma.2010

    • Author(s)
      S Kaneko
    • Journal Title

      Int J Cancer 126(9)

      Pages: 2164-2174

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive gene expression analysis of 5'-end of mRNA identified novel intronic transcripts associated with hepatocellular carcinoma.2010

    • Author(s)
      Y Hodo, SI Hashimoto, M Honda, T Yamashita, Y Suzuki, S Sugano, S Kaneko, K Matsushima.
    • Journal Title

      Genomics 95(4)

      Pages: 217-223

    • NAID

      120002086414

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD14+monocytes are vulnerable and functionally impaired under ER stress in patients with type 2 diabetes.2010

    • Author(s)
      T Komura, Y Sakai, M Honda, T Takamura, K Matsushima, S Kaneko.
    • Journal Title

      Diabetes 59(3)

      Pages: 634-643

    • NAID

      120002104558

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered hepatic gene expression profiles associated with myocardial ischemia.2010

    • Author(s)
      H Ootsuji, M Honda, S Kaneko, S Usui, M Okajima, H Okada, Y Sakai, T Takamura, K Horimoto, M Takamura.
    • Journal Title

      Circ Cardiovasc Genet 3(1)

      Pages: 68-77

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The histological course of nonalcoholic fatty liver disease in Japanese patients : Tight glycemic control, rather than weight reduction, ameliorates liver fibrosis.2010

    • Author(s)
      E Hamaguchi, T Takamura, M Sakurai, E Mizukoshi, Y Zen, Y Takeshita, S Kurita, K Arai, T Yamashita, M Sasaki, Y Nakanuma, S Kaneko.
    • Journal Title

      Diabetes Care 33(2)

      Pages: 284-286

    • NAID

      120001938902

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of intrahepatic metastasis of liver cancer by suicide gene therapy and chemokine ligand 2/monocyte chemoattractant protein-1 delivery in mice.2010

    • Author(s)
      K Kakinoki
    • Journal Title

      J Gene Med

      Volume: 12 Pages: 1002-1013

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A liver-derived secretory protein, selenoprotein P, causes insulin resistance.2010

    • Author(s)
      H Misu
    • Journal Title

      Cell Metab

      Volume: 12 Pages: 483-495

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of double filtration plasmapheresis in combination with interferon therapy for chronic hepatitis C.2010

    • Author(s)
      S Kaneko
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 1072-1081

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of hepatitis B and C viruses in almost all hepatocytes by modified PCR-based in situ hybridization.2010

    • Author(s)
      H Nuriya
    • Journal Title

      J Clin Microbiol

      Volume: 48 Pages: 3843-3851

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential interferon signaling in liver lobule and portal area cells under treatment foi chronic hepatitis C.2010

    • Author(s)
      M Honda
    • Journal Title

      J Hepatol

      Volume: 53 Pages: 317-826

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential gene expression profiling in blood from patients with digestive system cancers.2010

    • Author(s)
      M Honda
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 400 Pages: 7-15

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocellular Carcinoma : Signal Intensity at Gadoxetic Acid-enhanced MR Imaging--Correlation with Molecular Transporters and Histopathologic Features.2010

    • Author(s)
      A Kitao
    • Journal Title

      Radiology

      Volume: 256 Pages: 817-826

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor Effect after Radiofrequency Ablation of Murine Hepatoma Is Augmented by an Active Variant of CC Chemokine Ligand 3/Macrophage Inflammatory Protein-1α.2010

    • Author(s)
      N Iida
    • Journal Title

      Cancer Res

      Volume: 70 Pages: 6556-6565

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic ISG expression is associated with genetic variation in IL28B and the outcome of IFN therapy for chronic hepatitis C.2010

    • Author(s)
      M Honda
    • Journal Title

      Gastroenterology

      Volume: 139 Pages: 1499-509

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] La Protein Required for Internal Ribosome Entry Site-Directed Translation Is a Potential Therapeutic Target for Hepatitis C V rus Replication.2010

    • Author(s)
      T Shirasaki
    • Journal Title

      J Infect Dis

      Volume: 202 Pages: 75-85

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing henatocvtic differentiation.2010

    • Author(s)
      T Yamashita
    • Journal Title

      I Cancer Res

      Pages: 4687-4697

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTNI.2010

    • Author(s)
      Y Kato
    • Journal Title

      Pharm Res

      Volume: 27 Pages: 832-840

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Enhancement of tumor-specific T cell responses by transcatheter arterial embolization wit dendritic cell infusion for hepatocellular carcinoma.2010

