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Development of a method of functional integration between host and graft on the transplantation therapy of human iPS cell-derived cardiac tissues

Research Project

Project/Area Number 18H02887
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 55030:Cardiovascular surgery-related
Research InstitutionKyoto University

Principal Investigator

Kanemitsu Hideo  京都大学, 医学研究科, 助教 (60810166)

Co-Investigator(Kenkyū-buntansha) 湊谷 謙司  京都大学, 医学研究科, 教授 (20393241)
池田 義  京都大学, 医学研究科, 准教授 (40281092)
柴 祐司  信州大学, 学術研究院医学系, 教授 (70613503)
升本 英利  国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 (70645754)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords心臓再生医療 / iPS細胞 / バイオエンジニアリング / 再生医学
Outline of Final Research Achievements

In this study, we found very low propagation speed of iPS cell-derived cardiac tissues due to low expression level of KCNJ2 gene coding IK1 channel. To solve this problem, we conducted a combination of 3-dimensional composition of iPS cell-derived cardiomyocytes and vascular cells, and integration of electrical stimulation and dynamic rocking culture training and confirmed structural and electrophysiological maturation of the tissues. We also established a system to evaluate graft-to-host integration and local wall motion using trans-esophageal echocardiogram in a pig myocardial infarction model.

Academic Significance and Societal Importance of the Research Achievements

本研究は、これまでのiPS細胞による再生医療における治療メカニズムであるパラクライン効果を超えた、動力源としての心筋組織を疾患心に供給し、かつ機能させるという次世代の心臓再生医療の実現に向けた基礎研究的基盤を供給するものである。今後ますます増加が予想される重症心不全に対する新たな治療選択肢を供給しうる意味において、高い学術的ならびに社会的意義を有するものと考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (63 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (25 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 25 results,  Open Access: 12 results) Presentation (34 results) (of which Int'l Joint Research: 11 results,  Invited: 8 results) Book (2 results) Remarks (1 results)

  • [Int'l Joint Research] Louisville大学(米国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Strategies for immune regulation in iPS cell-based cardiac regenerative medicine2020

    • Author(s)
      Murata Kozue、Ikegawa Masaya、Minatoya Kenji、Masumoto Hidetoshi
    • Journal Title

      Inflammation and Regeneration

      Volume: 40 Issue: 1 Pages: 36-36

    • DOI

      10.1186/s41232-020-00145-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A rare case of primary angiosarcoma of the anterior mediastinum2020

    • Author(s)
      Yamazaki Kazuhiro、Minakata Kenji、Nakane Takeichiro、Kinoshita Hideyuki、Tanizawa Kiminobu、Sumiyoshi Shinji、Sato Hiroki、Minatoya Kenji、Sakata Ryuzo
    • Journal Title

      General Thoracic and Cardiovascular Surgery

      Volume: 69 Issue: 4 Pages: 766-769

    • DOI

      10.1007/s11748-020-01551-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothermic circulatory arrest for aortic dissection with cryoglobulinemia2020

    • Author(s)
      Yamazaki Kazuhiro、Minatoya Kenji、Sakamoto Kazuhisa、Kitagori Koji、Okuda Masanori、Murakami Kosaku
    • Journal Title

      Journal of Cardiac Surgery

      Volume: 35 Issue: 11 Pages: 3169-3172

    • DOI

      10.1111/jocs.14908

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of aggressive aortic prosthetic valve endocarditis aggressive caused by Staphylococcus lugdunensis2020

    • Author(s)
      Yamazaki Kazuhiro、Minakata Kenji、Sakamoto Kazuhisa、Sakai Jiro、Ide Yujiro、Kawatou Masahide、Kanemitsu Hideo、Ikeda Tadashi、Minatoya Kenji、Sakata Ryuzo
    • Journal Title

