In vivo pretreatment of bio-derived and synthetic for cardiovascular tissue regeneration.

• Project/Area Number: 18209042
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: NAKATANI Takeshi National Cardiovascular Center Research Institute, 臓器移植部, 部長 (60155752)
• Co-Investigator(Kenkyū-buntansha): YAMAOKA Tetsuji 国立循環器病センター研究所, 生体工学部, 部長 (50243126) ; FUJISATO Toshiya 国立循環器病センター研究所, 再生医療部, 室長 (60270732)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥49,530,000 (Direct Cost: ¥38,100,000、Indirect Cost: ¥11,430,000); Fiscal Year 2009: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000); Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000); Fiscal Year 2007: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000); Fiscal Year 2006: ¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
• Keywords: スキャホールド / 脱細胞 / ポリ乳酸 / 組織移植 / 再生医工学 / 生体内 / バイオロジックスキャホールド / プレインプラント / 自己組織化 / 吸収性血管 / 2回移植 / 補体活性 / 人工臓器額

Research Abstract

In pre-implantation of the synthetic biodegradable scaffolds (templates) the induced ingrowth of the surrounding tissue into the scaffolds and the suppressed hyperplasia based on the excess of tissue ingrowth cold be controlled by regulating the structure and chemical features of the nanofiber matrices for the scaffolds. In addition, in vivo acellularization of the small-diameter blood vessel based on the complement system has been found to be very effective to maintain the structure and mechanical property of the blood vessel walls.

Research Products

• [Journal Article] Periferal nerve regeneration and electrophysiological recovery with CIP-treated allogeneic acellular nerve (2010)
  • Author(s): T.Ehashi, A.Nishigaito, T.Fujisato, Y.Moritan, T.Yamaoka
  • Journal Title: J. Biomat. Sci. Pol. Ed (in press)
  • Peer Reviewed
• [Journal Article] Heart Transplantation (2009)
  • Author(s): Nakatani T
  • Journal Title: Circ J 73(SupplA)
  • NAID: 10025939172
  • Peer Reviewed
• [Journal Article] Body mass index is a useful predictor of prognosis after left ventricular assist system implantation (2009)
  • Author(s): Mano A, et al.(12人中11番目)
  • Journal Title: J Heart Lung Transplant 28 Pages: 428-433
  • Peer Reviewed
• [Journal Article] Stable modification of poly(lactic acid) surface with neurite outgrowth-promoting peptides via hydrophobic collagen-like sequence (2009)
  • Author(s): S.Kakinoki, T.Yamaoka
  • Journal Title: Acta Biomat (in press)
  • Peer Reviewed
• [Journal Article] Heart Transplantation (2009)
  • Author(s): Takeshi Nakatani
  • Journal Title: Circ J 73
  • NAID: 10025939172
  • Peer Reviewed
• [Journal Article] Body mass index is a useful predictor of prognosis after left ventricular assist system implantation (2009)
  • Author(s): Mano A, Fujita K, Uenomachi K, Kazama K, Katabuchi M, Wada K, Terakawa N, Arai K, Hori Y, Hashimoto S, Nakatani T, Kitamura S.
  • Journal Title: J Heart Lung Transplant 28 Pages: 428-433
  • Peer Reviewed
• [Journal Article] 心臓移植と待機患者への治療 (2009)
  • Author(s): 中谷武嗣
  • Journal Title: 内科 103 Pages: 521-525
• [Journal Article] 心臓 (2009)
  • Author(s): 中谷武嗣
  • Journal Title: 移植 44(特別号)
  • NAID: 10026247139
• [Journal Article] わが国における心臓移植でのエベロリムスの現状 (2009)
  • Author(s): 中谷武嗣、簗瀬正伸、村田欣洋、瀬口理、加藤倫子、戸田宏一、藤田知之、和田恭一、中野一也
  • Journal Title: 今日の移植 22 Pages: 674-678
• [Journal Article] In Vivo Tissue Response and Degradation Behavior of PLLA and Stereocomplexed PLA Nanofibers (2009)
  • Author(s): D.Ishii, T.Hui Ying, A.Mahara, S.Murakami, T.Yamaoka, W.Lee, T.Iwata
  • Journal Title: Biomacromolecules 10(2) Pages: 237-242
  • Peer Reviewed
• [Journal Article] Characterization and Biocompatibility of Biopolyester Nanofibers (2009)
  • Author(s): D.Ishii, T.Hui Ying, T.Yamaoka, T.Iwata
  • Journal Title: Biocompatibility of Materials 2 Pages: 1520-1546
  • Peer Reviewed
• [Journal Article] Beating behavior of primary neonatal cardiomyocytes and cardiac-differentiated P19CL6 cells on different extramatrix components (2009)
  • Author(s): A. Miskon