    • Author(s)
      E Mizukoshi
    • Journal Title

      Int J Cancer

      Volume: 126 Pages: 2164-2174

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver.2010

    • Author(s)
      Y Wu
    • Journal Title

      Oncogene

      Volume: 29 Pages: 2228-2237

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive gene expression analysis of 5'-end of mRNA identified novel intronic transcripts associated with hepatocellular carcinoma.2010

    • Author(s)
      Y Hodo
    • Journal Title

      Genomics

      Volume: 95 Pages: 217-223

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver2010

    • Author(s)
      Y Wu
    • Journal Title

      Oncogene (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive gene expression analysis of 5'-end of mRNA identified novel intronic transcripts associated with hepatocellular carcinoma2010

    • Author(s)
      Y Hodo
    • Journal Title

      Genomics (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] dUTP pyrophosphatase expression correlates with a poor prognosis in he patocellular carcinoma2010

    • Author(s)
      H Takatori
    • Journal Title

      Liver Int (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A randomized trial of 24 versus 48 weeks of peginterferon α-2a in patients infected with chronic hepatitis C virus genotype 2 or low viral load genotype 1 : a multicenter national study in Japan2010

    • Author(s)
      Y Iwasaki
    • Journal Title

      Hepatol Int (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of tumor-specific T cell responses by transcatheter arterial embolization with dendritic cell infusion for hepatocellular carcinoma2010

    • Author(s)
      E Mizukoshi
    • Journal Title

      Int J Cancer 126

      Pages: 2164-74

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD14+monocytes are vulnerable and functionally impaired under ER stress in patients with type 2 diabetes2010

    • Author(s)
      T Komura
    • Journal Title

      Diabetes 59

      Pages: 634-43

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The histological course of nonalcoholic fatty liver disease in Japanese patients : Tight glycemic control, rather than weight reduction, ameliorates liver fibrosis2010

    • Author(s)
      E Hamaguchi
    • Journal Title

      Diabetes Care 33

      Pages: 284-286

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes : an 8-year follow-up of relatively lean Japanese individuals.2009

    • Author(s)
      M Sakurai, K Miura, T Takamura, M Ishizaki, Y Morikawa, K Nakamura, K Yoshita, T Kido, Y Naruse, S Kaneko, H Nakagawa.
    • Journal Title

      Diabet Med 26(8)

      Pages: 753-759

    • NAID

      120001507851

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria.2009

    • Author(s)
      S Nakamura, T Takamura, N Matsuzawa-Nagata, H Takayama, H Misu, H Noda, S Nabemoto, S Kurita, T Ota, H Ando, K Miyamoto, S Kaneko.
    • Journal Title

      J Biol Chem 284(22)

      Pages: 14809-14818

    • NAID

      120002829203

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis.2009

    • Author(s)
      H Ando, T Takamura, N Matsuzawa-Nagata, KR Shima, S Nakamura, M Kumazaki, S Kurita, H Misu, N Togawa, T Fukushima, A Fujimura, S Kaneko.
    • Journal Title

      Biochem Biophys Res Commun 380(3)

      Pages: 684-688

    • NAID

      120001170074

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Middle-aged Japanese women are resistant to obesity-related metabolic abnormalities.2009

    • Author(s)
      M Sakurai, T Takamura, K Miura, S Kaneko, H Nakagawa.
    • Journal Title

      Metabolism 58(4)

      Pages: 456-459

    • NAID

      120001249808

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma.2009

    • Author(s)
      S Ura, M Honda, T Yamashita, T Ueda, H Takatori, R Nishino, H Sunakozaka, Y Sakai, K Horimoto, S Kaneko.
    • Journal Title

      Hepatology 49(4)

      Pages: 1098-1112

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features.2009

    • Author(s)
      T Yamashita, J Ji, A Budhu, M Forgues, W Yang, HY Wang, H Jia, Q Ye, LX Qin, E Wauthier, LM Reid, H Minato, M Honda, S Kaneko, ZY Tang, XW Wang.
    • Journal Title

      Gastroenterology 136(3)

      Pages: 1012-1024

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clock gene expression in peripheral leucocytes of patients with type 2 diabetes.2009

    • Author(s)
      H Ando, T Takamura, N Matsuzawa-Nagata, KR Shima, T Eto, H Misu, M Shiramoto, T Tsuru, S Irie, A Fujimura, S Kaneko.
    • Journal Title

      Diabetologia 52(2)

      Pages: 329-335

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma.2009

    • Author(s)
      T Yamashita, M Honda, H Takatori, R Nishino, H Minato, H Takamura, T Ohta, S Kaneko.
    • Journal Title

      J Hepatology 50(1)

      Pages: 100-110

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered hepatic gene expression profiles associated with myocardial is chemia2009

    • Author(s)
      H Ootsuji
    • Journal Title

      Circ Cardiovasc Genet 3

      Pages: 68-77

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes : an 8-year follow-up of relatively lean Japanese individuals2009

