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Elucidation of regulatory chemical messengers in oral cancer stem cell niche and its diagnostic and therapeutic application

Research Project

Project/Area Number 18H03000
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 57060:Surgical dentistry-related
Research InstitutionUniversity of East Asia (2020)
Hiroshima University (2018-2019)

Principal Investigator

OKMOTO TETUJI  東亜大学, その他の研究科, 教授 (00169153)

Co-Investigator(Kenkyū-buntansha) 吉岡 幸男  広島大学, 医系科学研究科(歯), 助教 (20335665)
工藤 保誠  徳島大学, 大学院医歯薬学研究部(歯学域), 教授 (50314753)
浜名 智昭  広島大学, 医系科学研究科(歯), 助教 (40397922)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords無血清培養 / 癌幹細胞 / 放射線耐性細胞 / HBp17/FGFBP-1 / miRNA / exosome / krt13 / IGF2 / がん幹細胞 / sphere 形成 / HBp17/FGFBP1 / 放射線耐性 / エクソソーム / 腫瘍微小環境 / 口腔扁平上皮癌細胞 / ゲノム編集 / プロテオーム解析 / sphere形成能 / 口腔癌幹細胞 / CD133 / 低線量放射線 / 高線量放射線 / ケラチン13遺伝子 / sphere形成細胞 / 細胞増殖因子 / 無血清培地 / 口腔扁平上皮癌 / sphere形成 / regulatory chemical messenger (RCM) / 制御性ケミカルメッセンジャー / オーガノイド形成
Outline of Final Research Achievements

Cancers consist of multiple cell populations, including highly proliferative cell populations and cells that have undergone some differentiation and maturation, and these consist of a small number of cancer stem cells (CSC). In this study, HBp17/FGFBP-1 (HBp17), which is highly expressed in OSCC and is closely involved in its growth and angiogenesis, is studied. In addition, surgical/radiation/chemo-therapy are effective in treating many cancers, and radiation therapy (RT) plays a major role in the treatment of OSCC. However, some tumors show radiation resistance. In addition, even if the case exhibited a clinically complete-response, there are cases where it recurs later. This is believed to be due to the presence of CSC. In order to elucidate the mechanism of Radiation resistance in OSCC, RR-SCC strains were isolated using two types of irradiation systems, HDR and LDR. The characteristics of the RR cells were clarified, and the genes involved in RR were clarified.

Academic Significance and Societal Importance of the Research Achievements

VD3/ED-71はOSCC細胞に対してregulatory chemical messengerとしてexosomal miR-6887-5pの培養上清中への分泌を上昇させ腫瘍細胞及び周囲細胞に働きHBp17の発現を制御し増殖を抑制していた。ED-71の扁平上皮癌に対する治療薬としての有用性が示された。放射線耐性OSCC細胞ではIGF2やkrt13遺伝子が過剰発現され癌幹細胞の性質を持った細胞集団が蓄積し、腫瘍原性が亢進し、放射線・化学療法後の癌再発をもたらすと考えられた。RR-SCCモデルの確立は放射線耐性メカニズムを解明する強力なツールとなり、新規診断及び治療法の開発に有用と考えられた。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (50 results)

All 2021 2020 2019 2018

All Journal Article (20 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 17 results,  Open Access: 11 results) Presentation (23 results) (of which Int'l Joint Research: 5 results,  Invited: 7 results) Book (5 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Enhanced KRT13 gene expression bestows radiation resistance in squamous cell carcinoma cells.2021

    • Author(s)
      Nguyen TQ, Hamada A, Yamada K, Higaki M, Shintani T, Yoshioka Y, Toratani S, Okamoto T
    • Journal Title

      In Vitro Cellular & Developmental Biology-Animal.

