| Project/Area Number |
18591708
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kyushu University |
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Principal Investigator |
AKATA Takashi Kyushu University, 大学院・医学研究院・麻酔・蘇生学, 准教授 (10260382)
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| Co-Investigator(Kenkyū-buntansha) |
SETOGUCHI Hidekazu 国立病院機構九州医療センター, 医師 (20325525)
MORIKAWA Keiko 国立病院機構九州医療センター, 医師 (60419603)
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| Research Collaborator |
YOSHINO Jun 九州大学, 大学院・医学研究院, 大学院生
SHIROZU Kazuhiro 九州大学, 大学院・医学研究院, 大学院生
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,040,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | 血管平滑筋 / 血管内皮 / 全身麻酔薬 / 揮発性麻酔薬 / 静脈麻酔薬 / 移植医療 / 吸入麻酔薬 / 交感神経系 / ノルアドレナリン / 血管平滑筋薬理学 / 臓器移植 / 周術期 / 周術期薬物 |
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| Research Abstract |
We investigated direct (i.e., non-neural) actions of general anesthestics on blood vessels of three transplantable organs liver, kidney, and small intestine (i.e., hepatic, renal, and mesenteric arteries), and their underlying mechanisms. To summarize clinical relevance of the obtained data, general anesthetics isoflurane, sevoflurane, and etomidate may reduce blood flow to the transplanted small intestine through their direct action on mesenteric arteries under light anesthesia or during administration of noradrenaline. However, they probably do not have such an injurious vascular action on the transplanted liver or kidney.
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