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New strategy to manage preterm delivery and pregnancy-induced hypertension in view of inflammation

Research Project

Project/Area Number 18591797
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Toyama

Principal Investigator

SHIOZAKI Arihiro (2007-2008)  University of Toyama, 大学病院, 講師 (00235491)

酒井 正利 (2006)  富山大学, 附属病院, 助教授 (90242502)

Co-Investigator(Kenkyū-buntansha) 齋藤 滋 (斎藤 滋)  富山大学, 大学院・医学薬学研究部, 教授 (30175351)
佐々木 泰  富山大学, 附属病院, 助手 (60324050)
塩崎 有宏  富山大学, 附属病院, 助手 (00235491)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,100,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥600,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywords妊娠高血圧症候群 / 妊娠高血圧腎症 / 早産 / 炎症 / 免疫 / 頸管中IL-8 / 頸管中顆粒球スメア / 絨毛膜羊膜炎 / サイトカイン / 細菌性膣症 / 子宮頸管長 / 子宮頸管炎 / 子宮頚管長
Research Abstract

妊娠高血圧腎症(PE)70例において免疫の指標となるTh1/Th2比をフローサイトメトリーで求めた。正常妊娠59例でも同様にTh1/Th2比を求め、正常妊娠の75%タイル値以上をTh1優位、25~75%タイルをTh1/Th2比正常、25%タイル以下をTh2優位と規定した。その結果3群間で臨床症状を比較したところ、重症型の蛋白尿はTh2優位型PEで75%とTh1優位型PEの32.6%に比し有意に高率であり、重度の蛋白尿を呈する症例ではTh2優位型PEが多いことを初めて明らかにした。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (86 results)

All 2008 2007 2006

All Journal Article (38 results) (of which Peer Reviewed: 21 results) Presentation (42 results) Book (6 results)

  • [Journal Article] Granulysin produced by uterine natural killer cells induces apoptosis of extravillous trophoblasts in spontaneous abortion2008

    • Author(s)
      Nakashima A, Shiozaki A, Myojo S, Ito M, Tatematsu M, Sakai M, Takamori Y, Ogawa K, Nagata K, Saito S
    • Journal Title

      Am J Pathol 173(3)

      Pages: 653-64

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 切迫早産とその取り扱い方.産婦人科治療増刊2008

    • Author(s)
      塩崎有宏、斎藤滋
    • Journal Title

      周産期診療プラクティス 96 Suppl

      Pages: 564-569

    • Related Report
      2008 Final Research Report
  • [Journal Article] 免疫と妊娠高血圧症候群2008

    • Author(s)
      塩崎有宏、斎藤滋
    • Journal Title

      産婦人科の実際 57(1)

      Pages: 23-30

    • Related Report
      2008 Final Research Report
  • [Journal Article] The balance between cytotoxic NK cells and regulatory NK cells in human pregnancy.2008

    • Author(s)
      Saito S, Nakashima A, Myojo-Higuma S, Shiozaki A
    • Journal Title

      J Reprod Immunol 77

      Pages: 14-22

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Granulysin produced by uterine natural killer cell induces apoptosis of extravillous trophoblast in spontaneous abortion.2008

    • Author(s)
      Nakashima A, Shiozaki A, Myojo S, Ito M, Tatematsu M, Sakai M, Takamori Y, Ogawa K, Nagata K, Saito S
    • Journal Title

      Am J Pathol 173

      Pages: 653-664

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TSLP-induced placental DC activation and IL-10+ NK cell expansion : Comparative study based on BALB/c x C57BL/6 and NOD/SCID x C57BL/6 pregnant models.2008

    • Author(s)
      Lin Y, Zhong Y, Saito S
    • Journal Title

      Clin Immunol 126

      Pages: 104-117

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin(IL)-17A stimulates IL-8 secretion, cyclooxy genase-2 expression, and cell preliferation of endometriotic stromal cells.2008

    • Author(s)
      Hirata T, Osuga Y, Hamasaki K, Yoshino O, Ito M, Hasegawa A, Takenuma Y, Hirota Y, Nose E, Morimoto C, Harada M, Koga K, Tajima T, Saito S, Yano T, Taketani Y
    • Journal Title