      Volume: 57(3) Issue: 3 Pages: 300-314

    • DOI

      10.1007/s11626-020-00542-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MICA A5.1 homozygous genotype is associated with a risk for early-onset oral cancer2021

    • Author(s)
      Tani R, Nanako Ito R, Matsui K, Yamasaki S, Hamada A, Tokumaru K, Toratani S, Okamoto T.
    • Journal Title

      Oral Oncology

      Volume: 116, May Pages: 105256-105256

    • DOI

      10.1016/j.oraloncology.2021.105256

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modified Submental Island Flap for the Surgical Treatment of 4 Patients With Stage 3 Medication-Related Osteonecrosis of the Mandible.2020

    • Author(s)
      Myoken Y, Fujita Y, Okamoto T.
    • Journal Title

      J Oral Maxillofac Surg

      Volume: Jan;78(1): Pages: 29-34

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reconstruction of an upper lip and intraoral defect following resection of an upper lip melanoma using a lower lip musculomucosal flap combined with a tongue flap2020

    • Author(s)
      Yukio Yoshioka, Yasutaka Hayashido, Yoku Ito, Shigeaki Toratani, Tetsuji Okamoto
    • Journal Title

      Journal of Surgical Case Reports

      Volume: 4 Issue: 4 Pages: 1-4

    • DOI

      10.1093/jscr/rjaa072

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Induction of integration-free human-induced pluripotent stem cells under serum- and feeder-free conditions.2020

    • Author(s)
      Atsuko Hamada, Eri Akagi, Sachiko Yamasaki, Hirotaka Nakatao, Fumitaka Obayashi, Manami Ohtaka, Ken Nishimura, Mahito Nakanishi, Shigeaki Toratani & Tetsuji Okamoto
    • Journal Title

      In Vitro Cell Dev Biol Anim.

      Volume: 56(1) Issue: 1 Pages: 85-95

    • DOI

      10.1007/s11626-019-00412-w

    • NAID

      120007132728

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modified Submental Island Flap for the Surgical Treatment of 4 Patients With Stage 3 Medication-Related Osteonecrosis of the Mandible2020

    • Author(s)
      Myoken Y, Fujita Y.,Okamoto T.
    • Journal Title

      J Oral Maxillofac Surg

      Volume: 78(1) Issue: 1 Pages: 29-34

    • DOI

      10.1016/j.joms.2019.08.028

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eldecalcitol (ED-71)-induced exosomal miR-6887-5p suppresses squamous cell carcinoma cell growth by targeting heparin-binding protein 17/fibroblast growth factor?binding protein-1 (HBp17/FGFBP-1)2020

    • Author(s)
      Higaki M.、Shintani T.、Hamada A.、Rosli S. N. Z.、Okamoto T.
    • Journal Title

      In Vitro Cellular & Developmental Biology - Animal

      Volume: 56 Issue: 3 Pages: 222-233

    • DOI

      10.1007/s11626-020-00440-x

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antimicrobial susceptibility surveillance of bacterial isolates recovered in Japan from odontogenic infections in 2013.2020

    • Author(s)
      Akihiro Kaneko, Tetsuya Matsumoto, Tetsuji Okamoto, Taku Kanda,Tetsuro Ikebe , Kenichiro Hashimoto, et al.
    • Journal Title

      J Infect Chemother.

      Volume: 26 Issue: 9 Pages: 882-889

    • DOI

      10.1016/j.jiac.2020.05.019

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral squamous cell carcinoma of the tongue dorsum with multiple cancer-associated mutations in the TP53 gene2020

    • Author(s)
      Yamasaki S., Tani R., Toratani S., Sakurai S., Toratani S., Okamoto T.
    • Journal Title

      Oral Oncol

      Volume: Oct Pages: 109-109

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of Noonan syndrome-specific human-induced pluripotent stem cells under serum-, feeder-, and integration-free conditions2020

    • Author(s)
      Atsuko Hamada, Eri Akagi, Fumitaka Obayashi, Sachiko Yamasaki, Koichi Koizumi, Manami Ohtaka, Ken Nishimura, Mahito Nakanishi, Shigeaki Toratani & Tetsuji Okamoto
    • Journal Title

      In Vitro Cellular & Developmental Biology - Animal

      Volume: 56(10) Issue: 10 Pages: 888-895

    • DOI

      10.1007/s11626-020-00515-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical investigation of oral cancer in adolescent and young adult generation2020

    • Author(s)
      Yoshioka Yukio、Sakaue Taishi、Matsui Kensaku、Tsushima Koji、Obayashi Fumitaka、Hamada Atsuko、Yamasaki Sachiko、Hamana Tomoaki、Sumi Kensaku、Kanda Taku、Koizumi Koichi、Tani Ryouji、Toratani Shigeaki、他10名
    • Journal Title

      Oral Science International

      Volume: ー Issue: 2 Pages: 20-27

    • DOI

      10.1002/osi2.1093

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel PTCH1 mutations in Japanese familial nevoid basal cell carcinoma syndrome2020

