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Formation of a strategic base for production of large animal models of inherited retinal diseases and their treatments

Research Project

Project/Area Number 18H02954
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionMie University

Principal Investigator

Kondo Mineo  三重大学, 医学系研究科, 教授 (80303642)

Co-Investigator(Kenkyū-buntansha) 杉本 昌彦  三重大学, 医学部附属病院, 講師 (00422874)
生杉 謙吾  三重大学, 医学系研究科, 准教授 (10335135)
松原 央  三重大学, 医学部附属病院, 講師 (20378409)
富田 浩史  岩手大学, 理工学部, 教授 (40302088)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2021: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2020: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Keywords網膜 / 夜盲 / 動物モデル / 犬 / 遺伝子 / 遺伝子治療 / 網膜電図 / 先天停在夜盲 / 先天停在性夜盲 / ウサギ / 網膜色素変性 / 双極細胞 / 動物実験 / 視覚電気生理 / 大型動物モデル / 動物モデル大型 / イヌ / 遺伝性網膜疾患 / 拠点形成
Outline of Final Research Achievements

In 2015, we discovered the dog model of complete-type congenital stationary night blindness (cCSNB dog), and successfully established its family lineage (Kondo et al. PLoS One. 2015). In this study, We have succeeded in identifying the causative gene of this cCSNB dog (Das et al. Sci Rep. 2019). The causative gene was LRIT3, which was identical to one of the causative genes of cCSNB in human. We further attempted gene therapy by intravitreal injection of adeno-associated viral vector (AAV) carrying the normal LRIT3 gene for cCSNB dogs. Although the experimental plan was delayed due to the coronavirus pandemic, our experiments are now underway to confirm the recovery of retinal function of cCSNB dogs after gene therapy.

Academic Significance and Societal Importance of the Research Achievements

遺伝性の網膜疾患に関しては、現在有効な治療法がほとんどない。網膜の中で光を受け取るために重要な視細胞や網膜色素上皮細胞の機能不全の一部の疾患には遺伝子治療が試みられている。しかし、網膜の中で情報伝達の2番目の細胞である双極細胞の機能不全疾患には全く治療法がない。今回の研究では、我々が2015年に世界で初めて発見した完全型先天停在夜盲の犬(cCSNB犬、双極細胞の機能障害による夜盲の犬)の原因遺伝子、LRIT3を同定した。さらにこの犬モデルの治療を目的として、正常なLRIT3遺伝子を搭載したウイルスベクターを作成し、遺伝子治療を行った。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (50 results)

All 2022 2021 2020 2019 2018

All Journal Article (38 results) (of which Int'l Joint Research: 19 results,  Peer Reviewed: 38 results,  Open Access: 30 results) Presentation (12 results) (of which Int'l Joint Research: 12 results,  Invited: 4 results)

  • [Journal Article] Visual Field Characteristics in East Asian Patients With Occult Macular Dystrophy (Miyake Disease): EAOMD Report No. 32022

    • Author(s)
      Ahn SJ, Yang L, Tsunoda K, Kondo M, Fujinami-Yokokawa Y, Nakamura N, Iwata T, Kim MS, Mun Y, Park JY, Joo K, Park KH, Miyake Y, Sui R, Fujinami K, Woo SJ; East Asia Inherited Retinal Disease Society Study Group
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 63 Issue: 1 Pages: 12-12

    • DOI

      10.1167/iovs.63.1.12

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of suspension of anti-vascular endothelial growth factor treatment for neovascular age-related macular degeneration in clinical setting2022

    • Author(s)
      Matsubara H, Matsui Y, Miyata R, Ichio A, Chujo S, Enomoto H, Sugimoto M, Kondo M
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: - Issue: 6 Pages: 1867-1876

    • DOI

      10.1007/s00417-021-05526-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Case of unilateral pellucid marginal corneal degeneration progressing to corneal perforation with keratoconus in contralateral eye2022

