Neuroendocrine mechanism for determination of sexual orientation in the rat
Project/Area Number |
18590225
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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Research Institution | Nippon Medical School |
Principal Investigator |
KONDO Yasuhiko Nippon Medical School, 医学部, 講師 (00192584)
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Project Period (FY) |
2006 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥4,410,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
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Keywords | 性行動 / 性分化 / 生殖 / 性指向性 / 哺乳類 / 嗅覚選好性 / 嗅上皮 / 扁桃体 / 視索前野 / 性ホルモン / ラット / 鋤鼻器 / 視床下部 / アンドロゲン / エストロゲン / 嗅覚 |
Research Abstract |
When being given a pair of odors of sexually active males and estrous females, sexually mature male rats show vigorous exploration toward the estrous odors while receptive female rats palpably prefer for sexual male odors to estrous odors. This sex difference in olfactory preference may reflect their sexual orientation. Our earlier studies of this project showed that those sexual dimorphic olfactory preferences are based on sensory signals received by the olfactory epithelium (OE) but not by the vomeronasal organ (VNO) which is believed to be involved in pheromonal perception. In the brain, we elucidated that olfactory preference of male rats is critically regulated in the medial preoptic area that receives olfactory signals through multiple pathways, including the amygdala nuclei.
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Report
(6 results)
Research Products
(103 results)
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[Journal Article] Maternal isobutyl-paraben exposure alters anxiety and passive avoidance test performance in adult male rats.2009
Author(s)
Kawaguchi, M., Irie, K., Morohoshi K., Watanabe, G., Taya, K., Morita, M., Kondo, Y., Imai, H., Himi, T
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Journal Title
Neuroscience Research 65
Pages: 136-140
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[Journal Article] Dehydroepiandrosterone alleviates copulatory disorder induced by social stress in male rats.2006
Author(s)
Mizuno, T., Yotsuyanagi, S., Kondo, Y., Komatsu, K., Ishiura, Y., Nakamura, Y., Nagasaka, Y., Yokoyama, O., Namiki, M
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Journal Title
Journal of Sexual Medicine, Erratum: Journal of Sexual Medicine 3
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[Journal Article] Dehydroepi-androsterone alleviates copulatory disorder induced by social stress in male rats2006
Author(s)
Mizuno, T., Yotsuyanagi, S., Kondo, Y., Komatsu, K., Ishiura, Y., Nakamura, Y., Nagasaka, Y., Yokoyama, O. and Namiki, M.
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Journal Title
Journal of Sexual Medicine(Erratum : Journal of Sexual Medicine 3 : 1090, 2006) 3
Pages: 612-618
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Peer Reviewed
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[Presentation] The necessity of oxytocin in devel- opment of male mouse ultrasonic vocal- ization in response to female odor.2009
Author(s)
Kondo, Y., Kromkhum, P., Tanaka, M., Nishimori, K., Saito, T.R., Sakuma, Y
Organizer
The 36th International Congress of Physiol- ogical Science
Place of Presentation
Kyoto, Japan
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[Presentation] Oxytocin is required for developing ultrasonic vocalization in mouse mating.2008
Author(s)
Kondo, Y., Saeki, T., Takahashi, Y., Tanaka, M., Nishimori, K., Saito, T.R., Sakuma, Y
Organizer
Society for Behav- ioral Neuroendocrinology
Place of Presentation
Groningen, Netherland
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[Presentation] Generation of the somatostatin neurons in the sex- ually dimorphic nucleus of the rat pre optic area.2008
Author(s)
Orikasa, C., Kondo, Y., Urakawa, S., Usui, S., Sakuma, Y
Organizer
Society for Behavioral Neuroendocrinology
Place of Presentation
Groningen, Neth- erland
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[Presentation] Oxytocin is required for developing ultrasonic vocalization in mouse mating2008
Author(s)
Kondo, Y., Saeki, T., Takahashi, Y., Tanaka, M., Nishimori, K., Saito, T.R. and Sakuma, Y.
Organizer
Society for Behavioral Neuroendocrinology
Place of Presentation
Groningen, Netherland
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[Presentation] Olfactory conditioning of copulatory behavior in male mice.2006
Author(s)
Kondo, Y., Sobukawa, A., Katou, M., Sakuma, Y., Saito, T. R
Organizer
Society for Behavioral Neuroendocrinology
Place of Presentation
Pittsburgh, PA
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