Pathophysiological functions via membrane progesterone receptors

• Project/Area Number: 18H02472
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 44040:Morphology and anatomical structure-related
• Research Institution: Kyoto University (2020); Tokyo University of Agriculture and Technology (2018-2019)
• Principal Investigator: Ikuo Kimura 京都大学, 生命科学研究科, 教授 (80433689)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: プロゲステロン / GPCR / 性ステロイドホルモン受容体 / MAPR / mPR

Outline of Final Research Achievements

Our study demonstrated that various physiological functions of sex steroid hormone via unknown mechanism partly involve non-genomic effects via membrane progesterone receptors. Further studies will proceed elucidation of molecular mechanism via sex steroid hormone-mediated non-genomic effects and understanding of systemic physiological functions, such as emotion, feeding, rhythm, sleep, memory, and learning, based on this mechanism.

Academic Significance and Societal Importance of the Research Achievements

本研究成果に基づいて、更にプロゲステロンの細胞膜上受容体の研究を進めることによって、性ステロイドホルモンの即時的反応の解明とそれに基づく生体機能調節機構の解明が可能になると予想される。そして、この研究は乳癌や不妊等の従来の性ステロイド関連疾患治療薬開発だけに留まらず、雌雄差、性差に関連した生活習慣病、睡眠・リズム障害の新規治療パラダイム発見の可能性と、さらにはそれからの美容・健康と化粧品の融合医学への新たな知見を提供すると期待される。

Research Products

• [Journal Article] Free Fatty Acid Receptors in Health and Disease (2020)
  • Author(s): Kimura Ikuo、Ichimura Atsuhiko、Ohue-Kitano Ryuji、Igarashi Miki
  • Journal Title: Physiological Reviews Volume: 100 Issue: 1 Pages: 171-210
  • DOI: 10.1152/physrev.00041.2018
  • Peer Reviewed / Open Access
• [Journal Article] 3-(4-Hydroxy-3-methoxyphenyl)propionic Acid Produced from 4-Hydroxy-3-methoxycinnamic Acid by Gut Microbiota Improves Host Metabolic Condition in Diet-Induced Obese Mice. (2019)
  • Author(s): Ohue-Kitano R, Taira S, Watanabe K, Masujima Y, Kuboshima T, Miyamoto J, Nishitani Y, Kawakami H, Kuwahara H, Kimura I.
  • Journal Title: Nutrients. Volume: 11 Issue: 5 Pages: 1036-1036
  • DOI: 10.3390/nu11051036
  • Peer Reviewed / Open Access
• [Journal Article] NAPE-PLD controls OEA synthesis and fat absorption by regulating lipoprotein synthesis in an in vitro model of intestinal epithelial cells (2019)
  • Author(s): Miki Igarashi、Kazuhide Watanabe、Tsuyoshi Tsuduki、Ikuo Kimura、Naoto Kubota
  • Journal Title: The FASEB Journal Volume: 33 Issue: 3 Pages: 3167-3179
  • DOI: 10.1096/fj.201801408r
  • Peer Reviewed
• [Journal Article] Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids. (2018)
  • Author(s): Watanabe K, Igarashi M, Li X, Nakatani A, Miyamoto J, Inaba Y, Sutou A, Saito T, Sato T, Tachibana N, Inoue H, Kimura I.
  • Journal Title: PLoS One. Volume: 13 Issue: 8 Pages: e0202083-e0202083
  • DOI: 10.1371/journal.pone.0202083
  • Peer Reviewed / Open Access
• [Presentation] 食由来栄養素と脂肪酸受容体 (2019)
  • Author(s): 木村 郁夫
  • Organizer: 第92回 日本内分泌学会学術総会
  • Invited
• [Presentation] 性ステロイドホルモンによる即時性反応を介した高次生理機能 (2018)
  • Author(s): 木村郁夫
  • Organizer: 第45回 日本毒性学会
  • Invited
• [Presentation] 腸内細菌代謝産物と宿主エネルギー代謝ネットワークの統合的理解 (2018)
  • Author(s): 木村郁夫
  • Organizer: Visionary農芸化学100
  • Invited
• [Book] 臨床免疫・アレルギー科 (2020)
  • Author(s): 宮本 潤基、吉本 亜由美、渡辺 啓太、木村 郁夫、長谷 耕二
  • Total Pages: 120
  • Publisher: 科学評論社
• [Book] 医学のあゆみ (2020)
  • Author(s): 渡辺 啓太、宮本 潤基、長谷 耕二、木村 郁夫
  • Total Pages: 70
  • Publisher: 医歯薬出版
• [Book] CARDIAC PRACTICE (2019)
  • Author(s): 清水 秀憲、大植 隆司、木村 郁夫
  • Total Pages: 72
  • Publisher: メディカルビュー社
  • ISBN: 9784779222115
• [Book] 脂質クオリティ（有田誠編） (2018)
  • Author(s): 木村郁夫
  • Total Pages: 246
  • Publisher: 羊土社
  • ISBN: 9784758103718
• [Remarks] 京都大学 木村研究室
  • URL: http://www.biosystem.lif.kyoto-u.ac.jp/
• [Remarks] 東京農工大学 木村研究室
  • URL: http://web.tuat.ac.jp/~kimura/