Bone and vascular signals during the repair process after bone and bone marrow injury
| Project/Area Number |
18390422
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
SAKAI Akinori University of Occupational and Environmental Health, Japan, 医学部, 准教授 (90248576)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Toshitaka 産業医科大学, 医学部, 教授 (50082235)
OKIMOTO Nobukazu 産業医科大学, 医学部, 助手 (70330991)
|
|---|
| Project Period (FY) |
2006 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥8,000,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥2,800,000 (Direct Cost: ¥2,800,000)
|
|---|
| Keywords | 骨髄損傷 / 骨芽細胞 / シグナル伝達 / ビタミンA / 血管 / VEGF / PECAM-1 / BMP-2 / HIF / HIF-1 / 骨・骨髄損傷 / HIF-1α / オステオカルシン / 骨形成 / 血管形成 / 髄内仮骨 / flt-1 / 破骨細胞 / 骨吸収 / 代謝回転 / 骨量 |
|---|
| Research Abstract |
The dis ruption of tyrosine kinase domain of flt-1, one of VEGF (vascular endothelial growth factor) receptors, disturbed osteoblast differentia tion and delayed the repair process after bone and bone marrow injury in mice. The production of alkaline phosphatase increased in osteoblasts co-cultured with endothelial cells. This increase was dose-dependently inhibited by PECAM-1 (platelet endothelial cell adhesion molecule-1) antibody. These findings demonstrated that vascular factors including VEGF and PECAM-1 significantly contributed to osteoblast development in the repairprocess afterbone and bone marrow injury.
|
Report
(6 results)
Research Products
(28 results)
-
-
-
-
-
-
[Journal Article] Genetic disruption of all NO synthase isoforms enhances BMD and bone turnover in mice in vivo: involvement of the renin-angiotensin system.2008
Author(s)
Sabanai K, Tsutsui M, Sakai A, Hirasawa H, Tanaka S, Nakamura E, Tanimoto A, Sasaguri Y, Ito M, Shimokawa H, Nakamura T, Yanagihara N
-
Journal Title
Journal of Bone and Mineral Research 23巻5号
Pages: 633-643
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Vitamin A deficiency delays healing process after cortical bone and bone marrow injury.2007
Author(s)
Tanaka K, Tanaka S, Sakai A, Hirasawa H, Katae Y, Nakura N, Menuki K, Yamane H, Sabanai K, Shimizu Y, Nakamura T
Organizer
The 17th Scientific Meeting International Bone and Mineral Society, Montreal, Canada
Place of Presentation
Montreal Convention Centre
Year and Date
2007-06-28
Related Report
-
-
-
-
-
