Role of mammalian-specific genes related to genomic imprinting in mammalian development and evolution

• Project/Area Number: 18GS0315
• Research Category: Grant-in-Aid for Creative Scientific Research
• Allocation Type: Single-year Grants
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: ISHINO Fumitoshi Tokyo Medical and Dental University, 難治疾患研究所, 教授 (60159754)
• Co-Investigator(Kenkyū-buntansha): KANEKO Tomoko 東海大学, 健康科学部, 教授 (20221757) ; 幸田 尚 東京医科歯科大学, 難治疾患研究所, 講師 (60211893) ; 小野 竜一 東京医科歯科大学, 難治疾患研究所, 助教 (10401358)
• Co-Investigator(Renkei-kenkyūsha): KOHDA Takashi 東京医科歯科大学, 難治疾患研究所, 准教授 (60211893) ; ONO Ryuichi 東京医科歯科大学, 難治疾患研究所, 助教 (10401358)
• Project Period (FY): 2006 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥415,090,000 (Direct Cost: ¥319,300,000、Indirect Cost: ¥95,790,000); Fiscal Year 2010: ¥75,530,000 (Direct Cost: ¥58,100,000、Indirect Cost: ¥17,430,000); Fiscal Year 2009: ¥74,360,000 (Direct Cost: ¥57,200,000、Indirect Cost: ¥17,160,000); Fiscal Year 2008: ¥77,740,000 (Direct Cost: ¥59,800,000、Indirect Cost: ¥17,940,000); Fiscal Year 2007: ¥84,110,000 (Direct Cost: ¥64,700,000、Indirect Cost: ¥19,410,000); Fiscal Year 2006: ¥103,350,000 (Direct Cost: ¥79,500,000、Indirect Cost: ¥23,850,000)
• Keywords: ゲノム機能 / 哺乳類 / 胎生 / レトロトランスポゾン / 発生と進化 / 哺乳類の進化 / 胎生・胎盤の進化 / ゲノムインプリンティング / 哺乳類特異的ゲノム機能 / 獲得遺伝子(イグザプテーション) / 大進化の分子機構 / エピジェネティク機構の進化 / 系統発生 / 胎盤形成 / 哺乳類進化 / 胎盤と胎生の進化 / 個体発生機構 / ゲノム機能進化 / 胎生(胎盤形成)の進化 / レトロトランスポゾ / エピジェネティック機構の進化 / 哺乳類の個体発生 / ヒト遺伝子疾患 / 哺乳類ゲノム機能 / 胎生(胎盤)の獲得 / Peg10 / Peg11 / Rtl1 / 有袋類 / ゲノムインプリンティング進化 / エピジェネティクスの進化

Research Abstract

Sushi-ichi retrotransposon-derived genes (Sirh family genes) are mammalian-specific genes. Among them, we have previously reported that Peg10 and Peg11/Rtl1 play essential roles in placenta formation and function. In this project, we have produced knockout mice of each gene and demonstrated that Sirh7 has mammalian-specific functions concerning implantation and pregnancy as well as placenta formation. Our systematic analysis suggests that other Sirh genes also have such functions.

Research Products

• [Journal Article] The X-linked imprinted gene family Fthl17 shows predominantly female expression following the two-cell stage in mouse embryos. (2010)
  • Author(s): Kobayashi S(7人中6番目)
  • Journal Title: Nuc Acids Res 38(11) Pages: 3672-3681
• [Journal Article] Retrotransposon silencing by DNA methylation contributed to the evolution of placentation and genomic imprinting in mammals. (2010)
  • Author(s): Kaneko-Ishino T, Ishino F.
  • Journal Title: Develop Growth Differ 52(6) Pages: 533-543
  • NAID: 10027565671
• [Journal Article] Impeding Xist expression from the active X chromosome improves mouse somatic cell cloning. (2010)
  • Author(s): Inoue K(17人中15番目)
  • Journal Title: Science 330(6003) Pages: 496-499
• [Journal Article] ゲノムインプリンティング (2010)
  • Author(s): 石野史敏
  • Journal Title: 炎症と免疫 18 Pages: 109-111
• [Journal Article] Efficient production of androgenetic embryos by round spermatid injection. (2009)
  • Author(s): Miki H(12人中11番目)
  • Journal Title: Genesis 47(3) Pages: 155-160
• [Journal Article] Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre-and postnatal growth retardation. (2009)
  • Author(s): Shiura H(9人中9番目と10番目.責任著者)
  • Journal Title: Hum Mol Genet 18(8) Pages: 1424-1438
• [Journal Article] Spinocerebellar Ataxia Type 31 Is Associated with "Inserted" Penta-Nucleotide Repeats Containing (TGGAA)n. (2009)
  • Author(s): Sato N(22人中10番目)
  • Journal Title: Am J Hum Genet 85(5) Pages: 544-557
• [Journal Article] Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardation (2009)
  • Author(s): Shiura H, Nakamura K, Hikichi T, Hino T, Oda K., Suzuki-Migishima R, Kohda T, Kaneko-Ishino T, Ishino, F.
  • Journal Title: Hum.Mol.Genet. 18 Pages: 1424-1438
  • Peer Reviewed
• [Journal Article] Efficient production of androgenetic embryos by round spermatid injection (2009)
  • Author(s): Miki H, Hirose M, Ogonuki, N, Inoue K, Kezuka F, Honda A, Mekada K, Hanaki K, Iwafune H, Yoshiki A, Ishino F, Ogura A.
