Study of mechanism of action of morphine and volatile anesthetics on neural network

• Project/Area Number: 18591722
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Juntendo University
• Principal Investigator: AKAZAWA Toshimasa Juntendo University, 医学部, 准教授 (60306941)
• Co-Investigator(Kenkyū-buntansha): NISHIMURA Kinya 順天堂大学, 医学部, 先任准教授 (80164581) ; SUZUKI Takeo 順天堂大学, 医学部, 准教授 (50306940)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,060,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥660,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: GABA性抑制性インターニューロン / 吸入麻酔薬 / 発火パターン / 海馬CA1 / GABA受容体 / bicuculline

Research Abstract

線条体および海馬体神経細胞に対してwhole-cell patch clamp法によって吸入麻酔薬添加ごの静止膜電位と発火パターンの変化を観察し、可逆的な発火パターンの著明な乱れを認めた。これら神経細胞における情報伝達の乱れが、吸入麻酔薬のメカニズムである可能性が示唆された。

Research Products

• [Journal Article] Preoperative plasma brain natriuretic peptide level is an independent predictor of postoperative atrial fibrillation following off-pump coronary artery bypass surgery. (2008)
  • Author(s): Akazawa T, et al
  • Journal Title: J Anesth 22 Pages: 347-53
  • NAID: 10024460450
  • Peer Reviewed
• [Journal Article] The degree of newly emerging mitral regurgitation during off-pump coronary artery bypass is predicted by preoperative left ventricular function. (2008)
  • Author(s): Akazawa T, et al
  • Journal Title: J Anesth 22 Pages: 13-27
  • NAID: 10024128485
  • Peer Reviewed
• [Journal Article] Nicorandil decteases cardiac events during and after noncardiac surgery (2007)
  • Author(s): Kashimoto S, Nishimura K, et. al.
  • Journal Title: J Clinc Anesthesia 19 Pages: 44-48
  • Peer Reviewed
• [Journal Article] ウサギ心室筋におけるL型カルシウムチャネル電流に対するイソフルランと亜酸化窒素の効果およびβアドレナリン受容体刺激による修飾 (2007)
  • Author(s): 苑 柳, 西村 欣也, 他5名
  • Journal Title: 麻酔 56 Pages: 386-394
  • Peer Reviewed
• [Presentation] Neuroprotective Action of Isoflurane Using Electrophysiological Recodings at Striatal Neurons of Mouse (2008)
  • Author(s): Kinya Nishimura, et al
  • Place of Presentation: Orlando FL
  • Year and Date: 2008-10-18
• [Presentation] 神経ネットワークへの吸入麻酔薬の影響 (2008)
  • Author(s): 西村欣也、赤澤年正、他
  • Organizer: 日本麻酔科学会第55回学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-12
• [Presentation] Neuroprotective Action of Volatile Anesthetics at Striatal Neurons of Mouse (2007)
  • Author(s): 西村 欣也
  • Organizer: 米国麻酔科学会
  • Place of Presentation: 米国サンフランシスコ
  • Year and Date: 2007-10-17
• [Presentation] 神経ネットワークへの吸入麻酔薬の影響 (2007)
  • Author(s): 赤澤年正、西村欣也、他
  • Organizer: 日本麻酔科学会第54回学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2007-05-31
• [Presentation] 吸入麻酔薬による脳保護効果はGABA受容体を介するか? (2006)
  • Author(s): 赤澤年正、西村欣也、他
  • Organizer: 日本麻酔科学会第53回学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2006-06-02