| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Outline of Final Research Achievements |
In this study, we successfully generated mice that sleep about half the normal amount of time. The method used to generate this condition was to delete a specific group of neurons located in the midbrain and pons regions of the brain, that release the neurotransmitter GABA. In this study, we found that the deficiency of these neurons leads to decreased sleep via nearby dopaminergic neurons and dopamine D2 receptors. On the other hand, we also found that the deficient mice exhibit manic-like behaviors, and furthermore, that these behaviors are regulated by a mechanism other than sleep regulation.
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