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Analysis of medullary mechanisms for tongue movements regulated by respiratory pacemaker neurons

Research Project

Project/Area Number 18592175
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

KOIZUMI Hidehiko  Osaka University, Dental Hospital, Assistant Professor (10324790)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,860,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsBrain / Neurophvsiology / Breathing / Patch-clamp
Research Abstract

We have investigated the medullary control mechanisms for tongue movements. In this study, we focused on respiratory hypoglossal motor activity that was regulated by respiratory pacemaker neurons. We first analyzed electrophysiological spiking properties of respiratory pacemaker neurons using patch-clamp technique in neonatal rat brainstem slice preparations in vitro and arterially perfused juvenile rat brainstem preparations in situ. We then investigated the cellular mechanisms for respiratory drive transmission from pacemaker neurons to hypoglossal motoneurons. We concluded that several Na^+, K^+, and Ca^<2+> currents such as Ca^<2+-> activated K^+ currents were responsible for repetitive spiking behavior in respiratory pacemaker neurons by affecting their membrane after-hyperpolarization, and that some subthreshold currents including persistent Na^+ (NaP) currents contributed to frequency control of rhythmical bursts in respiratory pacemaker neurons and hypoglossal motoneurons. We f … More urther demonstrated that during normal breathing inhibitory respiratory networks regulated by Cl currents rather than pacemaker excitatory networks regulated by NaP currents were critical for rhythm generation of respiratory hypoglossal activities. During hypoxia, however, respiratory rhythm generation relied on solely NaP cellular mechanisms.
We also developed the computational network models for respiratory tongue movements by using the data from our electrophysiological experiments. The computational simulation studies were performed with a collaborator, Dr. Smith at the NIH in the USA. In our network models we tested the role of NaP channel on several membrane properties of respiratory pacemaker neurons and hypoglossal motoneurons. We concluded that NaP currents were critical for rhythmical burst generation in pacemaker neurons, and that the conductance of NaP channels was responsible for pattern formation of respiratory hypoglossal motor activities including burst frequency, amplitude and duration.
The findings obtained in this study will provide useful information on treatments for several respiratory disorders such as sleep apnea. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (6 results)

All 2007

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] Inhibition of trigeminal respiratory activity by suckling2007

    • Author(s)
      H. Koizumi
    • Journal Title

      Journal of Dental Research 86

      Pages: 1073-1077

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Intrinsic bursters increase the robustness of rhythm generation in an excitatory network2007

    • Author(s)
      L. K. Purvis
    • Journal Title

      Journal of Neurophysiology 97

      Pages: 1515-1526

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Inhibition of trigeminal respiratory activity by suckling2007

    • Author(s)
      H., Koizumi
    • Journal Title

      Journal of Dental Research 86

      Pages: 1073-1077

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Intrinsic bursters increase the robustness of rhythm generation in an excitatory network2007

    • Author(s)
      L K., Purvis
    • Journal Title

      Journal of Neurophysiology 97

      Pages: 1515-1526

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Intrinsic bursters increase the robustness of rhythm generation in an excitatory network2007

    • Author(s)
      L.K. Purvis
    • Journal Title

      Journal of Neurophysiology 97

      Pages: 1515-1526

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Characterization of spiking properties of pre-Botzinger Complex neurons in vitro2007

    • Author(s)
      H. Koizumi
    • Organizer
      37th Annual meeting of Society for Neuroscience
    • Place of Presentation
      San Diego, CA USA
    • Year and Date
      2007-11-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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