    • Author(s)
      Nakase Y., Hamada A., Kitamura N., Hata T., Toratani S., Yamamoto T., Okamoto T.
    • Journal Title

      Hum Genome Var

      Volume: 7(1) Issue: 1 Pages: 38-38

    • DOI

      10.1038/s41439-020-00126-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comment on Surgical Management of Medication-Related Osteonecrosis of the Jaw Is Associated With Improved Disease Resolution: A Retrospective Cohort Study by El-Rabbany et al2020

    • Author(s)
      Fujita Y, Myoken Y., T. Okamoto
    • Journal Title

      J Oral Maxillofac Surg

      Volume: 78 (3) Issue: 3 Pages: 319-319

    • DOI

      10.1016/j.joms.2019.09.029

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 無血清培養系を用いた扁平上皮癌細胞株からの放射線耐性細胞の樹立とその機能解析、2019

    • Author(s)
      濱田 充子、岡本 哲治
    • Journal Title

      口腔組織培養学会誌

      Volume: 28巻1号 Pages: 33-34

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 疾患特異的induced pluripotent stem cell(DS-iPSC)の樹立と疾患研究2019

    • Author(s)
      中瀬 洋司、岡本 哲治
    • Journal Title

      口腔組織培養学会誌

      Volume: 28巻1号 Pages: 23-24

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 口腔原発神経内分泌癌由来細胞株の樹立 初代培養腫瘍細胞の増殖様態から診断されるに至った口腔原発神経内分泌癌2019

    • Author(s)
      佐藤 成紀、岡本 哲治
    • Journal Title

      口腔組織培養学会誌

      Volume: 28巻1号 Pages: 9-10

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Pathological factors involved in local failure in squamous cell carcinoma of the oral cavity: retrospective study and proposal of a new clinical classification.2019

    • Author(s)
      Toratani S, Ogawa I, Sasahara H, Yoshioka Y, Kanda T, Tani R, Okamoto T.
    • Journal Title

      Int J Oral Maxillofac Surg.

      Volume: 48 Issue: 2 Pages: 143-151

    • DOI

      10.1016/j.ijom.2018.07.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New Crambescidin-Type Alkaloids from the Indonesian Marine Sponge Clathria bulbotoxa2018

    • Author(s)
      Kasmiati Kasmiati ,Yukio Yoshioka , Tetsuji Okamoto, Makoto Ojika
    • Journal Title

      Marine Drugs

      Volume: 16,84 Issue: 3 Pages: 84-84

    • DOI

      10.3390/md16030084

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A tribute to Dr. Gordon Hisashi Sato (December 24, 1927 - March 31, 2017)2018

    • Author(s)
      Sato J. Denry、Okamoto Tetsuji、Barnes David、Hayashi Jun、Serrero Ginette、McKeehan Wallace L.
    • Journal Title

      In Vitro Cellular & Developmental Biology - Animal

      Volume: 54 Issue: 3 Pages: 177-193

    • DOI

      10.1007/s11626-018-0230-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Suture granulomas developing after the treatment of oral squamous cell carcinoma2018

    • Author(s)
      Yoshioka Y, Nakatao H, Hamana T, Hamada A, Kanda T, Koizumia K, Toratani S, Okamoto T
    • Journal Title

      International Journal of Surgery Case Reports

      Volume: 50 Pages: 68-71

    • DOI

      10.1016/j.ijscr.2018.07.021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 6.薬剤誘導性リプログラミングシステムを用いたがん幹細胞のin vitro休眠・増殖モデルの確立2020

    • Author(s)
      告 恭史郎, 矢野 公義, 濱田 充子, 岡本 哲治, 田原 栄俊, 嶋本 顕
    • Organizer
      第92回日本生化学会大会プログラム・講演要旨集[2P-269](2019.09)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 当科におけるニボルマブによる口腔がん治療の報告2020

    • Author(s)
      吉岡 幸男, 浜名 智昭, 松井 健作, 櫻井 繁, 神田 拓, 小泉 浩一, 谷 亮治, 虎谷 茂昭, 岡本 哲治
    • Organizer
      日本口腔科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 3.近赤外分光法(Near-infrared spectroscopy)を用いた歯科装具の装着刺激による脳血流動態の解析(第三報)2020