  • Journal Title: Genesis 47 Pages: 155-160
  • Peer Reviewed
• [Journal Article] Spinocerebellar Ataxia Type 31 Is Associated with "Inserted" Penta-Nucleotide Repeats Containing(TGGAA)n (2009)
  • Author(s): Sato N, Amino T, Kobayashi K, Asakawa S, Ishiguro T, Tsunemi T, Takahashi M, Matsuura T, Flanigan KM, Iwasaki S, Ishino F, Saito Y, Murayama S, Yoshida M, Hashizume Y, Takahashi Y, Tsuji S, Shimizu N, Toda T, Ishikawa K, Mizusawa, H.
  • Journal Title: Am.J.Hum.Genet. 85 Pages: 544-557
  • Peer Reviewed
• [Journal Article] ゲノム機能解析からみえてきた哺乳類の進化 (2009)
  • Author(s): 石野史敏、金児-石野知子
  • Journal Title: Biophilia 5 Pages: 44-48
• [Journal Article] 哺乳類における胎生の進化とレトロトランスポゾン (2009)
  • Author(s): 金児-石野知子、石野史敏
  • Journal Title: 実験医学 27 Pages: 3080-3086
• [Journal Article] Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardation. (2009)
  • Author(s): Shiura, H., Nakamura, K., Hikichi, T, . Hino, T., Oda, K., Suzuki-Migishima, R., Kohda, T., Kaneko-Ishino, T., Ishino, F.
  • Journal Title: Human Molecular Genetics 18(In press)
  • Peer Reviewed
• [Journal Article] Deletions and epimutations affecting the human chromosome 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes. (2008)
  • Author(s): Kagami M, et al(24人中23番目.責任著者)
  • Journal Title: Nat Genet 40(2) Pages: 237-242
• [Journal Article] Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta. (2008)
  • Author(s): Sekita Y, et al(14人中13番目と14番目.責任著者)
  • Journal Title: Nat Genet 40(2) Pages: 243-248
• [Journal Article] Nuclear transfer alters the DNA methylation status of specific genes in fertilized and parthenogenetically activated mouse embryonic stem cells. (2008)
  • Author(s): Hikichi T, et al(5人中4番目)
  • Journal Title: Stem Cells. 26(3) Pages: 783-788
• [Journal Article] Type 2 diabetes mellitus in a non- obese mouse model induced by Meg1/Grb10 overexpression. (2008)
  • Author(s): Yamamoto Y, et al(8人中2番目と3番目)
  • Journal Title: Exp Animals 57(4) Pages: 385-395
• [Journal Article] Ultrastructure of placental hyper- plasia in mice : Comparison of placental phenotypes with three different etiologies. (2008)
  • Author(s): Wakisaka N(9人中7番目と8番目)
  • Journal Title: Placenta 29(8) Pages: 753-759
• [Journal Article] Ultrastructure of placental hyperplasia in mice : Comparison of placental phenotypes with three different etiologies (2008)
  • Author(s): Wakisaka, N., Ogonuki, N., Miki, Y., Sekita, Y., Hanaki, K., Aikatsuka, A., Kaneko-Ishino, T., Ishino F., Ogura, A.
  • Journal Title: Placenta 29(8) Pages: 753-759
  • NAID: 130007022881
  • Peer Reviewed
• [Journal Article] Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta (2008)
  • Author(s): Sekita, Y., Wagatsuma, H., Nakamura, K., Ono, R., Kagami, M., Wakisaka-Saito, N., Hino, T., Suzuki-Migishima, R., Kohda, T., Ogura, A., Ogata, T. Yokoyama, M., Kaneko-Ishino T. and Ishino, F.
  • Journal Title: Nat. Genet 40(2) Pages: 243-248
• [Journal Article] Deletions and epimutations affecting the human chromosome 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes (2008)
  • Author(s): Kagami, M., Sekita, Y., Nishimura, G., Irie, M., Kato, F., Okada, M., Yamamori, S., Kishimoto, H., Nakayama, M., Tanaka, Y., Matsuoka, K., Takahashi, T., Noguchi, M., Tanaka, Y., Masumoto, K., Utsunomiya, T., Kouzan, H., Komatsu, Y., Ohashi, H., Kurosawa, K., Kosak, K., Ferguson-Smith, A. C., Ishino F. and Ogata, T.
  • Journal Title: Nat. Genet 40(2) Pages: 237-242
• [Journal Article] Nuclear transfer alters the DNA methylation status of specific genes in fertilized and parthenogenetically activated mouse embryonic stem cells (2008)
  • Author(s): Hikichi, T., Kohda, T., Wakayama, S., Ishino, F., Wakayama, T.
  • Journal Title: Stem Cells 26 Pages: 783-788
  • Peer Reviewed
• [Journal Article] Type 2 diabetes mellitus in a non-obese mouse model induced by Meg1/Grb10 overexpression. (2008)
  • Author(s): Yamamoto, Y., Ishino, F., Kaneko-Ishino, T., Shiura H., Uchio-Yamada, K., Matsuda, J., Suzuki, O., Sato. K.
  • Journal Title: Experimental Animals 57 Pages: 385-395
  • NAID: 10024166550
  • Peer Reviewed
• [Journal Article] Ultrastructure of placental hyperplasia in mice: Comparison of placental phenotypes with three different etiologies. (2008)
  • Author(s): Wakisaka, N., Ogonuki, N., Miki, Y., Sekita, Y., Hanaki, K., Aikatsuka, A., Kaneko-Ishino, T., Ishino F., Ogura, A.
