| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Outline of Final Research Achievements |
The reaction of finding homology between DNA sequences and exchanging homologous regions is called homologous recombination and is ubiquitous in life. RecA and its family of proteins (RecA homologs) play a central role in homologous recombination. Many eukaryotes have two RecA homologs, Rad51 and Dmc1. While Rad51 is expressed in both somatic and meiotic cells, Dmc1 is expressed only during meiosis. In this study, we found that Dmc1 is activated by two types of accessory factors through different mechanisms: the Swi5-Sfr1 complex functions in the stabilization of Dmc1 presynaptic filaments, whereas the Hop2-Mnd1 complex strongly promotes the initiation reaction of DNA strand exchange The Hop2-Mnd1 complex is thought to strongly promote the initiation reaction of DNA strand exchange.
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