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Validation of OMICS data of urological malignancies for the clinical use

Research Project

Project/Area Number 18209049
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionKyoto University

Principal Investigator

OGAWA Osamu (OSAMU Ogawa)  Kyoto University, 大学院・医学研究科, 教授 (90260611)

Co-Investigator(Kenkyū-buntansha) NISHIYAMA Hiroyuki  京都大学, 大学院・医学研究科, 准教授 (20324642)
INUI Kenichi  京都大学, 大学院・医学研究科, 教授 (70034030)
FUKUSHIMA Masanori  京都大学, 大学院・医学研究科, 教授 (80107820)
TUJIMOTO Gouzo  京都大学, 大学院・薬学研究科, 教授 (80172013)
NAKAMURA Eijiro  京都大学, 大学院・医学研究科, 講師 (90293878)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000)
Fiscal Year 2009: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2007: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2006: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Keywords泌尿器科癌 / OMICS / 遺伝子解析 / 網羅的発現解析 / プロテオーム / 綱羅的発現解析 / プロテオ-ム / 泌尿器科がん / 統合的OMICSデータ
Research Abstract

In this project we aimed to carry out experiments which were essential for application of our achieved findings to clinical settings. First, we developed a comprehensive database incorporating genomic data including gene polymorphism, transcriptome data, and proteomic data. Second, we explored novel molecular targets for diagnosis or treatment by analyzing this database and clinical information. Finally, functions and roles of the molecules were investigated using in-vitro and in-vivo experimental models.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (60 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (48 results) (of which Peer Reviewed: 42 results) Presentation (5 results) Remarks (3 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model.2010

    • Author(s)
      Terada N, Ogawa O, et al.
    • Journal Title

      Cancer Res (70)

      Pages: 1606-1615

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of Racl is closely related to androgen-independent cell proliferation of prostate cancer cells both in vitro and in vivo2010

    • Author(s)
      Kobayashi T, Nakamura E, Ogawa O, et al.
    • Journal Title

      Mol Endocrinol 24(4)

      Pages: 722-34

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model2010

    • Author(s)
      Terada, N., Ogawa, O, et al.
    • Journal Title

      Cancer Research 70

      Pages: 1606-1615

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Restoration of cyclin D2 has an inhibitory potential on the proliferation of LNCaP cells.2009

    • Author(s)
      Kobayashi T, Nakamura E, Ogawa O, et al.
    • Journal Title

      Biochem Biophys Res Commun. 387(1)

      Pages: 196-201

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescent imaging of high-grade bladder cancer using a specific antagonist for chemokine receptor CXCR4.2009

    • Author(s)
      Nishizawa K, Nishiyama H, Ogawa O, et al.
    • Journal Title

      Int J Cancer

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secreted CXCL1 is a potential mediator and marker of the tumor invasion of bladder cancer.2008

    • Author(s)
      Kawanishi H, Tsujimoto G, Nakamura E, Ogawa O, et al.
    • Journal Title

      Clin Cancer Res (14)

      Pages: 2579-2587

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cancer-specific enhancement of cisplatin-induced cytotoxicity with triptolide through an interaction ofinactivated glycogen synthase kinase-3beta with p53.2008

    • Author(s)
      Matsui Y, Ogawa O, Nishiyama H., et al.
    • Journal Title

      Oncogene (27)

      Pages: 4603-4614

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of genetic polymorphisms at 8q24 with the risk of prostate cancer in a Japanese population.2008

    • Author(s)
      Terada N, Ogawa O, et al.
    • Journal Title

      Prostate (68)

      Pages: 1689-1695

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microarray-based identification of CUB-domain containing protein 1 as a potentialprognostic marker in conventional renal cell carcinoma2008

    • Author(s)
      Awakura Y, Nakamura E, Tsujimoto G, Ogawa, et al.
    • Journal Title

      J Cancer Res Clin Oncol (134)

      Pages: 1363-1369

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methylation-associated silencing of TU3A in human cancers.2008

    • Author(s)
      Awakura Y, Nakamura E, Ogawa O, et al.
    • Journal Title

      Int J Oncol (33)

      Pages: 893-899

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methylation-associated silencing of SFRP1 in renal cell carcinoma.2008

    • Author(s)
      Awakura Y, Nakamura E, Ogawa O, et al.
    • Journal Title

      Oncol Rep. 20(5)

      Pages: 1257-63

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secreted CXCL1 is a potential mediator and marker of the tumor invasion of bladder cancer2008

