| Project/Area Number |
18H02830
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松岡 悠美 千葉大学, 大学院医学研究院, 講師 (10402067)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | マクロファージ / マスト細胞 |
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| Outline of Final Research Achievements |
It has been known that tissue macrophages are involved not only in the clearance of foreign materials such as microorganisms by phagosytosis, but also in the pathogenic reactions such as inflammation, immunity, allergic reactions, and tissue repairs in many diseases. Tissue-resident mast cells, on the other hand, are involved not only in allergic inflammation as effector cells, but also in responses such as immunity, inflammation, and repair of tissues. In this study, we discovered macrophage progenitor cells (named TRMP cells) that are found in the abdominal cavity and skin of mice, and we proved that tissue-resident mast cells in the abdominal cavity and skin control the numbers of tissue macrophages by promoting the presence of TRMP cells. We reveled that TRMP cells were strictly controlled by tissue mast cells and were important for the development of tissue-resident macrophages.
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| Academic Significance and Societal Importance of the Research Achievements |
これらのマスト細胞とマクロファージの組織における分化を介した関係は、新しく見出した研究成果である。この関係は、上記「研究成果の概要」の冒頭に述べた組織マクロファージとマスト細胞の従来の機能と様々な疾患の病態にかかわっている可能性があり、病態制御の新規の制御点となる可能性がある。その意味で、本研究は、炎症・アレルギーが関与する疾患の新しい治療法の新規作用点となる可能性を秘めており、その基盤を提供する意味で意義があると考えられる。
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