  • Journal Title: Journal of Artificial Organs (in press)
  • Peer Reviewed
• [Journal Article] In Vivo Tissue Response and Degradation Behavior of PLLA and Stereocomplexed PLA Nanofibers (2009)
  • Author(s): D. Ishii
  • Journal Title: Biomacromolecules 10 Pages: 237-242
  • Peer Reviewed
• [Journal Article] Modification of PLA Scaffolds Using Bioactive Peptide-Oligo (Lactic Acid) Conjugates (2009)
  • Author(s): S. Kakinoki
  • Journal Title: The Japanese Peptide Society Pages: 449-450
  • Peer Reviewed
• [Journal Article] Which factors predict the recovery of natural heart function after insertion of a left ventricular assist system? (2008)
  • Author(s): Mano A, et al.(16人中2番目)
  • Journal Title: Journal of Heart and Lung Ttansplantation 27 Pages: 869-874
  • Peer Reviewed
• [Journal Article] Cell removal with supercritical carbon dioxide for acellular artificial tissue (2008)
  • Author(s): K.Sawada, D.Terada, T.Yamaoka, S.Kitamura, T.Fujisato
  • Journal Title: Journal of Chemical Technology, Biotechnology 83(6) Pages: 943-949
  • Peer Reviewed
• [Journal Article] 心臓移植適応について検討した患者の予後-院内臓器移植医学的適応症例検討会に小児科から提示した症例- (2008)
  • Author(s): 小林奈歩、津田悦子、小野安生、塚野真也、矢崎論、山田修、越後茂之、中谷武嗣、八木原俊克
  • Journal Title: 日本小児循環器学会雑誌 24 Pages: 628-635
  • NAID: 10024844851
  • Peer Reviewed
• [Journal Article] Which factors predict the recovery of natural heart function after insertion of a left ventricular assist system? (2008)
  • Author(s): Mano A, Nakatani T, Oda N, Kato T,Niwaya K, Tagusari O, Nakajima H,Funatsu T, Hashimoto S, Komamura K, Hanatani A, Ueda I.H, Kitakaze M, Kobayashi J, Yagihara T, Kitamura S
  • Journal Title: Journal of Heart and Lung Ttansplantation 27 Pages: 869-874
  • Peer Reviewed
• [Journal Article] 心臓移植適応について検討した患者の予後-院内臓器移植医学的適応症例検討会に小児科から提示した症例- (2008)
  • Author(s): 小林奈歩
  • Journal Title: 日本小児循環器学会雑誌 24 Pages: 628-635
  • Peer Reviewed
• [Journal Article] Which factors predict the recovery of natural heart function after insertion of a left ventricular assist system? (2008)
  • Author(s): Mano A
  • Journal Title: Journal of Heart and Lung Ttansplantation 27 Pages: 869-874
  • Peer Reviewed
• [Journal Article] Heparin-induced thrombocytopenia clinical studies and the efficacy of argatroban in Japan (2008)
  • Author(s): Miyata S
  • Journal Title: Semin Thromb Hemost 34 Pages: 37-47
  • Peer Reviewed
• [Journal Article] Hemostatic management during oral surgery in patients with a left-ventricular assist system undergoing high-level anticoagulant therapy : efficacy of low molecular weight heparin (2008)
  • Author(s): Morimoto Y
  • Journal Title: Surg J Oral Maxillofac 66 Pages: 568-571
  • Peer Reviewed
• [Journal Article] Cell removal with supercritical carbon dioxide for acellular artificial tissue (2008)
  • Author(s): K. Sawada
  • Journal Title: Journal of Chemical Technology & Biotechnology 83 Pages: 943-949
  • Peer Reviewed
• [Journal Article] Scaffolds from electrospun polyhydroxyalkanoate copolymers : Fabrication, characterization, bioabsorption and tissue response (2008)
  • Author(s): T. H. Ying
  • Journal Title: Biomaterials 29 Pages: 1307-1317
  • Peer Reviewed
• [Journal Article] Fundamental Studies on Genetically Engineered Elastin Model Peptides for Biomaterials (2008)
  • Author(s): S. Kakinoki
  • Journal Title: The Japanese Peptide Society Pages: 427-428
  • Peer Reviewed
• [Journal Article] 新たな機能性を発揮する再生医療スキャホールド (2008)
  • Author(s): 山岡哲二
  • Journal Title: 工業材料 56 Pages: 70-73
• [Journal Article] 血液の細胞:宿敵か救世主か (2008)
  • Author(s): 江橋具
  • Journal Title: バイオマテリアル<生体材料> 26 Pages: 47-54
• [Journal Article] 異分野融合のためのバイオマテリアルの基礎PART4「血液の細胞:宿敵か救世主か」 (2008)
  • Author(s): 江橋 具
  • Journal Title: バイオマテリアル<生体材料> 26 Pages: 47-54
• [Journal Article] Is extracorporeal life support contraindicated in elderly patients? (2007)
  • Author(s): Saito S, Nakatani T, Kobayashi J, Tagusari O, Bando K, Niwaya K, Nakajima H, Miyazaki S, Yagihara T, Kitamura S
  • Journal Title: Ann Thorac Surg 83 Pages: 140-145
  • Peer Reviewed
