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Nerve-dependent tissue repair mechanism after damage

Research Project

Project/Area Number 18H02524
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 46010:Neuroscience-general-related
Research InstitutionNagoya University

Principal Investigator

Sumiko Kiryu-Seo  名古屋大学, 医学系研究科, 准教授 (70311529)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords組織修復 / 神経再生 / ペプチド / プロテアーゼ / 神経制御 / 創傷治癒 / 神経変性 / 神経損傷 / 免疫応答 / 組織再生 / 神経損傷応答性 / 損傷ニューロン
Outline of Final Research Achievements

Damage-induced neuronal endopeptidase (DINE) is a unique molecule which responds to various kinds of neuronal injuries both in CNS and PNS. Tissue injury such as skin injury is accompanied by the damage of sensory nerves, which abundantly distributed in skin. After tissue damage, injury-induced DINE might regulate the microenvironment through its cleaved peptide to promote tissue repair in a nerve-dependent manner.

Academic Significance and Societal Importance of the Research Achievements

神経精神疾患や生活習慣病など多くの疾患研究から脳・神経と臓器とが密接に関係することが近年次第に明らかになりつつあるが、組織・臓器の修復がいかに神経によって制御されるのかそのメカニズムは不明である。神経損傷応答性を利用したDINEによる神経依存性創傷治癒機構は組織修復時に問題となる瘢痕形成を回避するための新たなメカニズムと考えられ、この分子を標的とした創薬や再生医療への発展が期待される。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (18 results)

All 2021 2020 2019 2018

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (13 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Axonal injury alters the extracellular glial environment of the axon initial segment and allows substantial mitochondrial influx into axon initial segment2021

    • Author(s)
      Tamada H, Kiryu-Seo S, Sawada S, Kiyama H
    • Journal Title

      J Comp Neurol

      Volume: 529 Issue: 16 Pages: 3621-3632

    • DOI

      10.1002/cne.25212

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron‐autonomous manner2020

    • Author(s)
      Koinuma Shingo、Negishi Ryota、Nomura Riko、Sato Kazuki、Kojima Takuya、Segi‐Nishida Eri、Goitsuka Ryo、Iwakura Yoichiro、Wada Naoyuki、Koriyama Yoshiki、Kiryu‐Seo Sumiko、Kiyama Hiroshi、Nakamura Takeshi
    • Journal Title

      Journal of Neurochemistry

      Volume: - Issue: 4 Pages: 1196-1206

    • DOI

      10.1111/jnc.15235

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Zonisamide ameliorates neuropathic pain partly by suppressing microglial activation in the spinal cord in a mouse model2020

    • Author(s)
      Koshimizu Hiroyuki、Ohkawara Bisei、Nakashima Hiroaki、Ota Kyotaro、Kanbara Shunsuke、Inoue Taro、Tomita Hiroyuki、Sayo Akira、Kiryu-Seo Sumiko、Konishi Hiroyuki、Ito Mikako、Masuda Akio、Ishiguro Naoki、Imagama Shiro、Kiyama Hiroshi、Ohno Kinji
    • Journal Title

      Life Sciences

      Volume: 263 Pages: 118577-118577

    • DOI

      10.1016/j.lfs.2020.118577

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondrial behavior during axon regeneration/degeneration in vivo,2019

    • Author(s)
      Kiryu-Seo S, Kiyama H
    • Journal Title

      Neurosci Res

      Volume: 139 Pages: 42-47

    • DOI

      10.1016/j.neures.2018.08.014

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New Insights of a Neuronal Peptidase DINE/ECEL1: Nerve Development, Nerve Regeneration and Neurogenic Pathogenesis2018

    • Author(s)
      Kiryu-Seo Sumiko、Nagata Kenichi、Saido Takaomi C.、Kiyama Hiroshi
    • Journal Title

      Neurochemical Research

      Volume: - Issue: 6 Pages: 1279-1288

    • DOI

      10.1007/s11064-018-2665-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Injured motor neurons lose polarity in a proteasome-dependent manner to increase the mitochondrial transport into regenerative axons2021

