| Project/Area Number |
18591318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kyushu University (2007)
Fukuoka University (2006) |
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Principal Investigator |
EGASHIRA Nobuaki Kyushu University, Hospital Pharmacy, Associate Professor (80352269)
|
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Michihiro Fukuoka University, Faculty of Pharmaceutical Sciences, Professor (10091331)
IWASAKI Katsunori Fukuoka University, Faculty of Pharmaceutical Sciences, Professor (10183196)
MISHIMA Kenichi Fukuoka University, Faculty of Pharmaceutical Sciences, Associate Professor (00320309)
NISHIMURA Ryoji Fukuoka University, School of Medicine, Professor (10122722)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,920,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Δ^9-Tetrahvdrocannabinol / CB1 cannabinoid receptor / social interaction / vasopressin / autism / schizophrenia / 自閉症 / THC / Δ9-tetrahydrocannabinol(THC) |
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| Research Abstract |
In this study, we investigated on the impaired social interaction in cannabis-treated and psychiatric animals. We kound that Δ^9-tetrahydrocannabinol (THC), the major psychoactive component of cannabis, impaired the social interaction in mice. Similarly, we found that V1a receptor knock out mice exhibited the impaired social interaction and reduced anxiety-like behavior. THC caused behavioral changes such as sensorimotor deficits, depression, cognitive deficits and depressed consciousness in mice and rats. We found that the mechanism of these behavioral changes is different respectively. We also found that the CB1 receptors are involved in the THC-induced impaired social interaction.Furthermore, we found that these impairments of social interaction are not improved by acute treatment of antidepressants and antipsychotics. Therefore, chronic treatment of these drugs might be necessary to improve these impairments of social interaction.
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