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Analysis for the circadian rhythm of host defense system against the cutaneous viral infection

Research Project

Project/Area Number 18H02831
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 53050:Dermatology-related
Research InstitutionUniversity of Yamanashi

Principal Investigator

KAWAMURA Tatsuyoshi  山梨大学, 大学院総合研究部, 教授 (70262657)

Co-Investigator(Kenkyū-buntansha) 小川 陽一  山梨大学, 大学院総合研究部, 講師 (20377542)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Keywordsワクチン / 概日リズム / ヘルペスウイルス / 抗ウイルス免疫 / HSV / ウイルス感染 / 獲得免疫 / Herpes virus / 概日時計 / 生体防御 / 自然免疫
Outline of Final Research Achievements

This study sought to determine whether vaccine-induced anti-viral immunity is regulated by circadian rhythm. Specifically, this study sought an answer to the question "What time should we receive vaccine for the best efficacy?". To this end, mice were intradermally inoculated herpes simplex virus (HSV) antigen in either active or resting phase. The better vaccine efficacy was observed in mice who received vaccine in their active phase. These data might provide a following answer: anti-viral vaccine should be inoculated in active phase.

Academic Significance and Societal Importance of the Research Achievements

新型コロナウイルス感染症 (COVID-19)パンデミックに直面している我々に対して現在ワクチンの接種が進められている。COVID-19に対するワクチンは現在のところmRNAワクチンが使用されているため今回の研究とは直接的に関連しないが、抗ウイルスワクチンは1日のうち何時に接種するのが最も強い抗ウイルス免疫を誘導するのかは分かっていない。今回、我々はマウスにヘルペスウイルス抗原を用いたワクチンを行い、ヒトの日中 (活動期)にワクチンを接種した方が夜間 (休止期)に接種するより優れたワクチン効果が期待されることを明らかにした。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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