    • Author(s)
      M Sakurai
    • Journal Title

      Diabet Med 26

      Pages: 753-759

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria2009

    • Author(s)
      S Nakamura
    • Journal Title

      J Biol Chem 284

      Pages: 14809-14818

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis2009

    • Author(s)
      H Ando
    • Journal Title

      Biochem Biophys Res Commun 380

      Pages: 684-688

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Middle-aged Japanese women are resistant to obesity-related metabolic abnormalities2009

    • Author(s)
      M Sakurai
    • Journal Title

      Metabolism 58

      Pages: 456-459

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma2009

    • Author(s)
      S Ura
    • Journal Title

      Hepatology 49

      Pages: 1098-1112

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features2009

    • Author(s)
      T Yamashita
    • Journal Title

      Gastroenterology 136

      Pages: 1012-1024

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clock gene expression in peripheral leucocytes of patients with type 2 diabetes2009

    • Author(s)
      H Ando
    • Journal Title

      Diabetologia 52

      Pages: 329-335

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma2009

    • Author(s)
      T Yamashita
    • Journal Title

      J Hepatology 50

      Pages: 100-110

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma.2009

    • Author(s)
      S Ura
    • Journal Title

      Hepatology (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clock gene expression in peripheral leucocytes of patients with type 2 diabetes.2009

    • Author(s)
      H Ando
    • Journal Title

      Diabetologia 52

      Pages: 329-335

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Middle-aged Japanese women are resistant to obesity-related me tabolic abnormalities.2009

    • Author(s)
      M Sakurai
    • Journal Title

      Metabolism 58

      Pages: 456-459

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma.2009

    • Author(s)
      T Yamashita
    • Journal Title

      J Hepatology 50

      Pages: 100-110

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis.2009

    • Author(s)
      H Ando
    • Journal Title

      Biochem Biophys Res Commun 380

      Pages: 684-688

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common transcriptional signature of tumor-infiltrating mononuclear inflammatory cells and peripheral blood mononuclear cells in hepatocellular carcinoma patients.2008

    • Author(s)
      Y Sakai, M Honda, H Fujinaga, I Tatsumi, E Mizukoshi, Y Nakamoto, S Kaneko.
    • Journal Title

      Cancer Res 68(24)

      Pages: 10267-10279

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients.2008

    • Author(s)
      T Takamura, H Misu, N Matsuzawa-Nagata, M Sakurai, T Ota, A Shimizu, S Kurita, Y Takeshita, H Ando, M Honda, S Kaneko.
    • Journal Title

      Obesity (Silver Spring) 16(12)

      Pages: 2601-2609

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of proteome and transcriptome in human hepatocellular carcinoma using 2D-DIGE and SAGE.2008

    • Author(s)
      H Minagawa, T Yamashita, M Honda, Y Tabuse, K Kamijo, A Tsugita, S Kaneko.
    • Journal Title

      Protein J 27(7-8)

      Pages: 409-419

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] SAGE application in the study of diabetes.2008

    • Author(s)
      T Takamura, H Misu, T Yamashita, S Kaneko.
    • Journal Title

      Curr Pharm Biotechnol 9(5)

      Pages: 392-399

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optimal amount of monocyte chemoattractant protein-1 enhances antitumor effects of suiside gene therapy against hepatocelluar carcinoma by M1 macrophage activation.2008

    • Author(s)
      T Tsuchiyama, Y Nakamoto, Y Sakai, N Mukaida, S Kaneko.
    • Journal Title

      Cancer Sci 99(10)

      Pages: 2075-2082

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity.2008

    • Author(s)
      N Matsuzawa-Nagata, T Takamura, H Ando, S Nakamura, S Kurita, H Misu, T Ota, M Yokoyama, M Honda, K Miyamoto, S Kaneko.
    • Journal Title

      Metabolism 57(8)

      Pages: 1071-1077

    • NAID

      120001130340

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis.2008

    • Author(s)
      M Uno, S Kurita, H Misu, H Ando, T Ota, N Matsuzawa-Nagata, Y Kita, S Nabemoto, H Akahori, Y Zen, Y Nakanuma, S Kaneko, T Takamura.
    • Journal Title

      Hepatology 48(1)

      Pages: 109-118

    • NAID

      120001130339

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects.2008

    • Author(s)
      S Kurita, T Takamura, T Ota, N Matsuzawa-Nagata, Y Kita, M Uno, S Nabemoto, K Ishikura, H Misu, H Ando, Y Zen, Y Nakanuma, S Kaneko.
    • Journal Title

      Eur J Pharmacol 588(2-3)

