| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
|---|
| Outline of Final Research Achievements |
T cells are dysfunction in chronic infection and cancer. This dysfunction is induced by inhibitory signals through inhibitory receptors as PD-1. This study analyzed inhibitory mechanism of T cell activation and function by such inhibitory receptor LAG-3. LAG-3 induced cluster formation upon T cell activation which are co-localized with TCR-microclusters. LAG-3-mediated inhibition of T cell activation depends on cytoplasmic region of LAG-3, but the cluster formation did not require the cytoplasmic region. While anti-LAG-3 augmented T cell activation, bi-specific Ab against LAG-3 and PD-1 induced stronger activation. Analysis of inhibitory anti-LAG-3 Abs, it was suggested that inhibitory function of LAG-3 do not require MHC-II association but do need assembly with the TCR complex.
|
