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Development of a synthetic method of modified histone aiming at elucidation of the molecular mechanism of the gene expression regulation

Research Project

Project/Area Number 18310145
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Living organism molecular science
Research InstitutionOsaka University

Principal Investigator

AIMOTO Saburo  Osaka University, 蛋白質研究所, 教授 (80029967)

Co-Investigator(Kenkyū-buntansha) TAJIMA Shoji  大阪大学, 蛋白質研究所, 教授 (50132931)
KAWAKAMI Toru  大阪大学, 蛋白質研究所, 准教授 (70273711)
SUETAKE Isao  大阪大学, 蛋白質研究所, 准教授 (80304054)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥19,310,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2007: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2006: ¥4,100,000 (Direct Cost: ¥4,100,000)
Keywordsヒストン / メチル化 / 化学合成 / 翻訳後修飾 / 遺伝子発現 / メチル化リシン / ヒストンH3 / ライゲーション法 / ライブラリー / ライゲ-ション法
Research Abstract

To establish synthetic methods of histone H3 tail and modified histone H3, we searched methods for modified lysine synthesis, chemical synthesis of modified lysine-containing histone H3 tails, and chemical synthesis of full sequence histone H3. Synthetic modified histone H3 tails contributed to the biochemical elucidation of polycomb repressive complex 2. 9Lys(Me_3)-histone H3 was also synthezised.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (59 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (29 results) (of which Peer Reviewed: 27 results) Presentation (27 results) Remarks (3 results)

  • [Journal Article] Formation of Peptide Thioesters by an N to S Acyl Shift Reaction at the Cysteinyl Prolyl Cysteine Position2010

    • Author(s)
      Sakiko Shimizu, Saburo Aimoto, Toru Kawakami
    • Journal Title

      Peptide Science 2009

      Pages: 153-154

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Peptide Thioesters Based on an N to S Acyl Shift Reaction2010

    • Author(s)
      Toru Kawakami, Sakiko Shimizu, Saburo Aimoto
    • Journal Title

      Peptide Science 2009

      Pages: 79-80

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Formation of Peptide Thioesters by an N to S Acyl Shift Reaction at the Cysteinyl Prolyl Cysteine Position2010

    • Author(s)
      S.Shimizu
    • Journal Title

      Peptide Science 2009 (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Peptide Thioesters Based on an N to S Acyl Shift Reaction2010

    • Author(s)
      T.Kawakami
    • Journal Title

      Peptide Science 2009 (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Peptide Thioester, by the Cysteinyl Prolyl Ester (CPE) Method2009

    • Author(s)
      Toru Kawakami, Saburo Aimoto
    • Journal Title

      Peptide Science 2008

      Pages: 171-172

    • NAID

      10027166150

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 2-Nitrobenzylcarbamate-type Photocleavable Linker Having Fmoc-aminoalkyloxy Group: Preparation and Application to Peptide Purification2009

    • Author(s)
      Toshiaki Hara, Akira Tainosho, Toru Kawakami, Saburo Aimoto
    • Journal Title

      Peptide Science 2008

      Pages: 199-201

    • NAID

      10027166207

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methylthio Groups for Thiol Protection that realize the Sequential Ligation by Native Chemical Ligation followed by Thioester method2009

    • Author(s)
      Yuichi Akai, Lisa Takemura, Yuko Aoki, Masazumi Waseda, Toru Kawakami, Saburo Aimoto
    • Journal Title

      Peptide Science 2008

      Pages: 201-201

    • NAID

      10027166211

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peptide Purification Using The Selective Reaction Between Aminooxy Group and Isothiocyanate Group2009

    • Author(s)
      Akira Tainosho, Toshiaki Hara, Ken'ichiro Nakamura, Toru Kawakami, Saburo Aimoto
    • Journal Title

      Peptide Science 2008

      Pages: 205-207

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of peptide thioesters via an N-S acyl shift reaction under mild acidic conditions using an N-4, 5-dimethoxy-2-mercaptobenzyl auxiliary group2009

    • Author(s)
      Ken'ichiro Nakamura, Tomoki Kanao, Tomoya Uesugi, Toshiaki Hara, Takeshi Sato, Toru Kawakami, Saburo Aimoto
    • Journal Title

      J. Peptide Sci 15

      Pages: 731-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peptide purification by affinity chromatography based on a-ketoacyl group chemistry2009

    • Author(s)
      Toshiaki Hara, Akira Tainosho, Ken'ichiroh Nakamura, Takeshi Sato, Toru Kawakami, Saburo Aimoto
    • Journal Title

      J. Peptide Sci 15

      Pages: 369-376

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Use of a Cysteinyl Prolyl Ester (CPE) Autoactivating Unit in Peptide Ligation Reactions2009

