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Qualitative theory of differential equations describing dynamics of infectious disease

Research Project

Project/Area Number 18540122
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General mathematics (including Probability theory/Statistical mathematics)
Research InstitutionOkayama University

Principal Investigator

SASAKI Toru  Okayama University, 大学院・環境学研究科, 准教授 (20260664)

Co-Investigator(Kenkyū-buntansha) KAJIWARA Tsuyoshi  岡山大学, 大学院・環境学研究科, 教授 (50169447)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥2,750,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Keywords応用数学 / 微分方程式 / 関数方程式 / 感染症 / 応用解析 / 疫学 / 数理モデル / 微分方程式論 / 関数方程式論 / 免疫学 / 生態学 / 免疫 / 定性理論
Research Abstract

We obtained some results on qualitative properties of differential equation models describing the dynamics of infectious agents in a host. Here we dealt with the interaction among viruses, target cells, infected cells, and immunity. We showed for some models that the interior equilibrium, which corresponds to the infected state, is, under some conditions, globally asymptotically stable. In this connection, we considered some mathematical models of immunity, and established some properties of systems of differential equations describing autoimmunity.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (32 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (14 results) (of which Peer Reviewed: 9 results) Presentation (13 results) Book (5 results)

  • [Journal Article] Global stability of models of humoral immunity against multiple viral strains2009

    • Author(s)
      Toru Inoue, Tsuyoshi Kajiwara, Toru Sasaki
    • Journal Title

      Journal of Biological Dynamics (現在電子版のみ)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Global stability of pathogen-immune dynamics with absorption2009

    • Author(s)
      Tsuyoshi Kajiwara, Toru Sasaki
    • Journal Title

      Journal of Biological Dynamics (現在電子版のみ)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamical properties of autoimmune disease models: Tolerance, flare-up, dormancy2007

    • Author(s)
      Shingo Iwami, Yasuhiro Takeuchi, Yoshiharu Miura, Toru Sasaki, Tsuyoshi Kajiwara
    • Journal Title

      J. theor. Biol. 246

      Pages: 646-659

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Global dynamics of B cells and anti-idiotipic B cells and its application to autoimmunity2007

    • Author(s)
      Toru Sasaki, Tsuyoshi Kajiwara
    • Journal Title

      Japan Journal of Industrial and Applied Mathematics 24No.1

      Pages: 105-118

    • NAID

      10020152739

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Global dynamics of B cells and anti-idiotipic B cells and its application to autoimmunity2007

    • Author(s)
      Toru Sasaki and Tsuyoshi Kajiwara
    • Journal Title

      Japan Journal of Industrial and Applied Mathematics

      Pages: 24-1

    • NAID

      10020152739

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Dynamical properties of autoimmune disease models : Tolerance, flare-up, dormancy2007

    • Author(s)
      Shingo Iwamia, Yasuhiro Takeuchi, Yoshiharu Miura, Toru Sasaki and Tsuyoshi Kajiwara
    • Journal Title

      J. theor. Biol. 246

      Pages: 646-659

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Dynamical properties of autoimmune disease models: Tolerance, flare-up, dormancy2007

    • Author(s)
      S. Iwami. Y. Takeuchi, Y. Miura, T. Sasaki, T. Kajiwara
    • Journal Title

      J. theor. Biol. 246

      Pages: 646-659

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自己免疫疾患モデル2007

    • Author(s)
      岩見真吾、竹内康博、三浦義治、佐々木徹、梶原毅
    • Journal Title

      数理解析研究所講究録録 1551

      Pages: 169-175

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 腫瘍免疫反応の数理モデル2007

    • Author(s)
      安川昌宏、佐々木徹
    • Journal Title

      数理解析研究所講究録録 1551

      Pages: 163-168

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Asymptotic analysis of a chemotactic model of bacteria colonies2006

    • Author(s)
      Susumu Miyata, toru Sasaki
    • Journal Title

      Mathematical Biosciences 201

      Pages: 184-194

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Global stability of models of humoral immunity against multiple viral strains

    • Author(s)
      Toru Inoue, Tsuyoshi Kajiwara, Toru Sasaki
    • Journal Title

      Journal of Biological Dynamics

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Global stability of pathogen-immune dynamics with absorption

    • Author(s)
      Tsuyoshi Kajiwara, Toru Sasaki
    • Journal Title

      Journal of Biological Dynamics

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Global dynamics of B cells and anti-idiotipic B cells and its application to autoimmunity

    • Author(s)
      Toru Sasaki, Tsuyoshi Kajiwara
    • Journal Title

      Japan Journal of Industrial and Applied Mathematics 予定(確約有り)

