Development of micro-reactor system with embedded multifunctional CMOS sensor

• Project/Area Number: 18681024
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Microdevices/Nanodevices
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: TOKUDA Takashi Nara Institute of Science and Technology, 物質創成科学研究科, 准教授 (50314539)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥29,380,000 (Direct Cost: ¥22,600,000、Indirect Cost: ¥6,780,000); Fiscal Year 2008: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000); Fiscal Year 2007: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000); Fiscal Year 2006: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
• Keywords: マイクロリアクタ / イメージセンサ / CMOSセンサ / 電気化学測定 / 偏光分析 / in situ不斉計測

Research Abstract

本研究では、小型のチップの上で化学反応や分析を行う技術として研究が進められているマイクロケミストリシステムやuTAS (Micro Total Analysis System)へ搭載するためのCMOS多機能マイクロセンサチップを開発し、これを搭載したマイクロケミストリシステムの開発を行った。成果として、目標としていた各機能を実現するセンサ回路を実証し、マイクロケミストリシステムへの搭載についても基礎的検証に成功した。

Research Products

• [Journal Article] Polarization-Analyzing CMOS Image Sensor with Monolithically Embedded Polarizer for Microchemistry Systems (2009)
  • Author(s): Takashi Tokuda, Hirofumi Yamada, Kiyotaka Sasagawa, and Jun Ohta
  • Journal Title: IEEE Transactions on Biomedical Circuits and Systems (掲載確定)
  • Peer Reviewed
• [Journal Article] Polarization-analyzing CMOS photosensor with monolithically embedded wire grid polarizer (2009)
  • Author(s): Takashi Tokuda, Sho Sato, Hirofumi Yamada, Kiyotaka Sasagawa, and Jun Ohta
  • Journal Title: Electronics Letters Vol.45 Pages: 228-230
  • Peer Reviewed
• [Journal Article] Micro-Chamber Device Equipped with CMOS Optical Polarization Analyzer Chip for Micro Total Analysis System (2009)
  • Author(s): Kyosuke Minakawa, Hirofumi Yamada, Kyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
  • Journal Title: Japanese Journal of Applied Physics Vol.48
  • Peer Reviewed
• [Journal Article] 標準CMOSプロセスを用いたMicroTAS向け偏光検出イメージセンサ (2009)
  • Author(s): 徳田崇, 山田博文, 笹川清隆, 太田淳
  • Journal Title: 電気学会E部門論文誌 Vol.129(掲載確定)
  • Peer Reviewed
• [Journal Article] Polarization-Analyzing CMOS Image Sensor with Monolithically Embedded Polarizer for Microchemistry Systems (2009)
  • Author(s): T. Tokuda, et.al
  • Journal Title: IEEE Transactions on Biomedical Circuits and Systems (未定(採択済))
  • Peer Reviewed
• [Journal Article] Polarization-analyzing CMOS photosensor with monolithicall embedded wire arid polarizer (2009)
  • Author(s): T. Tokuda, et.al.
  • Journal Title: Electronics Letters 45(4) Pages: 228-230
  • Peer Reviewed
• [Journal Article] 標準CMOSプロセスを用いたMicroTAS向け偏光検出イメージセンサ (2009)
  • Author(s): 徳田崇, 山田博文, 笹川清隆, 太田淳
  • Journal Title: 電気学会E部門論文誌 129(8)(予定)(未定(採択済))
  • Peer Reviewed
• [Journal Article] Optical and Electrochemical dual-image CMOS sensor for on-chip biomolecular sensing applications (2007)
  • Author(s): T. Tokuda, K. Tanaka, M. Matsuo, K. Kagawa, M. Nunoshita, J. Ohta
  • Journal Title: Sensors & Actuators : A Vol.135 Pages: 315-322
  • Peer Reviewed
• [Journal Article] A new imaging scheme for on-chip DNA spots with optical/potential dual-image CMOS sensor in dry situation (2007)
  • Author(s): T. Tokuda, I. Kadowaki, K. Kagawa, M. Nunoshita, J. Ohta
  • Journal Title: Jpn. J. Appl. Phys. Vol.46 Pages: 2806-2810
  • Peer Reviewed
• [Journal Article] A new imaging scheme for on-chip DNA spots with optical / potential dual-image CMOS sensor in dry situation (2007)
  • Author(s): T.Tokuda, et. al.
  • Journal Title: Jpn. J. Appl. Phys Pages: 2806-2810
• [Journal Article] Optical and Electrochemical dual-image CMOS sensor for on-chip biomolecular sensing applications (2007)
