Nerve-dependent tissue repair mechanism after damage
Project/Area Number |
18H02524
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 46010:Neuroscience-general-related
|
Research Institution | Nagoya University |
Principal Investigator |
|
Project Period (FY) |
2018-04-01 – 2022-03-31
|
Project Status |
Completed (Fiscal Year 2021)
|
Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
|
Keywords | 組織修復 / 神経再生 / ペプチド / プロテアーゼ / 神経制御 / 創傷治癒 / 神経変性 / 神経損傷 / 免疫応答 / 組織再生 / 神経損傷応答性 / 損傷ニューロン |
Outline of Final Research Achievements |
Damage-induced neuronal endopeptidase (DINE) is a unique molecule which responds to various kinds of neuronal injuries both in CNS and PNS. Tissue injury such as skin injury is accompanied by the damage of sensory nerves, which abundantly distributed in skin. After tissue damage, injury-induced DINE might regulate the microenvironment through its cleaved peptide to promote tissue repair in a nerve-dependent manner.
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Academic Significance and Societal Importance of the Research Achievements |
神経精神疾患や生活習慣病など多くの疾患研究から脳・神経と臓器とが密接に関係することが近年次第に明らかになりつつあるが、組織・臓器の修復がいかに神経によって制御されるのかそのメカニズムは不明である。神経損傷応答性を利用したDINEによる神経依存性創傷治癒機構は組織修復時に問題となる瘢痕形成を回避するための新たなメカニズムと考えられ、この分子を標的とした創薬や再生医療への発展が期待される。
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Report
(5 results)
Research Products
(18 results)