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Development of a biosensing system with high sensitivity by the application of triangular gold nanoplates and lipid membranes

Research Project

Project/Area Number 18H01804
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 28010:Nanometer-scale chemistry-related
Research InstitutionHokkaido University

Principal Investigator

Mitomo Hideyuki  北海道大学, 電子科学研究所, 准教授 (50564952)

Co-Investigator(Kenkyū-buntansha) 矢野 隆章  徳島大学, ポストLEDフォトニクス研究所, 准教授 (90600651)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2020: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Keywords金ナノ構造 / 動的構造制御 / 表面プラズモン共鳴 / ゲル / 脂質膜 / 分子検出 / プラズモン / 金ナノ粒子
Outline of Final Research Achievements

Our previous study showed that actively tunable metal nanogap structures on hydrogels are useful platform for the biosensing. In this study, to improve this system for a highly sensitive biosensing substrate, an application of triangular gold nanoplates with sharp edges and lipid membranes with a fluidity was investigated. As a result, it is indicated that nanostructures on the hydrogel can rotate and simultaneously form sharp edge assembled structures at a point without a fluid membrane, when their distances become closer. On the other hand, the need of further contrivance for the efficient introduction of target molecules into the hot spots is also indicated. These results provided an important insight for the development of ultra-sensitive biosensing substrates.

Academic Significance and Societal Importance of the Research Achievements

金属のナノ構造体は表面プラズモン共鳴と呼ばれる特異な光学現象を示す。この表面プラズモン共鳴を利用した光エネルギーの効率的な利用や高感度なセンシング基材の開発などが期待されている。この表面プラズモン共鳴は金属ナノ構造体の大きさや形、構造体周囲の環境など、様々な因子の影響をうけるため、これまでその構造や形状の制御方法が開発されてきた。本研究では、高分子ゲルの体積変化を利用したナノメートルスケールで動的にナノ構造を制御する技術を発展させ、バイオセンシング基材へと展開するための実験を行い、鋭利な頂点を向かい合わせる方法を見いだした。本研究で得られた知見は、実用化に向けた重要な知見となる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (30 results)

All 2021 2020 2019 2018 Other

All Journal Article (10 results) (of which Peer Reviewed: 8 results,  Open Access: 7 results) Presentation (18 results) (of which Int'l Joint Research: 6 results,  Invited: 2 results) Remarks (2 results)

  • [Journal Article] Molecular configuration-mediated thermo-responsiveness in oligo(ethylene glycol) derivatives attached on gold nanoparticles2021

    • Author(s)
      Xiong Kun、Mitomo Hideyuki、Su Xueming、Shi Yier、Yonamine Yusuke、Sato Shin-ichiro、Ijiro Kuniharu
    • Journal Title

      Nanoscale Advances

      Volume: - Issue: 13 Pages: 3762-3769

    • DOI

      10.1039/d1na00187f

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assembly and Active Control of Nanoparticles using Polymer Brushes as a Scaffold2021

    • Author(s)
      Nakamura Satoshi、Mitomo Hideyuki、Ijiro Kuniharu
    • Journal Title

      Chemistry Letters

      Volume: 50 Issue: 2 Pages: 361-370

    • DOI

      10.1246/cl.200767

    • NAID

      130007986382

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Controlled Nanostructures Fabricated by the Self-assembly of Gold Nanoparticles via Simple Surface Modifications2021

    • Author(s)
      Mitomo Hideyuki、Ijiro Kuniharu
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: - Issue: 4 Pages: 1300-1310

    • DOI

      10.1246/bcsj.20210031

    • NAID

      130008037342

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reversible Changes in the Orientation of Gold Nanorod Arrays on Polymer Brushes2020

    • Author(s)
      Sekizawa Yu、Mitomo Hideyuki、Nihei Mizuki、Nakamura Satoshi、Yonamine Yusuke、Kuzuya Akinori、Wada Takehiko、Ijiro Kuniharu
    • Journal Title