• [Journal Article] Domestic and foreign trends in the prevalence of heart failure and the necessity of next-generation artificial hearts: a survey by the working group on establishment of assessment guidelines for next-generation artificial heart systems (2007)
  • Author(s): Tatsumi K, et al.(8人中2番目)
  • Journal Title: J Artif Organs 10 Pages: 187-194
  • Peer Reviewed
• [Journal Article] Initial experiences with the HeartMate vented electric left ventricular assist system in Japan (2007)
  • Author(s): Saito S, et al.(12人中2番目)
  • Journal Title: J Artif Organs 10 Pages: 118-121
  • Peer Reviewed
• [Journal Article] 組織移植の現状と今後の展望 (2007)
  • Author(s): 田中秀治
  • Journal Title: 移植 42(3) Pages: 242-252
• [Journal Article] 移植医療-機械的循環補助も含めて- (2007)
  • Author(s): 中谷武嗣
  • Journal Title: 循環器科 62(1) Pages: 67-73
• [Journal Article] 心臓移植の術後急性期管理 (2007)
  • Author(s): 高内裕司
  • Journal Title: 日集中医誌 14 Pages: 551-554
• [Journal Article] 心移植術後急性期の合併症と問題点 (2007)
  • Author(s): 今中秀光
  • Journal Title: 胸部外科 60 Pages: 958-962
• [Journal Article] 心臓移植(heartttransplantation) (2007)
  • Author(s): 中谷武嗣
  • Journal Title: 臨床検査 51 Pages: 1735-1744
• [Journal Article] Limited sampling strategy for mycophenolic acid in Japanese heart transplant recipients.-Comparison of cyclosporin and tacrolim us treatment- (2007)
  • Author(s): Wada K
  • Journal Title: Circulation Journal 71 Pages: 1022-1028
  • Peer Reviewed
• [Journal Article] Relationship between acute rejection and cyclosporine or mycophenolic acid levels in Japanese heart transplantation (2007)
  • Author(s): Wada K
  • Journal Title: Circ J 71 Pages: 289-293
  • Peer Reviewed
• [Journal Article] Drug interactions between tacrolimus and phenytoin in Japanese heart transplant recipients. : 2 case reports (2007)
  • Author(s): Wada K
  • Journal Title: International Journal of Clinical Pharmacology and Therapeutics 45 Pages: 524-528
  • Peer Reviewed
• [Journal Article] Radial Flow Type Bioreactor for Bioartificial Liver Assist System Using PTFE Non-Woven Fabric Coated with Poly-amino Acid Urethane Copolymer (2007)
  • Author(s): A. Miskon
  • Journal Title: Macromolecular Symposia 249 Pages: 151-158
  • Peer Reviewed
• [Journal Article] Selective photo-cross-linking of 2'-ο-p soralen-conjugated oligonucleotide with RNAs Having point mutations (2007)
  • Author(s): M. Higuchi
  • Journal Title: Nucleosides, Nucleotides, and Nucleic Acids 26 Pages: 277-290
  • Peer Reviewed
• [Journal Article] Cell removal with supercritical carbon dioxide for acellular artificial tissue (2007)
  • Author(s): K. Sawada
  • Journal Title: Journal of Chemical Technology & Biotechnology (in press)
  • Peer Reviewed
• [Journal Article] 医療用バイオベースマテリアル (2007)
  • Author(s): 山岡哲二
  • Journal Title: バイオベースマテリアルの新展開 Pages: 187-197
• [Journal Article] 再生医療への工学的アプローチ (2007)
  • Author(s): 山岡哲二
  • Journal Title: 高分子「高分子科学最近の進歩」 56 Pages: 625-630
  • NAID: 10019741858
• [Journal Article] バイオプラ最前線「ポリ乳酸をベースにした再生医療用バイオマテリアル」 (2007)
  • Author(s): 山岡哲二
  • Journal Title: バイオプラジャーナル 26 Pages: 20-25
  • NAID: 40015921795
• [Journal Article] Selective photo-cross-linking of 2-O-psoralen-conjugated oligonucleotide with RNAs having point mutations (2007)
  • Author(s): M.Higuchi, A.Yamayoshi, T.Yamaguchi, R.Iwase, T.Yamaoka, A.Kobori, A.Murakami
  • Journal Title: Nucleosides, Nucleotider and Nucleic Acids Vol.26 Pages: 3-3
• [Journal Article] Radial Flow Type Bioreactor for Bioartificial Liver Assist System Using PTFE Non-Woven Fabric Coated with Poly-amino Acid Urethane Copolymer (2007)
  • Author(s): Azizi Miskon, Noriko Sasaki, Tetsuji Yamaoka, Hiroshi Uyama, MakotoKodama
  • Journal Title: Macromolecular Symposia Vol.249 Pages: 151-158
• [Journal Article] Pharmacokinetic study and limited sampling strategy of cyclosporine in Japanese heart transplant recipients (2006)
  • Author(s): Wada K, et al.(7人中7番目)
  • Journal Title: Circ J 70(10) Pages: 1307-1311
  • Peer Reviewed