    • Author(s)
      Ueji N, Kato K, Yonekawa Y, Takeuchi M, Takashima Y, Hirano K, Kondo M
    • Journal Title

      Am J Ophthalmol Case Rep

      Volume: 25 Pages: 101293-101293

    • DOI

      10.1016/j.ajoc.2022.101293

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 36.Treatment of diabetic macular edema in real-world clinical practice: the effect of aging.2022

    • Author(s)
      Japan Clinical Retina Study (J-CREST) group
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 1 Issue: 8 Pages: 1-8

    • DOI

      10.1111/jdi.13801

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Case of cystoid macular edema induced by systemic administration of paclitaxel: evaluations with electroretinograms2021

    • Author(s)
      Kato K, Nagashima R, Sugimoto M, Ikesugi K, Matsubara H, Kondo M
    • Journal Title

      Doc Ophthalmol

      Volume: 143 Issue: 2 Pages: 229-235

    • DOI

      10.1007/s10633-021-09835-x

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema.2021

    • Author(s)
      Sugimoto M, Kondo M, Yasuma T, D'Alessandro-Gabazza CN, Toda M, Imai H, Nakamura M, Gabazza EC.
    • Journal Title

      Sci Rep

      Volume: 11 Issue: 1 Pages: 10449-10449

    • DOI

      10.1038/s41598-021-89870-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ocular findings in Japanese patients with hydroxychloroquine retinopathy developing within 3 years of treatment.2021

    • Author(s)
      Ozawa H, Ueno S, Ohno-Tanaka A, Sakai T, Hashiguchi M, Shimizu M, Fujinami K, Ahn SJ, Kondo M, Browning DJ, Shinoda K, Yokogawa N.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 65 Issue: 4 Pages: 472-481

    • DOI

      10.1007/s10384-021-00841-9

    • NAID

      40022621225

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A rat model for retinitis pigmentosa with rapid retinal degeneration enables drug evaluation in vivo2021

    • Author(s)
      Inoue C, Takeuchi T, Shiota A, Kondo M, Nshizawa Y.
    • Journal Title

      Biol Proced Online

      Volume: 23 Issue: 1 Pages: 11-11

    • DOI

      10.1186/s12575-021-00150-y

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Broad locations of antigenic regions for anti-TRPM1 autoantibodies in paraneoplastic retinopathy with retinal ON bipolar cell dysfunction2021

    • Author(s)
      Gyoten D, Ueno S, Okado S, Chaya T, Yasuda S, Morimoto T, Kondo M, Kimura K, Hayashi T, Leroy BP, Woo SJ, Mukai R, Joo K, Furukawa T.
    • Journal Title

      Exp Eye Res

      Volume: 212 Pages: 108770-108770

    • DOI

      10.1016/j.exer.2021.108770

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Background Factors Affecting Visual Acuity at Initial Visit in Eyes with Central Retinal Vein Occlusion: Multicenter Study in Japan2021

    • Author(s)
      Kondo M, Noma H, Shimura M, Sugimoto M, Matsui Y, Kato K, Saishin Y, Ohji M, Ishikawa H, Gomi F, Iwata K, Yoshida S, Kusuhara S, Hirai H, Ogata N, Hirano T, Murata T, Tsuboi K, Kamei M, Kinoshita T, Kuwayama S, Hirano Y, Ohta M, Kimura K, Takayama K, Takeuchi M, Takamura Y, Okamoto F, Mitamura Y, Terasaki H, Sakamoto T
    • Journal Title

      J Clin Med

      Volume: 10 Issue: 23 Pages: 5619-5619

    • DOI

      10.3390/jcm10235619

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness of microperimetry in evaluating anti-vascular endothelial growth factor therapy for diabetic macular edema patients with relatively good vision: A retrospective observational study2021

    • Author(s)
      Sugimoto M, Wakamatsu Y, Miyata R, Kato K, Matsubara H, Kondo M
    • Journal Title

      Medicine (Baltimore)