    • Author(s)
      Toru Kawakami, Saburo Aimoto
    • Journal Title

      Tetrahedron 65

      Pages: 3871-3877

    • Related Report
      2009 Final Research Report 2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Synthesis of peptide thioesters via an N-S acyl shift reaction under mild acidic conditions using an N-4, 5-dimethoxy-2-mercaptobenzyl auxiliary group2009

    • Author(s)
      K.Nakamura
    • Journal Title

      J.Peptide Science 15

      Pages: 731-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peptide purification by affinity chromatography based on α-ketoacyl group chemistry2009

    • Author(s)
      Toshiaki Hara, Akira Tainosho, Ken'ichiroh Nakamura, Takeshi Sato, Toru Kawakami, Saburo Aimoto
    • Journal Title

      J. Peptide Sci. 15

      Pages: 369-376

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Peptide purification by affinity chromatography based on α -ketoacyl group chemistry2009

    • Author(s)
      T. Hara
    • Journal Title

      Journal of Peptide Science (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2-Nitrobenzylcarbamate-type Photocleavable Linker Having Fmoc-amino alkyloxy Group : Preparation and Application to Peptide Purification2009

    • Author(s)
      T. Hara
    • Journal Title

      Peptide Science 2008 (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peptide Purification Using The Selective Reaction Between Aminooxy Group and Isothiocyanate Group, Followed by Edman Degradation.2009

    • Author(s)
      A. Tainosho
    • Journal Title

      Peptide Science 2008 (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Use of a Cysteinyl Prolyl Ester (CPE) Autoactivating Unit in Peptide Ligation Reactions2009

    • Author(s)
      T. Kawakami
    • Journal Title

      Tetrahedron (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of a Partial Sequence of Site-2008

    • Author(s)
      Hisao Fujimoto, Chieko Kita, Akira Tainosho, Yuichi Akai, Lisa Takemura, Hitomi Kanda, Toru, Kawakami, Saburo Aimoto
    • Journal Title

      Specifically Methylated Histone H3 Peptide Science 2007

      Pages: 209-210

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of a Partial Sequence of Site-Specifically Methylated Histone H32008

    • Author(s)
      H. Fujimoto
    • Journal Title

      Peptide Science 2007

      Pages: 209-210

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peptide Thioester Synthesis via an Auxiliary-Mediated N-S Acyl Shift Reaction in SolutionInt2007

    • Author(s)
      Ken'ichiro Nakamura, Hiroaki Mori, Toru Kawakami, Hironobi Hojo, Yoshiaki Nakahara, Saburo Aimoto
    • Journal Title

      J. Peptide Res. Therapeutics 13

      Pages: 191-202

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sequential Peptide Ligation by Using a Controlled Cysteinyl Prolyl Ester (CPE) Autoactivating Unit2007

    • Author(s)
      Toru Kawakami, Saburo Aimoto
    • Journal Title

      Tetrahedron Lett 48

      Pages: 1903-1905

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polypeptide Synthesis via the N-to S-Acyl Shift Reaction2007

    • Author(s)
      Toru Kawakami, Ken'ichiro Nakamura, Saburo Aimoto
    • Journal Title

      Peptides 2006

      Pages: 198-199

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peptide Ligation Using a Building Block Having a Cysteinyl Prolyl Ester (CPE) Autoactivating Unit at the Carboxy Terminus2007

    • Author(s)
      Toru Kawakami, Saburo Aimoto
    • Journal Title

      Chem. Lett 36

      Pages: 76-77

    • NAID

      10018663050

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sequential Peptide Ligation by Using a Controlled Cysteinyl Prolyl Ester (CPE) Autoactivating Unit2007

    • Author(s)
      Toru Kawakami, Saburo Aimoto
    • Journal Title

      Tetrahedron Lett. 48

      Pages: 1903-1905

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Peptide Ligation Using a Building Block Having a Cysteinyl Prolyl Ester (CPE) Autoactivating Unit at the Carboxy Terminus2007

    • Author(s)
      Toru Kawakami, Saburo Aimoto
    • Journal Title

      Chem. Lett. 36

      Pages: 76-77

    • NAID

      10018663050

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Sequential peptide ligation by using a controlled cysteinyl prolyl ester (CPE) autoactivating unit.2007

    • Author(s)
      T. Kawakami
    • Journal Title

      Tetrahedron Lett. 48

      Pages: 1903-1905

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polypeptide Synthesis via the N-to S-Acyl Shift Reaction2007

    • Author(s)
      T. Kawakami
    • Journal Title

      Peptides 2006

      Pages: 198-199

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peptide ligation thinvolves an intramolecular N to S acyl shift reaction2006