    • Author(s)
      Kawanishi H, Tsujimoto G, Nakamura E, Ogawa O, et.al.
    • Journal Title

      Clin Cancer Res 14

      Pages: 2579-2587

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Cancer-specific enhancement of cisplatin-induced cytotoxicity with triptolide through an interaction ofinactivated glycogen synthase kinase-3beta with p532008

    • Author(s)
      Matsui Y, Ogawa O, Nishiyama H., et.al.
    • Journal Title

      Oncogene 27

      Pages: 4603-4614

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Association of genetic polymorphisms at 8q24 with the risk of prostate cancer in a Japanese population2008

    • Author(s)
      Terada N, Ogawa O, et.al.
    • Journal Title

      Prostate 68

      Pages: 1689-1695

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Microarray-based identification of CUB-domain containing protein 1 as a potentialprognostic marker in conventional renal cell carcinoma2008

    • Author(s)
      Awakura Y, Nakamura E, Tsujimoto G, Ogawa O, et.al
    • Journal Title

      J Cancer Res Clin Oncol 134

      Pages: 1363-1369

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Methylation-associated silencing of TU3A in human cancers2008

    • Author(s)
      Awakura Y, Nakamura E, Ogawa O, et.al
    • Journal Title

      Int J Oncol 33

      Pages: 893-899

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Secreted CXCL1 is a potential mediator and marker of the tumor invasion of bladder cancer.2008

    • Author(s)
      Kawanishi H, Matsui Y, Tsujimoto G, Nakamura E, Ogawa O, et al.
    • Journal Title

      Clin Cancer Res 14

      Pages: 2579-2587

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer-specific enhancement of cisplatin-induced cytotoxicity with triptolide through an interaction of inactivated glycogen synthase kinase-3beta with p53.2008

    • Author(s)
      Matsui Y, Watanabe J, Ikegawa M, Kamoto T, Ogawa O, Nishiyama H.
    • Journal Title

      Oncogene 27

      Pages: 4603-4614

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of genetic polymorphisms at 8q24 with the risk of prostate cancer in a Japanese population.2008

    • Author(s)
      Terada N, Tsuchiya N, T, Habuchi T, Ogawa O, et al.
    • Journal Title

      Prostate 68

      Pages: 1689-1695

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microarray-based identification of CUB-domain containing protein 1 as a potentialprognostic marker in conventional renal cell carcinoma.2008

    • Author(s)
      Awakura Y, Nakamura E, Tsujimoto G, Ogawa O, et al.
    • Journal Title

      J Cancer Res Clin Oncol 134

      Pages: 1363-1369

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methylation-associated silencing of TU3A in human cancers.2008

    • Author(s)
      Awakura Y, Nakamura E, Ito N, Kamoto T, Ogawa O.
    • Journal Title

      Int J Oncol 33

      Pages: 893-899

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] P21-activated kinase 1: a new molecular marker for intravesical recurrence after transurethral resection of bladder cancer.2007

    • Author(s)
      Ito M, Nishiyama H, Ogawa O, et al.
    • Journal Title

      J Urol (178)

      Pages: 1073-1079

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis of multifocal superficial urothelial cancers by array-based comparative genomic hybridisation2007

    • Author(s)
      Kawanishi H, Nishiyama H, Ogawa O, et al.
    • Journal Title

      Br J Cancer (97)

      Pages: 260-266

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sensitizing effect of galectin-7 in urothelial cancer to cisplatin through the accumulation of intracellular reactive oxygen species.2007

    • Author(s)
      Matsui Y, Nishiyama H, Ogawa O, at al.
    • Journal Title

      Cancer Res (67)

      Pages: 1212-1220

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The roles of androgen-dependent and-independent activation of signal transduction pathways for cell proliferation of prostate cancer cells.2007

    • Author(s)
      Inoue T, Ogawa O, Nakamura E, et al.
    • Journal Title

      Expert Rev Endocrinol Metab (2)

      Pages: 689-704

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] STAT 3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma.2007

    • Author(s)
      Ito N, Nakamura E, Ogawa O, et al.
    • Journal Title

      J Clin Oncol (25)

      Pages: 2785-2791

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergy of interferon-alpha and 5-fluorouracil in human renal cell carcinoma requires p53 activity2007

    • Author(s)
      Shang D, Nishiyama H, Ogawa O, et al.
    • Journal Title

      Eur Urol 52

      Pages: 1131-1139

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Demethylating agent 5-aza-2'-deoxycytidine enhances susceptibility of renal cell carcinoma to paclitaxel.2007