  • Author(s): T.Tokuda, et. al.
  • Journal Title: Sensors and Actuators A: Physical Pages: 315-322
• [Journal Article] A new imaging scheme for on-chip DNA spots with optical / potential dual-image CMOS sensor in dry situation (2007)
  • Author(s): T.Tokuda
  • Journal Title: Jpn. J. Appl. Phys (未定)(掲載決定)
• [Journal Article] Optical and Electrochemical dual-image CMOS sensor for on-chip biomolecular sensing applications (2007)
  • Author(s): T.Tokuda
  • Journal Title: Sensors and Actuators A : Physical (未定)(掲載決定)
• [Journal Article] A CMOS image sensor with optical and potential dual imaging function for on-chip bioscientific applications (2006)
  • Author(s): T. Tokuda, A. Yamamoto, K. Kagawa, M. Nunoshita, J. Ohta
  • Journal Title: Sensors & Actuators : A Vol.125 Pages: 273-280
  • Peer Reviewed
• [Presentation] リアルタイム不斉度計測のための偏光分析CMOSイメージセンサ (2009)
  • Author(s): 下畠弘也, 山田博文, 笹川清隆, 徳田崇, 太田淳
  • Organizer: 第56回応用物理学関係連合講演会
  • Place of Presentation: 筑波大学
  • Year and Date: 2009-03-30
• [Presentation] マイクロケミストリに向けたイメージセンサ型偏光分析CMOSセンサ (2008)
  • Author(s): 山田博文, 笹川清隆, 徳田崇, 太田淳
  • Organizer: 第69回応用物理学会学術講演会
  • Place of Presentation: 中部大学
  • Year and Date: 2008-09-04
• [Presentation] イメージセンサ型偏光分析CMOSセンサ搭載マイクロチャネルデバイス (2008)
  • Author(s): 皆川亨介, 山田博文, 笹川清隆, 徳田崇, 太田淳
  • Organizer: 第69回応用物理学会学術講演会
  • Place of Presentation: 中部大学
  • Year and Date: 2008-09-04
• [Presentation] CMOS Optical Polarization Analyzer Chip for MicroTAS (2008)
  • Author(s): K. Minakawa, H. Yamada, K. Sasagawa, T. Tokuda and J. Ohta
  • Organizer: 2008 International Conference on Solid State Devices and Materials (SSDM 2008)
  • Place of Presentation: Tsukuba, Japan
  • Year and Date: 2008-08-25
• [Presentation] Polarization Analyzing CMOS Sensor for microchamber/Microfluidic System Based on Image Sensor Technology (2008)
  • Author(s): Takashi Tokuda, Sho Sato, Hirofumi Yamada, Jun Ohta
  • Organizer: IEEE Int'l Symposium on Circuits and Systems (ISCAS)
  • Place of Presentation: Seatle, WA.
  • Year and Date: 2008-05-21
• [Presentation] Polarization Analyzing CMOS Sensor for microchamber / Microfluidic System Based on Image Sensor Technology (2008)
  • Author(s): T. Toukda, et.al.
  • Organizer: IEEE Int'1 Symposium on Circuits and Systems (ISCAM)
  • Place of Presentation: Seatle, WA
  • Year and Date: 2008-05-21
• [Presentation] CMOS Optical Polarization Analyzer Chip for Micfochamber and Microfuidic System (2007)
  • Author(s): T. Tokuda, S. Sato, K. Kagawa, M. Nunoshita and J. Ohta
  • Organizer: The 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2007)
  • Place of Presentation: Paris, France
  • Year and Date: 2007-10-10
• [Presentation] CMOS Optical Polarization Analyzer Chip for μTAS (2007)
  • Author(s): T. Tokuda, S. Sato, M. Nunoshita and J. Ohta
  • Organizer: 2007 International Conference on Solid State Devices and Materials (SSDM 2007)
  • Place of Presentation: Tsukuba, Japan
  • Year and Date: 2007-09-21
• [Presentation] An optical/potential/voltammetric multifunctional CMOS image sensor for on-chip biomolecular/neural analytical applications (2007)
  • Author(s): T. Tokuda, S. Sato, K. Kagawa, M. Nunoshita, and J. Ohta
  • Organizer: 2007 International Image Sensor Workshop (IISW2007)
  • Place of Presentation: Ogunquit, Maine, USA.
  • Year and Date: 2007-06-07
• [Presentation] An Optical/Potential/Voltammetric Multifunctional CMOS Image Sensor for On-chip Biomolecular/Neural Sensing Applications (2006)
  • Author(s): T. Tokuda, I. Kadowaki, K. Kagawa, M. Nunoshita, J. Ohta
  • Organizer: Int'l Conf. Solid State Devices & Materials (SSDM2006)
  • Place of Presentation: Yokohama
  • Year and Date: 2006-09-15