Pathophysiological functions via membrane progesterone receptors
| Project/Area Number |
18H02472
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 44040:Morphology and anatomical structure-related
|
|---|
| Research Institution | Kyoto University (2020)
Tokyo University of Agriculture and Technology (2018-2019) |
|---|
Principal Investigator |
Ikuo Kimura 京都大学, 生命科学研究科, 教授 (80433689)
|
|---|
| Project Period (FY) |
2018-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
|---|
| Keywords | プロゲステロン / GPCR / 性ステロイドホルモン受容体 / MAPR / mPR |
|---|
| Outline of Final Research Achievements |
Our study demonstrated that various physiological functions of sex steroid hormone via unknown mechanism partly involve non-genomic effects via membrane progesterone receptors. Further studies will proceed elucidation of molecular mechanism via sex steroid hormone-mediated non-genomic effects and understanding of systemic physiological functions, such as emotion, feeding, rhythm, sleep, memory, and learning, based on this mechanism.
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究成果に基づいて、更にプロゲステロンの細胞膜上受容体の研究を進めることによって、性ステロイドホルモンの即時的反応の解明とそれに基づく生体機能調節機構の解明が可能になると予想される。そして、この研究は乳癌や不妊等の従来の性ステロイド関連疾患治療薬開発だけに留まらず、雌雄差、性差に関連した生活習慣病、睡眠・リズム障害の新規治療パラダイム発見の可能性と、さらにはそれからの美容・健康と化粧品の融合医学への新たな知見を提供すると期待される。
|
Report
(4 results)
Research Products
(13 results)
-
-
-
-
[Journal Article] Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids.2018
Author(s)
Watanabe K, Igarashi M, Li X, Nakatani A, Miyamoto J, Inaba Y, Sutou A, Saito T, Sato T, Tachibana N, Inoue H, Kimura I.
-
Journal Title
PLoS One.
Volume: 13
Issue: 8
Pages: e0202083-e0202083
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
[Book] 医学のあゆみ2020
Author(s)
渡辺 啓太、宮本 潤基、長谷 耕二、木村 郁夫
Total Pages
70
Publisher
医歯薬出版
Related Report
-
-
-
-