• [Journal Article] Heart-type fatty acid binding protein is a novel prognostic marker in patients with non-ischaemic dilated cardiomyopathy (2006)
  • Author(s): Komamura K, et al.(15人中11番目)
  • Journal Title: Heart 92 Pages: 615-618
  • Peer Reviewed
• [Journal Article] Suppressive effect of phosphodiesterase type 4 inhibition on systemic inflammatory responses after cardiopulmonary bypass (2006)
  • Author(s): Hamamoto M, et al.(8人中7番目)
  • Journal Title: J Artif Organs 9 Pages: 144-148
  • Peer Reviewed
• [Journal Article] Three-dimensional cell seeding and growth in radial-flow perfusion bioreactor for in vitro tissue reconstruction (2006)
  • Author(s): T.Kitagawa, T.Yamaoka, R.Iwase, A.Murakami
  • Journal Title: Biotechnology and Bioengineering Vol.93・No.5 Pages: 947-954
• [Journal Article] Real-Time monitoring of antibody secretion from hybridomas on a microchip by time-resolve luminescence anisotropy analysis (2006)
  • Author(s): T.Munaka, H.Abe, M.Kanai, T.Sakamoto, H.Nakanishi, T.Yamaoka, S.Shoji, A.Murakami
  • Journal Title: Analytical Biochemistry Vol.353・No.1 Pages: 1-6
• [Journal Article] Monitoring cellular events in living mast cells stimulated with an extremely small amount of fluid on a microchip (2006)
  • Author(s): T.Munaka, H.Abe, M.Kanai, T.Sakamoto, H.Nakanishi, T.Yamaoka, S.Shoji, A.Murakami
  • Journal Title: Jpn.J.Applied Physics Vol.45・No.24 Pages: 634-637
  • NAID: 10017653218
• [Journal Article] Various properties of polymeric carriers improved the transfection efficiency (2006)
  • Author(s): T.Hashimoto, A.Mahara, A.Kobori, A.Murakami, T.Yamaoka
  • Journal Title: Nucleic Acids Symposium Series No.50 Pages: 333-334
• [Presentation] 細胞外マトリックスにおける間葉系幹細胞から心筋細胞への分化誘導制御 (2009)
  • Author(s): 馬原淳
  • Organizer: 第7回生活支援工学系学会連合大会
  • Place of Presentation: 高知
  • Year and Date: 2009-09-25
• [Presentation] Effect of Extracellular Matrix Components on Beating Behavior of Cardiomyocytes and Differentiation Behavior of Stem Cells in vitro (2009)
  • Author(s): Azizi MISKON
  • Organizer: 2nd Asia Biomaterial Congress(2st ABMC)
  • Place of Presentation: シンガポール
  • Year and Date: 2009-06-26
• [Presentation] Heart transplantation and mechanical support in Japan (2009)
  • Author(s): Takeshi Nakatani
  • Organizer: 17th Asian Pacific Congress of Cardiology
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2009-05-20
• [Presentation] 組織再生用移植材料に対する初期生体応答 (2009)
  • Author(s): 江橋具
  • Organizer: 第8回日本再生医療学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-06
• [Presentation] Heart transplantation and mechanical support in Japan (2009)
  • Author(s): Nakatani T
  • Organizer: シンポジウム、17th Asian Pacific Congress of Cardiology
  • Place of Presentation: Kyoto, Japan
• [Presentation] Heart transplantation in Asia-pacific region -its status and tasks- (2009)
  • Author(s): Nakatani T
  • Organizer: ジョイントシンポジウム(コメンテーター), 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Fundamental Studies of Artificial Extra Cellular Matrix Composed of Laminin-derived sequence (2008)
  • Author(s): 柿木佐知朗
  • Organizer: The TERMIS-NA 2008 Annual Conference & Exposition
  • Place of Presentation: San Diego
  • Year and Date: 2008-12-09
• [Presentation] 埋入した人工臓器材料に対する免疫応答 (2008)
  • Author(s): 江橋具
  • Organizer: 第46回日本人工臓器学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-28
• [Presentation] ポリ(γ-グルタミン酸)/ポリビニルアルコール複合ハイドロゲルの創傷被覆材への応用 (2008)
  • Author(s): 北川偉之
  • Organizer: バイオマテリアル学会シンポジウム2008
  • Place of Presentation: 東京
  • Year and Date: 2008-11-18
• [Presentation] ラミニンの生理活性配列を付与した構造タンパク質の合成と評価 (2008)
  • Author(s): 柿木佐知朗
  • Organizer: バイオマテリアル学会シンポジウム2008
  • Place of Presentation: 東京
  • Year and Date: 2008-11-18
• [Presentation] 軟組織再生用マテリアルに対する生体応答 (2008)
  • Author(s): 江橋具
  • Organizer: バイオマテリアル学会シンポジウム2008
  • Place of Presentation: 東京
  • Year and Date: 2008-11-18
• [Presentation] MODIFICATION OF PLA SCAFFOLDS USING BIOACTIVE PEPTIDE-OLIGO (LACTIC ACID) CONJUGATES (2008)
  • Author(s): 柿木佐知朗
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-30
• [Presentation] ラミニンの機能を付与した人工細胞外基質の設計と評価 (2008)