  • Journal Title: Placenta 29 Pages: 753-759
  • NAID: 130007022881
  • Peer Reviewed
• [Journal Article] Efficient production of androgenetic embryos by round spermatid injection. (2008)
  • Author(s): Miki, H., Hirose, M., Ogonuki, N., Inoue, K., Kezuka, F., Honda, A., Mekada, K., Hanaki, K. I., Iwafune, H., Yoshiki, A., Ishino, F., Ogura, A
  • Journal Title: Genesis 47 Pages: 155-160
  • Peer Reviewed
• [Journal Article] ゲノムインプリンティングと進化 (2008)
  • Author(s): 金児-石野知子、石野史敏
  • Journal Title: 蛋白質・核酸・酵素 53 Pages: 836-843
• [Journal Article] Peg10 KOマウス(胎盤形成不全) (2008)
  • Author(s): 小野竜一, 成瀬美衣, 金児-石野知子、石野史敏
  • Journal Title: 分子細胞治療 29 Pages: 753-759
• [Journal Article] 哺乳類の個体発生とゲノムインプリンティング (2008)
  • Author(s): 石野史敏
  • Journal Title: 生体の科学 59 Pages: 408-409
  • NAID: 10007297436
• [Journal Article] 個体発生・成長とエピジェネティクス (2008)
  • Author(s): 石野史敏、金児-石野知子
  • Journal Title: 分子消化器病 5 Pages: 330-336
• [Journal Article] 染色体14番の父親性2倍体症候群の治療を目指したmicroRNA投与法の開発 (2008)
  • Author(s): 関田洋一、金児-石野知子、石野史敏
  • Journal Title: Chemical Biology 2 Pages: 12-13
• [Journal Article] 哺乳類の原点?カモノハシ-哺乳類のゲノム機能の進化を探る- (2008)
  • Author(s): 金児-石野知子、石野史敏
  • Journal Title: 蛋白質・核酸・酵素 54 Pages: 58-64
  • NAID: 40016392337
• [Journal Article] Identification of deletions and epimutations in the human chromosome 14q32.2 imprinted region in individuals with peaternal and maternal upd(14)-like phenotypes. (2008)
  • Author(s): Kagami M and Sekita Y, et. al.
  • Journal Title: Nature Genetics 40 Pages: 237-242
  • Peer Reviewed
• [Journal Article] Role of retrotransposon -derived imprinted gene, Rtll, in the feto-maternal interface of mouse placenta. (2008)
  • Author(s): Sekita Y, et. al.
  • Journal Title: Nature Genetics 40 Pages: 243-248
  • Peer Reviewed
• [Journal Article] Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner. (2007)
  • Author(s): Kamei Y(8人中4番目)
  • Journal Title: FEBS Lett. 581(1) Pages: 91-96
• [Journal Article] Retrotransposon Silencing by DNA Methylation Can Drive Mammalian Genomic Imprinting. (2007)
  • Author(s): Suzuki S(13人中11番目と13番目、責任著者)
  • Journal Title: PLoS Genetics 3 Pages: 55-55
• [Journal Article] Insulin is imprinted in the placenta of the marsupial, Macropus eugenii. (2007)
  • Author(s): Ager E(6人中5番目)
  • Journal Title: Dev Biol 309(2) Pages: 317-328
• [Journal Article] Retrotransposon Silencing by DNA Methylation Can Drive Mammalian Genomic Imprinting (2007)
  • Author(s): Suzuki, S., Ono, R., Narita, T., Pask, A. J., Shaw, G., Wang, C., Kohda, T., Alsop, A. E., Graves, J. A. M., Kohara, Y., Ishino, F., Renfree, M. B., Kaneko-Ishino, T.
  • Journal Title: PLoS Genetics 3
• [Journal Article] Retrotransposon Silencing by DNA Methylation Can Drive Mammalian Genomic Imprinting. (2007)
  • Author(s): Suzuki S., et. al.
  • Journal Title: PLoS Genetics 3
  • Peer Reviewed
• [Journal Article] Insulin is imprinted in the placenta of the marsupia1, Macropus eugenii. (2007)
  • Author(s): Ager E., et. al.
  • Journal Title: Developmental Biology 309 Pages: 317-328
  • Peer Reviewed
• [Journal Article] Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality. (2006)
  • Author(s): Ono R(15人中14番目と15番目、ダブル責任著者)
  • Journal Title: Nat Genet 38(1) Pages: 101-106
• [Journal Article] Aberrant regulation of imprinted gene expression in Gtl2^<lacZ> mice. (2006)
  • Author(s): Sekita Y(11人中10番目と11番目、ダブル責任著者)
  • Journal Title: Cytogenet Genome Res 113(1-4) Pages: 223-229
• [Journal Article] Complementation hypothesis : the necessity of a monoallelic gene expression mechanism in mammalian development. (2006)
  • Author(s): Kaneko-Ishino T, Kohda T, Ono R, Ishino F
  • Journal Title: Cytogenet Genome Res 113(1-4) Pages: 24-30
• [Journal Article] Expression of imprinted genes in cloned mice. (2006)
  • Author(s): Kohda T, Ishino F, Ogura A
  • Journal Title: Methods Mol Biol 348 Pages: 237-246
• [Journal Article] Chorioallantoic placenta defects in cloned mice. (2006)
  • Author(s): Wakisaka-Saito N(11人中9番目と11番目、責任著者)
  • Journal Title: Biochem Biophys Res Commn 349(1) Pages: 106-114
• [Journal Article] Estrogen agonists, 17beta-estradiol, bisphenol A, and diethylstilbestrol, decrease cortactin expression in the mouse testis. (2006)
  • Author(s): Anahara R(8人中6番目)
  • Journal Title: Arch Histol Cyto 169(2) Pages: 101-107
• [Journal Article] Anti-estrogen ICI 182.780 and anti-androgen flutamide induce tyrosine phosphorylation of cortactin in the ectoplasmic specialization between the Sertoli cell and spermatids in the mouse testis. (2006)
  • Author(s): Anahara R.(8人中6番目)
  • Journal Title: Biochem Biophys Res Commun 346(1) Pages: 276-280
• [Journal Article] Flutamide depresses expression of cortactin in the ectoplasmic specialization between the Sertoli cells and spermatids in the mouse testis. (2006)
  • Author(s): Anahara R(8人中6番目)
  • Journal Title: Food Chem Toxicol 44(7) Pages: 1050-1056
• [Journal Article] Anti-estrogen ICI 182.780 and anti-androgen flutamide induce tyrosine phosphorylation of cortactin in the ectoplasmic specialization between the Sertoli cell and spermatids in the mouse testis. (2006)
  • Author(s): Anahara, R., Toyama, Y., Maekawa, M., Yoshida, M., Kai, M., Ishino, F., Toshimori, K., Mori, C.
