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2009 Fiscal Year Final Research Report

Bone and vascular signals during the repair process after bone and bone marrow injury

Research Project

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Project/Area Number 18390422
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

SAKAI Akinori  University of Occupational and Environmental Health, Japan, 医学部, 准教授 (90248576)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Toshitaka  産業医科大学, 医学部, 教授 (50082235)
OKIMOTO Nobukazu  産業医科大学, 医学部, 助手 (70330991)
Project Period (FY) 2006 – 2009
Keywords骨髄損傷 / 骨芽細胞 / シグナル伝達 / ビタミンA / 血管 / VEGF / PECAM-1 / BMP-2
Research Abstract

The dis ruption of tyrosine kinase domain of flt-1, one of VEGF (vascular endothelial growth factor) receptors, disturbed osteoblast differentia tion and delayed the repair process after bone and bone marrow injury in mice. The production of alkaline phosphatase increased in osteoblasts co-cultured with endothelial cells. This increase was dose-dependently inhibited by PECAM-1 (platelet endothelial cell adhesion molecule-1) antibody. These findings demonstrated that vascular factors including VEGF and PECAM-1 significantly contributed to osteoblast development in the repairprocess afterbone and bone marrow injury.

  • Research Products

    (8 results)

All 2009 2008 2007 2006

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (3 results) Book (1 results)

  • [Journal Article] Elcatonin injections suppress systemic bone resorption without affecting cortical bone regeneration after drill-hole injuries in mice.2009

    • Author(s)
      Katae Y, Tanaka S, Sakai A, Nagashima M, Hirasawa H, Nakamura T
    • Journal Title

      Journal of Orthopaedic Research 27巻12号

      Pages: 1652-1658

    • Peer Reviewed
  • [Journal Article] Climbing exercise enhances osteoblast differentiation and inhibits adipogenic differentiation with high expression of PTH/PTHrP receptor in bone marrow cells.2008

    • Author(s)
      Menuki K, Mori T, Sakai A, Sakuma M, Okimoto N, Shimizu Y, Kunugita N, Nakamura T
    • Journal Title

      Bone 43巻3号

      Pages: 613-620

    • Peer Reviewed
  • [Journal Article] Genetic disruption of all NO synthase isoforms enhances BMD and bone turnover in mice in vivo: involvement of the renin-angiotensin system.2008

    • Author(s)
      Sabanai K, Tsutsui M, Sakai A, Hirasawa H, Tanaka S, Nakamura E, Tanimoto A, Sasaguri Y, Ito M, Shimokawa H, Nakamura T, Yanagihara N
    • Journal Title

      Journal of Bone and Mineral Research 23巻5号

      Pages: 633-643

    • Peer Reviewed
  • [Journal Article] Flt-1 tyrosine kinase-deficient homozygous mice result in decreased trabecular bone volume with reduced osteogenic potential.2007

    • Author(s)
      Otomo H, Sakai A, Uchida S, Tanaka S, Watanuki M, Moriwaki S, Niida S, Nakamura T
    • Journal Title

      Bone 40巻6号

      Pages: 1494-1501

    • Peer Reviewed
  • [Presentation] Skeletal loading enhances osteoblast differentiation and inhibits adipogenic differentiation in bone marrow cells.2008

    • Author(s)
      Sakai A, Menuki K, Nakamura T
    • Organizer
      International Society for Fracture Repair, International Symposium on Biophysical Stimulation on Bone and Fracture Healing, Kyoto
    • Place of Presentation
      Kyoto International Conference Center
    • Year and Date
      2008-11-26
  • [Presentation] Vitamin A deficiency delays healing process after cortical bone and bone marrow injury.2007

    • Author(s)
      Tanaka K, Tanaka S, Sakai A, Hirasawa H, Katae Y, Nakura N, Menuki K, Yamane H, Sabanai K, Shimizu Y, Nakamura T
    • Organizer
      The 17th Scientific Meeting International Bone and Mineral Society, Montreal, Canada
    • Place of Presentation
      Montreal Convention Centre
    • Year and Date
      2007-06-28
  • [Presentation] Changes of osteoblast development after unloading and reloading in murine models. International symposium2006

    • Author(s)
      Sakai A
    • Organizer
      第24回日本骨代謝学会
    • Place of Presentation
      東京都(東京ファッションタウン)
    • Year and Date
      2006-07-06
  • [Book] 1章骨構造と機能細胞とその機能、最新整形外科学大系1運動器の生物学と生体力学(総編集越智隆弘、専門編集中村利孝、吉川秀樹)2008

    • Author(s)
      酒井昭典
    • Total Pages
      7-11
    • Publisher
      中山書店

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Published: 2011-06-18   Modified: 2016-04-21  

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