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Ultrasonic-assisted mid-infrared spectroscopic imaging for non-invasive blood glucose sensor

Research Project

Project/Area Number 18H01452
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 21030:Measurement engineering-related
Research InstitutionKagawa University

Principal Investigator

Ichiro ISHIMARU  香川大学, 創造工学部, 教授 (70325322)

Co-Investigator(Kenkyū-buntansha) 和田 健司  香川大学, 医学部, 教授 (10243049)
西山 成  香川大学, 医学部, 教授 (10325334)
田中 直孝  香川大学, 農学部, 教授 (60324109)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywords中赤外分光法 / フーリエ分光法 / 超音波 / 定在波 / 非侵襲血糖値センサー / スマートトイレ / パラメトリック効果 / 赤外分光法 / 血糖値 / 超音波定在波 / 空間的位相シフト干渉法 / マルチスリット / グルコース / 赤外分光 / 中赤外分光 / 非球面レンズ / 反射防止コーティング / 高開口数レンズ / ラット
Outline of Final Research Achievements

An ultrasonic transducer (frequency: 800 kHz, applied voltage: 10 V) was placed under the mouse ear to generate parametric standing waves. Agar was placed between the ear and the transducer as acoustic impedance matching. Mid-infrared spectroscopic measurements of reflected light from inside the ear without ultrasound applied and with ultrasonic parametric standing waves generated were compared. The glucose-induced absorption peaks (@9.25 and 9.65 micrometers) were not observed in the ultrasound-off condition. However, when ultrasonic parametric standing waves were generated, the absorption peaks were successfully and stably observed.

Academic Significance and Societal Importance of the Research Achievements

この研究課題の核心をなす学術的「問い」とは、超音波定在波により試料内部の計測深さを任意設定することで、中赤外反射光を皮膚内部から検出できるか?と言うことである。
本研究の目的および学術的独自性と創造性は、日常生活空間での病態疾患モニタリングとして、非侵襲で血糖値を計測する基礎技術の確立である。従来、成分分析能力の高い中赤外分光法は、水分を多く含む皮膚などへの適用は困難であると考えられてきた。しかし、超音波定在波により計測試料表層近傍にアクティブに反射面を創生することにより、バイオテクノロジーをはじめとする様々な分析化学分野への中赤外分光法の適用を拡大することが可能になる。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (19 results)

All 2021 2019 2018 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (11 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] 】Identification of black microplastics using long-wavelength infrared hyperspectral imaging with imaging-type two-dimensional Fourier spectroscopy2021

    • Author(s)
      Kosuke Nogo, Kou Ikejima, Wei Qi, Natsumi Kawashima, Tomoya Kitazaki, Satoru Adachi, Kenji Wada, Akira Nishiyama, Ichiro Ishimaru
    • Journal Title

      Analytical Methods

      Volume: 13 Issue: 5 Pages: 647-659

    • DOI

      10.1039/d0ay01738h

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Palm-sized (80mm cube weighing 0.5 kg) low-price (several thousand USD) mid-infrared (wavelength 8micro) Fourier spectroscopic imager2019

    • Author(s)
      Ichiro ISHIMARU
    • Journal Title

      Proceedings of SPIE OPTICAL ENGINEERING + APPLICATIONS

      Volume: 11130 Pages: 23-23

    • DOI

      10.1117/12.2541389

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parametric standing wave generation of a shallow reflection plane in a nonrigid sample for use in a noninvasive blood glucose monitor2019

    • Author(s)
      Tomoya Kitazaki; Natsumi Kawashima; Naoyuki Yamamoto; Hiroyuki Nomura; Hanyue Kang; Akira Nishiyama; Kenji Wada; Ichiro Ishimaru
    • Journal Title

      Journal of Biomedical Optics

      Volume: 24(3) Issue: 03 Pages: 1-1

    • DOI

      10.1117/1.jbo.24.3.036003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ultrasonic standing wave preparation of a liquid cell for glucose measurements in urine by midinfrared spectroscopy and potential application to smart toilets2018

    • Author(s)
      Naoyuki Yamamoto Natsumi Kawashima Tomoya Kitazaki Keita Mori Hanyue Kang Akira Nishiyama Kenji Wada Ichiro Ishimaru
    • Journal Title

