| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
|---|
| Outline of Final Research Achievements |
The physiological role of the O-GlcNAcylation, a post-translational modification of proteins, in diabetes and diabetic complication-related organs and the relationship between its abnormalities and diabetes development. The results show that O-GlcNAc modification contributes to lipogenesis in white adipose tissue, exercise-induced glucose uptake and utilization in skeletal muscle, regulation of lipid absorption from the intestine, regulation of glucose absorption via SGLT1 expression from the intestine, and fatty acid oxidation and ATP production during fasting in the renal proximal tubules, and that abnormalities in these functions contribute to the development of abnormal glucose metabolism and diabetic kidney disease.
|