      Surgical Case Reports

      Volume: 6 Issue: 1 Pages: 280-280

    • DOI

      10.1186/s40792-020-01062-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accuracy of spiked cell counting methods for designing a pre-clinical tumorigenicity study model2020

    • Author(s)
      Osada H, Kawatou M, Takeda M, Jo JI, Murakami T, Tabata Y, Minatoya K, Yamashita JK, Masumoto H.
    • Journal Title

      Heliyon

      Volume: 6 Issue: 7 Pages: 311-318

    • DOI

      10.1016/j.heliyon.2020.e04423

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Basic fibroblast growth factor attenuates left-ventricular remodeling following surgical ventricular restoration in a rat ischemic cardiomyopathy model.2020

    • Author(s)
      Nagasawa A, Masumoto H, Yanagi S, Kanemitsu N, Ikeda T, Tabata Y, Minatoya K.
    • Journal Title

      Gen Thorac Cardiovasc Surg

      Volume: 68(4) Issue: 4 Pages: 311-318

    • DOI

      10.1007/s11748-019-01187-3

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function2020

    • Author(s)
      Abulaiti Mosha、Yalikun Yaxiaer、Murata Kozue、Sato Asako、Sami Mustafa M.、Sasaki Yuko、Fujiwara Yasue、Minatoya Kenji、Shiba Yuji、Tanaka Yo、Masumoto Hidetoshi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 19201-19201

    • DOI

      10.1038/s41598-020-76062-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thyroid storm after mitral valve repair in a patient with Becker muscular dystrophy2020

    • Author(s)
      Yamazaki Kazuhiro、Minakata Kenji、Nakane Takeichiro、Kawatou Masahide、Minatoya Kenji、Sakata Ryuzo
    • Journal Title

      Journal of Cardiac Surgery

      Volume: 36 Issue: 2 Pages: 739-742

    • DOI

      10.1111/jocs.15245

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The N-terminal lectin-like domain of thrombomodulin reduces acute lung injury without anticoagulant effects in a rat cardiopulmonary bypass model.2020

    • Author(s)
      Itonaga T, Hirao S, Yamazaki K, Ikeda T, Minatoya K, Masumoto H.
    • Journal Title

      Gen Thorac Cardiovasc Surg

      Volume: - Issue: 8 Pages: 785-792

    • DOI

      10.1007/s11748-020-01292-8

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Management of retrosternal adhesion after median sternotomy by controlling degradation speed of a dextran and ε-poly (L-lysine)-based biocompatible glue2020

    • Author(s)
      Takai F, Takeda T, Yamazaki K, Ikeda T, Hyon SH, Minatoya K, Masumoto H.
    • Journal Title

      Gen Thorac Cardiovasc Surg

      Volume: - Issue: 8 Pages: 793-800

    • DOI

      10.1007/s11748-020-01297-3

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure2020

    • Author(s)
      Nishio Hiroomi、Minatoya Kenji、Masumoto Hidetoshi
    • Journal Title

      Journal of Visualized Experiments

      Volume: 159 Issue: 159

    • DOI

      10.3791/60931

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Preparation of Mesh-Shaped Engineered Cardiac Tissues Derived from Human iPS Cells for In Vivo Myocardial Repair2020

    • Author(s)
      Nakane Takeichiro、Abulaiti Mosha、Sasaki Yuko、Kowalski William J.、Keller Bradley B.、Masumoto Hidetoshi
    • Journal Title

      Journal of Visualized Experiments

      Volume: 160 Issue: 160 Pages: 258-264

    • DOI

      10.3791/61246

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Novel device prototyping for endoscopic cell sheet transplantation using a three-dimensional printed simulator2020

    • Author(s)
      Osada Hiroaki、Ho Wen-Jin、Yamashita Hideki、Yamazaki Kazuhiro、Ikeda Tadashi、Minatoya Kenji、Masumoto Hidetoshi
    • Journal Title

