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Search for novel markers, and mechanisms of tumorigenesis and treatment responsiveness of central nervous system germ cell tumors

Research Project

Project/Area Number 18591605
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionSaitama Medical University

Principal Investigator

MATSUTANI Masao  Saitama Medical University, 医学部, 教授 (90010454)

Co-Investigator(Kenkyū-buntansha) NISHIKAWA Ryo  埼玉医科大学, 医学部, 教授 (90237678)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,150,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥750,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Keywords胚細胞腫瘍 / 腫瘍マーカー / BMP-4 / SOX-11 / Wnt
Research Abstract

:頭蓋内胚細胞腫瘍の凍結標本を用いたcDNA array による遺伝子発現解析を行いった.Germinoma に比べてnon-greminomatous germ cell tumor において有意に発現の高い遺伝子としてBone Morphogenetic Protein-4,SOX-11,Frizzled 7 をピックアップした.免疫組織化学染色による蛋白質発現の解析を行って,新規腫瘍マーカーとしての可能性を検討した.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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