| Project/Area Number |
18H02644
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 49030:Experimental pathology-related
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
ONAI Nobuyuki 金沢医科大学, 医学部, 教授 (50323605)
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| Co-Investigator(Kenkyū-buntansha) |
和田 俊樹 (矢部俊樹) 金沢医科大学, 医学部, 講師 (10451634)
松葉 慎太郎 金沢医科大学, 医学部, 助教 (40367462)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | 樹状細胞 / 前駆細胞 / 胎生期 / 抗原提示 / 炎症 / 生体防御 / 脳 / 発達異常 |
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| Outline of Final Research Achievements |
The foetation escapes from maternal immune cells to maintain pregnancy by immune tolerance. However, the immune reaction against pathogen, especially dendritic cells is not clear during the fetal period. The dendritic cell development and their function during the adult period have been studied well, but fetal period does not. In this study, we identify the dendritic cells and their progenitors in the fetal liver and perform their functional analysis.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果によって胎生期の胎仔肝臓中に樹状細胞が存在することが明らかになり、同細胞が制御性T細胞誘導し、免疫寛容に寄与する可能性が示唆された。妊娠期では免疫寛容が働き、胎児が母親由来の免疫細胞から攻撃されずに妊娠が維持されている。この免疫寛容の仕組みを理解することは、自己免疫疾患や移植医療に貢献する可能性があり、基礎医学・臨床研究において重要な研究成果である。
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