      Nanoscale Advances

      Volume: 2 Issue: 9 Pages: 3798-3803

    • DOI

      10.1039/d0na00315h

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Salt-triggered Active Plasmonic Systems Based on the Assembly/Disassembly of Gold Nanorods in a DNA Brush Layer on a Solid Substrate2020

    • Author(s)
      Nakamura Satoshi、Mitomo Hideyuki、Yonamine Yusuke、Ijiro Kuniharu
    • Journal Title

      Chemistry Letters

      Volume: 49 Issue: 7 Pages: 749-752

    • DOI

      10.1246/cl.200185

    • NAID

      130007872527

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Strategy for Finely Aligned Gold Nanorod Arrays using Polymer Brushes as a Template2020

    • Author(s)
      S. Nakamura, H. Mitomo*, Y. Sekizawa, T. Higuchi, Y. Matsuo, H. Jinnai, K. Ijiro*
    • Journal Title

      Langmuir

      Volume: 36 Issue: 13 Pages: 3590-3599

    • DOI

      10.1021/acs.langmuir.9b03835

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of sophisticated metal nanostructures for actively tunable plasmonic devices2020

    • Author(s)
      Mitomo Hideyuki
    • Journal Title

      Impact

      Volume: 2020 Issue: 1 Pages: 54-56

    • DOI

      10.21820/23987073.2020.1.54

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] ハイドロゲル表面に固定化した金ナノドット間距離の動的変化のナノスケール評価2019

    • Author(s)
      濱島 暁、三友秀之、居城邦治
    • Journal Title

      The Bulletin of the Nano Science and Technology(ナノ学会会誌)

      Volume: 18 Pages: 1-7

    • NAID

      40022060820

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Nanoscale uniformity in the active tuning of a plasmonic array using polymer gel volume change2019

    • Author(s)
      Satoru Hamajima, Hideyuki Mitomo, Takeharu Tani, Yasutaka Matsuo, Kenichi Niikura, Masayuki Naya, Kuniharu Ijiro
    • Journal Title

      Nanoscale Advances

      Volume: 1 Issue: 5 Pages: 1731-1739

    • DOI

      10.1039/c8na00404h

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Size-defined Cracked Vesicle Formation via Self-assembly of Gold Nanoparticles Covered with Carboxylic acid-Terminated Surface Ligands2018

    • Author(s)
      JinJian Wei, Hideyuki Mitomo, Takeharu Tani, Yasutaka Matsuo, Kenichi Niikura, Masayuki Naya, and Kuniharu Ijiro
    • Journal Title

      Langmuir

      Volume: 34 Issue: 41 Pages: 12445-12451

    • DOI

      10.1021/acs.langmuir.8b02966

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] DNA高分子ブラシを利用したpH依存的な金ナノロッド配向変化2021

    • Author(s)
      関澤祐侑、三友秀之、中村聡、与那嶺雄介、居城邦治
    • Organizer
      日本化学会 第101春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] オリゴエチレングリコール系分子での表面修飾による金ナノ粒子集合化の温度応答性の制御2021

    • Author(s)
      熊 坤、三友秀之、石 イーエル、与那嶺雄介、居城邦治
    • Organizer
      日本化学会 第101春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Thermo-Responsive Assembly of Gold Nanoparticles Depending on Oligo(ethylene glycol) Density at Their Surfaces2020

    • Author(s)
      Hideyuki Mitomo, Yier Shi, Yusuke Yonamine, and Kuniharu Ijiro
    • Organizer
      第69回高分子学会年次大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] DNAブラシに吸着した金ナノロッドのpH応答型配向変化2020

    • Author(s)
      関澤 祐侑・三友 秀之・中村 聡・与那嶺 雄介・居城 邦治
    • Organizer
      ナノ学会第18回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] DNA ブラシ基板上での金ナノロッドの pH 応答型配向変化2020

    • Author(s)
      三友 秀之・関澤 祐侑・中村 聡・与那嶺 雄介・居城 邦治
    • Organizer
      第30回バイオ高分子シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 金ナノ粒子表面のオリゴエチエレングリコールの 局所密度を利用した温度応答性制御2020

