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Functional analysis of fetal dendritic cells and elucidation of inflammation-induced brain development abnormality contributed by fetal dendritic cells

Research Project

Project/Area Number 18H02644
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 49030:Experimental pathology-related
Research InstitutionKanazawa Medical University

Principal Investigator

ONAI Nobuyuki  金沢医科大学, 医学部, 教授 (50323605)

Co-Investigator(Kenkyū-buntansha) 和田 俊樹 (矢部俊樹)  金沢医科大学, 医学部, 講師 (10451634)
松葉 慎太郎  金沢医科大学, 医学部, 助教 (40367462)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords樹状細胞 / 前駆細胞 / 胎生期 / 抗原提示 / 炎症 / 生体防御 / 脳 / 発達異常
Outline of Final Research Achievements

The foetation escapes from maternal immune cells to maintain pregnancy by immune tolerance. However, the immune reaction against pathogen, especially dendritic cells is not clear during the fetal period. The dendritic cell development and their function during the adult period have been studied well, but fetal period does not. In this study, we identify the dendritic cells and their progenitors in the fetal liver and perform their functional analysis.

Academic Significance and Societal Importance of the Research Achievements

本研究成果によって胎生期の胎仔肝臓中に樹状細胞が存在することが明らかになり、同細胞が制御性T細胞誘導し、免疫寛容に寄与する可能性が示唆された。妊娠期では免疫寛容が働き、胎児が母親由来の免疫細胞から攻撃されずに妊娠が維持されている。この免疫寛容の仕組みを理解することは、自己免疫疾患や移植医療に貢献する可能性があり、基礎医学・臨床研究において重要な研究成果である。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (6 results)

All 2021 2020 2018 Other

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Detailed Structure of Mouse Interferon α2 and Its Interaction with Sortilin2021

    • Author(s)
      Honoka Watanabe, Toshiki Yabe-Wada, Nobuyuki Onai, Masaki Unno
    • Journal Title

      Journal of Biochemistry

      Volume: in press Issue: 2 Pages: 265-273

    • DOI

      10.1093/jb/mvab038

    • NAID

      40022722389

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcium Pyrophosphate Dihydrate Crystals Increase the Granulocyte/Monocyte Progenitor (GMP) and Enhance Granulocyte and Monocyte Differentiation In Vivo2020

    • Author(s)
      Onai N, Ogasawara C.
    • Journal Title

      Int J Mol Sci .

      Volume: 22 Issue: 1 Pages: 262-262

    • DOI

      10.3390/ijms22010262

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PCBP2 post‐transcriptionally regulates sortilin expression by binding to a C‐rich element in its 3′ UTR2020

    • Author(s)
      Yabe‐Wada Toshiki、Philpott Caroline C.、Onai Nobuyuki
    • Journal Title

      FEBS Open Bio

      Volume: 10 Issue: 3 Pages: 407-413

    • DOI

      10.1002/2211-5463.12794

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Crystal structure of the ligand-free form of the Vps10 ectodomain of dimerized Sortilin at acidic pH.2018

    • Author(s)
      Yabe-Wada T, Matsuba S, Unno M, Onai N.
    • Journal Title

      FEBS Lett.

      Volume: 592 Issue: 15 Pages: 2647-2657

    • DOI

      10.1002/1873-3468.13181

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Flexible fate commitment of E2-2high common DC progenitors implies tuning in tissue microenvironments.2018

    • Author(s)
      Nobuyuki Onai, Junpei Asano, Rumiko Kurosaki, Shoko Kuroda, Toshiaki Ohteki.
    • Organizer
      第28回 日本樹状細胞研究会
    • Related Report
      2018 Annual Research Report
  • [Remarks] 金沢医科大学医学部免疫学講座ホームページ

    • URL

      http://www.kanazawa-med.ac.jp/~serol/Immunology/Top_Page.html

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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