      Volume: 100 Issue: 51 Pages: e28404-e28404

    • DOI

      10.1097/md.0000000000028404

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trends in the Prevalence and Progression of Diabetic Retinopathy Associated with Hyperglycemic Disorders during Pregnancy in Japan.2021

    • Author(s)
      Sugimoto M, Sampa K, Tsukitome H, Kato K, Matsubara H, Asami S, Sekimoto K, Kitano S, Yoshida S, Takamura Y, Hirano T, Murata T, Shimizu M, Kinoshita T, Kusuhara S, Sawada O, Ohji M, Yoshikawa R, Kimura K, Ishikawa H, Gomi F, Terasaki H, Kondo M, Ikeda T
    • Journal Title

      J Clin Med

      Volume: 11 Issue: 1 Pages: 165-165

    • DOI

      10.3390/jcm11010165

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spatial Functional Characteristics of East Asian Patients With Occult Macular Dystrophy (Miyake Disease); EAOMD Report No. 22021

    • Author(s)
      Yang L, Joo K, Tsunoda K, Kondo M, Fujinami-Yokokawa Y, Arno G, Pontikos N, Liu X, Nakamura N, Kurihara T, Tsubota K, Iwata T, Li H, Zou X, Wu S, Sun Z, Ahn SJ, Kim MS, Mun YS, Park KH, Robson AG, Miyake Y, Woo SJ, Sui R, Fujinami K; East Asia Inherited Retinal Disease Society Study Group
    • Journal Title

      Am J Ophthalmol

      Volume: 221 Pages: 169-180

    • DOI

      10.1016/j.ajo.2020.07.025

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Case of lens-induced uveitis associated with supernormal flicker ERG amplitudes after cataract surgery2021

    • Author(s)
      Kato K, Sugawara A, Nagashima R, Sugimoto M, Ikesugi K, Matsubara H, Takeuchi M, Kondo M
    • Journal Title

      Doc Ophthalmol

      Volume: 142 Issue: 2 Pages: 233-238

    • DOI

      10.1007/s10633-020-09786-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New variants and in silico analyses in GRK1 associated Oguchi disease2021

    • Author(s)
      Poulter JA, Gravett MSC, Taylor RL, Fujinami K, De Zaeytijd J, Bellingham J, Rehman AU, Hayashi T, Kondo M,
    • Journal Title

      Hum Mutat

      Volume: 42 Pages: 164-176

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Misalignment of foveal pit and foveal bulge determined by ultrahigh-resolution SD-OCT in normal eyes2020

    • Author(s)
      Matsui Y, Miyata R, Uchiyama E, Matsubara H, Kondo M
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 258 Issue: 10 Pages: 2131-2139

    • DOI

      10.1007/s00417-020-04813-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and Genetic Characteristics of 15 Affected Patients From 12 Japanese Families with GUCY2D-Associated Retinal Disorder2020

    • Author(s)
      Liu X, Fujinami K, Kuniyoshi K, Kondo M, Ueno S, Hayashi T, Mochizuki K, Kameya S, Yang L, Fujinami-Yokokawa Y, Arno G, Pontikos N, Sakuramoto H, Kominami T, Terasaki H, Katagiri S, Mizobuchi K, Nakamura N, Yoshitake K, Miyake Y, Li S, Kurihara T, Tsubota K, Iwata T, Tsunoda K; Japan Eye Genetics Consortium
    • Journal Title

      Transl Vis Sci Technol

      Volume: 11 Issue: 6 Pages: 2-2

    • DOI

      10.1167/tvst.9.6.2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Factors Affecting Photopic Negative Response Recorded with RETeval System: Study of Young Healthy Subjects2020

    • Author(s)
      Kato K, Sugawara A, Nagashima R, Ikesugi K, Sugimoto M, Kondo M
    • Journal Title