    • Author(s)
      宮田 秀政, 谷 亮治, 浜名 智昭, 虎谷 茂昭, 岡本 哲治
    • Organizer
      日本口腔科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 当科におけるAYA世代口腔がん患者の検討(第2報)2020

    • Author(s)
      吉岡 幸男, 坂上 泰士, 松井 健作, 小泉 浩一, 谷 亮治, 林堂 安貴, 虎谷 茂昭, 岡本 哲治
    • Organizer
      日本口腔科学会(2017.04.28)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 次世代シーケンサーを用いた口腔癌患者の口腔内細菌叢の多様性解析2020

    • Author(s)
      松井健作,谷亮治,濱田充子,虎谷茂昭,岡本哲治
    • Organizer
      日本口腔外科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Establishment and Characterization of Disease-specific Human iPSCs in Serum-, Integration- and Feeder-free Cultures2019

    • Author(s)
      A. Hamada, Y. Nakase, F. Obayashi, T. Fukutani, H. Nakatao, E. Sakaue , S. Yamasaki, T. Kanda, K. Koizumi, Y. Yoshioka, R. Tani , S. Toratani, JD. Sato, T. Okamoto
    • Organizer
      Annual Meeting of Society for In Vitro Biology Meeting (Tampa, Florida, USA)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Award Lecture, 2019 SIVB Lifetime Distinguished Achievement Award,2019

    • Author(s)
      Tetsuji Okamoto
    • Organizer
      Annual Meeting of Society for In Vitro Biology Meeting (Tampa, Florida, USA)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Microbiome related to oral cancer and Immunotherapy in oral cancer2019

    • Author(s)
      Tetsuji Okamoto
    • Organizer
      Invited lecture, Taipei Medical University Oct 21, 2019.
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Disease-specific Human iPSCs in Serum-, Integration- and Feeder-free Cultures,2019

    • Author(s)
      Tetsuji Okamoto
    • Organizer
      Tufts University School of Dental Medicine, Boston, 12 Nov, 2019.
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Examination and diagnosis based on oral and gut microbiome characteristic of oral cancer, and establishment and characterization of disease-specific induced pluripotent stem cells2018

    • Author(s)
      T.Okamoto
    • Organizer
      Symposium organized by the Japan Science Council co-sponsored by the Japan Oral Test Society
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Establishment and characterization of cranio-maxillofacial disease-specific induced pluripotent stem cells in feeder cell-, integration-, and serum-free defined culture2018

    • Author(s)
      T.Okamoto
    • Organizer
      Kuopio University School of Oral Medicine, Kuopio, Finland
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Examination and diagnosis based on oral and gut microbiome characteristic of oral cancer, and establishment and characterization of disease-specific induced pluripotent stem cells2018

    • Author(s)
      T. Okamoto
    • Organizer
      Taipei Medical University
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Establishment and characterization of radiation resistant strains from squamous cell carcinoma cell lines in serum-free defined culture2018

    • Author(s)
      Quang Nguyen, A. Hamada, S. Toratani, T. Okamoto
    • Organizer
      7th Hiroshima Conference on Education and Science in Dentistry, (Hiroshima)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic diagnosis of Neurofibromatosis type I (von Recklinghausen's disease, NF1) and establishment of NF1-specific induced pluripotent stem cells (iPSCs) for the study of disease mechanisms2018

    • Author(s)
      T. Fukutani, A. Hamada, H. Nakatao, F. Obayashi, S. Yamasaki, T. Kanda, K. Koizumi, S. Toratani, T. Okamoto
    • Organizer
      7th Hiroshima Conference on Education and Science in Dentistry, (Hiroshima)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Growth regulation by ED-71 of human squamous cell carcinoma cell lines through exosomal microRNA production in serum-free culture2018

    • Author(s)
      M.Higaki, T.Shintani , A.Hamada, S.N.Z. Rosli , E.Usui, T.Okamoto
    • Organizer
      7th Hiroshima Conference on Education and Science in Dentistry, (Hiroshima)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 海洋生物由来生理活性物質の探索研究2018

    • Author(s)
      吉岡幸男,濱田充子,中峠洋隆,小鹿 一,岡本哲治
    • Organizer
      第72回口腔科学会学術総会 , (愛知)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 活性型ビタミンD3誘導体ED-71によるexosomal microRNAを介した扁平上皮癌細胞の増殖制御2018