      Endocrinology 149

      Pages: 1260-1267

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] シンポジウム2「早産-予防・出生児の管理・手術の限界」日本における早産の実態と予防対策2008

    • Author(s)
      齋藤 滋
    • Journal Title

      日本周産期・新生児医学会雑誌 44

      Pages: 845-849

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 羊水中チオレドキシン、IL-6、IL-8からみたFIRS2008

    • Author(s)
      米田 哲, 伊奈志帆美, 塩崎有宏, 伊藤実香, 島 友子, 米田徳子, 齋藤 滋
    • Journal Title

      日本周産期・新生児医学会雑誌 44

      Pages: 1034-1038

    • NAID

      10025166905

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 周産期脳障害の原因とその予防-周産期脳障害の予防と治療-抗炎症、免疫調節による脳保護.2008

    • Author(s)
      齋藤 滋
    • Journal Title

      周産期医学 38

      Pages: 739-741

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 妊娠高血圧症候群の発症と免疫2008

    • Author(s)
      齋藤 滋
    • Journal Title

      臨床免疫・アレルギー科 50

      Pages: 82-89

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 病態生理を解く 免疫と妊娠高血圧症候群2008

    • Author(s)
      塩崎有宏, 齋藤 滋
    • Journal Title

      産婦人科の実際 57

      Pages: 23-30

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 45. 絨毛膜羊膜炎の検査2008

    • Author(s)
      塩崎有宏, 齋藤 滋
    • Journal Title

      周産期医学増刊 周産期臨床検査のポイント 38

      Pages: 200-206

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 周産期I. 母体感染症6. 絨毛膜羊膜炎2008

    • Author(s)
      伊奈志帆美, 米田 哲, 塩崎有宏, 齋藤 滋
    • Journal Title

      産科と婦人科 75

      Pages: 1550-1555

    • Related Report
      2008 Annual Research Report
  • [Journal Article] The balance between cytotoxic NK cells and regulatory NK cells in human pregnancy2007

    • Author(s)
      Saito S, Nakashima A, Myojo-Higuma S, Shiozaki A
    • Journal Title

      J Reprod Immunol 77

      Pages: 14-22

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sasaki Y, Nakashima A, Shiozaki A. : Inadequate tolerance induction may induce pre-eclampsia2007

    • Author(s)
      Saito S, Sakai M, Sasaki Y, Nakashima A, Shiozaki A
    • Journal Title

      J Reprod Immunol 76(1-2)

      Pages: 30-39

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proportion of peripheral blood and decidual CD4(+) CD25(bright) regulatory T cells in pre-eclampsia2007

    • Author(s)
      Sasaki Y, Darmochwal-Kolarz D, Suzuki D, Sakai M, Ito M, Shima T, Shiozaki A, Rolinski J, Saito S
    • Journal Title

      Clin Exp Immunol 149(1)

      Pages: 139-45

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory T cells and regulatory natural killer (NK) cells play important roles in feto-maternal tolerance2007

    • Author(s)
      Saito S, Shiozaki A, Sasaki Y, Nakashima A, Shima T, Ito M
    • Journal Title

      Semin Immunopathol 29

      Pages: 115-122

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of the immune system in preeclampsia2007

    • Author(s)
      Saito S, Shiozaki A, Nakashima A, Sakai M, Sasaki Y
    • Journal Title

      Mol Aspects Med 28(2)

      Pages: 192-209

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-8 and glucose in amniotic fluid, fetal fibronectin in vaginal secretions and preterm labor index based on clinical variables are optimal predictive markers for preterm delivery in patients with intact membranes2007

    • Author(s)
      Yoneda S, Sakai M, Sasaki Y, Shiozaki A, Hidaka T, Saito S
    • Journal Title

      J Obstet Gynecol Res 33

      Pages: 38-44

    • NAID

      10018494420

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 前回早産妊娠・分娩既往歴に基づくリスク予測と診療のコツ2007