  • Author(s): 柿木佐知朗
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-24
• [Presentation] 生体由来スキャフォールド移植による神経の機能再生 (2008)
  • Author(s): 江橋具
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-24
• [Presentation] Tsuyoshi Murase SurfaceModification of Poly(lacticacid)-based Nerve Conduit with Oligo(lactic acid)-Oligo peptideAmphiphilic Conjugates (2008)
  • Author(s): Tetsuji YAMAOKA, Sho UCHIDA, Hiroyuki Tanaka, Ko Temporin
  • Organizer: Society For Biomaterials 2008
  • Place of Presentation: Atlanta
  • Year and Date: 2008-09-12
• [Presentation] Surface Modification of Poly (lactic acid)-based Nerve Conduit with Oligo (lactic acid)-Oligo peptide Amphiphilic Conjugates (2008)
  • Author(s): 山岡哲二
  • Organizer: Society For Biomaterials 2008
  • Place of Presentation: Atlanta
  • Year and Date: 2008-09-12
• [Presentation] ポリ乳酸ナノファイバー表面特性の機能化と組織再生 (2008)
  • Author(s): 山岡哲二、佐々木愛、内田翔、村上章、森反俊幸
  • Organizer: 第37回医用高分子シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-07-28
• [Presentation] ステレオコンプレックスポリ乳酸ナノファイバーの in vivo および in vitro 分解挙動 (2008)
  • Author(s): 石井大輔
  • Organizer: 第54回 高分子研究発表会
  • Place of Presentation: 神戸
  • Year and Date: 2008-07-18
• [Presentation] ラミニン様人工細胞外基質の合成と評価 (2008)
  • Author(s): 柿木佐知朗
  • Organizer: 第54回 高分子研究発表会
  • Place of Presentation: 神戸
  • Year and Date: 2008-07-18
• [Presentation] ポリ乳酸ナノファイバーの機能化と組織再生 (2008)
  • Author(s): 山岡哲二
  • Organizer: 平成20年度繊維学会年次大会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-20
• [Presentation] ポリ(γ-グルタミン酸)/ポリビニルアルコール複合ハイドロゲルの創傷被覆材へに応用 (2008)
  • Author(s): 単錦宇
  • Organizer: 第57回高分子学会年次大会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-29
• [Presentation] バイオ人工血管移植による動脈再生 (2008)
  • Author(s): 寺田堂彦
  • Organizer: 第57回高分子学会年次大会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-29
• [Presentation] 毛細血管の再構築を誘導できる新規スキャホールドの開発 (2008)
  • Author(s): 江橋 具
  • Organizer: 第7回日本再生医療学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-03-14
• [Presentation] Electro spunp PLLA nonwoven nerve conduit modified with biologically active peptide sequenses (2008)
  • Author(s): 山岡 哲二
  • Organizer: Biologic Scaffolds for Regenerative Medicine 5th Symposium
  • Place of Presentation: フェニックス(米国)
  • Year and Date: 2008-02-15
• [Presentation] Novel biomaterirals for cell transplantation (2008)
  • Author(s): T.Yamaoka
  • Organizer: TERMIS-AP 2008
  • Place of Presentation: Taipei
• [Presentation] 心移植 : 既存抗体, 産生抗体のモニタリングと移植後の管理 (2008)
  • Author(s): 中谷武嗣、加藤倫子、簗瀬正伸、山本賢、瀬口周、舩津俊宏、小林順二郎、植田初江、佐田正晴
  • Organizer: 第44回日本移植学会総会
  • Place of Presentation: 大阪
• [Presentation] 心移植:既存抗体、産生抗体のモニタリングと移植後の管理 (2008)
  • Author(s): 中谷武嗣
  • Organizer: 第44回日本移植学会総会
  • Place of Presentation: 大阪
• [Presentation] 国立循環器病センター組織保存バンクの活動報告 (2008)
  • Author(s): 増谷友紀
  • Organizer: 第44回日本移植学会総会
  • Place of Presentation: 大阪
• [Presentation] わが国における補助人工心臓の将来 (2008)
  • Author(s): 中谷武嗣
  • Organizer: 第46回日本人工臓器学会大会
  • Place of Presentation: 東京
• [Presentation] State of the Art & Field-wide Challenges (2008)
  • Author(s): Bogaev B
  • Organizer: 16th Congress of the International Society for Rotary Blood Pumps
  • Place of Presentation: Houston
• [Presentation] Surface Modification of Poly(lactic acid)-ased Scaffolds with Oligo(lactic acid)-Oligopeptide Amphiphilic Conjugates (2007)
  • Author(s): T. Yamaoka
  • Organizer: 1st Asia Biomaterial Congress(1st ABMC)
  • Place of Presentation: つくば
  • Year and Date: 2007-12-06
• [Presentation] Fundamental Studies of Genetically Engineered Elastin Model Peptide for Scaffold Biomaterials (2007)
  • Author(s): S. Kakinoki
  • Organizer: 1st Asia Biomaterial Congress(1st ABMC)
  • Place of Presentation: つくば
  • Year and Date: 2007-12-06
• [Presentation] Syngeneic Cell Transplantation Using PLLA-Based Injectable Scaffold (2007)
  • Author(s): T. Yamaoka
  • Organizer: The 10th Pacific Polymer Conference(PPC10)
  • Place of Presentation: 神戸
  • Year and Date: 2007-12-05
• [Presentation] 高親水性高分子を用いた人工血管用スキャホールドの作製と評価 (2007)