      Regenerative Therapy

      Volume: 15 Pages: 258-264

    • DOI

      10.1016/j.reth.2020.10.007

    • NAID

      120006898124

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 腹部臓器虚血を伴う大動脈解離と周術期管理2020

    • Author(s)
      金光 ひでお,湊谷 謙司
    • Journal Title

      胸部外科

      Volume: 73 Pages: 783-788

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 大動脈基部拡大と二尖弁を伴うStanford A型急性大動脈解離に対する自己弁温存基部再建術の1例2020

    • Author(s)
      工藤 雅文,山﨑 和裕,境 次郎,川東 正英,坂本 和久,福嶋 崇志,山本 涼,井出 雄二郎,金光 ひ でお,池田 義,湊谷 謙司
    • Journal Title

      胸部外科

      Volume: 73 Pages: 936-939

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo2020

    • Author(s)
      Ichimura Hajime、Kadota Shin、Kashihara Toshihide、Yamada Mitsuhiko、Ito Kuniaki、Kobayashi Hideki、Tanaka Yuki、Shiba Naoko、Chuma Shinichiro、Tohyama Shugo、Seto Tatsuichiro、Okada Kenji、Kuwahara Koichiro、Shiba Yuji
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 11883-11883

    • DOI

      10.1038/s41598-020-68373-9

    • NAID

      120007006223

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Therapeutic Potential of Pluripotent Stem Cells for Cardiac Repair after Myocardial Infarction2019

    • Author(s)
      Okano S, Shiba Y.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 4 Pages: 524-530

    • DOI

      10.1248/bpb.b18-00257

    • NAID

      130007622149

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-04-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-145-loaded poly(lactic-co-glycolic acid) nanoparticles attenuate venous intimal hyperplasia in a rabbit model.2019

    • Author(s)
      Nishio H, Masumoto H, Sakamoto K, Yamazaki K, Ikeda T, Minatoya K.
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: In press Issue: 6 Pages: 2242-2251

    • DOI

      10.1016/j.jtcvs.2018.08.115

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic optical pacing conditioning of h-iPSC engineered cardiac tissues.2019

    • Author(s)
      Dwenger M, Kowalski WJ, Ye F, Yuan F, Tinney JP, Setozaki S, Nakane T, Masumoto H, Campbell P, Guido W, Keller BB.
    • Journal Title

      J Tissue Eng

      Volume: 10 Pages: 204173141984174-204173141984174

    • DOI

      10.1177/2041731419841748

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes.2019

    • Author(s)
      Sato M, Shiba N, Miyazaki D, Shiba Y, Echigoya Y, Yokota T, Takizawa H, Aoki Y, Takeda S, Nakamura A.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 520 Issue: 1 Pages: 179-185

    • DOI

      10.1016/j.bbrc.2019.09.095

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pluripotent stem cell-derived cardiomyocyte transplantation for heart disease treatment.2019

    • Author(s)
      Kadota Shin, Shiba Yuji
    • Journal Title

      Curr Cardiol Rep.

      Volume: 21 Issue: 8 Pages: 73-73

    • DOI

      10.1007/s11886-019-1171-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human iPS cell-derived cardiac tissue sheets for functional restoration of infarcted porcine hearts.2018

    • Author(s)
      Ishigami M, Masumoto H, Ikuno T, Aoki T, Kawatou M, Minakata K, Ikeda T, Sakata R, Yamashita JK, Minatoya K.
    • Journal Title

      PLoS One.

      Volume: 13 Issue: 8 Pages: e0201650-e0201650

    • DOI

      10.1371/journal.pone.0201650

    • NAID

      120006552912

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sustained release of basic fibroblast growth factor using gelatin hydrogel improved left ventricular function through the alteration of collagen subtype in a rat chronic myocardial infarction model.2018

    • Author(s)
      Li Z, Masumoto H, Jo JI, Yamazaki K, Ikeda T, Tabata Y, Minatoya K.
    • Journal Title

      Gen Thorac Cardiovasc Surg.