      Pages: 316-324

    • NAID

      120001130222

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein expression profile characteristic to hepatocellular carcinoma revealed by 2D-DIGE with supervised learning.2008

    • Author(s)
      R Teramoto, H Minagawa, M Honda, K Miyazaki, Y Tabuse, K Kamijo, T Ueda, S Kaneko.
    • Journal Title

      Biochim Biophys Acta 1784(5)

      Pages: 764-772

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] BMI may be better than waist circumference for defining metabolic syndrome in Japanese women.2008

    • Author(s)
      M Sakurai, T Takamura, K Miura, S Kaneko, H Nakagawa.
    • Journal Title

      Diabetes Care 31(3)

      Pages: 12-12

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative proteomic and transcriptomic profiling of the human hepatocellular carcinoma.2008

    • Author(s)
      H Minagawa, M Honda, K Miyazaki, Y Tabuse, R Teramoto, T Yamashita, R Nishino, H Takatori, T Ueda, K Kamijo, S Kaneko.
    • Journal Title

      Biochem Biophys Res Commun 366(1)

      Pages: 186-192

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cross talk of tumor necrosis factor-alpha and the renin-angiotensin system in tumor necrosis factor-alpha-induced plasminogen activator inhibitor-1 production from hepatocytes.2008

    • Author(s)
      Y Takeshita, T Takamura, H Ando, E Hamaguchi, A Takazakura, N Matsuzawa-Nagata, S Kaneko.
    • Journal Title

      Eur J Pharmacol 579(1-3)

      Pages: 426-432

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients2008

    • Author(s)
      T Takamura, H Misu, N Matsuzawa-Nagata, M Sakurai, T Ota, A Shimizu, S Kurita, Y Takeshita, H Ando, M Honda, S Kaneko
    • Journal Title

      Obesity 16(12)

      Pages: 2061-2609

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of proteome and transcriptome in human hepatocellular carcinoma using 2D-DIGE and SAGE2008

    • Author(s)
      H Minagawa, T Yamashita, M Honda, Y Tabuse, K Kamijo, A Tsugita and S Kaneko.
    • Journal Title

      Protein J 27(7-8)

      Pages: 409-419

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Common transcriptional signature of tumor-infiltrating mononuclear inflammatory cells and peripheral blood mononuclear cells in hepatocellular carcinoma patients.2008

    • Author(s)
      Y Sakai
    • Journal Title

      Cancer Res 68

      Pages: 10267-10279

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients.2008

    • Author(s)
      T Takamura
    • Journal Title

      Obesity 16

      Pages: 2601-2609

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of serial analysis of gene expression in cancer research.2008

    • Author(s)
      T Yamashita
    • Journal Title

      Curr Pharm Biotechnol 9

      Pages: 375-382

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BMI may be better than waist circumference for defining metabolie syndrome in Japanese women.2008

    • Author(s)
      M Sakurai
    • Journal Title

      Diabetes Care 31

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SAGE application in the study of diabetes.2008

    • Author(s)
      T Takamura
    • Journal Title

      Curr Pharm Biotechnol 9

      Pages: 392-399

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of proteome and transcriptome in human hepatocellular carcinoma using 2D-DIGE and SAGE.2008

    • Author(s)
      H Minagawa
    • Journal Title

      Protein J 27

      Pages: 409-419

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimal amount of monocyte chemoattractant protein-1 enhances antitumor effects of suiside gene therapy against hepatocelluar carcinoma by M1 macrophage activation.2008

    • Author(s)
      T Tsuchiyama
    • Journal Title

      Cancer Sci 99

      Pages: 2075-2082

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor cell apoptosis induces tumor-specific immunity in a CC chemokine receptor 1- and 5-dependent manner in mice.2008

    • Author(s)
      N Iida
    • Journal Title

      J Leukoc Biol 84

      Pages: 1001-1010

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of multidrug resistance-associated protein 3 and cytotoxic T cell responses in patients with hepatocellular carcinoma.2008

    • Author(s)
      E Mizukoshi
    • Journal Title

      J Hepatol 49

      Pages: 946-954

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity.2008

    • Author(s)
      N Matsuzawa-Nagata
    • Journal Title

      Metabolism 57

      Pages: 1071-1077

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tranilast, an antifibrogenic agent, ameliorates a dietary ratmodel of nonalcoholic steatohepatitis.2008

    • Author(s)
      M Uno
    • Journal Title

      Hepatology 48

      Pages: 109-118

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects.2008

    • Author(s)
      S Kurita
    • Journal Title

      Eur J Pharmacol 588

      Pages: 316-324

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma.2008

    • Author(s)
      R Nishino
    • Journal Title

      J Hepatol 49

      Pages: 207-216

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein expression profile characteristic to hepatocellular carcinoma revealed by 2D-DIGE with supervised learning.2008