    • Author(s)
      Sumiko Kiryu-Seo, Reika Matsushita, Yoshitaka Tashiro, Ryosuke Takahashi, Takeshi Yoshimura, Yohei Iguchi, Masahisa Katsuno, Hiroshi Kiyama
    • Organizer
      第126回日本解剖学会総会・全国学術集会・第98回日本生理学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Analysis of pain mechanism in an animal model for the fibromyalgia induced by repeated cold stress2021

    • Author(s)
      Koji Wakatsuki, Masaya Yasui, Sumiko Kiryu-Seo, Hiroshi Kiyama
    • Organizer
      第126回日本解剖学会総会・全国学術集会・第98回日本生理学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 様々な神経損傷に応答するプロテアーゼDINEの損傷運動ニューロン軸索再生効果2021

    • Author(s)
      長谷川将暉、桐生寿美子、永田健一、木山博資
    • Organizer
      日本解剖学会第81回中部支部学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 神経損傷に応答した軸索起始部のダイナミクス2021

    • Author(s)
      桐生寿美子、木山博資
    • Organizer
      第64回日本神経化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Injured motor neurons lose polarity in a proteasome dependent manner to increase the mitochondrial transport into regenerative axons2021

    • Author(s)
      Sumiko Kiryu-Seo, Reika Matsushita, Yoshitaka Tashiro, Ryosuke Takahash, Takeshi Yoshimura, Yohei Iguchi, Masahisa Katsuno, Hiroshi Kiyama
    • Organizer
      第126回日本解剖学会総会・全国学術集会/ 第98回日本生理学会大会合同大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Analysis of pain mechanism in an animal model for the fibromyalgia induced by repeated cold stress2021

    • Author(s)
      Koji Wakatsuki, Masaya Yasui, Sumiko Kiryu-Seo, Hiroshi Kiyama
    • Organizer
      第126回日本解剖学会総会・全国学術集会/ 第98回日本生理学会大会合同大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] The proteasome-mediated AIS plasticity contributes to the increased transport of mitochondria in damaged motor axon2020

    • Author(s)
      Sumiko Kiryu-Seo, Reika Matsushita, Yoshitaka Tashiro, Ryosuke Takahashi, Takeshi Yoshimura, Yohei Iguchi, Masahisa Katsuno, Hiroshi Kiyama
    • Organizer
      第63回日本神経化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 損傷運動ニューロンの軸索再生・変性に関わるプロテアソーム依存性ストレス応答2020

    • Author(s)
      桐生寿美子、松下鈴佳、田代善崇、高橋良輔、吉村武、井口洋平、勝野雅央、木山博資
    • Organizer
      第10回名古屋大学医学系研究科・生理学研究所合同シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 組織損傷に応答して発現誘導するプロテアーゼDINEは神経依存性に組織修復を促す2019

    • Author(s)
      桐生寿美子、松下鈴佳、島村徹平、高岡裕、木山博資
    • Organizer
      Neuro2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経再生プログラムにより賦活化されるプロテアーゼDINEの新たな可能性2019

    • Author(s)
      桐生寿美子, 木山博資
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 損傷運動ニューロンにおいてプロテアソームが関わる新たな神経再生メカニズム2019

    • Author(s)
      桐生寿美子、松下鈴佳、田代善崇、高橋良輔、吉村武、木山博資
    • Organizer
      第125回日本解剖学会総会・全国学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Mitochondria in the regenerating and degenerating neurons after nerve injury2018

    • Author(s)
      Sumiko Kiryu-Seo, Hiroshi Kiyama
    • Organizer
      Thr 8th Asia Pacific International Congress of Anatomists (APICA)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 神経損傷をスイッチとして働く分子DINEが関わる神経再生現象2018

    • Author(s)
      桐生寿美子
    • Organizer
      神経発達・再生研究会
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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