      Volume: 66 Issue: 11 Pages: 641-647

    • DOI

      10.1007/s11748-018-0969-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A therapeutic angiogenesis of sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel sheets in a canine chronic myocardial infarction model.2018

    • Author(s)
      Kumagai M, Minakata K, Masumoto H, Yamamoto M, Yonezawa A, Ikeda T, Uehara K, Yamazaki K, Ikeda T, Matsubara K, Yokode M, Shimizu A, Tabata Y, Sakata R, Minatoya K.
    • Journal Title

      Heart Vessels

      Volume: 33 Issue: 10 Pages: 1251-1257

    • DOI

      10.1007/s00380-018-1185-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human iPS cell-engineered three-dimensional cardiac tissues perfused by capillary networks between host and graft.2018

    • Author(s)
      Masumoto H, Yamashita JK.
    • Journal Title

      Inflamm Regen.

      Volume: 38 Issue: 1 Pages: 26-26

    • DOI

      10.1186/s41232-018-0084-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 疾患・再生研究における多様なモデル生物~大型動物から魚類まで~2021

    • Author(s)
      升本 英利
    • Organizer
      第85回日本循環器学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ヒト心臓組織機能評価のためのヒトiPS細胞を用いたハートオンチップ型マイクロデバイスの開発2021

    • Author(s)
      村田 梢, Mosha Abulaiti , 佐藤 麻子, 佐々木 裕子, 柴 祐司, 田中 陽 , 升本 英利
    • Organizer
      第20回日本再生医療学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 3Dプリントシミュレータを用いた心表面への内視鏡的細胞シート移植デバイスの開発2021

    • Author(s)
      長田 裕明,何文晋,山下 英樹,山崎 和裕,池田 義, 湊谷 謙司, 升本 英利
    • Organizer
      第20回日本再生医療学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Heart Failure Treatment Using Engineered 3D Cardiac Sheets2020

    • Author(s)
      Masumoto H
    • Organizer
      第84回日本循環器学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ヒトiPS細胞由来心血管系細胞多層体を用いた新たな重症心不全治療法2020

    • Author(s)
      升本 英利
    • Organizer
      第19回日本再生医療学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ヒトiPS細胞由来心血管系細胞多層体を用いた心不全治療法の開発2020

    • Author(s)
      升本 英利
    • Organizer
      第24回日本心不全学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 臨床グレードヒトiPS細胞由来心血管系細胞多層体移植によるラット心筋梗塞モデル心機能回復効果の検討2020

    • Author(s)
      長田 裕明,升本 英利,川東 正英,山﨑 和裕,池田 義,湊谷 謙司
    • Organizer
      第73回日本胸部外科学会定期学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] J2N-kハムスター拡張型心筋症モデルにおけるバイオマーカー探索および病態解明に向けたJ2N-kハムスター拡張型心筋症モデルにおけるバ イオマーカー探索および病態解明に向けたMALDiイメージング質量分析およびショットガンプロテオミクスの併用2020

    • Author(s)
      辻 崇,新谷 祈,石田 瑞樹,韮澤 崇,梶田 遼,Patrick Bruneval,植田 初江,升本 英利,湊谷 謙司,池川 雅哉
    • Organizer
      第73回日本胸部外科学会定期学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Views by a reluctant user of frozen elephant trunk2020

    • Author(s)
      湊谷 謙司
    • Organizer
      第48回日本血管外科学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 臨床グレードヒトiPS細胞由来心血管系細胞多層体による心不全治療効果の検討2020

    • Author(s)
      長田 裕明,升本 英利,川東 正英,湊谷 謙司
    • Organizer
      第10回DDS再生医療研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Cardiovascular Regenerative Medicine Supported By Biomaterials And Drug Delivery System2020

