| Project/Area Number |
18256001
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
ASAKAWA Yoshinori Tokushima Bunri University, 薬学部, 教授 (50033874)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUYAMA Yoshiyasu 徳島文理大学, 薬学部, 教授 (70208990)
HASHIMOTO Toshihiro 徳島文理大学, 薬学部, 教授 (10075955)
TOYOTA Masao 徳島文理大学, 薬学部, 教授 (50122586)
NAGASHIMA Fumihiro 徳島文理大学, 薬学部, 准教授 (60228012)
ITO Takuya 徳島文理大学, 薬学部, 助教 (90517484)
HARINANTENAINA Live 元徳島文理大学, 薬学部, DR.・博士研究員
RUKUNGA Geoge 元徳島文理大学, 薬学部, DR.・JICA派遣博士研究員
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥36,660,000 (Direct Cost: ¥28,200,000、Indirect Cost: ¥8,460,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2007: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2006: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
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| Keywords | マダガスカル / ケニア / 薬用植物 / テルペン / ビスビベンジル / 抗ウイルス / 抗肥満 / 薬学 / 生理活性 / 細胞毒性活性 / 抗インフルエンザ活性 / 微生物変換 / 抗がん / 肥満抑制 / bis-bibenzyls / Riccardin C / 肥満抑制活性 / LXRαアゴニスト / 抗がん活性 / シンナモスマ属 / ドリマン型セスキテルペノイド / 細胞毒性 / α-グルコシダーゼ阻害活性 / NO産生抑制 / 抗糖尿 / トリテルペン / 抗メラノーマ |
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| Research Abstract |
The Malagasy and Kenyan medicinal plans, especially, Cinnamosma and Warburgia species belonging to the Cannelaceae family were searched and collected in each country. Their secondary metabolites were separated and isolated and their chemical structures elucidated. A number of drimane-type sesquiterpenoids, cinnamodial, warburganal, caspicodendrin and macrocyclic bis-bibenzyls, marchantin A, isoplagiochin C and riccardin C which showed α-glucose inhibitory activity, anti-virus, anti-microbial and anti-fungal, anti-oxidant, anti-obesity activity.
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