Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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Outline of Final Research Achievements |
In this study, we investigated molecular and genetic mechanisms in which tissue and cancer stem cells specify their identity. Using a stem cell spheroid culture system, we demonstrated that transcriptional and epigenetic landscapes of normal tissue stem cells recapitulated their developmental stages. In colorectal cancer cells with low Wnt/beta-catenin signaling, cell growth and stemness were promoted partly by constitutive expression of MYC.
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