    • Author(s)
      Masumoto H
    • Organizer
      Controlled Release Society Virtual Annual Meeting 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Transplantation of clinical-grade human induced pluripotent stem cell derived cardiac tissues contributes to functional recovery in a rat myocardial infarction model2020

    • Author(s)
      Osada H, Masumoto H, Kawatou M, Ikeda T, Tabata Y, Minatoya K, Yamashita JK
    • Organizer
      European Society of Cardiology (ESC) Congress 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Therapeutic Potential of Clinical Grade Human Induced Pluripotent Stem Cell-derived Cardiac Tissues for a Rat Myocardial Infarction Model2020

    • Author(s)
      Osada H, Masumoto H, Kawatou M, Ikeda T, Tabata Y, Minatoya K.
    • Organizer
      AHA2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] iPS細胞由来三次元人工心臓組織作製技術の心臓再生医療への応用の試み2019

    • Author(s)
      升本 英利、川東 正英、金光 ひでお、山﨑 和裕、池田 義、湊谷 謙司
    • Organizer
      第119回日本外科学会定期学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 循環器の再生医療を支える組織工学  DDSからiPS細胞治療まで2019

    • Author(s)
      升本 英利
    • Organizer
      第40回日本炎症・再生医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ヒトiPS細胞由来心血管系細胞多層体移植による心臓再生治療に向けた前臨床有効性試験2019

    • Author(s)
      升本 英利
    • Organizer
      第72回日本胸部外科学会定期学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 僧帽弁逆流に対する僧帽弁形成術時の積極的な三尖弁手術併施は術後の心血管Event減少に寄与するか2019

    • Author(s)
      金光 ひでお、湊谷 謙司、福嶋 崇志、山本 涼、工藤 雅文、境 次郎、川東 正英、坂本 和久、山﨑 和裕、井出 雄二郎、池田 義
    • Organizer
      第72回日本胸部外科学会定期学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] iPS細胞由来心血管系細胞を用いた心臓再生医療2019

    • Author(s)
      升本 英利
    • Organizer
      第33回日本冠疾患学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] iPS細胞から作製した人工心臓組織を用いた再生医療・疾患再現・創薬研究の試み2019

    • Author(s)
      升本 英利
    • Organizer
      理研BDR-兵庫県立こども病院 第4回ジョイントシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Surgical management for heart failure:A comparison of left ventricular repair and ventricular assist device2019

    • Author(s)
      Kanemitsu H, Minatoya K, Yamazaki K, Sakamoto K, Kawatou M, Sakai J, Kudo M, Nakamura M, Yamamoto R, Kitagata Y, Ide Y, Ikeda T
    • Organizer
      ISHLT2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preclinical Efficacy Studies of Human iPS Cell-derived Cardiac Tissue Transplantation onto Animal Heart Disease Models2019

    • Author(s)
      Masumoto H, Hirao S, Takimoto S, Kawatou M, Ikeda T, Tabata Y, Yamashita JK, Minatoya K
    • Organizer
      AHA Scientific Sessions 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluations for patency and recellularization of decellularized vascular grafts with high hydrostatic pressure method in a xeno-implantation animal model2019

    • Author(s)
      Kurokawa S, Masumoto H, Hashimoto Y, Funamoto S, Ikeda T, Kishida A, Minatoya K
    • Organizer
      AHA Scientific Sessions 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The N-terminal lection-like domain of thrombomodulin reduces acute lung injury without anticoagulant effects in a rat cardiopulmonary bypass model2019

    • Author(s)
      Itonaga T, Masumoto H, Yamazaki K, Ikeda T, Minatoya K
    • Organizer
      AHA Scientific Sessions 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Drug Delivery System-based Cardiovascular Regenerative Medicine: From Bench to Bedside2019

    • Author(s)
      Masumoto H
    • Organizer
      The 15th US-Japan Symposium on Drug Delivery Systems
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 心臓再生医療用のヒトiPS細胞由来心血管系細胞多層体の開発2018