  • Journal Title: Biochem. Biophys. Res. Commun 346・1 Pages: 276-280
• [Journal Article] Chorioallantoic placenta defects in cloned mice. (2006)
  • Author(s): Wakisaka-Saito, N., Kohda, T., Inoue, K., Ogonuki, N., Miki, H., Hichiki, T., Mizutani, E., Wakayama T., Kaneko-Ishino, T., Ogura, A., Ishino, F.
  • Journal Title: Biochem. Biophys. Res. Commun 349・1 Pages: 106-114
• [Journal Article] レトロトランスポゾンが胎盤をつくる (2006)
  • Author(s): 小野竜一, 成瀬美衣, 金児-石野 知子, 石野史敏
  • Journal Title: BIONICS 3・6 Pages: 56-60
• [Journal Article] レトロトランスポゾン由来の遺伝子Peg10による哺乳類の胎盤形成 (2006)
  • Author(s): 石野史敏, 小野竜一, 金児-石野 知子
  • Journal Title: ブレインテクノニュース 116 Pages: 24-28
• [Journal Article] 体細胞クローンとエピジェネティクス ゲノムワイドに展開するエピジェネティクス医科学 (2006)
  • Author(s): 幸田尚, 金児-石野 知子, 石野史敏
  • Journal Title: 実験医学増刊 24・8 Pages: 152-157
• [Journal Article] レトロトランスポゾンと哺乳類進化 (2006)
  • Author(s): 金児-石野知子, 小野竜一, 石野史敏
  • Journal Title: 科学 77・1 Pages: 87-92
• [Journal Article] Identification of SIRH12, a retrotransposon-derivedgene specific to marsupial mammals.
  • Author(s): Ono R(11人中10番目と11番目.責任著者)
  • Journal Title: DNA Research in press
• [Journal Article] Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/ Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardation
  • Author(s): Shiura, H., Nakamura, K., Hikichi, T,. Hino, T., Oda, K., Suzuki-Migishima, R., Kohda, T., Kaneko-Ishino, T. and Ishino, F.
  • Journal Title: Hum. Mol. Genet (in press)
  • Peer Reviewed
• [Journal Article] Retrotransposon Silencing by DNA Methylation Can Drive Mammalian Genomic Imprinting.
  • Author(s): Shunsuke Suzuki, Ryuichi Ono, Takanori Narita, Andrew J.Pask, Geoffrey Shaw, Changshan Wang, Takashi Kohda, Amber E.Alsop, Jennifer A.Marshall Graves, Yuji Kohara, Fumitoshi Ishino^*, Marilyn B.Renfree^*, Tomoko Kaneko-Ishino^*.
  • Journal Title: PLoS Genetics (in press)
• [Presentation] ゲノムインプリンティング:ほ乳類におけるその生物学的意義 (2010)
  • Author(s): 石野史敏
  • Organizer: 第21回フォーラム・イン・ドージンエピジェネティクスによる細胞のメタモルフォーゼ
  • Place of Presentation: ホテルキャッスル熊本
  • Year and Date: 2010-11-26
• [Presentation] 哺乳類における胎生の進化とレトロトランスポゾン (2010)
  • Author(s): 石野史敏
  • Organizer: 第18回日本胎盤学会・第28回絨毛性疾患研究会教育講演
  • Place of Presentation: ホテル日航熊本
  • Year and Date: 2010-10-01
• [Presentation] 哺乳類における胎生の進化とレトロトランスポゾン (2010)
  • Author(s): 石野史敏、金児-石野知子
  • Organizer: 第19回三木成夫記念シンポジウム
  • Place of Presentation: 鶴見大学講堂
  • Year and Date: 2010-07-21
• [Presentation] Evolution of mammalian viviparity and genomic imprinting by retrotransposons. (2010)
  • Author(s): 石野史敏(7人中1番目と7番目)
  • Organizer: NAIST Global COE International Symposium 2010 Plasticity in Development and Evolution
  • Place of Presentation: NAIST Millennium Hall
• [Presentation] 哺乳類の胎生とゲノムインプリンティングの進化におけるレトロトランスポゾンの役割について (2009)
  • Author(s): 石野史敏
  • Organizer: 北海道大学医学部セミナー
  • Place of Presentation: 北海道大学医学部、札幌
  • Year and Date: 2009-11-05
• [Presentation] ゲノムインプリンティングの起源-そのとき哺乳類ゲノムに何が起きたのか?- (2009)
  • Author(s): 石野史敏、金児-石野知子
  • Organizer: 第82回日本生化学会年会 シンポジウムトランスポゾンとの共生が織りなすゲノムシステムのダイナミクス
  • Place of Presentation: 神戸国際会議場、神戸
  • Year and Date: 2009-10-14
• [Presentation] 哺乳類の胎生獲得におけるレトロトランスポゾンの寄与 (2009)
  • Author(s): 石野史敏
  • Organizer: 京都大学ウィルス研究所学術講演会
  • Place of Presentation: 芝蘭会館、京都大学
  • Year and Date: 2009-07-10
• [Presentation] レトロトランスポゾンはどのように哺乳類の進化に関わったか?-その Genetic な役割と Epigenetic な役割について- (2009)
  • Author(s): 石野史敏、金児-石野知子
  • Organizer: 第56回日本実験動物学会総会 シンポジウム哺乳動物の発生と進化におけるエピジェネティクスの役割
  • Place of Presentation: 大宮ソニックシティ大宮
  • Year and Date: 2009-05-14
• [Presentation] Epigenetics研究のtopics-哺乳類特異的ゲノム機構とレトロトランスポゾン- (2009)
  • Author(s): 金児-石野知子
  • Organizer: 第50回日本哺乳動物卵子学会シンポジウム生殖に関わるepigeneticsの基礎と臨床
  • Place of Presentation: 都市センターホテル、東京
  • Year and Date: 2009-05-09
• [Presentation] Epigenetics 研究の topics-哺乳類特異的ゲノム機構とレトロトランスポゾン- (2009)
  • Author(s): 金児-石野知子