    • Author(s)
      塩崎有宏、斎藤滋
    • Journal Title

      ペリネイタルケア 26

      Pages: 662-667

    • Related Report
      2008 Final Research Report
  • [Journal Article] 子宮内感染-超低出生体重児の予後に影響する出生前の要因2007

    • Author(s)
      伊奈志帆美、酒井正利、塩崎有宏、斎藤滋
    • Journal Title

      周産期医学 37

      Pages: 439-442

    • Related Report
      2008 Final Research Report
  • [Journal Article] Proportion of peripheral blood-and decfdual-CD4^+CD25^<bright>regulatory T cells in pre-eclampsia2007

    • Author(s)
      Sasaki Y, Darmochwa-Kolarz D, Suzuki D, Sakai M, Ito M, Shima T, Shiozaki A, Rolinski J, Saito S
    • Journal Title

      Clin Exp Immunol 149

      Pages: 139-145

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of the immune system in preeclampsia.2007

    • Author(s)
      Saito S, Shiozaki A, Nakashima A, Sakai M, Sakaki Y.
    • Journal Title

      Mol Asp Med 28

      Pages: 192-209

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activated T lymphocytes in pre-eclampsia2007

    • Author(s)
      Darmochwal-Kolarz D, Saito S, Rolinski J, Tabarkiewicz J, Kolarz B, Leszczynska=Gorzelak B, Oleszczuk J
    • Journal Title

      Am J Reprod Immunol 58

      Pages: 39-45

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inadequate tolerance induction may induce pre-eclampsia2007

    • Author(s)
      Saito S, Sakai M, Sasaki Y, NakaskLma A, Shiozaki A
    • Journal Title

      J Reprod Immunol 76

      Pages: 30-39

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] What is the role of regulatory T cells in the success of implantation and early pregnancy?2007

    • Author(s)
      Saito S, Shima T, Nakashima A, Shiozaki A, Ito M, Sasaki Y
    • Journal Title

      J Assist Reprod Genet 24

      Pages: 379-386

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory T cells and regulatory natural killer (NK) cells play important roles in feto-maternal tolerance2007

    • Author(s)
      Saito S, Shiozaki A, Sasaki Y, Nakashima A, Shima T, Ito M
    • Journal Title

      Semin Immunol Pathol 29

      Pages: 115-122

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-8 and glucose in amniotic fluid, fetal fibronectin in vaginal secretions and preterm labor index based on clinical variables are optimal predictive markers for preterm delivery in patients with intact membranes2007

    • Author(s)
      Yoneda S, Sakai M, Sasaki Y, S hiozaki A, Hidaka T, Saito S
    • Journal Title

      J Obstet Gynaecol Res 33

      Pages: 38-44

    • NAID

      10018494420

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tolerance signaling molecules and pregnancy: IDO, galectins, and Renaissance of regulatory T cells2007

    • Author(s)
      Terness P, Kallikourdis M, Betz AG, Rabinovich GA, Saito S, Clark DA
    • Journal Title

      Am J Reprod Immunol 58

      Pages: 235-254

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 妊娠維持機構におけるCD4^+CD25^+制御性T細胞の役割2007

    • Author(s)
      齋藤 滋、佐々木 泰、中島 彰俊
    • Journal Title

      免疫と炎症 15

      Pages: 73-81

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 脱落膜NK細胞に妊娠維持に対する役割2007

    • Author(s)
      中島 彰俊、立松 美樹子、伊藤 実香、明星 須晴、斎藤 滋
    • Journal Title

      臨床免疫・アレルギー 47

      Pages: 723-728

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Evaluation of effectiveness of prophylactic cerclage of a short cervix according to interleukin-8 in cervical mucus.2006

    • Author(s)
      Sakai M., et al.
    • Journal Title

      Am J Obstet Gynecol 194

      Pages: 14-19

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The incidence of pre-eclampsia among couples consisting of Japanese women and Caucasian men.2006

    • Author(s)
      Saito S., et al.
    • Journal Title

      J Reprod Immunol 70

      Pages: 93-98

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Plasma granulysin concentrations and preeclampsia risk.2006

    • Author(s)
      Qui C., et al.
    • Journal Title

      Clin Biochem 39

      Pages: 1016-21

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Fundamental study of a newly developed medium on detection of Lactobacillus.2006

