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Transgenic mice for imaging of cellular stress associated with diseases and aging

Research Project

Project/Area Number 18H02366
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 42040:Laboratory animal science-related
Research InstitutionKanazawa Medical University

Principal Investigator

IWAWAKI Takao  金沢医科大学, 総合医学研究所, 教授 (50342754)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords細胞ストレス / 生体イメージング / 疾患モデル / 老化モデル
Outline of Final Research Achievements

It is important in life science research to capture life phenomena as they are alive, and bioimaging technology for that purpose has been rapidly advancing in recent years. By making good use of this technology, it is becoming useful for investigating the cause and developing treatments for certain diseases. There is a model mouse that introduces an optical reporter to support this technology, but there are still insufficient types to make a deep contribution in a wider field. In this study, we aimed for developing a new model mouse for bioimaging that visualizes three types of stress that are closely related to our health problems, and established two types of model mice within the period.

Academic Significance and Societal Importance of the Research Achievements

本研究で開発したモデルマウスは健康および生命維持に重要な生体恒常性に影響を与え、その破綻は重篤な疾患や老化促進に繋がる細胞ストレスを可視化するものである。このマウスを利用することで特定疾患の病態を詳細に理解でき、さらには予防法や治療法の開発に繋げることができる。その意味で本研究は基礎生命科学研究に留まらず、医学研究や薬学研究とも有機的に結びつくものとなっている。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (58 results)

All 2020 2019 2018 Other

All Int'l Joint Research (16 results) Journal Article (27 results) (of which Int'l Joint Research: 18 results,  Peer Reviewed: 26 results,  Open Access: 12 results) Presentation (13 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Remarks (2 results)

  • [Int'l Joint Research] Baylor College of Medicine/University of California, San Diego/University of Washington, Seattle(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] McGill University(カナダ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University College London(英国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Linkoping University(スウェーデン)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of Minnesota/Cornell University/University of Michigan(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Northumbria University(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Ajou University(韓国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Linkoping University(スウェーデン)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Universidad de Chile(チリ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] TAMU/Baylar College/NINDS/NIH(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Martin Luther University/University Hospital Tubingen(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Institute of Zoology, CAS/National Center of Biomedical Analysis(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] VIB(ベルギー)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Chile(チリ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Apelin/APJ signaling suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model2020

    • Author(s)
      Yamazaki Sahori、Sekiguchi Akiko、Uchiyama Akihiko、Fujiwara Chisako、Inoue Yuta、Yokoyama Yoko、Ogino Sachiko、Torii Ryoko、Hosoi Mari、Akai Ryoko、Iwawaki Takao、Ishikawa Osamu、Motegi Sei-ichiro
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 1349-1349

    • DOI

      10.1038/s41598-020-58452-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transgenic mouse model exhibiting weak red fluorescence before and strong green fluorescence after Cre/loxP-mediated recombination2020

    • Author(s)
      Akai Ryoko、Saito Michiko、Kohno Kenji、Iwawaki Takao
    • Journal Title

      Experimental Animals

      Volume: 69 Issue: 3 Pages: 306-318

    • DOI

      10.1538/expanim.19-0085

    • NAID

      130007884759

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protective effect of dimethyl fumarate for the development of pressure ulcers after cutaneous ischemia‐reperfusion injury2020

    • Author(s)
      Inoue Yuta、Uchiyama Akihiko、Sekiguchi Akiko、Yamazaki Sahori、Fujiwara Chisako、Yokoyama Yoko、Ogino Sachiko、Torii Ryoko、Hosoi Mari、Akai Ryoko、Iwawaki Takao、Ishikawa Osamu、Motegi Sei‐ichiro
    • Journal Title

      Wound Repair and Regeneration

      Volume: 28 Issue: 5 Pages: 600-608

    • DOI

      10.1111/wrr.12824

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AAV-mediated ERdj5 overexpression protects against P23H rhodopsin toxicity2020

    • Author(s)
      Aguila Monica、Bellingham James、Athanasiou Dimitra、Bevilacqua Dalila、Duran Yanai、Maswood Ryea、Parfitt David A、Iwawaki Takao、Spyrou Giannis、Smith Alexander J、Ali Robin R、Cheetham Michael E
    • Journal Title