    • Author(s)
      R Teramoto
    • Journal Title

      Biochim Blophys Acta 1784

      Pages: 764-772

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross talk of tumor necrosis factor-alpha and the renin-angiotensin system in tumor necrosis factor-alpha-induced plasminogen activator inhibitor-1 production from hepatocytes2008

    • Author(s)
      Y Takeshita
    • Journal Title

      Eur J Pharmacol 579

      Pages: 426-432

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative proteomic and transcriptomic profiling of human hepatoce11 ular carcinoma2008

    • Author(s)
      H Minagawa
    • Journal Title

      Biochem Biophys Res Commun 366

      Pages: 186-192

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of diabetes mellitus on prognosis of patients infected with hepatitis C virus.2007

    • Author(s)
      Y Kita, E Mizukoshi, T Takamura, M Sakurai, Y Takata, K Arai, T Yamashita, Y Nakamoto, S Kaneko.
    • Journal Title

      Metabolism 56(12)

      Pages: 1682-1288

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line.2007

    • Author(s)
      A Shimizu, T Takamura, N Matsuzawa, S Nakamura, S Nabemoto, Y Takeshita, H Misu, S Kurita, M Sakurai, M Yokoyama, Y Zen, M Sasaki, Y Nakanuma, S Kaneko.
    • Journal Title

      Metabolism 56(11)

      Pages: 1478-1485

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet.2007

    • Author(s)
      N Matsuzawa, T Takamura, S Kurita, H Misu, T Ota, H Ando, M Yokoyama, M Honda, Y Zen, Y Nakanuma, K Miyamoto, S Kaneko.
    • Journal Title

      Hepatology 46(5)

      Pages: 1392-1403

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profiles in peripheral blood mononuclear cells reflect the pathophysiology of type 2 diabetes.2007

    • Author(s)
      T Takamura, M Honda, Y Sakai, H Ando, A Shimizu, T Ota, M Sakurai, H Misu, S Kurita, N Matsuzawa-Nagata, M Uchikata, S Nakamura, R Matoba, M Tanino, K Matsubara, S Kaneko.
    • Journal Title

      Biochem Biophys Res Commun 361(2)

      Pages: 379-384

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible role of alpha-cell insulin resistance in exaggerated glucagon responses to arginine in type 2 diabetes.2007

    • Author(s)
      N Tsuchiyama, T Takamura, H Ando, M Sakurai, A Shimizu, K Kato, S Kurita, S Kaneko.
    • Journal Title

      Diabetes Care 30(10)

      Pages: 2583-2587

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease.2007

    • Author(s)
      M Sakurai, T Takamura, T Ota, H Ando, H Akahori, K Kaji, M Sasaki, Y Nakanuma, K Miura, S Kaneko.
    • Journal Title

      J Gastroenterol 42(4)

      Pages: 312-317

    • NAID

      10019483538

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis.2007

    • Author(s)
      T Takamura, A Shimizu, H Ando, S Kaneko.
    • Journal Title

      Intern Med 46(9)

      Pages: 579-581

    • NAID

      130000078717

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pioglitazone in nonalcoholic steatohepatitis.2007

    • Author(s)
      T Ota, T Takamura, S Kaneko.
    • Journal Title

      N Engl J Med 356(10)

      Pages: 1068-1068

    • NAID

      120000806619

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of reactive oxygen species from isolated rat glomeruli by protein kinase C activation and TNF-α stimulation, and effects of a phosphodiesterase inhibitor.2007

    • Author(s)
      N Koike, T Takamura, S Kaneko.
    • Journal Title

      Life Sci 80(18)

      Pages: 1721-1278

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of the C825T polymorphism of the G-protein β3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese.2007

    • Author(s)
      T Hayakawa, T Takamura, T Abe, SKaneko.
    • Journal Title

      Metabolism 56(1)

      Pages: 44-48

    • NAID

      120000809436

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comment on : Nathan DM, Buse JB, Davidson MB et al. (2006) Management of hyperglycaemia in type 2 diabetes : a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes.2007

    • Author(s)
      Takamura, A Shimizu, H Ando, S Kaneko.
    • Journal Title

      Diabetologia 50(1)

      Pages: 229-330

    • NAID

      120000809528

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes.2007

    • Author(s)
      H Misu, T Takamura, N Matsuzawa, A Shimizu, T Ota, M Sakurai, H Ando, K Arai, T Yamashita, M Honda, T Yamashita, S Kaneko.
    • Journal Title

      Diabetologia 50(2)