    • Author(s)
      Toru Kawakami, Ken'ichiro Nakamura, Saburo Aimoto
    • Journal Title

      Peptide Science 2006 29

    • Related Report
      2009 Final Research Report
  • [Journal Article] N-S acyl shift reaction on peptide backbone and its application to preparation of peptide thioesters2006

    • Author(s)
      Ken'ichiro Nakamura, Toru Kawakami, Hironobu Hojo, Yoshiaki Nakahara, Saburo Aimoto
    • Journal Title

      Peptide Science 2006 42

    • NAID

      10020528860

    • Related Report
      2009 Final Research Report
  • [Presentation] 2-ニトロベンジルカルバメイト型光分解リンカーを用いる化学合成ペプチドの精製2010

    • Author(s)
      原利明、田結荘明、川上徹、相本三郎
    • Organizer
      日本化学会第90回春季年会
    • Place of Presentation
      近畿大学、東大阪市
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Cys-Pro-Cys部位におけるN-Sアシル基転位反応を利用したペプチドチオエステルの合成2010

    • Author(s)
      清水咲子、相本三郎、川上徹
    • Organizer
      日本化学会第90回春季年会
    • Place of Presentation
      近畿大学、東大阪市
    • Year and Date
      2010-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] Cys-Pro-Cys部位におけるN-5アシル基転位反応を利用したペプチドチオエステルの合成2010

    • Author(s)
      清水咲子
    • Organizer
      日本化学会第90回春季年会
    • Place of Presentation
      近畿大学、東大阪市
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Histone H3K9 trimethylation stimulates the histone H3K27 methylation activity of PRC2 bypassing Eed2010

    • Author(s)
      Isao Suetake, Saburo Aimoto, Yuko Aoki, Kyoichi Isono, Toru Kawakami, Hiroshi Kimura, Akihiko Koseki, Yuichi Mishima; Osamu Nishimura, Shoji Tajima, Makoto Watanabe
    • Organizer
      Keystone symposium
    • Place of Presentation
      Sagebrush Inn and Conference Center, Taos, New Mexico
    • Year and Date
      2010-01-20
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Synthesis of Peptide Thioesters Based on an N to S Acyl Shift Reaction2009

    • Author(s)
      Toru Kawakami, Sakiko Shimizu, Saburo Aimoto
    • Organizer
      第46回ペプチド討論会
    • Place of Presentation
      北九州国際会議場、北九州市
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Formation of Peptide Thioesters by an N to S Acyl Shift Reaction at the Cysteinyl Prolyl Cysteine Position2009

    • Author(s)
      Sakiko Shimizu, Saburo Aimoto, Toru Kawakami
    • Organizer
      第46回ペプチド討論会
    • Place of Presentation
      北九州国際会議場、北九州市
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] ポリコーム群蛋白質複合体PRC2によるH3K27メチル化の新たな活性調節機構2009

    • Author(s)
      三島優一、磯野協一、青木優子、川上徹、渡辺真、木村宏、西村紀、相本三郎、古関明彦、田嶋正二、末武勲
    • Organizer
      第82回日本生化学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2009-10-23
    • Related Report
      2009 Final Research Report
  • [Presentation] ボリコーム群蛋白質複合体PRC2によるH3K27メチル化の新たな活性調節機構2009

    • Author(s)
      三島優一
    • Organizer
      第82回 日本生化学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] メチルチオ基をチオール保護基として用いるネイティブケミカルライゲーション法とチオエステル法による連続ライゲーション法2009

    • Author(s)
      赤井優一、早稲田真澄、青木優子、竹村梨沙、川上徹、相本三郎
    • Organizer
      日本化学会第89春季年会
    • Place of Presentation
      千葉
    • Year and Date
      2009-03-29
    • Related Report
      2009 Final Research Report
  • [Presentation] アミノオキシ基とイソチオシアネート基の選択的化学反応とそれに続くエドマン分解を利用したペプチドの精製2008

    • Author(s)
      田結荘明、原利明、中村健一郎、川上徹、相本三郎
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-30
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] ネイティブケミカルライゲーション法とチオエステル法の併用を可能にするチオール保護基としてのメチルチオ基の利用2008

    • Author(s)
      赤井優一、竹村梨沙、青木優子、早稲田真澄、川上徹、相本三郎
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-30
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Synthesis of Peptide Thioester by the Cysteinyl Prolyl Ester (CPE) Method2008

    • Author(s)
      Toru Kawakami, Saburo Aimoto
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-30
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Fmoc-アミノプロピルオキシ基を導入した2-ニトロベンジルカルバメイト型リンカーの合成とペプチド精製への応用2008