    • Author(s)
      檜垣美雷, 新谷智章, 濱田充子, S.N.Z. Rosli, 笛吹恵美子, 岡本哲治
    • Organizer
      第72回口腔科学会学術総会 , (愛知)
    • Related Report
      2018 Annual Research Report
  • [Presentation] レックリングハウゼン病由来iPS細胞のインテグレーションフリー・フィーダーフリー・無血清培養系での樹立による疾患研究2018

    • Author(s)
      福谷多恵子, 濱田充子, 中峠洋隆, 大林史誠,山崎佐知子, 神田 拓, 小泉浩一, 虎谷茂昭, 岡本哲治
    • Organizer
      第72回口腔科学会学術総会 , (愛知)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Establishment and characterization of radiation resistant strains from squamous cell carcinoma cell lines in serum-free defined culture2018

    • Author(s)
      Tam Quang NGUYEN, Atsuko HAMADA, Shigeaki TORATANI, Tetsuji OKAMOTO
    • Organizer
      第72回口腔科学会学術総会, (愛知)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 口腔癌患者におけるMICA遺伝子多型と臨床病態2018

    • Author(s)
      谷 亮治, 山崎佐知子, 松井健作, 濱田充子, 三島健史, 内迫香織, 笹原妃佐子, 虎谷茂昭, 岡本哲治
    • Organizer
      第72回日本口腔科学会学術総会, (愛知)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 口腔癌における免疫チェックポイント関連分子の発現と腸内ならびに口腔内細菌叢の影響研究2018

    • Author(s)
      松井健作,谷 亮治,山崎佐知子,濱田充子,三島健史,内迫香織,笹原妃佐子,虎谷茂昭,大友 剛,徳丸浩一郎,岡本哲治
    • Organizer
      第72回口腔科学会学術総会, (愛知)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 口腔癌患者における腸内ならびに口腔内細菌叢の多様性解析2018

    • Author(s)
      松井健作,山崎佐知子,濱田充子,三島健史,内迫香織,笹原妃佐子,虎谷茂昭,大友 剛,徳丸浩一郎,岡本哲治
    • Organizer
      第72回口腔科学会学術総会, (愛知)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 完全無血清・フィーダーフリー・ウイルスインテグレーションフリー培養系での疾患特異的iPS細胞の樹立と病態モデル研究第二報2018

    • Author(s)
      濱田充子,中瀬洋司,中峠洋隆,大林史誠,福谷多恵子,山崎佐知子,神田 拓,小泉浩一,虎谷茂昭,岡本哲治
    • Organizer
      第72回口腔科学会学術総会 , (愛知)
    • Related Report
      2018 Annual Research Report
  • [Book] 「歯科医師のための内科学」2021

    • Author(s)
      新谷智章、岡本哲治,(千葉俊美 編)
    • Total Pages
      297
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2020 Annual Research Report
  • [Book] 14歳からの生物学」学校では教えてくれない〈ヒト〉の科学2020

    • Author(s)
      松田良一 (監修, 翻訳)、岡本哲治 (監修, 翻訳)、サリーヒル (編集)
    • Total Pages
      234
    • Publisher
      白水社
    • ISBN
      9784560097748
    • Related Report
      2020 Annual Research Report
  • [Book] 口腔外科学 第4版2020

    • Author(s)
      白砂兼光・古郷幹彦 編著;良性腫瘍:岡本哲治、林堂安貴
    • Total Pages
      884
    • Publisher
      医歯薬出版
    • ISBN
      9784263458433
    • Related Report
      2019 Annual Research Report
  • [Book] 生きるための生物学2020

    • Author(s)
      サリー・ヒル 編/岡本哲治、松田良一 監訳
    • Total Pages
      240
    • Publisher
      白水社
    • ISBN
      9784560097748
    • Related Report
      2019 Annual Research Report
  • [Book] 最新歯科内科学「神経内科疾患の認知症、アルツハイマー型認知症」2020

    • Author(s)
      千葉 俊美 編、岡本哲治、新谷智章
    • Total Pages
      300
    • Publisher
      医歯薬出版
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 癌リスクの判定方法2018

    • Inventor(s)
      岡本哲治
    • Industrial Property Rights Holder
      岡本哲治
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 癌治療後に予後良好群に属するかを判定する方法、及び若年性癌発症リスク群に属するかを判定する方法2018

    • Inventor(s)
      岡本哲治
    • Industrial Property Rights Holder
      岡本哲治
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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