      Pages: 268-277

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis.2007

    • Author(s)
      T Ota, T Takamura, S Kurita, N Matsuzawa, Y Kita, M Uno, H Akahori, H Misu, M Sakurai, Y Zen, Y Nakanuma, S Kaneko.
    • Journal Title

      Gastroenterology 132(1)

      Pages: 282-293

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Factors associated with improvement of fasting plasma glucose level by mealtime dosing of a rapid-acting insulin analog in type 2 diabetes.2007

    • Author(s)
      T Takamura, M Sakurai, M Nakamura, A Shimizu, T Ota, H Misu, Y Takeshita, N Tsuchiyama, S Kurita, H Ando, S Kaneko.
    • Journal Title

      Diabetes Res Clin Pract 75(3)

      Pages: 278-284

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet2007

    • Author(s)
      N Matsuzawa, T Takamura, S Kurita, H Misu, T Ota, H Ando, M Yokoyama, M Honda, Y Zen, Y Nakanuma, K Miyamoto and S Kaneko
    • Journal Title

      Hepatology 46(5)

      Pages: 1392-1403

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes2007

    • Author(s)
      H Misu, T Takamura, N Matsuzawa, A Shimizu, T Ota, M Sakurai, H Ando, K Arai, T Yamashita, M Honda, T Yamashita and S Kaneko.
    • Journal Title

      Diabetologia 50(2)

      Pages: 268-277

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis2007

    • Author(s)
      T Ota, T Takamura, S Kurita, N Matsuzawa, Y Kita, M Uno, H Akahori, H Misu, M Sakurai, Y Zen, Y Nakanuma and S Kaneko
    • Journal Title

      Gastroenterology 132(1)

      Pages: 282-293

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Impact of diabetes mellitus on prognosis of patients infected with hepatitis C virus2007

    • Author(s)
      Y Kita
    • Journal Title

      Metabolism 56

      Pages: 1682-1288

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line2007

    • Author(s)
      A Shimizu
    • Journal Title

      Metabolism 56

      Pages: 1478-1485

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet2007

    • Author(s)
      N Matsuzawa
    • Journal Title

      Hepatology 46

      Pages: 1392-1403

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis B virus X protein overcomes oncogenic RAS-induced senescence in human immnrtalized cells2007

    • Author(s)
      N 0ishi
    • Journal Title

      Cancer Sci 98

      Pages: 1540-1548

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profiles in peripheral blood mononuclear cells reflect the pathophysiology of type 2 diabetes2007

    • Author(s)
      T Takamura
    • Journal Title

      Biochem Biophys Res Commun 361

      Pages: 379-384

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible role of alpha-cell insulin resistance in exaggerated glucagon resPonses to arginine in type 2 diabetes2007

    • Author(s)
      N Tsuchiyama
    • Journal Title

      Diabetes Care 30

      Pages: 2583-2587

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of diabetes on recurrence of hepatocellular carcinoma after surgical treatment in patients with viral hepatitis2007

    • Author(s)
      T Komura
    • Journal Title

      Am J Gastroenterol 102

      Pages: 1939-1946

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fupctional interaction of hepatitis C Virus NS5B with Nucleolin GAR domain.2007

    • Author(s)
      T Kusakawa
    • Journal Title

      J Biochem (Tokyo) 141

      Pages: 917-927

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease2007

    • Author(s)
      M Sakurai
    • Journal Title

      J Gastroenterol 42

      Pages: 312-317

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of hepatitis C virus-specific CD8+ T-cells with HLA-A*24 tetramers during Phlebotomy and interferon therapy for chronic hepatitis C2007

    • Author(s)
      K Kaji
    • Journal Title

      Oncol Rep 18

      Pages: 993-998

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Double filtration plasmapheresis and interferon combination therapy for chronic hepatitis C patients with genotype 1 and high viral load2007

    • Author(s)
      K Fujiwara
    • Journal Title

      Hepatol Res 37

      Pages: 701-710

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrahepatic interleukin-8 production during disease progression of chronic hepatitis C2007

    • Author(s)
      Y Tachibana
    • Journal Title

      Cancer Lett 251

      Pages: 36-42

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective estrogen receptor modulator raloxifene-associated aggravaticn of nonalcoholic steatohepatitis2007

    • Author(s)
      T Takamura
    • Journal Title

      Intern Med 46

      Pages: 579-581

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pioglitazone in nonalcoholic steatohepatitis2007

    • Author(s)
      T Ota
    • Journal Title

      N Engl J Med 356

      Pages: 1068-1068

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis C virus and its susceptibility to interferon2007

    • Author(s)
      N Hiraga
    • Journal Title

      FEBS Lett 581

      Pages: 1983-1987

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of reactive oxygen species from isolated rat glomeruli by protein kinase C activation and TNF-α stimulation,and effects of a phosphodiesterase inhibitor2007