  • Author(s): 佐々木 愛
  • Organizer: 第29回 日本バイオマテリアル学会 : 大阪
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-27
• [Presentation] ポリ乳酸-ポリエチレングリコール共重合体を用いた細胞注入用スキャホールドの開発 (2007)
  • Author(s): 馬城 朋之
  • Organizer: 第29回 日本バイオマテリアル学会 : 大阪
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-27
• [Presentation] 心臓移植後拒絶反応の非侵襲的評価法;経胸壁心エコーによるストレイン映像法の有用性 (2007)
  • Author(s): 加藤倫子
  • Organizer: 第43回日本移植学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-11-24
• [Presentation] Fundamental Studies on Genetically Engineered Elastin Model Peptides for Biomaterials (2007)
  • Author(s): 柿木 佐知朗
  • Organizer: 第44回ペプチド討論会
  • Place of Presentation: 富山
  • Year and Date: 2007-11-07
• [Presentation] Over one year support by left ventricular assist system at NCVC (2007)
  • Author(s): Nakatani T
  • Organizer: 第45回日本人工臓器学会大会 第2回国際人工臓器学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-30
• [Presentation] Tissue regeneration by acellular scaffolds prepared by detergent-free treatment (2007)
  • Author(s): Fujisato T
  • Organizer: 第45回日本人工臓器学会大会 第2回国際人工臓器学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-30
• [Presentation] Surface modification of PLLA scaffolds using oligo(lactic acid)-peptide conjugates (2007)
  • Author(s): 山岡哲二
  • Organizer: 第45回日本人工臓器学会大会(JSAO and IFAO Joint Congress)
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-29
• [Presentation] ポリ乳酸ナノ繊維の機能化 (2007)
  • Author(s): 山岡哲二
  • Organizer: 繊維学会 2007 秋季研究発表会
  • Place of Presentation: 京都
  • Year and Date: 2007-10-26
• [Presentation] オリゴ乳酸-オリゴペプチド結合体によるポリ乳酸スキャホールドの機能化 (2007)
  • Author(s): 山岡哲二
  • Organizer: 第56回 高分子討論会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-09-21
• [Presentation] MSC の高純度ポピュレーション分離と細胞機能評価 (2007)
  • Author(s): 馬原 淳
  • Organizer: 第56回 高分子討論会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-09-19
• [Presentation] 高機能性医療用人工タンパク質ゲルの開発 (2007)
  • Author(s): 柿木佐知朗
  • Organizer: 第56回 高分子討論会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-09-19
• [Presentation] Differentiation Property of Mesenchymal Stem Cells Isolated by Ligand-Immobilized Column System (2007)
  • Author(s): Mahara A
  • Organizer: 2007 Regenerate World Congress on Tissue Engineering and Regenerative Medicine(TERMIS-EU)
  • Place of Presentation: ロンドン(英国)
  • Year and Date: 2007-09-07
• [Presentation] Preliminary Study of In Vitro Niche Effect on Differentiation of Rat Bone Marrow Stem Cells to Cardiomyocytes-Like Cells (2007)
  • Author(s): A. Miskon
  • Organizer: 2007 Regenerate World Congress on Tissue Engineering and Regenerative Medicine(TERMIS-EU)
  • Place of Presentation: ロンドン(英国)
  • Year and Date: 2007-09-06
• [Presentation] In vitro 血管組織のための灌流型バイオリアクター内遺伝子導入システム (2007)
  • Author(s): 山本敬介
  • Organizer: 第2回関西若手研発表会
  • Place of Presentation: 大阪
  • Year and Date: 2007-08-03
• [Presentation] オリゴ乳酸-ペプチドコンジュゲートを用いたポリ乳酸スキャホールドの表面修飾 (2007)
  • Author(s): 内田 翔
  • Organizer: 第56回高分子学会年次大会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-30
• [Presentation] ポリ乳酸ナノファイバーの生体適合性 (2007)
  • Author(s): 石井大輔
  • Organizer: 第56回高分子学会年次大会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-29
• [Presentation] 血管再生用スキャフォールドに対する組織反応の解析と制御 (2007)
  • Author(s): 岡田康彰
  • Organizer: 第56回高分子学会年次大会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-29
• [Presentation] Electrospun nanofibrous scaffold made from PHA copolymers (2007)
  • Author(s): Hui Ying Tang,
  • Organizer: 第56回高分子学会年次大会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-29
• [Presentation] In vitro 血管組織再生のための灌流型バイオリアクター内遺伝子導入システム (2007)
  • Author(s): 山本敬介
  • Organizer: 第56回高分子学会年次大会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-29
• [Presentation] Therapeutic monitoring of mycophenolate mofetile dose by twelve-hour-area under the curve to avoide acute rejection in heart transplant recipients (2007)
  • Author(s): Wada K
  • Organizer: International Society for Heart and Lung Transplantation 24th Annual Meeting and Scientific Sessions
  • Place of Presentation: San Francisco, CA, U.S.A.