  • Organizer: 第50回日本哺乳動物卵子学会シンポジウム生殖に関わる epigenetics の基礎と臨床
  • Place of Presentation: 都市センターホテル東京
  • Year and Date: 2009-05-09
• [Presentation] 哺乳類に特異的に存在するレトロトランスポゾン由来の遺伝子と胎盤形成 (2009)
  • Author(s): 石野史敏、小野竜一、関田洋一、鈴木俊介、金児-石野知子
  • Organizer: 第147回日本獣医学会学術集会ワークショップレトロエレメントのダイナミズム
  • Place of Presentation: 栃木県総合文化センター宇都宮
  • Year and Date: 2009-04-21
• [Presentation] Retrotramnspopsons and Evolution of Genomic Imprinting and Placentation in Mammals. (2009)
  • Author(s): 石野史敏(7人中1番目と7番目)
  • Organizer: Symposium : Epigenetic impacts for differentiation and patterning. The 42^<nd> Annual Meeting for the Japanese Society of Developmental Biologists.
  • Place of Presentation: Toki Messe, Niigata
• [Presentation] Contribution of Retrotransposons to the Evolution of Genomic Imprinting and Placentation in Mammals (2009)
  • Author(s): 石野史敏(7人中1番目と7番目)
  • Organizer: The 24^<th> NAITO Conference on Nuclear Dynamics and RNA (II)
  • Place of Presentation: Sapporo, Hokkaido
• [Presentation] Retorotransposons and trophoblast biology. (2009)
  • Author(s): 石野史敏
  • Organizer: Trophoblast Day Meeting.
  • Place of Presentation: Univ. Cambridge, UK
• [Presentation] Retorotransposon-derived imprinted genes, Peg10 and Peg11/Rtl1 and their relation to the origin of viviparity in mammals. (2009)
  • Author(s): 石野史敏
  • Organizer: From Imprinting to the Epigenome in 25 years.
  • Place of Presentation: Univ. Cambridge, UK
• [Presentation] Retrotramnspopsons and Evolution of Genomic Imprinting and Placentation in Mammals (2009)
  • Author(s): Fumitoshi Ishino, Ryuichi Ono, Shunsuke Suzuki, Yoichi Sekita Mie Naruse, Takashi Kohda, Tomoko Kaneko-Ishino
  • Organizer: Symposium : Epigenetic impacts for differentiation and patterning.The 42^<nd> a Annual Meeting for the Japanese Society of Developmental Biologists
  • Place of Presentation: Toki Messe, Niigata
• [Presentation] Contribution of Retrotransposons to the Evolution of Genomic Imprinting and Placentation in Mammals (2009)
  • Author(s): Fumitoshi Ishino, Ryuichi Ono, Shunsuke Suzuki, Yoichi Sekita, Mie Naruse, Takashi Kohda, Tomoko Kaneko-Ishino
  • Organizer: The 24^<th> NAITO Conference on Nuclear Dynamics and RNA(II)
  • Place of Presentation: Chateraise Gateaux Kingdom, Sapporo
• [Presentation] Retorotransposons and trophoblast biology (2009)
  • Author(s): 石野史敏
  • Organizer: Trophoblast Day Meeting
  • Place of Presentation: University of Cambridge, UK
• [Presentation] Retorotransposon-derived imprinted genes, Peg10 and Peg11/Rtl1 and their relation to the origin of viviparity in mammals (2009)
  • Author(s): 石野史敏
  • Organizer: From Imprinting to the Epigenome in 25 years
  • Place of Presentation: University of Cambridge, UK
• [Presentation] Mammalian-specific genes derived from retrotransposons functioning placenta formation (2009)
  • Author(s): Fumitoshi Ishino, Ryuichi Ono, Yoichi Sekita, Shunsuke Suzuki, Mie Naruse, Takashi Kohda, Atsuo Ogura, Kenji Nakamura, Minesuke Yokoyama, Marylin Renfree, Tomoko Kaneko-Ishino
  • Organizer: The 32^<nd> Annual Meeting of the Moleluclar Biology Society of Japan.Workshop : Integrative approaches towards evolutionary studies
  • Place of Presentation: Pacifico Yokohama, Yokohama
• [Presentation] The effects of maternal undermutrition on fetal growth (2009)
  • Author(s): Hisako Watanabe, Masahito Irie, Takashi Kohda, Fumitoshi Ishino, Tomoko Kaneko-Ishino
  • Organizer: The 32^<nd> Annual Meeting of the Moleluclar Biology Society of Japan
  • Place of Presentation: Pacifico Yokohama, Yokohama
• [Presentation] Analysis on mutant mice exhibiting abnormal methylation in DMR (2009)
  • Author(s): Hirotaka Iwafune, Yuki Yamaguchi, Tomohiro Suzuki, Hiroyasu Furumi, Masakazu Hashimoto, Takashi Kohda, Hideaki Kaneda, Shigeharu Wakana, Toshihiko Shiroishi, Hiroyuki Sasaki, Fumitoshi Ishino
