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Effects of relaxin on collagen metabolism by human periodontal ligament cells

Research Project

Project/Area Number 18592252
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionNihon University

Principal Investigator

YAMAGUCHI Masaru  Nihon University, 松戸歯学部, 准教授 (60333100)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,060,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥660,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsRelaxin / ヒト歯根膜線維芽細胞 / 細胞外マトリックス代謝 / 伸展力 / relaxin / 細胞外マトリックス
Research Abstract

伸展された歯根膜細胞にrelaxin刺激を行った結果, Col-Iタンパク産生量およびmRNA発現量はrelaxin濃度依存的に減少が認められたが, MMP-1の発現量は濃度依存的に増加が認められた。relaxinが伸展されたヒト歯根膜細胞におけるCol-IとMMP-1の発現に影響を与えたことより, このホルモンが矯正治療後の後戻りを防止するのに有効である可能性が示唆された

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (15 results)

All 2008 2007 2006 Other

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (7 results)

  • [Journal Article] Relaxin modulates collagen type I and metalloproteinase-1 expression by human periodontal ligament cells2008

    • Author(s)
      Takano M, Yamaguchi M, Nakajima R, Kojima T, Kasai K.
    • Journal Title

      J Oral Bioscience 50(4)

      Pages: 222-229

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of relaxin in rat periodontal ligament, dental pulp tissue, and midpalatal suture2008

    • Author(s)
      Yamaguchi M, Kubo R, Utsunomiya T, Yamamoto H, Kasai K.
    • Journal Title

      Int J Oral-Med Sci 7

      Pages: 35-39

    • NAID

      130000411391

    • Related Report
      2008 Final Research Report
  • [Journal Article] Immunohistochemical localization of relaxin in rat periodontal ligament, dental pulp tissue, and midpalatal suture2008

    • Author(s)
      Yamaguchi M, Kubo R, Utsunomiva T. Yamamoto H., et al.
    • Journal Title

      Int J Oral-Med Sci 7

      Pages: 35-39

    • NAID

      130000411391

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relaxin modulates collagen type I and metalloproteinase-1expression by human periodontal ligament cells2008

    • Author(s)
      Takano M, Yamaguchi M, Nakajima R, Kojima T, Kasai K.
    • Journal Title

      J Oral Bioscience 50 (4)

      Pages: 222-229

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of compression force on fibroblast growth factor-2 and receptor activator of nuclear factor kappa B ligand production by periodontal ligament cells in vitro.2008

    • Author(s)
      Nakajima R, Yamaguchi M, Kojima T, Takano M, Kasai K.
    • Journal Title

      Journal of Periodontal Research 43

      Pages: 168-173

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of orthodontic mechanics on the dental pulp.2007

    • Author(s)
      Yamaguchi M, Kasai K.
    • Journal Title

      Seminars in Orthodontics 13

      Pages: 272-280

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of relaxin on collagen type I released by stretched human periodontal ligament cells

    • Author(s)
      Takano M, Yamaguchi M, Nakajima R, Fujita S, Kojima T, Kasai K.
    • Journal Title

      Orthod Craniofacial Res (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histopathological Study of Inhibitory Effects for Relapse by Relaxin after Expansion in Rat Midpalatal Suture

    • Author(s)
      Kubo R, Utsunomiya T, Yamaguchi M.
    • Journal Title

      Int J Oral-Med Sci (in press)

    • NAID

      130000411431

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Relaxinがヒト歯根膜由来細胞のコラーゲン代謝に及ぼす影響2008

    • Author(s)
      高野真知、山口大、中嶋亮、藤田祥仁、児島格、葛西一貴,
    • Organizer
      第50回歯科基礎医学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-23
    • Related Report
      2008 Final Research Report
  • [Presentation] Relaxin modulates collagen type I and matrix metalloproteinase-1 expression by human periodontal ligament cells2008

    • Author(s)
      Takano M, Yamaguchi M, Nakajima R, Kojima T, Kasai K.
    • Organizer
      86th General Session and Exhibition of the International Association for Dental Reserch
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-07-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Relaxin modulates collagen type I and matrix metalloproteinase-1 expression by human periodontal ligament cells.2008

    • Author(s)
      Takano M, Yamaguchi M, Nakajima R, Kojima T, Kasai K
    • Organizer
      86th General Session and Exhibition of the International Association for Dental Reserch
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-07-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト歯根膜由来細胞におけるLGR7、LGR8発現の検討2007

    • Author(s)
      高野 真知、中嶋 亮、児島 格 山口 大、葛西 一貴
    • Organizer
      第66回日本矯正歯科学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-09-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒト歯根膜由来細胞におけるLGR7,LGR8発現の検討2007

    • Author(s)
      高野真知、中嶋亮、児島格、山口大、葛西一貴
    • Organizer
      第66回日本矯正歯科学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-09-20
    • Related Report
      2008 Final Research Report
  • [Presentation] ラット正中口蓋縫合拡大によるrelaxin発現とType I collagen 発現の変化について2007

    • Author(s)
      久保利枝、山口大、宇都宮忠彦、山本浩嗣、葛西一貴
    • Organizer
      第66回日本矯正歯科学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-09-20
    • Related Report
      2008 Final Research Report
  • [Presentation] ラット正中口蓋縫合拡大によるrelaxin発現の変化について2006

    • Author(s)
      久保利枝、山口大, 兼川美香, 宇都宮忠彦、山本浩嗣、葛西一貴
    • Organizer
      第65回日本矯正歯科学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2006-09-14
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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