  • Year and Date: 2007-04-27
• [Presentation] Reduced systolic strain and systolic strain rate could detect subclinical acute refection in heart transplant recipients (2007)
  • Author(s): Kamiya C
  • Organizer: International Society for Heart and Lung Transplantation 24th Annual Meeting and Scientific Sessions
  • Place of Presentation: San Francisco, CA, U.S.A.
  • Year and Date: 2007-04-27
• [Presentation] Time lapse analysis of changes in Doppler-derived index of coronary flow reserve over time could reduce frequency of endomyocardial biopsy (2007)
  • Author(s): Oda N
  • Organizer: International Society for Heart and Lung Transplantation 24th Annual Meeting and Scientific Sessions
  • Place of Presentation: San Francisco, CA, U.S.A.
  • Year and Date: 2007-04-26
• [Presentation] Clinical utility of coronary perfusion reserse and strain rate imaging obtained by echocardiography as a noninvasive evaluation for sub-clinical acute rejection in heart transplant recipients (2007)
  • Author(s): Kato T. S.
  • Organizer: International Society for Heart and Lung Transplantation 24th Annual Meeting and Scientific Sessions
  • Place of Presentation: San Francisco, CA, U.S.A.
  • Year and Date: 2007-04-26
• [Presentation] In vitro 血管組織再生のための灌流型バイオリアクター内遺伝子導入システム (2007)
  • Author(s): 山本敬介
  • Organizer: 第46回日本生体工学会大会
  • Place of Presentation: 仙台
  • Year and Date: 2007-04-25
• [Presentation] 末期心不全患者に対する治療選択としての心臓移植と補助人工心臓 (2007)
  • Author(s): 中谷武嗣
  • Organizer: 第107回日本外科学会定期学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-11
• [Presentation] Therapeutic monitoring of mycophenolate mofetile dose by twelve-hour-area under the curve to avoide acute rejection in heart transplant recipients (2007)
  • Author(s): Wada K, et al.(8人中8番目)
  • Organizer: International Society for Heart and Lung Transplantation 24th Annual Meeting and Scientific Sessions
  • Place of Presentation: San Francisco, CA, U.S.A
• [Presentation] Surface Modification of Poly(lactic acid)-ased Scaffolds with Oligo(lactic acid)-Oligopeptide Amphiphilic Conjugates (2007)
  • Author(s): T.Yamaoka
  • Organizer: 1st Asia Biomaterial Congress (1st ABMC)
  • Place of Presentation: Tsukuba
• [Presentation] Regenerative Tissue Scaffolds Prepared by Gamma Ray Irradiation (2007)
  • Author(s): Toshia Fujisato
  • Organizer: アメリカバイオマテリアル学会2007
  • Place of Presentation: シカゴ(米国)
• [Presentation] Over one year support by using extracorporeal left ventricular assist system (2006)
  • Author(s): Nakatani T, et al.(12人中1番目)
  • Organizer: Panel discussion, American Society for Artificial Internal Organs 52nd Annual Conference
  • Place of Presentation: Chicago, U.S.A
• [Presentation] Clinical experience of ventrcular assist systems and heart transplantation i n Japan (2006)
  • Author(s): Nakatani T, Kitamura S
  • Organizer: ジョイントシンポジウム、第10回日本日本心不全学会学術集会
  • Place of Presentation: 東京
• [Book] 最新循環器診療マニュアル(総編集 友池仁暢, 心筋疾患心臓移植) (2009)
  • Author(s): 中谷武嗣
  • Publisher: 中山書店
• [Book] 重症心不全の予防と治療(編著 北風政史, 人工心臓) (2009)
  • Author(s): 中谷武嗣、簗瀬正伸、戸田宏一
  • Publisher: 中外医学社
• [Book] 最新循環器診療マニュアル (2009)
  • Author(s): 中谷武嗣
  • Total Pages: 822
  • Publisher: 中山書店、東京
• [Book] 重症心不全の予防と治療 (2009)