    • Author(s)
      Tanaka Y., et al.
    • Journal Title

      JARMAN 17

      Pages: 23-32

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 細菌性膣症,頚管炎からみた早産の予知・予防2006

    • Author(s)
      酒井正利, 他
    • Journal Title

      産婦人科の実際 55

      Pages: 23-29

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 妊娠高血圧症候群の病態における免疫の関与と対策2006

    • Author(s)
      斉藤 滋, 他
    • Journal Title

      産婦人科の実際 58

      Pages: 29-37

    • Related Report
      2006 Annual Research Report
  • [Presentation] IL-17 in the pathogenesis of preterm labor2008

    • Author(s)
      Ito M, Nakashima A, Ina S, Okabe M, Yoneda S, Shiozaki A, Nikaido T, Saito S
    • Organizer
      Amerian society for reproductive immunology
    • Place of Presentation
      Chicago, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Symposium 2, "Preeclampsia" The role of immune system in pre-eclampsia2008

    • Author(s)
      Saito S
    • Organizer
      15^<th> Congress of the federation of Asia and Oceania perinatal societies
    • Place of Presentation
      Nagoya (Invited speaker)
    • Related Report
      2008 Final Research Report
  • [Presentation] Luncheon seminar. Prevention of preterm birth and treatment for women in preterm labor2008

    • Author(s)
      Saito S
    • Organizer
      15^<th> Congress of the federation of Asia and Oceania perinatal societies
    • Place of Presentation
      Nagoya (Invited speaker)
    • Related Report
      2008 Final Research Report
  • [Presentation] Th1/Th2比正常型PEの臨床症状2008

    • Author(s)
      塩崎有宏、稲田貢三子、伊藤実香、伊奈志保美、明星須晴、米田哲、斎藤滋
    • Organizer
      第29回日本妊娠高血圧学会
    • Place of Presentation
      福島
    • Related Report
      2008 Final Research Report
  • [Presentation] Th1/Th2バランスからみた妊娠高血圧腎症の臨床症状2008

    • Author(s)
      塩崎有宏、伊藤実香、米田徳子、立松美樹子、明星須晴、米田哲、斎藤 滋
    • Organizer
      第44回日本周産期・新生児医学会学術講演会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 周産期免疫 : 常態と病態2妊娠高血圧症候群2008

    • Author(s)
      塩崎有宏、米田哲、斎藤滋
    • Organizer
      日本産婦人科・新生児血液学会シンポジウム
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] Luncheon Seminar. Prevention of preterm birth and treatment for women in preterm labor. (Invited Speaker)2008

    • Author(s)
      Saito S
    • Organizer
      15^<th> Congress of the Federation of Asia and Oceania Perinatal Societies.
    • Place of Presentation
      Nagoya
    • Related Report
      2008 Annual Research Report
  • [Presentation] Symposium 2. “Preeclampsia" The role of immune system in pre-eclampsia. (Invited Speaker)2008

    • Author(s)
      Saito S
    • Organizer
      15^<th> Congress of the Federation of Asia and Oceania Perinatal Societies.
    • Place of Presentation
      Nagoya
    • Related Report
      2008 Annual Research Report
  • [Presentation] IL-17 in the pathogenesis of preterm labor.2008

    • Author(s)
      Ito M, Nakashima A, Ina A, Okabe M, Yoneda S, Shiozaki A, Saito S
    • Organizer
      American Society for Reproductive Immunology.
    • Place of Presentation
      Chicago, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] 周産期免疫 : シンポジウム「常態と病態 2 妊娠高血圧症候群」2008

    • Author(s)
      塩崎有宏, 米田 哲, 齋藤 滋
    • Organizer
      第18回日本産科婦人科・新生児血液学会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] Th1/Th2バランスからみた妊娠高血圧腎症の臨床症状.2008

    • Author(s)
      塩崎有宏, 伊藤実香, 米田徳子, 立松美樹子, 明星須晴, 米田 哲, 齋藤 滋
    • Organizer
      第44回日本周産期・新生児医学会総会・学術集会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] Th1/Th2比正常型PEの臨床症状.2008