    • Author(s)
      升本 英利,中根 武一郎,平尾 慎吾,瀧本 真也,李 子澎,金光 ひでお,植山 浩二,山﨑 和裕,池田 義,田畑 泰彦,山下 潤,湊谷 謙司
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ミニブタ心筋梗塞モデルに対するヒトiPS細胞由来積層化心臓組織シート移植による心機能改善効果の検討2018

    • Author(s)
      平尾 慎吾,升本 英利,西尾 博臣,川東 正英,金光 ひでお,植山 浩二,山﨑 和裕,池田 義,田畑 泰彦,山下 潤,湊谷 謙司
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マウス下肢虚血モデルにおけるゼラチンスポンジを用いたiPS細胞由来血管構成細胞移植による血流改善および血管再生効果の検討2018

    • Author(s)
      津丸 真一,升本 英利,川東 正英,幾野 毅,金光 ひでお,植山 浩二,山﨑 和裕,池田 義,湊谷 謙司
    • Organizer
      第46回日本血管外科学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Human iPSC-derived cardiac tissue transplantation to a rat unloaded ischemic heart model2018

    • Author(s)
      Heima D, Masumoto H, Kawatou M, Osada H, Takeda M, Ikeda T, Tabata Y, Minatoya K, Yamashita J.K.
    • Organizer
      第2回日本循環器学会基礎研究フォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒトiPS細胞を用いた致死性心室性不整脈再現3次元心臓組織モデルの開発2018

    • Author(s)
      川東 正英,升本 英利,金光 ひでお,山﨑 和裕,池田 義,湊谷 謙司
    • Organizer
      第71回日本胸部外科学会定期学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 左室補助装置下の虚血性心疾患におけるヒトiPS細胞由来心臓組織移植の効果について:ラット異所性移植モデルを用いた検討2018

    • Author(s)
      平間 大介,升本 英利,川東 正英,金光 ひでお,山﨑 和裕,池田 義,湊谷 謙司
    • Organizer
      第71回日本胸部外科学会定期学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Updates for Cardiovascular Regenerative Medicine Based on Biomaterials and Beyond.2018

    • Author(s)
      Masumoto H.
    • Organizer
      第5回国際組織工学・再生医療学会世界会議
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Torsade de Pointes arrhythmia model in vitro with 3D human iPS cell-engineered heart tissue2018

    • Author(s)
      Kawatou M, Masumoto H, Ashihara T, Yamashita JK.
    • Organizer
      第5回国際組織工学・再生医療学会世界会議
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Human iPS Cell-Derived Cardiac Tissue Transplantation to a Rat Unloaded Ischemic Heart Model Mimicking Left Ventricular Assist Device Implantation2018

    • Author(s)
      Heima D, Masumoto H, Kawatou M, Osada H, Ikeda T, Tabata Y, Minatoya K, Yamashita J.K.
    • Organizer
      AHA (American Heart Association) Scientific Sessions 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 同種 iPS 細胞を用いた心不全治療を目指して:これからの心不全治療における iPS 細胞を用いた再生医療の役割2018

    • Author(s)
      升本英利
    • Organizer
      第18回再生医療学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Book] 先端医療シリーズ50 「循環器疾患の最新医療」2019

    • Author(s)
      升本 英利
    • Total Pages
      512
    • Publisher
      寺田国際事務所/先端医療技術研究所
    • ISBN
      9784925089623
    • Related Report
      2019 Annual Research Report
  • [Book] Stem Cells in Clinical Practice and Tissue Engineering2018

    • Author(s)
      Nakane, T, Masumoto H, Keller BB.
    • Total Pages
      333
    • Publisher
      InTech Open
    • ISBN
      9781789230116
    • Related Report
      2018 Annual Research Report
  • [Remarks] 京都大学 心臓血管外科

    • URL

      http://kyoto-cvs.jp/

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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