      Transl Vis Sci Technol

      Volume: 9 Issue: 9 Pages: 19-19

    • DOI

      10.1167/tvst.9.9.19

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of 2-Year Outcomes between Intravitreal Ranibizumab and Intravitreal Aflibercept for Diabetic Macular Edema with "Treat-and-Extend" Regimen-Its Usefulness and Problems2020

    • Author(s)
      Chujo S, Sugimoto M, Sasaki T, Matsui Y, Kato K, Ichio A, Miyata R, Matsubara H, Kondo M
    • Journal Title

      J Clin Med

      Volume: 9 Issue: 9 Pages: 2848-2848

    • DOI

      10.3390/jcm9092848

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Intravitreal Aflibercept on Retinal Function and Improvement of Macular Edema Associated With Diabetic Retinopathy2020

    • Author(s)
      Ichio A, Sugimoto M, Matsubara H, Mochida D, Kato K, Kondo M
    • Journal Title

      Transl Vis Sci Technol

      Volume: 9 Issue: 11 Pages: 2-2

    • DOI

      10.1167/tvst.9.11.2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RDH5-Related Fundus Albipunctatus in a Large Japanese Cohort.2020

    • Author(s)
      Katagiri S, Hayashi T, Nakamura M, Mizobuchi K, Gekka T, Komori S, Ueno S, Terasaki H, Sakuramoto H, Kuniyoshi K, Kusaka S, Nagashima R, Kondo M, Fujinami K, Tsunoda K, Matsuura T, Kondo H, Yoshitake K, Iwata T, Nakano T.
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 61 Issue: 3 Pages: 53-53

    • DOI

      10.1167/iovs.61.3.53

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency.2020

    • Author(s)
      Yang L, Fujinami K, Ueno S, Kuniyoshi K, Hayashi T, Kondo M, Mizota A, Naoi N, Shinoda K, Kameya S, Fujinami-Yokokawa Y, Liu X, Arno G, Pontikos N, Kominami T, Terasaki H, Sakuramoto H, Katagiri S, Mizobuchi K, Nakamura N, Mawatari G, Kurihara T, Tsubota K, Miyake Y, Yoshitake K, Iwata T, Tsunoda K; JEGC study group.
    • Journal Title

      Sci Rep.

      Volume: 10 Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41598-020-62119-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genome-wide association study and whole-genome sequencing identify a deletion in LRIT3 associated with canine congenital stationary night blindness.2019

    • Author(s)
      Das RG, Becker D, Jagannathan V, Goldstein O, Santana E, Carlin K, Sudharsan R, Leeb T, Nishizawa Y, Kondo M, Aguirre GD, Miyadera K
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 14166-14166

    • DOI

      10.1038/s41598-019-50573-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparisons of Effective Fields of Two Ultra-Widefield Ophthalmoscopes, Optos 200Tx and Clarus 5002019

    • Author(s)
      Matsui Y, Ichio A, Sugawara A, Uchiyama E, Suimon H, Matsubara H, Sugimoto M, Ikesugi K, Kondo M
    • Journal Title

      Biomed Res Int

      Volume: 2019 Pages: 7436293-7436293

    • DOI

      10.1007/978-3-030-27378-1_60

    • ISBN
      9783030273774, 9783030273781
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ISCEV extended protocol for the S-cone ERG2019

    • Author(s)
      Perlman I, Kondo M, Chelva E, Robson AG, Holder GE
    • Journal Title

      Doc Ophthalmol

      Volume: 140 Issue: 2 Pages: 95-101

    • DOI

      10.1007/s10633-019-09730-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Electrically Evoked Potentials Are Reduced Compared to Axon Numbers in Rhodopsin P347L Transgenic Rabbits With Severe Photoreceptor Degeneration.2019

    • Author(s)
      Kominami T, Ueno S, Nishida K, Inooka D, Kominami A, Kondo M, Terasaki H.
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 60 Issue: 7 Pages: 2543-2550

    • DOI

      10.1167/iovs.19-26972

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Course of loss of photoreceptor function and progressive Mueller cell gliosis in rhodopsin P347L transgenic rabbits.2019