    • Author(s)
      塩崎有宏, 稲田貢三子, 伊藤実香, 伊奈志帆美, 明星須晴, 米田 哲, 齋藤 滋
    • Organizer
      第29回日本妊娠高血圧学会
    • Place of Presentation
      福島
    • Related Report
      2008 Annual Research Report
  • [Presentation] シンポジウム2「羊水中サイトカインと胎児心拍モニタリングによるFIRSの予測2008

    • Author(s)
      米田 哲, 伊奈志帆美, 塩崎有宏, 齋藤 滋
    • Organizer
      第18回日本産婦人科・新生児血液学会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] 妊娠27週未満の胎胞形成症例と前期破水症例の検討.2008

    • Author(s)
      米田 哲, 米田徳子, 立松美樹子, 伊奈志帆美, 塩崎有宏, 齋藤滋
    • Organizer
      第44回日本周産期・新生児医学会総会・学術集会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] 未破水切迫早産症例の分娩時期は予測できるのか?2008

    • Author(s)
      米田 哲, 稲田貢三子, 島 友子, 伊藤実香, 塩崎有宏, 齋藤 滋
    • Organizer
      第56回日本産科婦人科学会北日本連合地方部会総会・学術講演会
    • Place of Presentation
      弘前
    • Related Report
      2008 Annual Research Report
  • [Presentation] 未破水切迫早産症例の分娩時期は羊水中IL-8値と臨床症状を指標としたPreterm Labor Indexで予測できる.2008

    • Author(s)
      米田 哲, 稲田貢三子, 島 友子, 伊藤実香, 伊奈志帆美, 塩崎有宏, 齋藤 滋
    • Organizer
      第23回日本生殖免疫学会総会・学術集会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] Preterm PROMでは羊膜中のalpha 1 antitrypsinが酸化され、その活性が低下している2008

    • Author(s)
      米田徳子, 中島彰俊, 戸田文香, 西山玲奈, 米澤理可, 伊藤実香, 米田 哲, 塩崎有宏, 齋藤 滋, 二階堂敏雄
    • Organizer
      第60回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] 妊娠におけるTh17細胞の役割についての検討.2008

    • Author(s)
      伊藤実香, 中島彰俊, 米田 哲, 立松美樹子, 稲坂 淳, 塩崎有宏, 齋藤 滋
    • Organizer
      第60回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] 好中球、単球、T細胞から産生されるIL-17はTNFαと相乗的に作用し羊膜上皮、間葉系細胞からのIL-8産生を亢進させる.2008

    • Author(s)
      伊藤実香, 中島彰俊, 伊奈志帆美, 岡部素典, 米田 哲, 塩崎有宏, 二階堂敏雄, 齋藤 滋
    • Organizer
      第23回日本生殖免疫学会総会・学術集会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] Local regulation of uterine lymphocytes in human2007

    • Author(s)
      Saito S
    • Organizer
      14^<th> congress on gestational trophoblastic diseases
    • Place of Presentation
      Fukuoka (Invited Lecture)
    • Related Report
      2008 Final Research Report
  • [Presentation] Clinical management for prevention of preterm birth and fetal inflammatory response syndrome (FIRS)2007

    • Author(s)
      Saito S
    • Organizer
      3^<rd> Congress of Asian society for pediatric research
    • Place of Presentation
      Tokyo (Invited Lecture)
    • Related Report
      2008 Final Research Report
  • [Presentation] Decidual natural killer cell derived granulysin induces apoptosis of extravillous trophoblast in miscarriage2007

    • Author(s)
      Nakashima A, Shiozaki A, Myojo S, Ito M, Tatematsu M, Saito S
    • Organizer
      13^<th> Internation Federation of placental associations meeting 2007
    • Place of Presentation
      Kingston, Canada.
    • Related Report
      2008 Final Research Report
  • [Presentation] Cervical inflammation is an indicator for treatment to prevent preterm labor2007

