| Project/Area Number |
18591086
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Dokkyo Medical University |
|---|
Principal Investigator |
YAMAGATA Tetsuya Dokkyo Medical University, 医学部, 准教授 (30424047)
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| Co-Investigator(Kenkyū-buntansha) |
牧 和宏 獨協医科大学, 医学部, 講師 (50337391)
佐々木 光 獨協医科大学, 医学部, 講師 (60282638)
三谷 絹子 獨協医科大学, 医学部, 教授 (50251244)
江口 真理子 獨協医科大学, 医学部, 講師 (40420781)
江口 峰斉 獨協医科大学, 医学部, 講師 (50420782)
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| Co-Investigator(Renkei-kenkyūsha) |
MAKI Kazuhiro 獨協医科大学, 医学部, 講師 (50337391)
SASAKI Ko 獨協医科大学, 医学部, 講師 (60282638)
MITANI Kinuko 獨協医科大学, 医学部, 教授 (50251244)
EGUCHI Mariko 獨協医科大学, 医学部, 講師 (40420781)
EGUCHI Minenori 獨協医科大学, 医学部, 講師 (50420782)
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|---|
| Project Period (FY) |
2006 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,360,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 血液内科学 / microRNA / AML / RUNX1 / 予後不良因子 / 生存率 / 再発率 / Runx1 / 白血病 / ES細胞 / Ruxn1 / AML1 / 造血 |
|---|
| Research Abstract |
We have found that microRNA-9 (mir-9), one of miRNAs that regulates RUNX1 protein translation, is over-expressed in the bone marrow cells of nearly 15% of acute myelogenous leukemia AML patients. The mir-9-expressing AML patients show short remission-free survival and short overall survival than the non-expressing AML patients. Thus, the over-expression of mir-9 may cause aggressive form of AML through suppressing the translation of RUNX1 and hence its function, which leads to the aberrant expression of its target genes.
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