    • Author(s)
      原利明、田結荘明、川上徹、相本三郎
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-29
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Peptide thioester preparation and peptide ligation using cysteinyl prolyl ester (CPE) autoactivating unit2008

    • Author(s)
      T o ru Ka wak ami, Sab uro A imo to
    • Organizer
      30 th Eu rop ean P ept ide Symposium
    • Place of Presentation
      ヘルシンキ
    • Year and Date
      2008-09-01
    • Related Report
      2009 Final Research Report
  • [Presentation] Peptide thioester preparation and peptide ligation using cysteinyl prolyl ester (CPE) autoactivating unit2008

    • Author(s)
      Toru Kawakami
    • Organizer
      3oth European Peptide Symposium
    • Place of Presentation
      ヘルシンキ
    • Year and Date
      2008-09-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] ペプチドCys-Proエステルを合成ブロックとして用いるトリメチルリシン含有ヒストンH3合成法の研究2008

    • Author(s)
      赤井優一、藤本久雄、竹村梨沙、田結荘明、喜多知恵子、神田仁美、川上徹、相本三郎
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] α-ケトアシル基の形成と切断を鍵反応とするペプチド精製法の開発2008

    • Author(s)
      原利明、田結荘明、藤本大樹、川上徹、相本三郎
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] ペプチドCys-Proエステルを合成ブロックとして用いるトリメチルリシン含有ヒストンH3合成法の研究2008

    • Author(s)
      赤井 優一, 他
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京池袋
    • Year and Date
      2008-03-27
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] ベプチドCys-Proエステルを合成ブロックとして用いるトリメチルリシン含有ヒストンH3合成法の研究2008

    • Author(s)
      赤井 優一
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] ペプチドCys-Proエステルを合成ブロックとして用いるトリメチルリシン含有ヒストンH3 合成法の研究2008

    • Author(s)
      赤井優一
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京都
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 部位特異的に修飾されたヒストンH3部分配列の合成2007

    • Author(s)
      藤本久雄、喜多千恵子、田結荘明、赤井優一、竹村梨沙、神田仁美、川上徹、相本三郎
    • Organizer
      第44回ペプチド討論会
    • Place of Presentation
      富山市
    • Year and Date
      2007-11-08
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] N to S Acyl Shift Reaction in Peptide Ligation2007

    • Author(s)
      Toru Kawakami, Ken'ichiroh Nakamura, Hisao Fujimoto, Saburo Aimoto
    • Organizer
      4th international Peptide Symposium
    • Place of Presentation
      ーストラリア・ケアンズ
    • Year and Date
      2007-10-23
    • Related Report
      2009 Final Research Report
  • [Presentation] N to S Acyl Shift Reaction in Peptide Ligation2007

    • Author(s)
      T. Kawakami
    • Organizer
      4th international Peptide Symposium
    • Place of Presentation
      オーストラリア・ケアンズ
    • Year and Date
      2007-10-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] PEPTIDE THIOESTER SYNTHESIS BY AN ON-RESIN AUXILIARY-MEDIATED N-S ACYL SHIFT REACTION2007

    • Author(s)
      Saburo Aimoto
    • Organizer
      Modern Solid Phase Peptide Synthesis, Its Applications
    • Place of Presentation
      オーストラリア・ポートダグラス
    • Year and Date
      2007-10-19
    • Related Report
      2009 Final Research Report
  • [Presentation] PEPTIDE THIOESTER SYNTHESIS BY AN ON-RESINAUXILIARY-MEDIATED N-S ACYL SHIFT REACTION2007

    • Author(s)
      S. Aimoto
    • Organizer
      Modern Solid Phase Peptide Synthesis & Its Applications
    • Place of Presentation
      オーストラリア・ポートダグラス
    • Year and Date
      2007-10-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] Peptide Ligation via the N to S Acyl Shift Reaction2007

    • Author(s)
      oru Kawakami, Saburo Aimoto
    • Organizer
      Chemical Protein Synthesis Meeting
    • Place of Presentation
      オーストラリア・ヘロン島
    • Year and Date
      2007-10-18
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] Peptide Ligation via the In-Situ Transformation of an Amide into a Thioester at a Cysteine Residue2007

    • Author(s)
      Toru Kawakami, Saburo Aimoto
    • Organizer
      20th American Peptide Society Symposium
    • Place of Presentation
      カナダ・モントリオール
    • Year and Date
      2007-06-27
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.protein.osaka-u.ac.jp/organic/index.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.protein.osaka-u.ac.jp/organic/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.protein.osaka-u.ac.jp/organic/index.html

    • Related Report
      2008 Self-evaluation Report

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Published: 2006-04-01   Modified: 2016-04-21  

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