| Project/Area Number |
18208026
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
HORIUCHI Motohiro Hokkaido University, 大学院・獣医学研究科, 教授 (30219216)
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| Co-Investigator(Kenkyū-buntansha) |
INANAMI Osamu 北海道大学, 大学院・獣医学研究科, 教授 (10193559)
KIMURA Kazuhiro 北海道大学, 大学院・獣医学研究科, 教授 (30192561)
OCHIAI Kenji 北海道大学, 大学院・獣医学研究科, 准教授 (80214162)
HASEBE Rie 北海道大学, 大学院・獣医学研究科, 助教 (70431335)
URYU Masahide (株)応用医学研究所, 研究員 (00399990)
SON Chang-hyun 北海道大学, 大学院・獣医学研究科, 博士研究員 (70547786)
OOSHIMA Masanobu 金沢大学, がん研究所, 教授 (40324610)
FURUOKA Hidefumi 帯広畜産大学, 畜産学部, 教授 (60238665)
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥38,090,000 (Direct Cost: ¥29,300,000、Indirect Cost: ¥8,790,000)
Fiscal Year 2009: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2008: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2007: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2006: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
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| Keywords | プリオン / DNAマイクロアレイ / 神経変性 / ミクログリア / スクレイピー / BSE / アストロサイト / DNA マイクロアレイ |
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| Research Abstract |
To identify host genes whose expression is up-regulated in the early stage of prion-infection, DNA microarray analysis was carried out and involvement of the genes in pathobiology of prion diseases was analyzed. The results showed that Cd14 molecule, known as receptor for LPS, influences the progression of the disease, whereas, Cxcl10, known as chemokine with neuroprotective effect, plays a role in antagonizing the disease progression. In addition, microglial activation was suggested to have a protective effect on the disease progression.
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