  • Author(s): 中谷武嗣、簗瀬正伸、戸田宏一
  • Total Pages: 524
  • Publisher: 中外医学社、東京
• [Book] 第46回日本人工臓器学会大会 教育講演「吸収性材料と組織再生」 (2009)
  • Author(s): 山岡哲二
  • Total Pages: 5
  • Publisher: 人工臓器、38巻1号
• [Book] 心臓疾患における幹細胞移植とイメージング (2009)
  • Author(s): 橘洋一、山岡哲二
  • Total Pages: 2
  • Publisher: JSMI Report日本分子イメージング学会機関紙、3巻1号
• [Book] 3大疾病の教科書 がん・心臓病・脳卒中をストップ!(国立がんセンター・国立循環器病センター編, 心臓移植医療, ビジュアル版) (2008)
  • Author(s): 中谷武嗣
  • Publisher: 三省堂
• [Book] 心臓移植医療 ビジュアル版「3大疾病の教科書 がん・心臓病・脳卒中をストップ!」 (2008)
  • Author(s): 中谷武嗣
  • Total Pages: 126
  • Publisher: 三省堂
• [Book] 人工心臓 ビジュアル版「3大疾病の教科書 がん・心臓病・脳卒中をストップ!」 (2008)
  • Author(s): 中谷武嗣
  • Total Pages: 126
  • Publisher: 三省堂
• [Book] 心臓移植医療ビジュアル版「3大疾病の教科書 がん・心臓病・脳卒中をストップ!」 (2008)
  • Author(s): 中谷武嗣
  • Total Pages: 126
  • Publisher: 三省堂
• [Book] 人工心臓ビジュアル版「3大疾病の教科書 がん・心臓病・脳卒中をストップ!」 (2008)
  • Author(s): 中谷武嗣
  • Total Pages: 126
  • Publisher: 三省堂
• [Book] 新 目でみる循環器病シリーズ 15 心筋症(心臓移植) (2007)
  • Author(s): 中谷武嗣
  • Publisher: メジカルビュー社
• [Book] バイオベースマテリアルの新展開(医療用バイオベースマテリアル, 第3編 応用編, 第1章) (2007)
  • Author(s): 山岡哲二、木村良晴、藤里俊哉
  • Publisher: シーエムシー出版
• [Book] ポリ乳酸をベースにした再生医療用バイオマテリアル(バイオプラ最前線, No.26) (2007)
  • Author(s): 山岡哲二
  • Publisher: バイオプラジャーナル
• [Book] 心臓移植「新 目でみる循環器病シリーズ15 心筋症」 (2007)
  • Author(s): 中谷武嗣
  • Publisher: メジカルレビュー社
• [Book] カチオン性ポリマー (2006)
  • Author(s): 橋本朋子, 山岡哲二
  • Total Pages: 8
  • Publisher: 株式会社 メディカルドゥ
• [Book] 再生医療のための生体吸収性材料 (2006)
  • Author(s): 山岡哲二
  • Total Pages: 6
  • Publisher: 日本人工臓器学会
• [Book] 再生医療における工学技術 (2006)
  • Author(s): 山岡哲二
  • Total Pages: 8
  • Publisher: 生命科学研究会
• [Book] カチオン性ポリマー (2006)
  • Author(s): 山岡哲二, 木村良晴, 藤里俊哉
  • Total Pages: 8
  • Publisher: シーエムシー出版
• [Book] 3大疾病の教科書 がん・心臓病・脳卒中をストップ!(国立がんセンター・国立循環器病センター編, 人工心臓, ビジュアル版)
  • Author(s): 中谷武嗣
  • Publisher: 三省堂
• [Book] 内科学第九版(補助循環・人工心臓)
  • Author(s): 中谷武嗣
  • Publisher: 朝倉書店
• [Patent(Industrial Property Rights)] ポリビニルアルコールとポリ(γ-グルタミン酸) 塩との複合ゲルの製造方法 (2008)
  • Inventor(s): 宇山 浩、単 錦宇、山岡 哲二
  • Industrial Property Rights Holder: 国立大学法人大阪大学、国立循環器病センター総長
  • Industrial Property Number: 2008-071806
  • Filing Date: 2008-03-19
• [Patent(Industrial Property Rights)] 神経誘導管 (2007)
  • Inventor(s): 山岡哲二、加藤 聡
  • Industrial Property Rights Holder: 国立循環器病センター総長、三菱化学株式会社
  • Industrial Property Number: 2007-238434
  • Filing Date: 2007-09-13
• [Patent(Industrial Property Rights)] 生体適合性多孔質シートおよびそれを用いた人工皮膚 (2006)
  • Inventor(s): 山岡 哲二, 馬原 淳
  • Industrial Property Rights Holder: 山岡 哲二, 東洋紡績株式会社
  • Industrial Property Number: 2006-214385
  • Filing Date: 2006-09-21
• [Patent(Industrial Property Rights)] 金属キレート複合体およびプロトン緩和速度増強剤並びにMRI造影剤 (2006)
  • Inventor(s): 山岡 哲二, 橘 洋一, 飯田 秀博
  • Industrial Property Rights Holder: 財団法人ヒューマンサイエンス振興財団
  • Industrial Property Number: 2006-310159
  • Filing Date: 2006-11-16
• [Patent(Industrial Property Rights)] 血液凝固抑制材料並びにそれを用いたコーディング材料 (2006)
  • Inventor(s): 山岡 哲二, 加藤 聡
  • Industrial Property Rights Holder: 北村 惣一郎, 三菱化学株式会社
  • Industrial Property Number: 2006-312167
  • Filing Date: 2006-11-17
• [Patent(Industrial Property Rights)] 細胞の分取方法、及び当該方法に用いる基材 (2006)
  • Inventor(s): 山岡 哲二, 馬原 淳, 北村 惣一郎
  • Industrial Property Rights Holder: 山岡 哲二, 東洋紡績株式会社
  • Filing Date: 2006-11-06