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Development of oxygen molecular imaging of the brain

Research Project

Project/Area Number 18591324
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionHokkaido University

Principal Investigator

TERAE Satoshi  Hokkaido University, Hokkaido University Hospital, Associate Professor (40240634)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Toru  Hokkaido University, Faculty of Health Sciences, School of Medicine, Professor (80261361)
KATOH Chietsugu  Hokkaido University, Faculty of Health Sciences, School of Medicine, Associate Professor (10292012)
KURODA Satoshi  Hokkaido University, Hokkaido University Hospital, Lecturer (10301904)
KUDO Kohsuke  Hokkaido University, Hokkaido University Hospital, Assistant Professor (10374232)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,790,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsMRI / susceptibility-weighted imaging / deoxyhemoglobin
Research Abstract

Using susceptibility-weighted imaging (SWI) of MRI (magnetic resonance imaging), we tried to develop a method to measure regional oxygen consumption of the brain. We evaluated local inhomogeneity of the magnetic field caused by deoxyhemoglobin (deoxyHb) in the cerebral vein using the phase information of SWI. We found that the local inhomogeneity observed by SWI is strongly affected by an angle between the longitudinal axis of the vein and the direction of the static magnetic field of the MRI unit. Therefore, the angle has to be incorporated to calculate local deoxyHb concentration of the vein.
In normal volunteers, the phase shift increased under hyperventilation and it decreased under breath hold. Changes in oxygen saturation of the veins and in cerebral blood flow, that were calculated by using the difference in phase shift, showed the same results. This indicates that we can measure deoxyHb concentration of the cerebral veins by SWI if we can establish a reference of relationship between the amount of phase shift and deoxyHb concentration in the vein.
In a patient with acute cerebral infarct, the largest local phase shift was observed in the infracted area. The phase shift was the largest immediately after the onset, and it decreased gradually during the first 20 days. In contrast, in another patient with chronically impaired blood flow and increased oxygen extraction fraction (OEF) in left anterior and middle cerebral artery territory that was caused by left internal carotid artery occlusion, there was no difference in the phase shift between the ischemic area and the contralateral healthy area. These results imply that SWI can detect increased deoxyHb in the veins of acute ischemic area, but cannot detect increased OEF in chronic phase.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (13 results)

All 2008 2007 2006

All Presentation (13 results)

  • [Presentation] 呼吸負荷SWIを用いた定量的脳血流評価法の検討2008

    • Author(s)
      石坂欣也、工藤與亮、谷津リエ、藤間憲幸、財津有里、尾松美香、寺江聡。
    • Organizer
      第64回日本放射線技術学会総会学術大会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Quantitative Cerebral Blood Flow Measurement by SWI with breathhold, hyperventilation and oxygen inhalation2008

    • Author(s)
      Ishizaka K, Kudo K, Yazu R, Fujima N, Zaitsu Y, Omatsu M, Terae S.
    • Organizer
      Japanese Society of Radiological Technology 64^<th> scientific meeting & exhibition.
    • Place of Presentation
      Yokohama, Japan.
    • Year and Date
      2008-04-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DeveloPment of Perfusion Mismatch Analyzer (PMA): Fully Automated, Operator-Independent and Standardized PWI-DWI Analysis Software.2007

    • Author(s)
      Kudo K, Sasaki M, Momoshima S, Yamada K, Terae S, Shirato H.
    • Organizer
      93rd RSNA scientific assembly and annual meeting
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dependency of the Venous Phase Shift Upon Positioning Angle in Susceptibility Weighted Imaging.2007

    • Author(s)
      Ishizaka K, Kudo K, Yoshida Y, Oka M, Terae S.
    • Organizer
      15th International Society for Magnetic Resonance in Medicine
    • Place of Presentation
      Berlin, Germany
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] High Resolution PWI of the Brain: Comparison with SWI, MRA, and T1-CBV images.2007

    • Author(s)
      Kudo K, Li M, Ciulla C, Manova E, Latif Z, Hu J, Haacke M.
    • Organizer
      15th International Society for Magnetic Resonance in Medicine
    • Place of Presentation
      Berlin, Germany
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Development of Perfusion Mismatch Analyzer (PMA): Fully annual Automated, Operator-Independent and Standardized PWI-DWI Analysis Software.2007

    • Author(s)
      Kudo K, Sasaki M, Momoshima S, Yamada K, Terae S, Shirato H.
    • Organizer
      93rd RSNA scientific assembly and meeting.
    • Place of Presentation
      Chicago, USA.
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dependency of the Venous Phase Shift Upon Positioning Angle in Susceptibility Weighted Imaging.2007

    • Author(s)
      Ishizaka K, Kudo K, Yoshida Y, Oka M, Terae S.
    • Organizer
      15th International Society for Magnetic Resonance in Medicine.
    • Place of Presentation
      Berlin, Germany.
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] High Resolution PWI of the Brain; Comparison with SWI, MRA, and T1-CBV images.2007

    • Author(s)
      Kudo K, Li M, Ciulla C, Manova E, Latif Z, Hu J, Haacke M.
    • Organizer
      15th International Society for Magnetic Resonance in Medicine.
    • Place of Presentation
      Berlin, Germany.
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dependency of the Venous Phase Shift Upon Positioning Angle in Susceptibility Weighted Imaging2007

    • Author(s)
      Ishizaka K、Kudo K、Yoshida Y、Oka M、Terae S.
    • Organizer
      15th ISMRM(International Society for Magnetic Resonance in Medicine)
    • Place of Presentation
      Berlin, Germany ICC Berlin
    • Related Report
      2007 Annual Research Report
  • [Presentation] High Resolution PWI of the Brain; Comparison with SWI, MRA, and T1-CBV images2007

    • Author(s)
      Kudo K, Li M, Ciulla C, Manova E, Latif Z, Hu J, Haacke M.
    • Organizer
      15th ISMRM(International Society for Magnetic Resonance in Medicine)
    • Place of Presentation
      Berlin, Germany ICC Berlin
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of Perfusion Mismatch Analyzer(PMA): Fully Automated, Operator-Independent and Standardized PWI-DWI Analysis Software2007

    • Author(s)
      Kudo K、Sasaki M、Momoshima S、Yamada K、Terae S、Shirato H.
    • Organizer
      93rd RSNA scientific assembly and annual meeting
    • Place of Presentation
      シカゴ市、マコーミックプレイス、米国
    • Related Report
      2007 Annual Research Report
  • [Presentation] Susceptibility Weighted Imagingにおける角度依存性の検討2006

    • Author(s)
      石坂欣也、工藤與亮、吉田有里、岡美香、寺江聡。
    • Organizer
      第34回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば市
    • Year and Date
      2006-09-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of Positioning angle of the Head on Venous Phase Shift in Susceptibility Weighted Imaging.2006

    • Author(s)
      Ishizaka K, Kudo K, Yosida Y, Oka M, Terae S.
    • Organizer
      JSMRM (Japanese Society for Magnetic Resonance Imaging in Medicine) 34th scientific meeting & exhibition
    • Place of Presentation
      Tsukuba, Japan
    • Year and Date
      2006-09-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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