    • Author(s)
      N Koike
    • Journal Title

      Life Sci 80

      Pages: 1721-1278

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiling of periphera1-blood mononuclear cells from patients with chronic hepatitis C undergoing interferon therapy2007

    • Author(s)
      M Tateno
    • Journal Title

      J Infect Dis 195

      Pages: 255-267

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of the C825T polymorphism ofthe G-protein β3 subunit gene with hypertension,obesity,hyperlipidemia, insulin resistance,diabetes,diabetic complications,and diabetic therapies among Japanese2007

    • Author(s)
      T Hayakawa
    • Journal Title

      Metabolism 56

      Pages: 44-48

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes2007

    • Author(s)
      T Takamura
    • Journal Title

      Diabetologia 50

      Pages: 229-330

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolonged, NK cell-mediated antitumor effects of suicide gene therapy combined with monocyte chemoattractant protein-1 against hepatocellular carcinoma.2007

    • Author(s)
      T Tsuchiyama
    • Journal Title

      J Immunol 178・1

      Pages: 574-583

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Combined therapy of transcatheter hepatic arterial embolization with intratumoral dendritic cell infusion for hepatocellular carcinoma; clinical safety.2007

    • Author(s)
      Y Nakamoto
    • Journal Title

      Clin Exp Immunol 147・1

      Pages: 296-305

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes.2007

    • Author(s)
      H Misu
    • Journal Title

      Diabetologia 50・2

      Pages: 268-277

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis.2007

    • Author(s)
      T Ota
    • Journal Title

      Gastroenterology 132・1

      Pages: 282-293

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Factors associated with improvement of fasting plasma glucose level by mealtime dosing of a rapid-acting insulin analog in type 2 diabetes.2007

    • Author(s)
      T Takamura
    • Journal Title

      Diabetes Res Clin Pract 75・3

      Pages: 278-284

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Clinical challenges and images in GI.Yersiniaenterocolitica mesenteric adenitis and terminal ileitis.2006

    • Author(s)
      S Kaneko
    • Journal Title

      Gastroenterology 131(5)

      Pages: 1379-1659

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Erythrocyte sorbitol level as a predictor of the efficacy of epalrestat treatment for diabetic peripheral polyneuropathy.2006

    • Author(s)
      H Ando, T Takamura, Y Nagai, S Kaneko.
    • Journal Title

      J Diabetes Complications 20(6)

      Pages: 367-370

    • NAID

      120000809564

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different signaling pathways in the livers of patients with chronic hepatitis B or chronic hepatitis C.2006

    • Author(s)
      M Honda, T Yamashita, T Ueda, H T, R Nishino, S Kaneko.
    • Journal Title

      Hepatology 44(5)

      Pages: 1122-1138

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor necrosis factor-alpha-induced production of plasminogen activator inhibitor 1 and its regulation by pioglitazone and cerivastatin in a nonmalignant human hepatocyte cell line.2006

    • Author(s)
      Y Takeshita, T Takamura, E Hamaguchi, A Shimizu, T Ota, M Sakurai, S Kaneko.
    • Journal Title

      Metabolism 55(11)

      Pages: 1464-1472

    • NAID

      120000809721

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis.2006

    • Author(s)
      S Kaneko
    • Journal Title

      P Natl Acad Sci USA 103(38)

      Pages: 14098-14103

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pancreatic exocrine and endocrine events occur concomitantly but independently during the course of fulminant type 1 diabetes.2006

    • Author(s)
      T Kahara, T Takamura, M Sakurai, H Misu, R Usuda, T Hayakawa, Y Nishimura, Y Bando, T Nagaoka, Y Nagai, S Kaneko.
    • Journal Title

      Diabetes Res Clin Pract 71(3)

      Pages: 241-246

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical challenges and images in GI. Yersinia enterocolitica mesenteric adenitis and terminal ileitis.2006

    • Author(s)
      U Fuchizaki
    • Journal Title

      Gastroenterology 131・5

      Pages: 1379-1659

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Erythrocyte sorbitol level as a predictor of the efficacy of epalrestat treatment for diabetic peripheral polyneuropathy.2006

    • Author(s)
      H Ando
    • Journal Title

      J Diabetes Complications 20・6

      Pages: 367-370

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Different signaling pathways in the livers of patients with chronic hepatitis B or chronic hepatitis C.2006

    • Author(s)
      M Honda
    • Journal Title

      Hepatology 44・5

      Pages: 1122-1138

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Tumor necrosis factor-alpha-induced production of plasminogen activator inhibitor 1 and its regulation by pioglitazone and cerivastatin in a nonmalignant human hepatocyte cell line.2006