  • Organizer: The 32^<nd> Annual Meeting of the Moleluclar Biology Society of Japan
  • Place of Presentation: Pacifico Yokohama, Yokohama
• [Presentation] AntiPeg11/Rtl1, essential antisense RNA of retrotransposon derived gene plays two different roles in mouse development (2009)
  • Author(s): Daisuke Endo, Yoichi Sekita, Tomoko Kaneko-Ishino, Masayo Kagami, Ryuichi Ono, Takashi Kohda, Tsutomu Ogata, Fumitoshi Ishino
  • Organizer: The 32^<nd> Annual Meeting of the Moleluclar Biology Society of Japan
  • Place of Presentation: Pacifico Yokohama, Yokohama
• [Presentation] Analysis of retrotransposon-derived genes, Sirh4, Sirh5 and Sirh6 (2009)
  • Author(s): Masayuki, Ishii, Ryuichi Ono, Mie Naruse, Daisuke Endo, Masahito Irie, Hirotaka Iwafune, Takashi Kohda, Tomoko Kaneko-Ishino, Fumitoshi Ishino
  • Organizer: The 32^<nd> Annual Meeting of the Moleluclar Biology Society of Japan
  • Place of Presentation: Pacifico Yokohama, Yokohama
• [Presentation] Verification of the imprinting status of retrotransposon-derived Pnma-family genes (2009)
  • Author(s): Sawa Iwasaki, Takashi Kohda, Tomoko Kaneko-Ishino, Fumitoshi Ishino
  • Organizer: The 32^<nd> Annual Meeting of the Moleluclar Biology Society of Japan
  • Place of Presentation: Pacifico Yokohama, Yokohama
• [Presentation] The epigenetic shift and random drift of the genome induced by embryo manipulations (2009)
  • Author(s): Takashi Kohda, Kimiko Inoue, Narumi Ogonuki, Sawa Iwasaki, Xijia Xia, Teruhiko Wakayama, Atsuo Ogura, Tomoko Kaneko-Ishino, Fumitoshi Ishino
  • Organizer: The 32^<nd> Annual Meeting of the Moleluclar Biology Society of Japan
  • Place of Presentation: Pacifico Yokohama, Yokohama
• [Presentation] The function of retrotransposon-derived gene (2009)
  • Author(s): Ryuichi Ono, Mie Naruse, Kenji Nakamura, Toshiaki HinoDaisuke Endo, Masahito Irie, Hirotaka Iwafune, Masayuki, Ishii, Takako Usami, Takashi Kohda, Atsuo Ogura, Minesuke Yokoyama, Tomoko Kaneko-Ishino, Fumitoshi Ishino
  • Organizer: The 32^<nd> Annual Meeting of the Moleluclar Biology Society of Japan
  • Place of Presentation: Pacifico Yokohama, Yokohama
• [Presentation] Retrotransposon-derived Sirh-family genes and mammalian viviparity (2009)
  • Author(s): Mie Naruse, Ryuichi Ono, Yoichi Sekita, Daisuke Endo, Masahito Irie, Hirotaka Iwafune, Masayuki Ishii, Kenji Nakamura, Toshiaki Hino, Takashi Kohda, Minesuke Yokoyama, Tomoko Kaneko-Ishino, Fumitoshi Ishino
  • Organizer: The 32^<nd> Annual Meeting of the Moleluclar Biology Society of Japan
  • Place of Presentation: Pacifico Yokohama, Yokohama
• [Presentation] Genomic imprinting diseases: Patients with paternal UPD14 and maternal deletion of imprinting control region in 14q32. 2 charac terized by bell-shaped thorax. (2008)
  • Author(s): Ishino F
  • Organizer: Global COE Kickoff Symposium
  • Place of Presentation: Tokyo Garden Palace, Tokyo
  • Year and Date: 2008-11-06
• [Presentation] "生殖細胞研究・発生研究"から"生殖医療・再生医療へ"-鍵をにぎるエピジェネティック制御- (2008)
  • Author(s): 石野史敏
  • Organizer: 特定胚及びヒトES細胞等研究専門委員会
  • Place of Presentation: 文部科学省, 東京
  • Year and Date: 2008-08-26
• [Presentation] ゲノムインプリンティングからみた哺乳類の進化-生物進化におけるレトロトランスポゾンの役割- (2008)
  • Author(s): 石野史敏
  • Organizer: かずさDNA研究所所長セミナー
  • Place of Presentation: かずさDNA研究所、千葉
  • Year and Date: 2008-05-14
• [Presentation] Evolution of genomid imprinting and placentation in mammals by retrotransposons. (2008)
  • Author(s): Ishino F
  • Organizer: 6th NIBB-EMBL Joint Meeting on"Evolution of Epigenetic Regulaton"
  • Place of Presentation: EMBL(Heidelberg,独)
  • Year and Date: 2008-03-19
• [Presentation] Evolution of genomic imprinting and placentation in mammals by retrotransposons. (2008)
  • Author(s): 石野史敏(5人中1番目と5番目)