      Human Molecular Genetics

      Volume: 29 Issue: 8 Pages: 1310-1318

    • DOI

      10.1093/hmg/ddaa049

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival2020

    • Author(s)
      Batista Alyssa、Rodvold Jeffrey J.、Xian Su、Searles Stephen C.、Lew Alyssa、Iwawaki Takao、Almanza Gonzalo、Waller T. Cameron、Lin Jonathan、Jepsen Kristen、Carter Hannah、Zanetti Maurizio
    • Journal Title

      PLOS Biology

      Volume: 18 Issue: 6 Pages: e3000687-e3000687

    • DOI

      10.1371/journal.pbio.3000687

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions2020

    • Author(s)
      Xu Longyong、Iwawaki Takao、Chen Xi et al
    • Journal Title

      Nature Cell Biology

      Volume: 22 Issue: 10 Pages: 1162-1169

    • DOI

      10.1038/s41556-020-00581-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Role of IRE1α in podocyte proteostasis and mitochondrial health2020

    • Author(s)
      Navarro-Betancourt Jos? R.、Papillon Joan、Guillemette Julie、Iwawaki Takao、Chung Chen-Fang、Cybulsky Andrey V.
    • Journal Title

      Cell Death Discovery

      Volume: 6 Issue: 1 Pages: 128-128

    • DOI

      10.1038/s41420-020-00361-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] IRE1α Promotes Zika Virus Infection via XBP12020

    • Author(s)
      Kolpikova Elena P.、Tronco Ana R.、Den Hartigh Andreas B.、Jackson Konner J.、Iwawaki Takao、Fink Susan L.
    • Journal Title

      Viruses

      Volume: 12 Issue: 3 Pages: 278-278

    • DOI

      10.3390/v12030278

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Salmonella exploits HLA-B27 and host unfolded protein responses to promote intracellular replication2019

    • Author(s)
      Antoniou AN, Lenart I, Kriston-Vizi J, Iwawaki T, Turmaine M, McHugh K, Ali S, Blake N, Bowness P, Bajaj-Elliott M, Gould K, Nesbeth D, Powis SJ
    • Journal Title

      Ann Rheum Dis

      Volume: 78 Issue: 1 Pages: 74-82

    • DOI

      10.1136/annrheumdis-2018-213532

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8+ T Cell Priming2019

    • Author(s)
      Medel B, Costoya C, Fernandez D, Pereda C, Lladser A, Sauma D, Pacheco R, Iwawaki T, Salazar-Onfray F, Osorio F
    • Journal Title

      Front Immunol

      Volume: 9 Pages: 3050-3050

    • DOI

      10.3389/fimmu.2018.03050

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells2019

    • Author(s)
      Liu L, Zhao M, Jin X, Ney G, Yang KB, Peng F, Cao J, Iwawaki T, Del Valle J, Chen X, Li Q
    • Journal Title

      Nat Cell Biol

      Volume: 21 Issue: 3 Pages: 328-337

    • DOI

      10.1038/s41556-019-0285-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ablation of the Chaperone Protein ERdj5 Results in a Sjogren's Syndrome-Like Phenotype in Mice, Consistent With an Upregulated Unfolded Protein Response in Human Patients2019

    • Author(s)
      Apostolou E, Moustardas P, Iwawaki T, Tzioufas AG, Spyrou G
    • Journal Title

      Front Immunol

      Volume: 10 Pages: 506-506

    • DOI

      10.3389/fimmu.2019.00506

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ERdj5 in Innate Immune Cells Is a Crucial Factor for the Mucosal Adjuvanticity of Cholera Toxin2019

    • Author(s)
      Kim MS, Yi EJ, Kim YI, Kim SH, Jung YS, Kim SR, Iwawaki T, Ko HJ, Chang SY
    • Journal Title

      Front Immunol

      Volume: 10 Pages: 1249-1249

    • DOI

      10.3389/fimmu.2019.01249

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap12019

    • Author(s)
      Suzuki Takafumi、Muramatsu Aki、Saito Ryota、Iso Tatsuro、Shibata Takahiro、Kuwata Keiko、Kawaguchi Shin-ichi、Iwawaki Takao、Adachi Saki、Suda Hiromi、Morita Masanobu、Uchida Koji、Baird Liam、Yamamoto Masayuki
    • Journal Title

      Cell Reports

      Volume: 28 Issue: 3 Pages: 746-758

    • DOI

      10.1016/j.celrep.2019.06.047

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain2019

    • Author(s)
      Chopra S, Giovanelli P, Alvarado-Vazquez PA, Alonso S, Song M, Sandoval TA, Chae CS, Tan C, Fonseca MM, Gutierrez S, Jimenez L, Subbaramaiah K, Iwawaki T, Kingsley PJ, Marnett LJ, Kossenkov AV, Crespo MS, Dannenberg AJ, Glimcher LH, Romero-Sandoval EA, Cubillos-Ruiz JR
    • Journal Title

