| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
|
|---|
| Outline of Final Research Achievements |
Causative proteins of neurodegenerative diseases and their associated lesions were examined in animal brains and compared between different species. Lesions comparable to human Alzheimer's disease were found in the brains of sea lions and other several species. We found that the nature of the proteins, such as amino acid sequence, expressed isoforms, and aggregability, were associated with different lesions in the brain among species. Also, results of experimental studies have shown that different causative proteins interact with each other via activation of kinase, and promote lesion formation.
|
