THE STUDY OF REAL-TIME LIVING BODY MONITORING USING CARBON NANOTUBE SENSOR

• Project/Area Number: 18390170
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Hokkaido University
• Principal Investigator: CHIBA Hitoshi Hokkaido University, 大学院・保健科学研究院, 教授 (70197622)
• Co-Investigator(Kenkyū-buntansha): ISHII Kojiro 同志社大学, スポーツ健康科学部, 教授 (30243520) ; MUKASA Koichi 北海道大学, 創成科学共同研究機構, 特任教授 (00001280)
• Co-Investigator(Renkei-kenkyūsha): ISHII Kojiro 同志社大学, スポーツ健康科学部, 教授 (30243520)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥16,140,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥2,040,000); Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2007: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2006: ¥7,300,000 (Direct Cost: ¥7,300,000)
• Keywords: カーボンナノチューブ / バイオセンサー / 乳酸 / 酸化ストレス / リアルタイムモニタリング / センサー / 高齢者 / 運動プログラム

Research Abstract

高齢者でも乳酸閾値レベル(疲労物質の乳酸が蓄積しはじめる直前のレベル)の運動を持続すると体力向上が得られる。そのために手軽に血中の乳酸値を運動中に測定できる簡便な測定装置が求められている。また、高齢者は抗酸化能が低下するため、酸化ストレスレベルを測定して動脈硬化防止策を講じる必要がある。本研究で開発したカーボンナノチューブセンサーは、乳酸や酸化ストレスレベルを簡便に測定できる。