  • Organizer: 6th NIBB-EMBL Joint Meeting "Evolution of Epigenetic Regulaton"
  • Place of Presentation: EMBL Heidelberg, Germany
• [Presentation] Origins of retrotransposon-derived PEG10 and imprinted regulation by DNA methylation. (2008)
  • Author(s): Tomoko Kaneko-Ishino(7人中1番目と7番目)
  • Organizer: EMBO Workshop on Genomic Imprinting
  • Place of Presentation: TEMASEK LifeScience Laboratory, Singapore
• [Presentation] Evolution of placentation in eutherian mammals contributed by exaptation of PEG10 and PEG11/RTL1 from retrotransposons. (2008)
  • Author(s): 石野史敏(7人中1番目と7番目)
  • Organizer: 8th NIBB-EMBL Joint Meeting "Evolution : Genomces, Cell Types and Shapes"
  • Place of Presentation: Okazaki Conference Center, Okazaki
• [Presentation] 哺乳類特異的なレトロトランスポゾンによる哺乳類の胎生進化 (2008)
  • Author(s): 石野史敏、小野竜一、関田洋一、鈴木俊介、成瀬美衣、入江将仁、幸田尚、横山峯介、中村健司、金児-石野知子
  • Organizer: シンポジウム"哺乳類成立の為の分子基盤"
  • Place of Presentation: 神戸ポートアイランド、神戸
• [Presentation] Evolution of placentation in eutherian mammals contributed by exaptation of PEG10 and PEG11/RTL1 from retrotransposons (2008)
  • Author(s): Fumitoshi Ishino, Ryuichi Ono, Sunsuke Suzuki, Yoichi Sekita, Mie Naruse, Takashi Kohda and Tomoko Kaneko-Ishino
  • Organizer: 8th NIBB-EMBL Joint Meeting "Evolution : Genomces, Cell Types and Shapes"
  • Place of Presentation: Okazaki Conference Center, Okazaki
• [Presentation] Roles of Peg11/Rtl1 in neo- and postnatal growth (2008)
  • Author(s): Yocihi Sekita, Masayo Kagami, Daisuke Endo, Ryuichi Ono, Takashi Kohda, Tsutomo Ogata, Tomoko Kaneko-Ishino and Fumitoshi Ishino
  • Organizer: EMBO Workshop on Genomic Imprinting
  • Place of Presentation: TEMASEK LifeScience Laboratory, Singapore
• [Presentation] 哺乳類の胎生はどのように獲得されたのか? (2008)
  • Author(s): 石野史敏
  • Organizer: 第17回大学院医歯学総合研究科セミナー"ポストゲノム時代の発生生物学展望"
  • Place of Presentation: 東京医科歯科大学, 東京
• [Presentation] Phenotypic analysis of Peg10 KO mouse placenta (2008)
  • Author(s): Ono R, Naruse M, Nakamura K, Hinno T, Suzuki-Migishima R, Usami T, Cross J, Kaneko-Ishino T, Ishino F.
  • Organizer: European Placenta Group Meeting 14^<th> IFPA Conference
  • Place of Presentation: Seggau Castle, Austria
• [Presentation] Roles of Peg11/Rt11 in neo- and postnatal growth. (2008)
  • Author(s): Sekita Y, Kagami M, Endo D, Ono R, Kohda T, Ogata T, Kaneko-Ishino T, Ishino F.
  • Organizer: EMBO Workshop on Genomic Imprinting
  • Place of Presentation: TEMASEK LifeScience Laboratory, Singapore
• [Presentation] Disruption of imprinted regulation in Meg1/Grb10 cluster results in pre- and postnatal growth retardation (2008)
  • Author(s): Shiura H, Hikichi T, Nakakura K, Hino T, Oda K, Suzuki-Migishima R, Kohda T, Kaneko-Ishino T, Ishino F.
  • Organizer: EMBO Workshop on Genomic Imprinting
  • Place of Presentation: EMBO Workshop on Genomic Imprinting
• [Presentation] Evolution of placentation in eutherian mammals contributed by exaptation of PEG10 and PEG11/RTL1 from retrotransposons. (2008)
  • Author(s): Ishino F, Ono R, Suzuki S, Sekita Y, Naruse M, Kohda T, Kaneko-Ishino T
  • Organizer: 8th NIBB-EMBL Joint Meeting "Evolution: Genomces, Cell Types and Shapes"
  • Place of Presentation: Okazaki Conference Center, Okazaki
• [Presentation] 哺乳類特異的なレトロトランスポゾンによる哺乳類の胎生進化 (2008)
  • Author(s): 石野史敏、小野竜一、関田洋一、鈴木俊介、成瀬美衣、入江将仁、幸田尚、横山峯介、中村健司、金児-石野知子
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] 個体発生に重要な役割を果たすアンチセンスRNA:RNAi機構を介したアンチセンスRNAによるPeg11/Rt11遺伝子の発現制御 (2008)
  • Author(s): 金児-石野知子、関田洋一、遠藤大輔、鏡雅代、小野竜一、幸田尚、緒方勤、石野史敏
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] レトロトランスポゾン由来の遺伝子Sirh-familyの解析 (2008)
  • Author(s): 成瀬美衣、小野竜一、関田洋一、石井雅之、中村健司、日野敏昭、鈴木-右島理可、幸田尚、横山峯介、金児-石野知子、石野史敏
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] レトロトランスポゾン由来の遺伝子Peg10の胎盤での機能 (2008)
  • Author(s): 小野竜一、成瀬美衣、中村健司、日野敏昭、鈴木-右島理可、高部美穂、宇佐美貴子、幸田尚、小倉敦郎、横山峯介、金児-石野知子、石野史敏