    • Author(s)
      Ueno S, Kominami T, Okado S, Inooka D, Kondo M, Terasaki H.
    • Journal Title

      Experimental Eye Research

      Volume: 184 Pages: 192-200

    • DOI

      10.1016/j.exer.2019.04.026

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ISCEV extended protocol for the stimulus-response series for light-adapted full-field ERG2019

    • Author(s)
      McCulloch DL, Kondo M, Hamilton R, Lachapelle P, Messias AMV, Robson AG, Ueno S
    • Journal Title

      Doc Ophthalmol

      Volume: 印刷中 Issue: 3 Pages: 205-215

    • DOI

      10.1007/s10633-019-09685-8

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CLINICAL COURSE OF PARANEOPLASTIC RETINOPATHY WITH ANTI-TRPM1 AUTOANTIBODY IN JAPANESE COHORT2019

    • Author(s)
      Ueno S, Inooka D, Nakanishi A, Okado S, Yasuda S, Kominami T, Sayo A, Morimoto T, Kondo M, Katagiri S, Hayashi T, Terasaki H
    • Journal Title

      Retina

      Volume: 印刷中 Issue: 12 Pages: 2410-2418

    • DOI

      10.1097/iae.0000000000002329

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] New clinical ultrahigh-resolution SD-OCT using A-scan matching algorithm2019

    • Author(s)
      Matsui Y, Kondo M, Uchiyama E, Mityata R, Matsubara H
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 257 Issue: 2 Pages: 255-263

    • DOI

      10.1007/s00417-018-4183-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Novel mutations in the RS1 gene in Japanese patients with X-linked congenital retinoschisis2019

    • Author(s)
      Kondo Hiroyuki、Oku Kazuma、Katagiri Satoshi、Hayashi Takaaki、Nakano Tadashi、et al.
    • Journal Title

      Human Genome Variation

      Volume: 6 Issue: 1 Pages: 3-3

    • DOI

      10.1038/s41439-018-0034-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Scleral buckling versus vitrectomy for young japanese patients with rhegmatogenous retinal detachment in the era of microincision surgery: real-world evidence from a multicentre study in Japan2019

    • Author(s)
      Shu I, Ishikawa H, Nishikawa H, Morikawa S, Okamoto F, Sakamoto T, Sugimoto M, Kondo M, Iwasaki M, Kinoshita T, Toibana T, Mitamura Y, Takamura Y, Motohashi R, Shimura M, Sakurai Y, Takeuchi M, Gomi F
    • Journal Title

      Acta Ophthalmol

      Volume: 印刷中 Issue: 5

    • DOI

      10.1111/aos.14050

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association between Retinal Nerve Fiber Layer Thickness and Eye Fatigue2019

    • Author(s)
      Ayaki M, Kuze M, Kondo M, Tsubota K, Negishi K
    • Journal Title

      Biomed Res Int

      Volume: 2019 Pages: 3014567-3014567

    • DOI

      10.1155/2019/3014567

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Central serous chorioretinopathy with and without steroids: A multicenter survey2019

    • Author(s)
      Araki T, Ishikawa H, Iwahashi C, Niki M, Mitamura Y, Sugimoto M, Kondo M, Kinoshita T, Nishi T, Ueda T, Kato A, Yasukawa T, Takamura Y, Gomi F.
    • Journal Title

      PLoS One

      Volume: 14

    • NAID

      120006812008

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genotype determination of the OPN1LW/OPN1MW genes: novel disease-causing mechanisms in Japanese patients with blue cone monochromacy.2018

    • Author(s)
      Katagiri S, Iwasa M, Hayashi T, Hosono K, Yamashita T, Kuniyoshi K, Ueno S, Kondo M, Ueyama H, Ogita H, Shichida Y, Inagaki H, Kurahashi H, Kondo H, Ohji M, Hotta Y, Nakano T.
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 11507-11507