    • Author(s)
      Shang D, Ogawa O, et al.
    • Journal Title

      Urology 69

      Pages: 1007-1012

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] P21-activated kinase 1 : a new molecular marker for intravesical recurrence after transurethral resection of bladder cancer2007

    • Author(s)
      Ito M, Nishiyama H, Ogawa O, et.al.
    • Journal Title

      J Urol 178

      Pages: 1073-1079

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis of multifocal superficial urothelial cancers by array-based comparative genomic hybridisation2007

    • Author(s)
      Kawanishi H, Nishiyama H, Ogawa O, et.al.
    • Journal Title

      Br J Cancer 97

      Pages: 260-266

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Sensitizing effect of galectin-7 in urothelial cancer to cisplatin through the accumulation of intracellular reactive oxygen species.2007

    • Author(s)
      Matsui Y, Nishiyama H, Ogawa O, et.al.
    • Journal Title

      Cancer Res 67

      Pages: 1212-1220

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] The roles of androgen-dependent and -independent activation of signal transduction pathways for cell proliferation of prostate cancer cells2007

    • Author(s)
      Inoue T, Ogawa O, Nakamura E, et.al.
    • Journal Title

      Expert Rev Endocrinol Metab 2

      Pages: 689-704

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] STAT3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma2007

    • Author(s)
      Ito N, Nakamura E, Ogawa O, et.al.
    • Journal Title

      J Clin Oncol 25

      Pages: 2785-2791

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Increased Akt and phosphorylated Akt expression associated with malignant biological features of2007

    • Author(s)
      Shimizu Y, Segawa T, Inoue T, Shiraishi T, Yoshida T, Toda Y,
    • Journal Title

      BJU Int 100

      Pages: 685-690

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The roles of androgen-dependent and -independent activation of signal transduction pathways for cell proliferation of prostate cancer cells.2007

    • Author(s)
      Inoue T, Kobayashi T, Terada N, Shimizu Y, Kamoto T, Ogawa O Nakamura E.
    • Journal Title

      Expert Rev Endocrinol Metab 2

      Pages: 689-704

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] STAT3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma.2007

    • Author(s)
      Ito N, Ogawa O, et. al.
    • Journal Title

      J Clin Oncol 25

      Pages: 2785-2791

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitizing effect of galectin-7 in urothelial cancer to cisplatin through the accumulation of intracellular reactive oxygen species.2007

    • Author(s)
      Matsui Y, Ogawa O, at al
    • Journal Title

      Cancer Res 67

      Pages: 1212-1220

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis of multifocal superficial urothelial cancers by array-based comparative genomic2007

    • Author(s)
      Kawanishi H, Ogawa O, et. al.
    • Journal Title

      Br J Cancer 97

      Pages: 260-266

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] P21-activated kinase 1: a new molecular marker for intravesical recurrence after transurethral resection of bladder cancer.2007

    • Author(s)
      Ito M, Nishiyama H, Kawanishi H, Matsui S, Guilford P, Reeve A, Ogawa O.
    • Journal Title

      J Urol 178

      Pages: 1073-1079

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic Characterization of Multiple Clinical Phenotypes of Cancer Using Multivariate Linear Regression Models.2007

    • Author(s)
      Matsui S, Ito M, Nishiyama H, Uno H, Kotani H, Watanabe J, Guilford P, Reeve A, Fukushima M, Ogawa O.
    • Journal Title

      Bioinformatics

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von hippel-lindau tumor suppressor protein.2006

    • Author(s)
      Nakamura E, Ogawa O, et al.
    • Journal Title

      Am J Pathol 168

      Pages: 574-584

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of Androgen-Dependent Activation of Protein Kinase C{zeta} for Androgen-Dependent Cell Proliferation in LNCaP Cells and Its Roles in Transition to Androgen-Independent Cells.2006

    • Author(s)
      Inoue T, Yoshida T, Shimizu Y, Kobayashi T, Yamasaki T, Toda Y, Segawa T, Kamoto T, Nakamura E, Ogawa O
    • Journal Title

      Mol Endocrinol. 20

      Pages: 3053-3069

    • Related Report
      2006 Annual Research Report
  • [Journal Article] High throughput comparative genomic hybridization array analysis of multifocal urothelial cancers.2006

    • Author(s)
      Kawanishi H, Takahashi T, Ito M, Watanabe J, Higashi S, Kamoto T, Habuchi T, Kadowaki T, Tsujimoto G, Nishiyama H, Ogawa O.
    • Journal Title

