| Project/Area Number |
18H02955
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 56060:Ophthalmology-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宮田 学 京都大学, 医学研究科, 助教 (00548505)
三宅 正裕 京都大学, 医学研究科, 特定助教 (90812793)
大石 明生 京都大学, 医学研究科, 特定病院助教 (50572955)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2020: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2019: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Keywords | 眼科 / 近視 / 強度近視 / 最強度近視 / 全ゲノム解析 / 変性近視 / ゲノムワイド関連解析 / 全エキソン解析 / 近視性網脈絡膜萎縮 / 近視性脈絡膜新生血管 |
|---|
| Outline of Final Research Achievements |
In this study, we conducted a genomic and epidemiological study to elucidate the pathogenesis of myopia-induced blindness. We have published the results of a genome-wide association analysis related to myopic maculopathy, an important cause of blindness associated with intense myopia (Nature Communications, 2018). In addition, we identified several disease susceptibility genes associated with high myopia in collaboration with Yokohama City University (Ophthalmology, 2020). Furthermore, by analyzing ocular shape parameters using data from the Nagahama Study, we pointed out that spherical enlargement of the eyeball and the restriction of equatorial ocular expansion of the eyeball may interact to contribute to the elongation of ocular axial length (Ophthalmology, 2020).
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、近視による失明の病態解明に近づいた。今後更に強度近視や近視性黄斑症の疾患感受性遺伝子が多数特定されれば、将来的には近視による失明のリスク予想などに繋がるほか、パスウェイ解析を行うことにより更なる病態解明につながる。
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