      Journal of Biomedical Optics

      Volume: 23(5) Issue: 05 Pages: 1-1

    • DOI

      10.1117/1.jbo.23.5.050503

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 地方大学が中核になったオープンイノベーションによる新産業創出2021

    • Author(s)
      石丸伊知郎
    • Organizer
      第42回日本臨床薬理学会学術総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 非侵襲血糖値センサを目指した非冷却マイクロボロメーターアレイセンサを用いた新たな中赤外パッシブ分光イメージングの提案2021

    • Author(s)
      北崎 友哉, 野郷 孝介, 足立 智, 岩城 順也, 森本 裕介, 宮村 匡雅, 西山 成, 和田 健司, 石丸 伊知郎
    • Organizer
      Optics & Photonics Japan2021(OPJ2021)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Mid-infrared (LWIR) passive-active spectroscopic imaging for non-invasive blood glucose sensors2021

    • Author(s)
      Ichiro ISHIMARU
    • Organizer
      European Japan Experts Association International Conference 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マルチスリット搭載型高感度中赤外ワンショットフーリエ分光器2019

    • Author(s)
      川嶋なつみ,北崎友哉,西山成,和田健司,石丸伊知郎,
    • Organizer
      Optics & Photonics Japan 2019, PDP3,大阪,2019.12
    • Related Report
      2019 Annual Research Report
  • [Presentation] イヤリング型非侵襲血糖値センサーを目指した皮膚表層近傍における微弱な反射光検出が可能な高感度中赤外分光法2019

    • Author(s)
      川嶋なつみ,北崎友哉,西山成,和田健司,石丸伊知郎,
    • Organizer
      第4回黒潮カンファレンス,P37,沖縄,2019.11
    • Related Report
      2019 Annual Research Report
  • [Presentation] イヤリング型非侵襲血糖値センサーを目指した超音波アシスト中赤外フーリエ分光法2019

    • Author(s)
      川嶋なつみ,北崎友哉,西山成,和田健司,石丸伊知郎
    • Organizer
      2019年度精密工学会秋季大会学術講演会,L46,静岡,2019.09
    • Related Report
      2019 Annual Research Report
  • [Presentation] Ultrasonic-assisted point one-shot mid-infrared Fourier spectroscopy for realization of ear-clip-type non-invasive blood glucose sensors:2019

    • Author(s)
      石丸伊知郎
    • Organizer
      SPIE Bios2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] イヤリング型非侵襲血糖値センサーを目指した超音波アシスト中赤外ポイント分光システムの提案~感度及びSN比の改善を目的とした高開口数ポイントワンショット中赤外分光法2018

    • Author(s)
      川嶋なつみ
    • Organizer
      日本光学会年次大会 OPJ2019
    • Related Report
      2018 Annual Research Report
  • [Presentation] 豆粒大中赤外分光ユニットによる透析装置のin-situ血糖値モニタリング2018

    • Author(s)
      乃村宏幸
    • Organizer
      2018年度精密工学会秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Measurement of glucose concentrations inside agar using parametric standing wave to realize non-invasive blood glucose sensor2018

    • Author(s)
      北崎友哉
    • Organizer
      Optical Society of America Imaging and Applied Optics Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of Blood Glucose Level in Mice using Ultrasonic-assisted Mid-infrared Fourier Spectroscopy for realizing Earring-type Non-invasive Blood Glucose Sensors2018

    • Author(s)
      川嶋なつみ
    • Organizer
      Optical Society of America Imaging and Applied Optics Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Book] 赤外線の化学利用 近赤外からテラヘルツまで2021

    • Author(s)
      石丸伊知郎 他
    • Total Pages
      186
    • Publisher
      化学同人
    • ISBN
      9784759814026
    • Related Report
      2020 Annual Research Report
  • [Remarks] 石丸研ホームページ

    • URL

      http://www.eng.kagawa-u.ac.jp/~ishimaru/

    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 分光測定装置2019

    • Inventor(s)
      石丸伊知郎
    • Industrial Property Rights Holder
      石丸伊知郎
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 分光測定装置2018

    • Inventor(s)
      石丸伊知郎
    • Industrial Property Rights Holder
      香川大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Acquisition Date
      2018
    • Related Report
      2018 Annual Research Report
    • Overseas

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

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