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] マウスMeg1/Grb10領域のインプリンティング発現制御と個体成長への影響 (2008)
  • Author(s): 志浦寛相、引地貴亮、中村健司、日野敏昭、小田佳奈子、鈴木-右島理可、幸田尚、金児-石野知子、石野史敏
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] 顕微授精によるエピジェネティックシフトの誘導 (2008)
  • Author(s): 幸田尚、井上貴美子、引地貴亮、岩崎佐和、越後貫成美、三木洋美、若山照彦、小倉敦郎、金児-石野知子、石野史敏
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] Contribution of Retrotransposons to the Evolution of Genomic Imprinting and Placentation in Mammals (2008)
  • Author(s): Ishino F, Ono R, Suzuki S, Sekita Y, Naruse M, Kohda T, Kaneko-Ishino T
  • Organizer: International Symposium on Decoding Epigenetic Code
  • Place of Presentation: Tokyo University, Tokyo
• [Presentation] レトロトランスポゾンによるゲノムインプリンティング領域の成立シンポジウム (2007)
  • Author(s): 金児-石野知子、鈴木俊介、小野竜一、幸田尚、小原雄治、Marilyn Renfree、石野史敏
  • Organizer: 哺乳類の発生システムとエピゲノム
  • Place of Presentation: 横浜、バシフィコ横浜
  • Year and Date: 2007-12-12
• [Presentation] ゲノムインプリンティングからみた哺乳類の進化 (2007)
  • Author(s): 石野史敏
  • Organizer: 異分野関連セミナー日本免疫学会年会
  • Place of Presentation: 高輪プリンス、品川
  • Year and Date: 2007-11-20
• [Presentation] Essential roles of retrotranposon-derived roles of retrotranposon-derived imprinted genes, Peg10 and Peg11/Rtl1, in mammalian placenta development and evolution. (2007)
  • Author(s): 石野史敏(5人中1番目と5番目)
  • Organizer: 14th World Congress on Gestational Trophoblastic Disease
  • Place of Presentation: Fukuoka
  • Year and Date: 2007-11-12
• [Presentation] ゲノムインプリンティングと成長発達 (2007)
  • Author(s): 石野史敏
  • Organizer: ランチョンセミナー日本小児内分泌学会年会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2007-11-08
• [Presentation] ゲノムインプリンティングからみた哺乳類の進化生物進化におけるレトロトランスポゾンの役割 (2007)
  • Author(s): 石野史敏
  • Organizer: 基礎生物学研究所セミナー
  • Place of Presentation: 基礎生物学研究所、岡崎
  • Year and Date: 2007-09-11
• [Presentation] Role of PEG10 in mammalian placenta development and evolution (2007)
  • Author(s): Fumitoshi Ishino, Ryuichi Ono, Sunsuke Suzuki, Tomoko Kaneko-Ishino
  • Organizer: 34th Fetal and Neonatal Physiological Scociety Annual Meeting
  • Place of Presentation: Sendai
  • Year and Date: 2007-08-29
• [Presentation] ゲノムインプリンティング領域の成立とレトロトランスポゾン (2007)
  • Author(s): 金児-石野知子(7人中1番目と7番目)
  • Organizer: トッピック講演日本エピジェネティクス研究会
  • Place of Presentation: 大阪大学、大阪
• [Presentation] レトロトランスポゾンンによる哺乳類特異的ゲノム機能の進化 (2006)
  • Author(s): 石野史敏
  • Organizer: 第18回高遠分子細胞生物学シンポジウム
  • Place of Presentation: 伊那
  • Year and Date: 2006-08-24
• [Book] エピジェネティクスベーシックマスター発生生物学(東中川徹ほか編)12章 (2008)
  • Author(s): 石野史敏
  • Publisher: オーム社
• [Book] ベーシックマスター発生生物学(東中川徹, 八杉貞雄, 西駕秀俊)(オーム社) (2008)
  • Author(s): 石野史敏
  • Publisher: エピジェネティクス
• [Book] ゲノムインプリンティング再生医療のための分子生物学再生医療の基礎シリーズ3(仲野徹編) (2006)
  • Author(s): 石野史敏、金児-石野知子
  • Publisher: コロナ社
• [Book] ゲノムインプリンティング新編精子学(毛利秀雄・星元紀監修)11章 (2006)
  • Author(s): 石野史敏、金児-石野知子
  • Publisher: 東京大学出版会
• [Book] ゲノムインプリンティング 新編 精子学 11章(毛利秀雄・星元紀監修) (2006)
  • Author(s): 石野史敏, 金児-石野 知子
  • Publisher: 東京大学出版会
• [Book] ゲノムインプリンティング 再生医療のための分子生物学 再生医療の基礎シリーズ3 (2006)
  • Author(s): 石野史敏, 金児-石野 知子
  • Publisher: コロナ社
• [Remarks] ホームページ等
  • URL: http://www.tmd.ac.jp/mri/epgn/index.html
• [Remarks]
  • URL: http://www.tmd.ac.jp/mri/epgn/index.html
• [Remarks] 朝日新聞 : 2007年7月6日「「刷り込み」の起源DNA断片が関係-」、2008年1月7日「「スシイチ」胎盤成長に大事」読売新聞 : 2008年1月7日「胎盤働かす遺伝子発見」
• [Remarks] 毎日新聞 : 2008年1月13日「胎児毛細血管維持に必要な遺伝子発見」
• [Remarks] 共同通信配信で2008年1月13日に京都新聞、神戸新聞、山形新聞、茨城新聞、東奥日報、河北新報で「胎盤遺伝子はウィルス由来」「胎盤はウィルス由来」等
• [Remarks] NHK : 2009年1月18日「女と男-最新科学が読み解く性-」第3回男が消える-人類も消える-の番組制作協力者
• [Remarks]
  • URL: http://www.tmd.ac.jp/mri/epgn/index.htm
• [Remarks]
  • URL: http://www.tmd.ac.jp/mri/epgn/index.html
• [Patent(Industrial Property Rights)] クローン動物の作出方法 (2010)
  • Inventor(s): 小倉淳郎、幸田尚、石野史敏, 他
  • Industrial Property Rights Holder: 理化学研究所、東京医科歯科大学, 他
  • Industrial Property Number: 2010-197583
  • Filing Date: 2010-09-03