| Budget Amount *help |
¥47,710,000 (Direct Cost: ¥36,700,000、Indirect Cost: ¥11,010,000)
Fiscal Year 2009: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2008: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2007: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2006: ¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
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| Research Abstract |
We have identified several factors that influence activity of orexin-producing neurons, including vasopressin, neurotensin, and thyrotropin-releasing hormone (TRH). We also revealed that orexin-producing neurons express an orphan receptor, BRS-3, which might be also involved in the regulation of orexin neurons. The activation of orexin neurons by vasopressin has an important role in the regulation of spontaneous locomotor activity in mice. This system appears to play a role in water deprivation-induced hyperlocomotor activity, a response to dehydration that increases the chance of locating water in nature. We also found that thyrotropin-releasing hormone modulates behavioral arousal and sympathetic outflow, in part, through the orexin system. We also analyze the in vivo and in vitro phenotype of mice lacking the GABA_<B1> gene specifically in orexin neurons, and demonstrate that GABA_B receptors on orexin neurons are essential in stabilizing and consolidating sleep/wake states.
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