    • Author(s)
      Y Takeshita
    • Journal Title

      Metabolism 55・11

      Pages: 1464-1472

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis.2006

    • Author(s)
      N Sakai
    • Journal Title

      P Natl Acad Sci USA 103・38

      Pages: 14098-14103

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Virological effects and safety of combined double filtration plasmapheresis (DFPP) and interferon therapy in patients with chronic hepatitis C : A preliminary study.2006

    • Author(s)
      T Yamashita
    • Journal Title

      Hepatol Res 36・3

      Pages: 167-175

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Transgenic mice aberrantly expressing pyruvate dehydrogenase complex E2 component on biliary epithelial cells do not show primary biliary cirrhosis.2006

    • Author(s)
      K Inamura
    • Journal Title

      Clin Exp Immunol 145・1

      Pages: 93-100

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Analysis of intrahepatic lymphocyte subsets in a transgenic mouse model of immune-mediated hepatocarcinogenesis.2006

    • Author(s)
      Y Nakamoto
    • Journal Title

      J Exp Clin Cancer Res 25・1

      Pages: 55-57

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cytotoxic T cell responses to human telomerase reverse transcriptase in patients with hepatocellular carcinoma.2006

    • Author(s)
      E Mizukoshi
    • Journal Title

      Hepatology 43・6

      Pages: 1284-1294

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effect of hepatitis C virus (HCV) NS5B-nucleolin interaction on HCV replication with HCV subgenomic replicon.2006

    • Author(s)
      T Shimakami
    • Journal Title

      J Virol 80・7

      Pages: 3332-3340

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Monocyte chemoattractant protein-1 gene delivery enhances antitumor effects of herpes simplex virus thymidine kinase/ganciclovir system in a model of colon cancer.2006

    • Author(s)
      T Kagaya
    • Journal Title

      Cancer Gene Ther 13・4

      Pages: 357-366

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pancreatic exocrine and endocrine events occur concomitantly but independently during the course of fulminant type 1 diabetes.2006

    • Author(s)
      T Kahara
    • Journal Title

      Diabetes Res Clin Pract 71・3

      Pages: 241-246

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression.2006

    • Author(s)
      X Yang
    • Journal Title

      Int J Cancer 118・8

      Pages: 1869-1876

    • Related Report
      2006 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://m-kanazawa.jp/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://m-kanazawa.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://m-kanazawa.jp/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.m-kanazawa.jp

    • Related Report
      2008 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.m-kanazawa.jp

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 脂肪組織由来間質細胞群を含む肝炎治療剤2010

    • Inventor(s)
      東元真実、金子周一、酒井佳夫
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Number
      2010-203796
    • Filing Date
      2010-09-11
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 脂肪組織由来間質細胞群を含む肝炎治療剤2010

    • Inventor(s)
      東元真実, 金子周一, 酒井佳夫
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Number
      2010-203796
    • Filing Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 腎症の進行度の判定方法並びに線維化抑制剤2010

    • Inventor(s)
      坂井宣彦, 金子周一, 和田隆志
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Number
      2010-281080
    • Filing Date
      2010-12-16
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 遺伝子発現プロファイルによる消化器癌、胃癌、大腸癌及び膵臓癌の検出2009

    • Inventor(s)
      金子周一、本多政夫、酒井佳夫、山下太郎
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Number
      2009-193702
    • Filing Date
      2009-08-24
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 遺伝子発現プロファイルによる消火器癌, 胃癌, 大腸癌及び膵臓癌の検出2009

    • Inventor(s)
      金子周一, 本多政夫, 酒井佳夫
    • Industrial Property Rights Holder
      国立大学法人 金沢大学
    • Industrial Property Number
      2009-193702
    • Filing Date
      2009-08-24
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 生理的状態分析方法、生理的状態分析システム、及びコンピュータシステムに生理的状態を分析するための処理を実行させるコンピュータープログラム2008

    • Inventor(s)
      松原謙一、下田正文、的場亮、谷野元彦、中村誠二、岡山利次、田村卓郎、金子周一、篁俊成、河合昴三
    • Industrial Property Rights Holder
      (株) DNAチップ研究所、ビッツ(株)
    • Industrial Property Number
      2008-311346
    • Filing Date
      2008-12-05
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 生理的状態分析方法、生理的状態分析システム、及びコンピュータシステムに生理的状態を分析するための処理を実行させるコンピュータープログラム2008

    • Inventor(s)
      松原謙一, 下田正文, 的場亮, 谷野元彦, 中村誠二, 岡山利次, 田村卓郎, 金子周一, 篁俊成, 河合昴三
    • Industrial Property Rights Holder
      (株)DNAチップ研究所, ビッツ(株)
    • Filing Date
      2008-12-05
    • Related Report
      2008 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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