    • Author(s)
      三友 秀之・熊 坤・石 軼尓・与那嶺 雄介・居城 邦治
    • Organizer
      第69回高分子討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Active Gap Control of Gold Nanodots using Gels in Nanoscale2019

    • Author(s)
      Hideyuki Mitomo, Satoru Hamajima, Kuniharu Ijiro
    • Organizer
      The 3rd International Symposium for Advanced Gel Materials & Soft Matters (ISAGMSM), Xi’an, China
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Active Tuning of Plasmonic Nanostructures Using Polymer Gels2019

    • Author(s)
      Hideyuki Mitomo, Satoru Hamajima, Kuniharu Ijiro
    • Organizer
      10th International Conference on Materials for Advanced Technologies (ICMAT 2019), Singapore, Singapore
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tuning of Thermo-responsive Assembly of Gold Nanoparticles Coated with Oligo(Ethylene Glycol) Derivatives2019

    • Author(s)
      Hideyuki Mitomo, Yier Shi, Ryo Iida, Yusuke Yonamine, Kuniharu Ijiro
    • Organizer
      Okinawa Colloids 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DNAブラシを利用した金ナノロッドの外部環境変化に依存した配向変化2019

    • Author(s)
      三友 秀之、二瓶 瑞生、中村 聡、松尾 保孝、居城 邦治
    • Organizer
      ナノ学会 第17回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ポリマーゲル表面に固定化した金ナノドットパターンの動的変化の評価2019

    • Author(s)
      三友 秀之、濱島 暁、松尾 保孝、新倉 謙一、居城 邦治
    • Organizer
      第68回高分子学会年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] DNAブラシ基板上に吸着させたカチオン性金ナノロッドのpHに依存した配向変化2019

    • Author(s)
      三友 秀之、関澤 祐侑、二瓶 瑞生、中村 聡、与那嶺 雄介、松尾 保孝、居城 邦治
    • Organizer
      第68回 高分子学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Alignment Change of AuNRs on the DNA Brush Substrates by the Applied Electric Field towards Active Plasmonic Control2018

    • Author(s)
      Hideyuki Mitomo, Mizuki Nihei, Satoshi Nakamura, Yasutaka Matsuo, Kuniharu Ijiro
    • Organizer
      SPIE optics + Photonics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Two-Step Assembly of Gold Nanorods Using Curvature-Dependent Dehydration of the Surface Ligands2018

    • Author(s)
      Hideyuki Mitomo, Ryo Iida, Kenichi Niikura, Kuniharu Ijiro
    • Organizer
      17th International Conference on Organized Molecular Films (ICOMF17)-LB17
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Active Gap Control of Gold Nanodots on the Gel Surface2018

    • Author(s)
      Hideyuki Mitomo, Satoru Hamajima, Yasutaka Matsuo, Kenichi Niikura, Kuniharu Ijiro
    • Organizer
      Asian Conference on Nanoscience and Nanotechnology (AsiaNANO 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 単一のリガンド分子で修飾した金ナノロッドの二段階温度応答性自己集合2018

    • Author(s)
      三友 秀之、飯田 良、新倉 謙一、居城 邦治
    • Organizer
      第67回高分子学会年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高分子ゲル表面に配置した金ナノドット間のギャップ距離変化の評価2018

    • Author(s)
      濱島 暁、三友 秀之、松尾 保孝、新倉 謙一、居城 邦治
    • Organizer
      日本化学会北海道支部2018年夏季研究発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高分子ゲルを利用した金ナノドット間距離と表面プラズモンの制御2018

    • Author(s)
      濱島 暁、三友 秀之、松尾 保孝、新倉 謙一、居城 邦治
    • Organizer
      第67回高分子討論会
    • Related Report
      2018 Annual Research Report
  • [Remarks] 研究室HP

    • URL

      https://chem.es.hokudai.ac.jp

    • Related Report
      2020 Annual Research Report
  • [Remarks] 研究室HP

    • URL

      https://chem.es.hokudai.ac.jp

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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