Development of the cell transplantation therapy for the tooth regeneration using the committed progenitor cell of the tooth established from the tooth germ
| Project/Area Number |
18300159
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Akita University |
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Principal Investigator |
SUGIYAMA Toshihiro Akita University, 医学部, 教授 (00127242)
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| Co-Investigator(Kenkyū-buntansha) |
KOYOTA Souichi 秋田大学, 医学部, 講師 (80400480)
UENO Yasuharu 横浜市立大学, 医学部, 助教 (60375235)
MIYAMOTO Youzi 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (20200214)
NAGAI Hirokazu 徳島大学, 大学院ヘルスバイオサイエンス研究部, 准教授 (50282190)
NAKATA Akira 秋田大学, 医学部, 助教 (50400510)
KOIZUMI Yukio 秋田大学, 医学部, 助教 (80353465)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥17,820,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2007: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2006: ¥5,600,000 (Direct Cost: ¥5,600,000)
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| Keywords | 細胞工学 / 歯胚 / エナメル芽細胞 / 象牙芽細胞 / 歯再生 |
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| Research Abstract |
マウス胎児の歯牙から象牙芽前駆細胞(odontoblast-lineage cell (OLC))を樹立した。そこで、ヌードマウスの皮膚にPura Matrixに播種したOLCを移植したところ、8週間後に移植したOLCの約25%に有意な石灰化したコラーゲン塊が出現した。次に、歯胚上皮組織とOLCの三次元培養系、及びin vivo三次元再構成体の腎移植系において歯冠の形成を観察できた。
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] I. REG I α is a reliable marker of chemoradiosensitivity in squamous cell esophageal cancer patients2008
Author(s)
Hayashi K, Motoyama S, Sugiyama T, Izumi JI, Anbai A, Nanjo H, Watanabe H, Maruyama K, Minamiya Y, Koyota S, Koizumi Y, Takasawa S, Murata K, Ogawa J
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Journal Title
Ann. Surg. Oncol. 15
Pages: 1224-1231
Related Report
Peer Reviewed
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[Journal Article] Acute effects on the lung and the liver of oral administration of cerium chloride on adult, neonatal and fetal mice2008
Author(s)
Kawagoe M, Ishikawa K, Wang S.-C, Yoshikawa K, Arany S, Zhou XP, Wang J.-S, Ueno Y, Koizumi Y, Kameda T, Koyota S, Sugiyam T.
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Journal Title
J. Trace Elem. 22
Pages: 59-65
Related Report
Peer Reviewed
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[Journal Article] Niemann-Pick C1 protein transports copper to the secretory compartment from late endosomes where ATP7B resides2008
Author(s)
Harada M, Kumemura H, Koga H, Kawaguchi T,Terada K, Hanada S, Taniguchi E, Koizumi Y, Koyota S, Ninomiya H, Ueno K, Sugiyama T, Sata M.
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Journal Title
Exp. Cell Res 315
Pages: 119-126
Related Report
Peer Reviewed
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[Presentation] Study of butyrate signal transduction pathways in rat hepatic stem-like cells. Animal Cell Technology in Bioscience2008
Author(s)
Saheki T, Mukai Y, Saito K, Tajima E,Katakura K, Nishina A, Kishi M, Izumi T, Sugiyama T, Kojima I.
Organizer
Bioengineering and Bioindustries
Place of Presentation
November, Fukuoka
Related Report
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