      Science

      Volume: 365 Issue: 6450

    • DOI

      10.1126/science.aau6499

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin2019

    • Author(s)
      Nakamura H, Sekiguchi A, Ogawa Y, Kawamura T, Akai R, Iwawaki T, Makiguchi T, Yokoo S, Ishikawa O, Motegi SI
    • Journal Title

      J Dermatol Sci

      Volume: 95 Issue: 2 Pages: 62-69

    • DOI

      10.1016/j.jdermsci.2019.07.004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MITOL prevemts ER stress-induced apoptosis by IRE1 ubiquitylation at mitochondrial-ER contact sites.2019

    • Author(s)
      Takeda, K., Nagashima, S., Shiiba, I., Uda, A., Tokuyama, T., Ito, N., Fukuda, T., Matsushita, N., Ishido, S., Iwawaki, T., Uehara, T., Inatome, R., and Yanagi, S.
    • Journal Title

      EMBO J.

      Volume: 38 Issue: 15

    • DOI

      10.15252/embj.2018100999

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibitory effect of kaempferol on skin fibrosis in systemic sclerosis by the suppression of oxidative stress2019

    • Author(s)
      Sekiguchi A, Motegi SI, Fujiwara C, Yamazaki S, Inoue Y, Uchiyama A, Akai R, Iwawaki T, Ishikawa O
    • Journal Title

      J Dermatol Sci

      Volume: 96 Issue: 1 Pages: 8-17

    • DOI

      10.1016/j.jdermsci.2019.08.004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD2019

    • Author(s)
      Koehn BH, Saha A, McDonald-Hyman C, Loschi M, Thangavelu G, Ma L, Zaiken M, Dysthe J, Krepps W, Panthera J, Hippen K, Jameson SC, Miller JS, Cooper MA, Farady CJ, Iwawaki T, Ting JP, Serody JS, Murphy WJ, Hill GR, Murray PJ, Bronte V, Munn DH, Zeiser R, Blazar BR
    • Journal Title

      Blood

      Volume: 134 Issue: 19 Pages: 1670-1682

    • DOI

      10.1182/blood.2019001950

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine?kinase IRE1alpha2018

    • Author(s)
      Govindarajan S, Gaublomme D, Van der Cruyssen R, Verheugen E, Van Gassen S, Saeys Y, Tavernier S, Iwawaki T, Bloch Y, Savvides SN, Lambrecht BN, Janssens S, Elewaut D, Drennan MB
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 5340-5340

    • DOI

      10.1038/s41467-018-07758-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 小胞体ストレスの生体イメージング2018

    • Author(s)
      岩脇隆夫, 赤井良子
    • Journal Title

      THE BONE

      Volume: 32 Pages: 171-177

    • Related Report
      2018 Annual Research Report
  • [Journal Article] IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A2018

    • Author(s)
      Urra H, Henriquez DR, Canovas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S, Figueroa R, Vidal RL, Rodriguez DA, Rivera CA, Court FA, Couve A, Qi L, Chevet E, Akai R, Iwawaki T, Concha ML, Glavic A, Gonzalez-Billault C, Hetz C
    • Journal Title

      Nature Cell Biology

      Volume: 20 Issue: 8 Pages: 942-953

    • DOI

      10.1038/s41556-018-0141-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] タンパク質恒常性と糖代謝異常に関わる小胞体ストレス応答の役割2018

    • Author(s)
      岩脇隆夫
    • Journal Title

      金沢医科大学雑誌

      Volume: 43 Pages: 15-22

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Botulinum toxin B suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model: Possible regulation of oxidative and endoplasmic reticulum stress2018

    • Author(s)
      Sekiguchi A, Motegi SI, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Perera B, Nakamura H, Ogino S, Yokoyama Y, Akai R, Iwawaki T, Ishikawa O
    • Journal Title

      Journal of Dermatological Science

      Volume: 90 Issue: 2 Pages: 144-153

    • DOI

      10.1016/j.jdermsci.2018.01.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Activation of Host IRE1α-Dependent Signaling Axis Contributes the Intracellular Parasitism of Brucella melitensis2018