      Cancer Sci. 97

      Pages: 746-752

    • NAID

      10018768276

    • Related Report
      2006 Annual Research Report
  • [Journal Article] High-grade and hormone-treated prostate cancer express high levels of thymidylate synthase.2006

    • Author(s)
      Inoue, T, Segawa, T, Shiraishi, T, Yamada, T, Kinukawa, N, Yoshida, T, Toda, Y, Shimizu, Y, Nakamura, E, Kinoshita, H, Kamoto, T, Ogawa, O.
    • Journal Title

      BJU Int 98

      Pages: 197-200

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Matrix metalloproteinase-9 polymorphisms and renal cell carcinoma in a Japanese population.2006

    • Author(s)
      Awakura Y, Ito N, Nakamura E, Takahashi T, Kotani H, Mikami Y, Manabe T, Kamoto T, Habuchi T, Ogawa O
    • Journal Title

      Cancer Lett. 241

      Pages: 59-63

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Dicoumarol potentiates cisplatin-induced apoptosis mediated by c-Jun N-terminal kinase in p53 wild-type urogenital cancer cell lines.2006

    • Author(s)
      Watanabe J, Nishiyama H, Matsui Y, Ito M, Kawanishi H, Kamoto T, Ogawa O
    • Journal Title

      Oncogene 25

      Pages: 2500-2508

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Increased Akt and phosphorylated Akt expression associated with malignant biological features of prostate cancer in Japanese men.

    • Author(s)
      Shimizu Y, Nakamura E, Ogawa O., et al.
    • Journal Title

      BJU Int

      Pages: 685-690

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased Akt and phosphorylated Akt expression associated with malignant biological features of prostate cancer in Japanese men.

    • Author(s)
      Shimizu Y, Nakamura E, Ogawa O., et.al.
    • Journal Title

      BJU Int 100

      Pages: 685-690

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Presentation] 新規前立腺癌Xenograftを用いたアンドロゲン非依存性前立腺癌治療標的分子EP4の同定2009

    • Author(s)
      寺田直樹、小川修, ほか
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanisms of Acquiring Androgen-Independence in Novel Prostate Cancer Xenograft Model2008

    • Author(s)
      寺田直樹, 小川修, ほか
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mechanisms of Acquiring Androgen-Independence in Novel Prostate Cancer Xenograft Model2007

    • Author(s)
      寺田 直樹、小川 修、ほか
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cell culture proteome identifies CXCL1 as a secreted marker and mediator for the tumor invasion of bladder cancer2007

    • Author(s)
      Kawanishi H, Ogawa O, et. al.
    • Organizer
      2007米国泌尿器科学会総会
    • Place of Presentation
      アナハイム
    • Year and Date
      2007-05-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Triptolide (PG490)-mediated sensitization of urothelial cancer cells to cisplatin-induced apoptosis2007

    • Author(s)
      Matsui Y, Ogawa O, et. al.
    • Organizer
      2007米国癌学会総会
    • Place of Presentation
      ロサンゼルス
    • Year and Date
      2007-04-16
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.urology.kuhp.kyoto-u.ac.jp/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.urology.kuhp.kyoto-u.ac.jp/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.urologv.kuhp.kvoto-u.ac.ip/

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 前立腺癌のホルモン不応性獲得に関与する遺伝子および治療薬2009

    • Inventor(s)
      小川修、辻本豪三, 他
    • Industrial Property Rights Holder
      松本紘、川〓和一十
    • Filing Date
      2009-01-30
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 前立腺癌のホルモン不応性獲得に関与する遺伝子および治療薬2009

    • Inventor(s)
      小川修、辻本豪三, ほか
    • Industrial Property Rights Holder
      松本紘、川〓和一十
    • Acquisition Date
      2009-01-30
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 前立腺癌のホルモン不応性獲得に関与する遺伝子および治療薬2009

    • Inventor(s)
      小川修, 辻本豪三, ほか
    • Industrial Property Rights Holder
      松本紘, 川〓和一十
    • Filing Date
      2009-01-30
    • Related Report
      2008 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 前立腺癌のホルモン不応性獲得に関与する遺伝子および治療薬2009

    • Inventor(s)
      小川修, 辻本豪三, ほか
    • Industrial Property Rights Holder
      松本紘, 川〓和 和一十
    • Filing Date
      2009-01-30
    • Related Report
      2008 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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