    • Author(s)
      Saito S, Sakai M, Shiozaki A, Yoneda S
    • Organizer
      20^th Asian and oceanic congress of obstetircs and gynecology
    • Place of Presentation
      Tokyo (Invited speaker)
    • Related Report
      2008 Final Research Report
  • [Presentation] Regulatory T cells and regulatory NK cells in normal pregnancy and spontaneous abortion cases2007

    • Author(s)
      Saito S
    • Organizer
      5^<th> European congress of reproductive immunology
    • Place of Presentation
      Berlin (Invited Lecture)
    • Related Report
      2008 Final Research Report
  • [Presentation] Saito S : The balance between immunostimulation an immunoregulation during pregnancy2007

    • Author(s)
      Saito S
    • Organizer
      10^<th> International congress of reproductive immunology
    • Place of Presentation
      Opatija, Croatia (Invited Lecture)
    • Related Report
      2008 Final Research Report
  • [Presentation] Proportion of peripheral blood and decidual-CD4+CD25brightregulatory T cells and the expression of Toll like receptor on interstitial extravillous trophoblast in pre-eclampsia2007

    • Author(s)
      Ito M, Sasaki Y, Suzuki D, Sakai M, Shima T, Shiozaki A, Saito S, Darmochwal-Kolarz D
    • Organizer
      10^<th> International congress of reproductive immunology
    • Place of Presentation
      Opatija, Croatia
    • Related Report
      2008 Final Research Report
  • [Presentation] 長期間蛋白尿が持続したTh2型妊娠高血圧腎症の1例2007

    • Author(s)
      塩崎有宏、橋本佳子、米田徳子、立松美樹子、伊奈志帆美、稲坂 淳、若杉聡美、米田 哲、斎藤 滋
    • Organizer
      第28回日本妊娠高血圧学会総会・学術集会
    • Place of Presentation
      愛媛
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Th1型PEとTh2型PEでは臨床経過が異なる2007

    • Author(s)
      塩崎有宏、酒井正利、田畑実香、立松美樹子、佐々木泰、岡田俊則、斎藤 滋
    • Organizer
      第43回日本周産期・新生児医学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Th1型PEとTh2型PEでは臨床経過が異なる2007

    • Author(s)
      塩崎有宏、酒井正利、伊藤実香、立松美樹子、佐々木泰、岡田俊則、斎藤 滋
    • Organizer
      第59回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      東京(会長賞受賞)
    • Related Report
      2008 Final Research Report
  • [Presentation] Cervical inflammation os an indicator for treatment to prevent preterm labor2007

    • Author(s)
      Saito S, Sakai M, Shiozaki A, Yoneda S
    • Organizer
      The XX Asian and Oceanic Congress of Obstetrics and Gynecology
    • Place of Presentation
      Tokyo
    • Related Report
      2007 Annual Research Report
  • [Presentation] The balance between immunostimulation and immunoregulation during pregnancy2007

    • Author(s)
      Saito S
    • Organizer
      Xth International Congress of Reproductive Immunology
    • Place of Presentation
      Opatija, Croatia
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulatory T cells and regulatory NK cells in normal pregnancy and spontaneous abortion case2007

    • Author(s)
      Saito S
    • Organizer
      5th European Congress of renrod Immunology
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2007 Annual Research Report
  • [Presentation] Clinical management for prevention of preterm birth and fetal inflammatory response syndrome (FIRS)2007

    • Author(s)
      Saito S
    • Organizer
      3rd Congress of Asian Society for Pediatric Research
    • Place of Presentation
      Tokyo
    • Related Report
      2007 Annual Research Report
  • [Presentation] Local regulation of uterine lymphocytes in human2007

    • Author(s)
      Saito S
    • Organizer
      The 14th World Congress on Gestational Trophoblastic Diseases
    • Place of Presentation
      Fukuoka
    • Related Report
      2007 Annual Research Report
  • [Presentation] The balance between cytotoxic NK cells and regulatory NK cells during pregnancy2007

    • Author(s)
      Nakashima A
    • Organizer
      13th International Federation of Placenta Associations Meeting 2007
    • Place of Presentation
      Kingston. Canada
    • Related Report
      2007 Annual Research Report
  • [Presentation] Decidual Natual Killer cell derived granulysin induces apoptosis of extravillous trophoblast in miscarriage2007