Research Products

• [Journal Article] Lipoprotein metabolism, insulin resistance, and adipocytokine levels in Japanese female adolescents with a normal body mass index and high body fat mass (2009)
  • Author(s): Kishimoto N, Okita K, Takada S, Sakuma I, Sajo Y, Chiba H, Ishii K, Kishi R, Tsutsumi H.
  • Journal Title: Circ J 73 Pages: 534-539
  • NAID: 110007126722
  • Peer Reviewed
• [Journal Article] Lipoprotein profiles in children with two common cholesteryl ester transfer protein gene mutations, D442G and 114A during the first year of life (2009)
  • Author(s): Nagasaka H, Yorifuji T, Momoi T, Yorifuji J, Hirano K, Ota A, Takatani T, Tsukahara H, Takayanagi M, Kobayashi K, Chiba H, Sato Y, Miida T.
  • Journal Title: Clin Chim Acta 406 Pages: 52-56
  • Peer Reviewed
• [Journal Article] Elevated plasma plasminogen activator inhibitor-1 in CD36 deficiency (2008)
  • Author(s): Yanai H, Chiba H, Matsuno K.
  • Journal Title: Diabetes Care 31
  • Peer Reviewed
• [Journal Article] Reduced apolipoprotein E-rich high-density lipoprotein level at birth is restored to the normal range in patients with familial hypercholesterolemia in the first year of life (2008)
  • Author(s): Nagasaka H, Miida T, Hirano K, Ota A, Yorifuji T, Takatani T, Tsukahara H, Takayanagi M, Hui SP, Kobayashi K, Chiba H.
  • Journal Title: J Clin Endocrinol Metab 93 Pages: 779-783
  • Peer Reviewed
• [Journal Article] Fluctuation of lipoprotein metabolism linked with bile acid-activated liver nuclear receptors in Alagille syndrome (2008)
  • Author(s): Nagasaka H, Miida T, Hirano KI, Ota A, Murayama K, Yorifuji T, Kobayashi K, Takatani T, Tsukahara H, Hui SP, Takayanagi M, Chiba H.
  • Journal Title: Atherosclerosis 198 Pages: 434-440
  • Peer Reviewed
• [Journal Article] ULTRASENSITIVE DETECTION OF ORGANOPHOSPHATE INSECTICIDES BY C ARBON NANOTUBE FIELD-EFFECT TRANSESTOR (2008)
  • Author(s): Ishii A., ほか
  • Journal Title: J Colloids and Surfaces A : Physicochem. Eng Aspects 313-314 Pages: 456-460
  • Peer Reviewed
• [Journal Article] Pedometer accuracy during stair climbing and bench stepping exercises (2008)
  • Author(s): Ayabe M., ほか
  • Journal Title: J Sports Sci & Med 7 Pages: 249-254
  • Peer Reviewed
• [Journal Article] Accuracy of Spring-levered and Piezo-electric Pedometers in Primary School Japanese Children (2008)
  • Author(s): Nakae S., ほか
  • Journal Title: J Physiol Anthropol 27 Pages: 233-239
  • Peer Reviewed
• [Journal Article] Increased Fructose 2, 6-bisphosphate in Peripheral Blood Mononuclear Cells of Patients with Diabetes (2007)
  • Author(s): Atsumi T, Chiba H, Yoshioka N, Bucala R, Koike T
  • Journal Title: Endocr J 54 Pages: 517-520
  • NAID: 10019809194
  • Peer Reviewed
• [Journal Article] Attenuated aerobic exercise capacity in CD36 deficiency (2007)
  • Author(s): Yanai H, Watanabe I, Ishii K, Morimoto M, Fujiwara H, Yoshida S, Hui SP, Matsuno K, Chiba H.
  • Journal Title: J Med Genet. 44 Pages: 445-447
  • Peer Reviewed
• [Journal Article] Depletion of High-density Lipoprotein and Appearance of Triglyceride-rich Low-density Lipoprotein in a Japanese Patient With FIC1 Deficiency Manifesting Benign Recurrent Intrahepatic Cholestasis (2007)
  • Author(s): Hironori Nagasaka, Hitoshi Chiba, Shu-Ping Hui, Hajime Takikawa, Takashi Miida, Masaki Takayanagi, Tohru Yorifuji, Makoto Hasegawa, Akemi Ota, Ken-ichi Hirano, Hideaki Kikuchi, Hirokazu Tsukahara, Kunihiko Kobayashi
  • Journal Title: J Pediatr Gastroenterol Nutr 45 Pages: 96-105
  • Peer Reviewed
• [Journal Article] An Improved HPLC Assay for Phosphatidylcholine Hydroperoxides (PCOOH) in Human Plasma with synthetic PCOOH as Internal Standard (2007)
  • Author(s): Shu-Ping Hui, Hitoshi Chiba, Toshihiro Sakurai, Chitose Asakawa, Hironori Nagasaka, Tsuyoshi Murai, Hajime Ide, Takao Kurosawa
  • Journal Title: Journal of Chromatography B 857 Pages: 158-163
  • NAID: 10025809024
  • Peer Reviewed
• [Journal Article] Angiotensin I converting enzyme gene polymorphism and exercise trainability in elderly women : An electrocardiological approach (2007)
  • Author(s): Tobina T, Kiyonaga A, Akagi Y, Mori Y, Ishii K, Chiba H, Shindo M, Tanaka H.
  • Journal Title: J Clin Spports Scie Med 6 Pages: 22-226
  • Peer Reviewed
• [Journal Article] 高齢者の生活習慣病予防および介護予防を目的とした実際的な運動プログラム (2007)
  • Author(s): 石井好二郎
  • Journal Title: フードリサーチ 625 Pages: 22-29
• [Journal Article] 運動療法を高める食事療法とは? (2007)
  • Author(s): 石井好二郎
  • Journal Title: 肥満と糖尿病 6 Pages: 1002-1004
• [Journal Article] 歩数計と印刷物を用いた1年間の歩数量増加の運動介入が高齢者の身体組成, 血圧および血液性状に及ぼす影響 (2007)
  • Author(s): 中江悟司
  • Journal Title: 肥満研究 13 Pages: 130-136
  • Peer Reviewed
• [Journal Article] ANGIOTENSIN I CONVERTING ENZYME GENE POLYMORPHISM AND EXERCISE TRAINABILITY IN ELDERLY WOMEN : AIDELECTROCARDIOLOGICAL APPROACH (2007)
  • Author(s): Tobina, T., et al.
  • Journal Title: Journal of Sports Science and Medicine (印刷中)
• [Journal Article] Attenuated aerobic exercise capacity in CD36 deficiency (2007)
  • Author(s): Yanai, H., et al.
  • Journal Title: J Med Genet (印刷中)
• [Journal Article] Acute effect of static stretching on power output during concentric dynamic constant external resistance leg extension (2006)
  • Author(s): Yamaguchi, T., et al.
  • Journal Title: J Strength Cond Res.2006 Nov ; 20(4):804-10 20・4 Pages: 804-810
• [Journal Article] Comparison of inter-device measurement difference of pedometers in younger and older adults
  • Author(s): Ayabe M., ほか
  • Journal Title: Br J Sports Med (in press)
  • Peer Reviewed
• [Presentation] カーボンナノチューブ-バイオセンサーを用いた乳酸の測定 (2009)
  • Author(s): 千葉仁志, ほか
  • Organizer: 日本臨床化学会年次学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2009-09-18
• [Presentation] 「転換期を迎えた脂質検査」(教育講演) (2009)
  • Author(s): 千葉仁志
  • Organizer: 日本臨床化学会年次学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2009-09-18
• [Presentation] 新しい脂質の時代」(ランチョンセミナー) (2009)
  • Author(s): 千葉仁志
  • Organizer: 日本臨床検査医学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-08-28
• [Presentation] カーボンナノチューブ-バイオセンサーを用いた乳酸の測定 (2009)
  • Author(s): 千葉仁志, 武笠幸一, ほか
  • Organizer: 日本臨床検査医学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-08-28
• [Presentation] 「大きな変革の時代に来た脂質・リポ蛋白検査」(シンポジウム) (2009)
  • Author(s): 千葉仁志
  • Organizer: 日本医学検査学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-07-31
• [Presentation] 在宅運動および健康教室併用プログラム継続参加者および新規参加者に及ぼす効果 (2007)
  • Author(s): 東保子
  • Organizer: 日本体力医学会
  • Place of Presentation: ノースアジア大学(秋田市)
  • Year and Date: 2007-09-14
• [Patent(Industrial Property Rights)] CNTセンサーによる過酸化物を電気的に測定する方法 (2009)
  • Inventor(s): 千葉仁志, 武田晴治, 石井睦, 中村基訓, 武笠幸一, 惠淑萍, 黒澤隆夫
  • Industrial Property Rights Holder: 国立大学法人 北海道大学, 惠淑萍 (北海道医療大学), 黒澤隆夫 (北海道医療大学)
  • Filing Date: 2009-07-17