    • Author(s)
      Pandey A, Lin F, Cabello AL, da Costa LF, Feng X, Feng HQ, Zhang MZ, Iwawaki T, Rice-Ficht A, Ficht TA, de Figueiredo P, Qin QM
    • Journal Title

      Frontiers in Cellular and Infection Microbiology

      Volume: 8 Pages: 103-103

    • DOI

      10.3389/fcimb.2018.00103

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells2018

    • Author(s)
      Yuichi Tsuchiya, Michiko Saito, Hiroshi Kadokura, Jun-ichi Miyazaki, Fumi Tashiro, Yusuke Imagawa, Takao Iwawaki, Kenji Kohno
    • Journal Title

      The Journal of Cell Biology

      Volume: 217 Issue: 4 Pages: 1287-1301

    • DOI

      10.1083/jcb.201707143

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response2018

    • Author(s)
      Chapple RH, Hu T, Tseng YJ, Liu L, Kitano A, Luu V, Hoegenauer KA, Iwawaki T, Li Q, Nakada D
    • Journal Title

      eLife

      Volume: 7

    • DOI

      10.7554/elife.31159

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ストレス可視化モデルマウスの開発と疲労研究への応用2020

    • Author(s)
      岩脇隆夫、赤井良子
    • Organizer
      第16回日本疲労学会総会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] IRE1α Is Essential for Podocyte Proteostasis and Mitochondrial Health2020

    • Author(s)
      Jose R. Navarro-Betancourt, Joan Papillon, Julie Guillemette, Takao Iwawaki, Andrey V. Cybulsky
    • Organizer
      KIDNEY WEEK 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of IRE1α in Podocyte Proteostasis2019

    • Author(s)
      Jose R Navarro-Betancourt, Joan Papillon, Julie Guillemette, Takao Iwawaki, Andrey V Cybulsky
    • Organizer
      KIDNEY WEEK 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 小胞体ストレス応答分子により制御される過食行動の分子メカニズム2019

    • Author(s)
      岩脇隆夫、赤井良子
    • Organizer
      第14回臨床ストレス応答学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Comparison between endoscopic and histopathological findings in patients with ulcerative colitis2019

    • Author(s)
      Tetsuo Nakayama, Shiko Kuribayashi, Junko Hirato, Takao Iwawaki, Ko Nakata, Hirohito Tanaka, Taku Tomizawa, Hiroko Hosaka, Yasuyuki Shimoyama, Osamu Kawamura, Motoyasu Kusano, Toshio Uraoka
    • Organizer
      Digestive Disease Week 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 睡眠不足モデルマウスにおける細胞ストレス応答と炎症反応の生体イメージング2019

    • Author(s)
      赤井良子、岩脇隆夫
    • Organizer
      第66回日本実験動物学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ATF4の翻訳活性化機構を利用した統合ストレス可視化モデルマウスの開発2018

    • Author(s)
      赤井良子, 岩脇隆夫
    • Organizer
      住商ファーマインターナショナル株式会社in vivoイメージングフォーラム2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] 細菌によって利用される宿主細胞の生体防御反応~小胞体ストレス応答~2018

    • Author(s)
      岩脇隆夫
    • Organizer
      第55回日本細菌学会中部支部学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 細胞ストレスおよび炎症可視化モデルマウスの開発とその性能2018

    • Author(s)
      岩脇隆夫
    • Organizer
      第342回熊本大学・発生研セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 細胞ストレスおよび炎症可視化モデルマウスの開発とその性能2018

    • Author(s)
      岩脇隆夫
    • Organizer
      第16回京都薬科大学・実験動物セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 『見えない』を『見える』にするマウス2018

    • Author(s)
      岩脇隆夫
    • Organizer
      第20回KMU研究推進セミナー
    • Related Report
      2018 Annual Research Report
  • [Presentation] ATF4の翻訳活性化機構を利用した統合ストレス可視化モデルマウスの開発と疲労研究への応用2018

    • Author(s)
      岩脇隆夫, 赤井良子
    • Organizer
      第14回日本疲労学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ATF4の翻訳活性化機構を利用した統合ストレス可視化モデルマウスの開発2018

    • Author(s)
      赤井良子, 岩脇隆夫
    • Organizer
      第65回日本実験動物学会
    • Related Report
      2018 Annual Research Report
  • [Remarks]

    • URL

      http://mri-cell-medicine.kanazawa-med.labos.ac/one/

    • Related Report
      2018 Annual Research Report
  • [Remarks]

    • URL

      http://www.kanazawa-med.ac.jp/~souiken/ls/dcm/

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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