    • DOI

      10.1038/s41598-018-29891-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical preferences and trends of anti-vascular endothelial growth factor treatments for diabetic macular edema in Japan2018

    • Author(s)
      Sugimoto Masahiko、Tsukitome Hideyuki、Okamoto Fumiki、Oshika Tetsuro、Ueda Tetsuo、Niki Masanori、Mitamura Yoshinori、Ishikawa Hiroto、Gomi Fumi、Kitano Shigehiko、Noma Hidetaka、Shimura Masahiko、Sonoda Shozo、Sawada Osamu、Ohji Masahito、Harimoto Kozo、Takeuchi Masaru、Takamura Yoshihiro、Kondo Mineo、Sakamoto Taiji
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 10 Issue: 2 Pages: 475-483

    • DOI

      10.1111/jdi.12929

    • NAID

      120006980552

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Case of Focal Choroidal Excavation Development Associated with Multiple Evanescent White Dot Syndrome2018

    • Author(s)
      Matsubara H, Uchiyama E, Suzuki K, Matsuda Y, Kondo M
    • Journal Title

      Case Rep Ophthalmol

      Volume: 9 Issue: 2 Pages: 388-394

    • DOI

      10.1159/000492747

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Supernormal Flicker ERGs in Eyes With Central Retinal Vein Occlusion: Clinical Characteristics, Prognosis, and Effects of Anti-VEGF Agent2018

    • Author(s)
      Miyata Ryohei、Kondo Mineo、Kato Kumiko、Sugimoto Masahiko、Matsubara Hisashi、Ikesugi Kengo、Ueno Shinji、Yasuda Shunsuke、Terasaki Hiroko
    • Journal Title

      Investigative Opthalmology & Visual Science

      Volume: 59 Issue: 15 Pages: 5854-5854

    • DOI

      10.1167/iovs.18-25087

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Topics and clinical application of hand-held small ERG device, RETeval2021

    • Author(s)
      Kondo M
    • Organizer
      Korean Society for Clinical Electrophysiology of Vision
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Kondo M: How to evaluate ischemia in CRVO?2021

    • Author(s)
      Kondo M
    • Organizer
      Retina World Congress
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] How basic research can enhance visual diagnosis in the clinical setting2021

    • Author(s)
      Kondo M
    • Organizer
      International Society for Clinical Electrophysiology of Vision
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exploration of novel clinical benefits with high resolution OCT and OCT angiography2021

    • Author(s)
      Kondo M
    • Organizer
      The 2nd International Ocular Circulation Society
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of recording sequence on flicker electroretinographics recorded with natural pupils corrected for pupil area2020

    • Author(s)
      Kondo M
    • Organizer
      International Society for Clinical Electrophysiology of Vision
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multifocal ERG2020

    • Author(s)
      Kondo M
    • Organizer
      International Society for Clinical Electrophysiology of Vision
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical approach to nyctalopia2019

    • Author(s)
      Kondo M
    • Organizer
      The Visual System: Structure Meets Function (Singapore) 招待講演
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Clinical applications of the mfERG2019

    • Author(s)
      Kondo M
    • Organizer
      57th ISCEV Symposium (Seoul, Korea) 教育講演
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Clinical Usefulness of Electrophysiology2019

    • Author(s)
      Kondo M
    • Organizer
      Asia-Pacific Academy of Ophthalmology (Bangkok, Thailand) 教育講演
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Supernormal Flicker ERGs in Eyes With Central Retinal Vein Occlusion: Clinical Characteristics, Prognosis, and Effects of Anti-VEGF Agent2019

    • Author(s)
      Kondo M
    • Organizer
      Macula Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical application of multifocal ERG2018

    • Author(s)
      Kondo M
    • Organizer
      The 50th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] upernormal flicker ERGs in eyes with central retinal vein occlusion: Clinical characteristics, prognosis, and effects of anti-VEGF agent2018

    • Author(s)
      Kondo M
    • Organizer
      The 11th Joint Meeting of Japan-Korea-China Ophthalmologists
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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