    • NAID

      10020152739

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Dynamical properties of autoimmune disease models : Tolerance,foare-up,dormancy

    • Author(s)
      Shingo Iwami, Yasuhiro Takeuchi, Yoshiharu Miura, Toru Sasaki, Tsuyoshi Kajiwara
    • Journal Title

      Journal of Theoretical Bology 予定(確約有り)

    • Related Report
      2006 Annual Research Report
  • [Presentation] 重複感染モデルの大域安定性2010

    • Author(s)
      佐々木徹
    • Organizer
      研究集会「数理と生物・生命科学との融合に向けて-MathESDの実践-」
    • Place of Presentation
      岡山大学
    • Year and Date
      2010-02-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 免疫数理モデルの安定性2009

    • Author(s)
      梶原毅
    • Organizer
      日本数理生物学会年会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-09
    • Related Report
      2009 Final Research Report
  • [Presentation] 複数ウイルス株に対する体液性免疫モデル2009

    • Author(s)
      井上徹
    • Organizer
      日本数理生物学会年会
    • Place of Presentation
      東京大学
    • Year and Date
      2009-09-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 免疫数理モデルの安定性2009

    • Author(s)
      梶原毅
    • Organizer
      日本数理生物学会年会
    • Place of Presentation
      東京大学
    • Year and Date
      2009-09-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 感染症ダイナミクスの安定性解析2008

    • Author(s)
      佐々木徹
    • Organizer
      日本応用数理学会オーガナイズドセッション
    • Place of Presentation
      柏
    • Year and Date
      2008-09-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 感染症ダイナミクスの安定性解析2008

    • Author(s)
      佐々木徹, 梶原毅
    • Organizer
      日本応用数理学会
    • Place of Presentation
      東京大学柏キャンパス
    • Year and Date
      2008-09-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 吸収効果をもっ体内の感染症モデル2008

    • Author(s)
      梶原毅, 佐々木徹
    • Organizer
      日本数理生物学会
    • Place of Presentation
      同志社大学
    • Year and Date
      2008-09-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mathematical model for autoimmunity disease2007

    • Author(s)
      T. Kajiwara and T. Sasaki
    • Organizer
      International Symposium "Comprehensive understanding of diverse biological timing mechanims"
    • Place of Presentation
      Okayama
    • Year and Date
      2007-11-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] 体内における感染症数理モデルの数理解析2007

    • Author(s)
      梶原毅、佐々木徹
    • Organizer
      生物数学の理論とその応用
    • Place of Presentation
      数理解析研究所
    • Year and Date
      2007-11-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Mathematical models describing autoimmunity2007

    • Author(s)
      Toru Sasaki
    • Organizer
      International Symposium on Dynamical Systems Theory and Its Applications
    • Place of Presentation
      浜松
    • Year and Date
      2007-03-14
    • Related Report
      2009 Final Research Report
  • [Presentation] Mathematical models describing autoimmunity2007

    • Author(s)
      Toru Sasaki
    • Organizer
      International Symposium on Dynamical Systems Theory and Its Applications to Biology and Environmental Sciences
    • Place of Presentation
      Shizuoka University, Hamamatsu, Japan
    • Year and Date
      2007-03-14
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Global behavior of a B model incorporating autoimmunity2006

    • Author(s)
      Toru Sasaki
    • Organizer
      Japanese-Korean Joint Meeting for Mathematical Biology (第16回日本数理生物学会大会)
    • Place of Presentation
      福岡
    • Year and Date
      2006-09-16
    • Related Report
      2009 Final Research Report
  • [Presentation] Global behavior of a B model incorporating autoimmunity2006

    • Author(s)
      Toru Sasaki
    • Organizer
      Japanese-Korean Joint Meeting for Mathematical Biology
    • Place of Presentation
      九州大学
    • Year and Date
      2006-09-16
    • Related Report
      2008 Self-evaluation Report
  • [Book] 感染症の数理モデル2008

    • Author(s)
      稲葉寿編著
    • Publisher
      培風館
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Book] 数の数理生物学2008

    • Author(s)
      日本数理生物学会編集
    • Publisher
      共立出版
    • Related Report
      2009 Final Research Report
  • [Book] 感染症の数理モデル2008

    • Author(s)
      稲葉寿
    • Publisher
      培風館
    • Related Report
      2008 Self-evaluation Report
  • [Book] 「数」の数理生物学,シリーズ 数理生物学要論(日本数理生物学会)2008

    • Publisher
      共立出版
    • Related Report
      2008 Self-evaluation Report
  • [Book] 「数」の数理生物学2008

    • Author(s)
      日本数理生物学会編集
    • Publisher
      共立出版
    • Related Report
      2008 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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