Investigation of membrane protein functions by changing curvature and asymmetric lipid membrane of vesicles
| Project/Area Number |
18H02092
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 37010:Bio-related chemistry
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| Research Institution | Gunma University |
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Principal Investigator |
Koki Kamiya 群馬大学, 大学院理工学府, 助教 (70612315)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | リポソーム / 人工細胞膜 / マイクロデバイス / リン脂質非対称膜 / 人工細胞モデル / ガングリオシド / 膜タンパク質 / 人工細胞膜モデル / エキソサイトーシス / ベシクル |
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| Outline of Final Research Achievements |
Cell membranes of eukaryotic cells were composed of an asymmetric lipid bilayer. In this study, to understand biological phenomena involved in the asymmetric lipid bilayer, we generated an automatic device of cell-sized asymmetric lipid vesicles, nano-sized asymmetric lipid vesicles, vesicles-in-a-vesicle with asymmetric lipid membranes, and cell-sized asymmetric lipid vesicles using a fusion between nano-sized lipid vesicles and a planar lipid bilayer.
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| Academic Significance and Societal Importance of the Research Achievements |
ナノサイズからマイクロサイズのリン脂質非対称膜リポソームの作製を成功している。このリン脂質非対称膜リポソームを用いて、リン脂質の非対称の生命現象への関与が詳細に観察できると考える。また、ナノサイズリポソームは、新しいドラッグデリバリーシステムの担体として利用可能である。
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Molecular and functional analysis of pore-forming toxin Monalysin from entomopathogenic bacterium Pseudomonas entomophila2020
Author(s)
2.Nonaka S†, Salim E†, Kamiya K*, Hori A, Nainu F, Asri RM, Masyita A, Nishiuchii T, Takeuchi S, Kodera N*, Kuraishi T*
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Journal Title
Front. Immunol.
Volume: 11
Pages: 520-520
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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