    • Author(s)
      Nakashima A, Shiozaki A, Myojo S, Ito M, Tatematsu M, Saito S
    • Organizer
      13th International Federation of Placenta Associations Meeting 2007
    • Place of Presentation
      Kingston. Canada
    • Related Report
      2007 Annual Research Report
  • [Presentation] Alpha l antitrypsin activity in preterm premature runture of amniotic membrane2007

    • Author(s)
      Yoneda N, 0kabe M, Higuchi 0, Nogami M, Nishiyama R, Ito M, Shiozaki A, Yoshida T, SaitoS, Nikaido T
    • Organizer
      13th International Federation of Placenta Associations Meeting 2007
    • Place of Presentation
      Kingston, Canada
    • Related Report
      2007 Annual Research Report
  • [Presentation] Proportion of peripheral blood and decidual-CD4^+CD^(bright)regulatory T cells and expression of tool like recector 4 on interstitial extravillous trophoblast in pre-eclampsia2007

    • Author(s)
      Ito M, Sasaki Y, Suzuki D, Sakai M, Shima T, Shiozaki A, Saito S, Darmochmal-Kolarz D
    • Organizer
      Xth International Congress of Reproductive Immunology
    • Place of Presentation
      Opatija
    • Related Report
      2007 Annual Research Report
  • [Presentation] Th1型PEとTh2型PEでは臨床経過が異なる2007

    • Author(s)
      塩崎 有宏、酒井 正利、伊藤 実香、立松 美樹子、佐々木 泰、岡田 俊則、斎藤 滋
    • Organizer
      第59回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      京都
    • Related Report
      2007 Annual Research Report
  • [Presentation] Th1型PEとTh2型PEでは臨床経過が異なる2007

    • Author(s)
      塩崎 有宏、酒井 正利、伊藤 実香、立松 美樹子、佐々木 泰、岡田 俊則、斎藤 滋
    • Organizer
      第43回日本同産期・新生児医学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 妊娠高血圧症候群と免疫・妊娠高血圧症候群におけるT細胞とNK細胞の役割2007

    • Author(s)
      中島 彰俊
    • Organizer
      第22回日本生殖免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 妊娠高血圧症候群と免疫2006

    • Author(s)
      塩崎有宏、佐々木泰、鈴木大輔、斎藤滋
    • Organizer
      第27回日本妊娠高血圧学会シンポジウム
    • Place of Presentation
      新潟
    • Year and Date
      2006-10-07
    • Related Report
      2008 Final Research Report
  • [Book] 絨毛膜羊膜炎の検査, 周産期医学増刊 周産期臨床検査のポイント2008

    • Author(s)
      塩崎有宏、斎藤滋
    • Publisher
      東京医学社
    • Related Report
      2008 Final Research Report
  • [Book] 妊娠の生理.産婦人科学テキスト2008

    • Author(s)
      塩崎有宏、酒井正利、斎藤滋
    • Publisher
      中外医学社
    • Related Report
      2008 Final Research Report
  • [Book] ベットサイドで役立つ30症例2007

    • Author(s)
      塩崎有宏、酒井正利、斎藤滋、金芳堂、佐川典正、小西郁生、杉野法広
    • Publisher
      プライマリケア産婦人科
    • Related Report
      2008 Final Research Report
  • [Book] 最新の知見と取り扱い2007

    • Author(s)
      塩崎有宏、酒井正利、斎藤滋
    • Publisher
      メジカルビュー社
    • Related Report
      2008 Final Research Report
  • [Book] プライマリケア産婦人科 ベットサイドで役立つ30症例 (分担執筆:症例2早産)2007

    • Author(s)
      塩崎 有宏、酒井 圧利、浙藤 滋
    • Publisher
      金芳堂
    • Related Report
      2007 Annual Research Report
  • [Book] 早産 最新の知見と取り扱い (分担執筆:前期破水)2007

    • Author(s)
      塩崎 有宏、酒井 正利、斎藤 滋
    • Publisher
      MEDICAL VIEW
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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